JP2018536686A5

JP2018536686A5 -

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Publication number: JP2018536686A5
Authority: JP; Japan
Prior art keywords: oxo; thia; dihydro; carboxamide; triazaacenaphthylene
Prior art date: 2016-12-09
Legal status : Granted

Application number

JP2018530000A

Other languages

English (en)

Japanese (ja)

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JP6835846B2 (ja

JP2018536686A (ja

Filing date

2016-12-09

Publication date

2019-11-07

2016-12-09 Application filed filed Critical

2016-12-09 Priority claimed from PCT/US2016/065954 external-priority patent/WO2017100662A1/en

2018-12-13 Publication of JP2018536686A publication Critical patent/JP2018536686A/ja

2019-11-07 Publication of JP2018536686A5 publication Critical patent/JP2018536686A5/ja

2021-02-24 Application granted granted Critical

2021-02-24 Publication of JP6835846B2 publication Critical patent/JP6835846B2/ja

Status Active legal-status Critical Current

2036-12-09 Anticipated expiration legal-status Critical

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-1 2 -cyclohexyl Chemical group 0.000 claims 57
150000001875 compounds Chemical class 0.000 claims 23
125000000217 alkyl group Chemical group 0.000 claims 22
125000004076 pyridyl group Chemical group 0.000 claims 12
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 8
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 8
150000003857 carboxamides Chemical class 0.000 claims 7
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 7
PPYVYZDICQYBLL-UHFFFAOYSA-N acenaphthylene-1-carboxamide Chemical compound C1=CC(C(C(=O)N)=C2)=C3C2=CC=CC3=C1 PPYVYZDICQYBLL-UHFFFAOYSA-N 0.000 claims 6
229910052739 hydrogen Inorganic materials 0.000 claims 6
150000003839 salts Chemical class 0.000 claims 6
125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 5
229910052799 carbon Inorganic materials 0.000 claims 5
229910052736 halogen Inorganic materials 0.000 claims 5
150000002367 halogens Chemical class 0.000 claims 5
125000001424 substituent group Chemical group 0.000 claims 5
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
125000002098 pyridazinyl group Chemical group 0.000 claims 4
125000000714 pyrimidinyl group Chemical group 0.000 claims 4
GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 3
KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 3
101150065749 Churc1 gene Proteins 0.000 claims 3
102100038239 Protein Churchill Human genes 0.000 claims 3
201000010099 disease Diseases 0.000 claims 3
230000000155 isotopic effect Effects 0.000 claims 3
238000000034 method Methods 0.000 claims 3
UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical compound OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 claims 3
ZGWFHMXPULDFEC-UHFFFAOYSA-N N-(2-hydroxycyclohexyl)-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound OC1C(CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C ZGWFHMXPULDFEC-UHFFFAOYSA-N 0.000 claims 2
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
230000000694 effects Effects 0.000 claims 2
230000001404 mediated effect Effects 0.000 claims 2
GQVWEKIMMYAKLO-UHFFFAOYSA-N 2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaene-3-carboxamide Chemical compound S1C(C2=NC=NC3=CC=NC1=C23)C(=O)N GQVWEKIMMYAKLO-UHFFFAOYSA-N 0.000 claims 1
YKBDBGSSFOHULY-SFHVURJKSA-N 3-[(3S)-3-(dimethylamino)pyrrolidine-1-carbonyl]-7-(2-methyl-4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraen-6-one Chemical compound CN([C@@H]1CN(CC1)C(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C)C YKBDBGSSFOHULY-SFHVURJKSA-N 0.000 claims 1
ZGPVHGYQTVWRIQ-KRWDZBQOSA-N 3-[(3S)-3-(methylamino)pyrrolidine-1-carbonyl]-7-(2-methyl-4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraen-6-one Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N1C[C@H](CC1)NC)=O ZGPVHGYQTVWRIQ-KRWDZBQOSA-N 0.000 claims 1
JQDXZJYAUSVHDH-UHFFFAOYSA-N 3-chloropropanamide Chemical compound NC(=O)CCCl JQDXZJYAUSVHDH-UHFFFAOYSA-N 0.000 claims 1
FGSAOLLJLDHZJT-UHFFFAOYSA-N 5-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound O(C1=CC=CC=C1)C1=CC=C(C=C1)N1C2=C(SC=3N=CC=C(NC1)C=32)C(=O)N FGSAOLLJLDHZJT-UHFFFAOYSA-N 0.000 claims 1
XVLIKCUEMWVBPD-RTBURBONSA-N 6-oxo-7-(2-phenoxypyrimidin-5-yl)-N-[(1R,2R)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=NC=1)OC1=CC=CC=C1 XVLIKCUEMWVBPD-RTBURBONSA-N 0.000 claims 1
CQFKEHASURJFEH-QZTJIDSGSA-N 6-oxo-7-(2-phenoxypyrimidin-5-yl)-N-[(1R,2R)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=NC=1)OC1=CC=CC=C1 CQFKEHASURJFEH-QZTJIDSGSA-N 0.000 claims 1
XVLIKCUEMWVBPD-RBUKOAKNSA-N 6-oxo-7-(2-phenoxypyrimidin-5-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=NC=1)OC1=CC=CC=C1 XVLIKCUEMWVBPD-RBUKOAKNSA-N 0.000 claims 1
CQFKEHASURJFEH-ZWKOTPCHSA-N 6-oxo-7-(2-phenoxypyrimidin-5-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=NC=1)OC1=CC=CC=C1 CQFKEHASURJFEH-ZWKOTPCHSA-N 0.000 claims 1
ZUWQTSFCVNBPBR-CVEARBPZSA-N 6-oxo-7-(2-phenoxypyrimidin-5-yl)-N-[(1S,3R)-3-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=NC=1)OC1=CC=CC=C1 ZUWQTSFCVNBPBR-CVEARBPZSA-N 0.000 claims 1
BVJBZAJSQKJWBL-WOJBJXKFSA-N 6-oxo-7-(2-phenylpyridin-4-yl)-N-[(1R,2R)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 BVJBZAJSQKJWBL-WOJBJXKFSA-N 0.000 claims 1
FPPWGACDNZMKGK-RTBURBONSA-N 6-oxo-7-(2-phenylpyridin-4-yl)-N-[(1R,2R)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 FPPWGACDNZMKGK-RTBURBONSA-N 0.000 claims 1
BVJBZAJSQKJWBL-VQTJNVASSA-N 6-oxo-7-(2-phenylpyridin-4-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 BVJBZAJSQKJWBL-VQTJNVASSA-N 0.000 claims 1
FPPWGACDNZMKGK-RBUKOAKNSA-N 6-oxo-7-(2-phenylpyridin-4-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 FPPWGACDNZMKGK-RBUKOAKNSA-N 0.000 claims 1
KRORFASSQTWHOT-RTBURBONSA-N 6-oxo-7-(2-phenylpyridin-4-yl)-N-[(1R,3R)-3-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 KRORFASSQTWHOT-RTBURBONSA-N 0.000 claims 1
CJEVONWGXKCHDU-QZTJIDSGSA-N 6-oxo-7-(2-phenylpyridin-4-yl)-N-[(1R,3R)-3-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1C[C@@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 CJEVONWGXKCHDU-QZTJIDSGSA-N 0.000 claims 1
KRORFASSQTWHOT-RBUKOAKNSA-N 6-oxo-7-(2-phenylpyridin-4-yl)-N-[(1R,3S)-3-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 KRORFASSQTWHOT-RBUKOAKNSA-N 0.000 claims 1
CJEVONWGXKCHDU-ZWKOTPCHSA-N 6-oxo-7-(2-phenylpyridin-4-yl)-N-[(1R,3S)-3-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1C[C@@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 CJEVONWGXKCHDU-ZWKOTPCHSA-N 0.000 claims 1
VRWRXDNYQADQCM-MOPGFXCFSA-N 6-oxo-7-(2-phenylpyridin-4-yl)-N-[(1S,2R)-2-(propanoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound O=C1NC2=C(SC=3N=CC=C(N1C1=CC(=NC=C1)C1=CC=CC=C1)C=32)C(=O)N[C@@H]1[C@@H](CCC1)NC(CC)=O VRWRXDNYQADQCM-MOPGFXCFSA-N 0.000 claims 1
KRORFASSQTWHOT-MOPGFXCFSA-N 6-oxo-7-(2-phenylpyridin-4-yl)-N-[(1S,3R)-3-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1C[C@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 KRORFASSQTWHOT-MOPGFXCFSA-N 0.000 claims 1
CJEVONWGXKCHDU-MSOLQXFVSA-N 6-oxo-7-(2-phenylpyridin-4-yl)-N-[(1S,3R)-3-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 CJEVONWGXKCHDU-MSOLQXFVSA-N 0.000 claims 1
KRORFASSQTWHOT-OALUTQOASA-N 6-oxo-7-(2-phenylpyridin-4-yl)-N-[(1S,3S)-3-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1C[C@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 KRORFASSQTWHOT-OALUTQOASA-N 0.000 claims 1
CJEVONWGXKCHDU-ROUUACIJSA-N 6-oxo-7-(2-phenylpyridin-4-yl)-N-[(1S,3S)-3-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 CJEVONWGXKCHDU-ROUUACIJSA-N 0.000 claims 1
UYORDUPFUBHQJU-HZPDHXFCSA-N 6-oxo-7-(2-propan-2-ylpyridin-4-yl)-N-[(1R,2R)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C(C)C UYORDUPFUBHQJU-HZPDHXFCSA-N 0.000 claims 1
UYORDUPFUBHQJU-JKSUJKDBSA-N 6-oxo-7-(2-propan-2-ylpyridin-4-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C(C)C UYORDUPFUBHQJU-JKSUJKDBSA-N 0.000 claims 1
OMHQGMOICBPRMI-FCHUYYIVSA-N 6-oxo-7-(3-phenylphenyl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1(=CC(=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1[C@H](CCCC1)NC(C=C)=O)=O)C1=CC=CC=C1 OMHQGMOICBPRMI-FCHUYYIVSA-N 0.000 claims 1
YEPZECYUHRUYES-LEWJYISDSA-N 6-oxo-7-(3-phenylphenyl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1(=CC(=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1[C@H](CCC1)NC(C=C)=O)=O)C1=CC=CC=C1 YEPZECYUHRUYES-LEWJYISDSA-N 0.000 claims 1
RYQXWGPPLUFSGK-RBUKOAKNSA-N 6-oxo-7-(4-phenylpyridin-2-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=CC(=C1)C1=CC=CC=C1 RYQXWGPPLUFSGK-RBUKOAKNSA-N 0.000 claims 1
YNTRPPAKXHOPQC-IAGOWNOFSA-N 6-oxo-7-(5-phenoxypyrazin-2-yl)-N-[(1R,2R)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(N=C1)OC1=CC=CC=C1 YNTRPPAKXHOPQC-IAGOWNOFSA-N 0.000 claims 1
UTHORYWCAZKPFF-ZWKOTPCHSA-N 6-oxo-7-(5-phenoxypyrazin-2-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(N=C1)OC1=CC=CC=C1 UTHORYWCAZKPFF-ZWKOTPCHSA-N 0.000 claims 1
YNTRPPAKXHOPQC-DLBZAZTESA-N 6-oxo-7-(5-phenoxypyrazin-2-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(N=C1)OC1=CC=CC=C1 YNTRPPAKXHOPQC-DLBZAZTESA-N 0.000 claims 1
QWIDKTQHPPJGTL-WOJBJXKFSA-N 6-oxo-7-(5-phenoxypyridin-2-yl)-N-[(1R,2R)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=C1)OC1=CC=CC=C1 QWIDKTQHPPJGTL-WOJBJXKFSA-N 0.000 claims 1
MWFIXLOMZIFJCH-RTBURBONSA-N 6-oxo-7-(5-phenoxypyridin-2-yl)-N-[(1R,2R)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=C1)OC1=CC=CC=C1 MWFIXLOMZIFJCH-RTBURBONSA-N 0.000 claims 1
QWIDKTQHPPJGTL-VQTJNVASSA-N 6-oxo-7-(5-phenoxypyridin-2-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=C1)OC1=CC=CC=C1 QWIDKTQHPPJGTL-VQTJNVASSA-N 0.000 claims 1
MWFIXLOMZIFJCH-RBUKOAKNSA-N 6-oxo-7-(5-phenoxypyridin-2-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=C1)OC1=CC=CC=C1 MWFIXLOMZIFJCH-RBUKOAKNSA-N 0.000 claims 1
YSXYNNJTXCWFBG-SJORKVTESA-N 6-oxo-7-(5-phenoxypyridin-2-yl)-N-[(1S,3R)-3-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=C1)OC1=CC=CC=C1 YSXYNNJTXCWFBG-SJORKVTESA-N 0.000 claims 1
YXWOWTHSPPWVAZ-UHFFFAOYSA-N 6-oxo-7-(5-phenoxypyridin-2-yl)-N-[3-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)NC1CC(CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=C1)OC1=CC=CC=C1 YXWOWTHSPPWVAZ-UHFFFAOYSA-N 0.000 claims 1
YSXYNNJTXCWFBG-UHFFFAOYSA-N 6-oxo-7-(5-phenoxypyridin-2-yl)-N-[3-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)NC1CC(CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=C1)OC1=CC=CC=C1 YSXYNNJTXCWFBG-UHFFFAOYSA-N 0.000 claims 1
QPRLLPPRAWRXQT-QZTJIDSGSA-N 6-oxo-7-(5-phenoxypyrimidin-2-yl)-N-[(1R,2R)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=N1)OC1=CC=CC=C1 QPRLLPPRAWRXQT-QZTJIDSGSA-N 0.000 claims 1
ZVJGHYBRRLOIMT-RBUKOAKNSA-N 6-oxo-7-(5-phenoxypyrimidin-2-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=N1)OC1=CC=CC=C1 ZVJGHYBRRLOIMT-RBUKOAKNSA-N 0.000 claims 1
QPRLLPPRAWRXQT-ZWKOTPCHSA-N 6-oxo-7-(5-phenoxypyrimidin-2-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=N1)OC1=CC=CC=C1 QPRLLPPRAWRXQT-ZWKOTPCHSA-N 0.000 claims 1
HRCMBDVJVKZUBC-ZWKOTPCHSA-N 6-oxo-7-(5-phenylpyridazin-3-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1N=NC=C(C=1)C1=CC=CC=C1 HRCMBDVJVKZUBC-ZWKOTPCHSA-N 0.000 claims 1
VWJDZBKSWDLOGD-VQTJNVASSA-N 6-oxo-7-(5-phenylpyridin-3-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC=C(C=1)C1=CC=CC=C1 VWJDZBKSWDLOGD-VQTJNVASSA-N 0.000 claims 1
IVZYJLFVEPEDSK-WOJBJXKFSA-N 6-oxo-7-(6-phenoxypyridin-3-yl)-N-[(1R,2R)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1)OC1=CC=CC=C1 IVZYJLFVEPEDSK-WOJBJXKFSA-N 0.000 claims 1
HWDLMKFCSUXPDJ-RTBURBONSA-N 6-oxo-7-(6-phenoxypyridin-3-yl)-N-[(1R,2R)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1)OC1=CC=CC=C1 HWDLMKFCSUXPDJ-RTBURBONSA-N 0.000 claims 1
IVZYJLFVEPEDSK-VQTJNVASSA-N 6-oxo-7-(6-phenoxypyridin-3-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1)OC1=CC=CC=C1 IVZYJLFVEPEDSK-VQTJNVASSA-N 0.000 claims 1
HWDLMKFCSUXPDJ-RBUKOAKNSA-N 6-oxo-7-(6-phenoxypyridin-3-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1)OC1=CC=CC=C1 HWDLMKFCSUXPDJ-RBUKOAKNSA-N 0.000 claims 1
CCJJLKVOAVLPCN-DLBZAZTESA-N 6-oxo-7-(6-phenoxypyridin-3-yl)-N-[(1R,3S)-3-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1C[C@@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1)OC1=CC=CC=C1 CCJJLKVOAVLPCN-DLBZAZTESA-N 0.000 claims 1
DYBHFNINALCOJE-ROUUACIJSA-N 6-oxo-7-(6-phenoxypyridin-3-yl)-N-[(1S,3S)-3-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1C[C@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1)OC1=CC=CC=C1 DYBHFNINALCOJE-ROUUACIJSA-N 0.000 claims 1
CCJJLKVOAVLPCN-UHFFFAOYSA-N 6-oxo-7-(6-phenoxypyridin-3-yl)-N-[3-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)NC1CC(CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1)OC1=CC=CC=C1 CCJJLKVOAVLPCN-UHFFFAOYSA-N 0.000 claims 1
OMAHGKITIOBWKH-ZWKOTPCHSA-N 6-oxo-7-(6-phenylpyridazin-4-yl)-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CN=NC(=C1)C1=CC=CC=C1 OMAHGKITIOBWKH-ZWKOTPCHSA-N 0.000 claims 1
PHJQLEDGCYUHHE-QZTJIDSGSA-N 6-oxo-N-[(1R,2R)-2-(prop-2-enoylamino)cyclopentyl]-7-(2-pyridin-2-ylpyridin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N1=C(C=C(C=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1[C@@H](CCC1)NC(C=C)=O)=O)C1=NC=CC=C1 PHJQLEDGCYUHHE-QZTJIDSGSA-N 0.000 claims 1
BLTPIVWKJWSXEJ-QZTJIDSGSA-N 6-oxo-N-[(1R,2R)-2-(prop-2-enoylamino)cyclopentyl]-7-(2-pyridin-3-ylpyridin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N1=C(C=C(C=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1[C@@H](CCC1)NC(C=C)=O)=O)C=1C=NC=CC=1 BLTPIVWKJWSXEJ-QZTJIDSGSA-N 0.000 claims 1
PHJQLEDGCYUHHE-ZWKOTPCHSA-N 6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-7-(2-pyridin-2-ylpyridin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N1=C(C=C(C=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1[C@H](CCC1)NC(C=C)=O)=O)C1=NC=CC=C1 PHJQLEDGCYUHHE-ZWKOTPCHSA-N 0.000 claims 1
BLTPIVWKJWSXEJ-ZWKOTPCHSA-N 6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-7-(2-pyridin-3-ylpyridin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N1=C(C=C(C=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1[C@H](CCC1)NC(C=C)=O)=O)C=1C=NC=CC=1 BLTPIVWKJWSXEJ-ZWKOTPCHSA-N 0.000 claims 1
SAXPRFARFGULJX-JKSUJKDBSA-N 6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-7-(5-pyridazin-3-yloxypyridin-2-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=C1)OC=1N=NC=CC=1 SAXPRFARFGULJX-JKSUJKDBSA-N 0.000 claims 1
VGOSGMOLJKYZLW-DLBZAZTESA-N 6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-7-(5-pyridin-2-yloxypyridin-2-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=C1)OC1=NC=CC=C1 VGOSGMOLJKYZLW-DLBZAZTESA-N 0.000 claims 1
ZFZDSKFHERYTNT-ZWKOTPCHSA-N 6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-7-(5-pyridin-3-yloxypyridin-2-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=C1)OC=1C=NC=CC=1 ZFZDSKFHERYTNT-ZWKOTPCHSA-N 0.000 claims 1
FFNHQAVGZRRILD-JKSUJKDBSA-N 6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-7-(5-pyrimidin-2-yloxypyridin-2-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=C1)OC1=NC=CC=N1 FFNHQAVGZRRILD-JKSUJKDBSA-N 0.000 claims 1
YDSCERZGYGDBJX-DLBZAZTESA-N 6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-7-(5-pyrimidin-5-yloxypyridin-2-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=C1)OC=1C=NC=NC=1 YDSCERZGYGDBJX-DLBZAZTESA-N 0.000 claims 1
PSCWTGORUCDDNV-IAGOWNOFSA-N 7-(2-cyclobutylpyridin-4-yl)-6-oxo-N-[(1R,2R)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1CCC1 PSCWTGORUCDDNV-IAGOWNOFSA-N 0.000 claims 1
PSCWTGORUCDDNV-DLBZAZTESA-N 7-(2-cyclobutylpyridin-4-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1CCC1 PSCWTGORUCDDNV-DLBZAZTESA-N 0.000 claims 1
MQUSJGYYIIAMIS-FGZHOGPDSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(1R,2R)-2-(propanoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1[C@@H](CCCC1)NC(CC)=O)=O MQUSJGYYIIAMIS-FGZHOGPDSA-N 0.000 claims 1
JUXWVTOZBUYJBD-NHCUHLMSSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(1R,2R)-2-(propanoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1[C@@H](CCC1)NC(CC)=O)=O JUXWVTOZBUYJBD-NHCUHLMSSA-N 0.000 claims 1
MQUSJGYYIIAMIS-FCHUYYIVSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(1R,2S)-2-(propanoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1[C@H](CCCC1)NC(CC)=O)=O MQUSJGYYIIAMIS-FCHUYYIVSA-N 0.000 claims 1
JUXWVTOZBUYJBD-LEWJYISDSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(1R,2S)-2-(propanoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1[C@H](CCC1)NC(CC)=O)=O JUXWVTOZBUYJBD-LEWJYISDSA-N 0.000 claims 1
AYJXOAOLPKBJSB-RTBURBONSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(1R,3R)-3-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1C[C@@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C AYJXOAOLPKBJSB-RTBURBONSA-N 0.000 claims 1
SBXKMQMRSLKALS-VQTJNVASSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(1R,3S)-3-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C SBXKMQMRSLKALS-VQTJNVASSA-N 0.000 claims 1
ZWTAFPNHNSTUJJ-YADHBBJMSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(1S,2R)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1[C@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C ZWTAFPNHNSTUJJ-YADHBBJMSA-N 0.000 claims 1
MGHYGYDMVWSPBS-RTWAWAEBSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(1S,2R)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1[C@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C MGHYGYDMVWSPBS-RTWAWAEBSA-N 0.000 claims 1
MQUSJGYYIIAMIS-YADHBBJMSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(1S,2R)-2-(propanoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@@H]1[C@@H](CCCC1)NC(CC)=O)=O MQUSJGYYIIAMIS-YADHBBJMSA-N 0.000 claims 1
JUXWVTOZBUYJBD-RTWAWAEBSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(1S,2R)-2-(propanoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@@H]1[C@@H](CCC1)NC(CC)=O)=O JUXWVTOZBUYJBD-RTWAWAEBSA-N 0.000 claims 1
MGHYGYDMVWSPBS-SFTDATJTSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(1S,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C MGHYGYDMVWSPBS-SFTDATJTSA-N 0.000 claims 1
MQUSJGYYIIAMIS-VXKWHMMOSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(1S,2S)-2-(propanoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@@H]1[C@H](CCCC1)NC(CC)=O)=O MQUSJGYYIIAMIS-VXKWHMMOSA-N 0.000 claims 1
JUXWVTOZBUYJBD-SFTDATJTSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(1S,2S)-2-(propanoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@@H]1[C@H](CCC1)NC(CC)=O)=O JUXWVTOZBUYJBD-SFTDATJTSA-N 0.000 claims 1
AYJXOAOLPKBJSB-MOPGFXCFSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(1S,3R)-3-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C AYJXOAOLPKBJSB-MOPGFXCFSA-N 0.000 claims 1
USJLLWWXTRSZFM-MOPGFXCFSA-N 7-(2-methyl-4-phenoxyphenyl)-6-oxo-N-[(1S,3R)-3-(propanoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@@H]1C[C@@H](CC1)NC(CC)=O)=O USJLLWWXTRSZFM-MOPGFXCFSA-N 0.000 claims 1
NPFWBEIFYAXDPP-SJORKVTESA-N 7-(2-methyl-4-propan-2-yloxyphenyl)-6-oxo-N-[(1S,3R)-3-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC(C)C)C NPFWBEIFYAXDPP-SJORKVTESA-N 0.000 claims 1
QQVJVVRVKUYSHK-RBUKOAKNSA-N 7-(2-methyl-4-pyridazin-3-yloxyphenyl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC=1N=NC=CC=1)C QQVJVVRVKUYSHK-RBUKOAKNSA-N 0.000 claims 1
OTRSFBJPGVKANY-ZWKOTPCHSA-N 7-(2-methyl-4-pyridazin-3-yloxyphenyl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC=1N=NC=CC=1)C OTRSFBJPGVKANY-ZWKOTPCHSA-N 0.000 claims 1
RNJLVHMFGICOOR-VQTJNVASSA-N 7-(2-methyl-4-pyridin-2-yloxyphenyl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=NC=CC=C1)C RNJLVHMFGICOOR-VQTJNVASSA-N 0.000 claims 1
GNCMPTKYSPOAPT-RBUKOAKNSA-N 7-(2-methyl-4-pyridin-2-yloxyphenyl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=NC=CC=C1)C GNCMPTKYSPOAPT-RBUKOAKNSA-N 0.000 claims 1
NTIAXSFVCRNXRL-VQTJNVASSA-N 7-(2-methyl-4-pyridin-3-yloxyphenyl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC=1C=NC=CC=1)C NTIAXSFVCRNXRL-VQTJNVASSA-N 0.000 claims 1
NHILMYFILIPFBJ-ZWKOTPCHSA-N 7-(2-methyl-4-pyrimidin-2-yloxyphenyl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=NC=CC=N1)C NHILMYFILIPFBJ-ZWKOTPCHSA-N 0.000 claims 1
YZCWVUBWUHQPHP-RBUKOAKNSA-N 7-(2-methyl-4-pyrimidin-5-yloxyphenyl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC=1C=NC=NC=1)C YZCWVUBWUHQPHP-RBUKOAKNSA-N 0.000 claims 1
RMPHJYPCBFKDTN-UHFFFAOYSA-N 7-(2-methyl-6-phenoxypyridin-3-yl)-6-oxo-N-[2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)NC1C(CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C(=NC(=CC=1)OC1=CC=CC=C1)C RMPHJYPCBFKDTN-UHFFFAOYSA-N 0.000 claims 1
WZCBHWNYAOHGJI-DLBZAZTESA-N 7-(2-methyl-6-propan-2-yloxypyridin-3-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C(=NC(=CC=1)OC(C)C)C WZCBHWNYAOHGJI-DLBZAZTESA-N 0.000 claims 1
IYAMVFYRDYMMIK-DLBZAZTESA-N 7-(2-methyl-6-pyridazin-3-yloxypyridin-3-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C(=NC(=CC=1)OC=1N=NC=CC=1)C IYAMVFYRDYMMIK-DLBZAZTESA-N 0.000 claims 1
FWDNGRUJDDDMIR-JKSUJKDBSA-N 7-(2-methyl-6-pyridazin-3-yloxypyridin-3-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C(=NC(=CC=1)OC=1N=NC=CC=1)C FWDNGRUJDDDMIR-JKSUJKDBSA-N 0.000 claims 1
NKNWYDAZXZWGII-DLBZAZTESA-N 7-(2-methyl-6-pyridin-2-yloxypyridin-3-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C(=NC(=CC=1)OC1=NC=CC=C1)C NKNWYDAZXZWGII-DLBZAZTESA-N 0.000 claims 1
SMHALHAOZNQSBR-ZWKOTPCHSA-N 7-(2-methyl-6-pyridin-3-yloxypyridin-3-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C(=NC(=CC=1)OC=1C=NC=CC=1)C SMHALHAOZNQSBR-ZWKOTPCHSA-N 0.000 claims 1
LFSVEMKSPMCOOH-DLBZAZTESA-N 7-(2-methyl-6-pyrimidin-5-yloxypyridin-3-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C(=NC(=CC=1)OC=1C=NC=NC=1)C LFSVEMKSPMCOOH-DLBZAZTESA-N 0.000 claims 1
IFORKKQWHSIMOT-XXGTVTCJSA-N 7-(3-chloro-4-phenoxyphenyl)-N-[(1S,3R)-3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]cyclopentyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound ClC=1C=C(C=CC=1OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@@H]1C[C@@H](CC1)NC(\C=C\CN(C)C)=O)=O IFORKKQWHSIMOT-XXGTVTCJSA-N 0.000 claims 1
XOMGBYWYISMHDI-DLBZAZTESA-N 7-(4-methyl-6-propan-2-yloxypyridin-3-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OC(C)C XOMGBYWYISMHDI-DLBZAZTESA-N 0.000 claims 1
MKDQWWFDVFCDLL-DLBZAZTESA-N 7-(4-methyl-6-pyridazin-3-yloxypyridin-3-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OC=1N=NC=CC=1 MKDQWWFDVFCDLL-DLBZAZTESA-N 0.000 claims 1
POFCLDIIOZEGFS-JKSUJKDBSA-N 7-(4-methyl-6-pyridazin-3-yloxypyridin-3-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OC=1N=NC=CC=1 POFCLDIIOZEGFS-JKSUJKDBSA-N 0.000 claims 1
BXQGRZDSHSBUER-DLBZAZTESA-N 7-(4-methyl-6-pyridin-2-yloxypyridin-3-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OC1=NC=CC=C1 BXQGRZDSHSBUER-DLBZAZTESA-N 0.000 claims 1
WAMLODOVSQCTNW-ZWKOTPCHSA-N 7-(4-methyl-6-pyridin-3-yloxypyridin-3-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OC=1C=NC=CC=1 WAMLODOVSQCTNW-ZWKOTPCHSA-N 0.000 claims 1
PEGCDRHHNBAKDY-JKSUJKDBSA-N 7-(4-methyl-6-pyrimidin-2-yloxypyridin-3-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OC1=NC=CC=N1 PEGCDRHHNBAKDY-JKSUJKDBSA-N 0.000 claims 1
YYQUCUXTLGSWIS-DLBZAZTESA-N 7-(4-methyl-6-pyrimidin-5-yloxypyridin-3-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OC=1C=NC=NC=1 YYQUCUXTLGSWIS-DLBZAZTESA-N 0.000 claims 1
TWBUIEYZGFQTFP-ZWKOTPCHSA-N 7-(6-cyclobutyloxy-2-methylpyridin-3-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C(=NC(=CC=1)OC1CCC1)C TWBUIEYZGFQTFP-ZWKOTPCHSA-N 0.000 claims 1
PPIYSEOEVNBRBL-ZWKOTPCHSA-N 7-(6-cyclobutyloxy-4-methylpyridin-3-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OC1CCC1 PPIYSEOEVNBRBL-ZWKOTPCHSA-N 0.000 claims 1
MBKQUWCTBAFNLA-RBUKOAKNSA-N 7-(6-cyclopentyloxy-4-methylpyridin-3-yl)-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OC1CCCC1 MBKQUWCTBAFNLA-RBUKOAKNSA-N 0.000 claims 1
QXJMDEJZGKMMJG-VQTJNVASSA-N 7-[2-methyl-4-(2-methylpyridin-3-yl)oxyphenyl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC=1C(=NC=CC=1)C)C QXJMDEJZGKMMJG-VQTJNVASSA-N 0.000 claims 1
VVHVOUFWNYZVNY-VQTJNVASSA-N 7-[2-methyl-4-(6-methylpyridin-2-yl)oxyphenyl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=NC(=CC=C1)C)C VVHVOUFWNYZVNY-VQTJNVASSA-N 0.000 claims 1
CJPXSYSUJSKQQH-LEWJYISDSA-N 7-[2-methyl-4-(6-methylpyridin-3-yl)oxyphenyl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC=1C=NC(=CC=1)C)C CJPXSYSUJSKQQH-LEWJYISDSA-N 0.000 claims 1
FMIBCOPWVWSWMB-VQTJNVASSA-N 7-[2-methyl-4-(oxan-4-yloxy)phenyl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1CCOCC1)C FMIBCOPWVWSWMB-VQTJNVASSA-N 0.000 claims 1
FHBXDAHQHQPREH-CEXWTWQISA-N 7-[2-methyl-4-[(3R)-oxolan-3-yl]oxyphenyl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)O[C@H]1COCC1)C FHBXDAHQHQPREH-CEXWTWQISA-N 0.000 claims 1
FHBXDAHQHQPREH-GBESFXJTSA-N 7-[2-methyl-4-[(3S)-oxolan-3-yl]oxyphenyl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)O[C@@H]1COCC1)C FHBXDAHQHQPREH-GBESFXJTSA-N 0.000 claims 1
PPCVYWJRXVZWIY-ZWKOTPCHSA-N 7-[2-methyl-6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C(=NC(=CC=1)OC=1C(=NC=CC=1)C)C PPCVYWJRXVZWIY-ZWKOTPCHSA-N 0.000 claims 1
MBBHAQKJGRFJRE-DLBZAZTESA-N 7-[2-methyl-6-(2-oxopyridin-1-yl)pyridin-3-yl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=CC(=NC=1C)N1C(C=CC=C1)=O MBBHAQKJGRFJRE-DLBZAZTESA-N 0.000 claims 1
PAIGAXAHPCOGJY-RBUKOAKNSA-N 7-[2-methyl-6-(6-methylpyridin-3-yl)oxypyridin-3-yl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C(=NC(=CC=1)OC=1C=NC(=CC=1)C)C PAIGAXAHPCOGJY-RBUKOAKNSA-N 0.000 claims 1
JHEAFISMWNWZIH-VQTJNVASSA-N 7-[4-(2-methylpyridin-3-yl)oxyphenyl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC=C(C=C1)OC=1C(=NC=CC=1)C JHEAFISMWNWZIH-VQTJNVASSA-N 0.000 claims 1
QFTIHUOWDQFSGA-VQTJNVASSA-N 7-[4-(6-methylpyridin-2-yl)oxyphenyl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC=C(C=C1)OC1=NC(=CC=C1)C QFTIHUOWDQFSGA-VQTJNVASSA-N 0.000 claims 1
ZYZHHKUZGDICRE-LEWJYISDSA-N 7-[4-(6-methylpyridin-3-yl)oxyphenyl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC=C(C=C1)OC=1C=NC(=CC=1)C ZYZHHKUZGDICRE-LEWJYISDSA-N 0.000 claims 1
VPZQYRUAFIBJFO-VQTJNVASSA-N 7-[4-(oxan-4-yloxy)phenyl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC=C(C=C1)OC1CCOCC1 VPZQYRUAFIBJFO-VQTJNVASSA-N 0.000 claims 1
ICJOTJPGHKXWMO-ZWKOTPCHSA-N 7-[4-methyl-6-(2-methylpropoxy)pyridin-3-yl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OCC(C)C ICJOTJPGHKXWMO-ZWKOTPCHSA-N 0.000 claims 1
QKHBPCSJUVRSHE-DLBZAZTESA-N 7-[4-methyl-6-(2-methylpropoxy)pyridin-3-yl]-6-oxo-N-[(1R,3S)-3-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1C[C@@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OCC(C)C QKHBPCSJUVRSHE-DLBZAZTESA-N 0.000 claims 1
ACFCTYVQWPVGDR-ZWKOTPCHSA-N 7-[4-methyl-6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OC=1C(=NC=CC=1)C ACFCTYVQWPVGDR-ZWKOTPCHSA-N 0.000 claims 1
QUQLXEDSAHSHRZ-ZWKOTPCHSA-N 7-[4-methyl-6-(6-methylpyridin-2-yl)oxypyridin-3-yl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OC1=NC(=CC=C1)C QUQLXEDSAHSHRZ-ZWKOTPCHSA-N 0.000 claims 1
QIMUGVPFDNFUPE-RBUKOAKNSA-N 7-[4-methyl-6-(6-methylpyridin-3-yl)oxypyridin-3-yl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OC=1C=NC(=CC=1)C QIMUGVPFDNFUPE-RBUKOAKNSA-N 0.000 claims 1
XBWLYQYHVTUOAS-JKSUJKDBSA-N 7-[4-methyl-6-(propan-2-ylamino)pyridin-3-yl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)NC(C)C XBWLYQYHVTUOAS-JKSUJKDBSA-N 0.000 claims 1
BAWCMBROASXGHG-ZWKOTPCHSA-N 7-[5-(2-methylpyridin-3-yl)oxypyridin-2-yl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=C1)OC=1C(=NC=CC=1)C BAWCMBROASXGHG-ZWKOTPCHSA-N 0.000 claims 1
MEMOBIHKPOZZRO-ZWKOTPCHSA-N 7-[5-(6-methylpyridin-2-yl)oxypyridin-2-yl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=C1)OC1=NC(=CC=C1)C MEMOBIHKPOZZRO-ZWKOTPCHSA-N 0.000 claims 1
HSORJRQTRJAUGC-RBUKOAKNSA-N 7-[5-(6-methylpyridin-3-yl)oxypyridin-2-yl]-6-oxo-N-[(1R,2S)-2-(prop-2-enoylamino)cyclopentyl]-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C=C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=C(C=C1)OC=1C=NC(=CC=1)C HSORJRQTRJAUGC-RBUKOAKNSA-N 0.000 claims 1
102000001714 Agammaglobulinaemia Tyrosine Kinase Human genes 0.000 claims 1
108010029445 Agammaglobulinaemia Tyrosine Kinase Proteins 0.000 claims 1
VBJUELWAGRIOKC-UHFFFAOYSA-N N-(3-aminocyclopentyl)-7-(4-methyl-6-phenoxypyridin-3-yl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound NC1CC(CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OC1=CC=CC=C1 VBJUELWAGRIOKC-UHFFFAOYSA-N 0.000 claims 1
TVHWNFSRMOKWOU-FYYLOGMGSA-N N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CN([C@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C)C TVHWNFSRMOKWOU-FYYLOGMGSA-N 0.000 claims 1
HIECXPCJFDWTBC-IFMALSPDSA-N N-[(1R,2R)-2-(dimethylamino)cyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CN([C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C)C HIECXPCJFDWTBC-IFMALSPDSA-N 0.000 claims 1
YYSNEJBUAMRHDX-WOJBJXKFSA-N N-[(1R,2R)-2-(methylamino)cyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1[C@@H](CCC1)NC)=O YYSNEJBUAMRHDX-WOJBJXKFSA-N 0.000 claims 1
JTOYEYNFXIKFEC-FGZHOGPDSA-N N-[(1R,2R)-2-acetamidocyclohexyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C)(=O)N[C@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C JTOYEYNFXIKFEC-FGZHOGPDSA-N 0.000 claims 1
WCGZILVSWSLCFZ-NHCUHLMSSA-N N-[(1R,2R)-2-acetamidocyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C)(=O)N[C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C WCGZILVSWSLCFZ-NHCUHLMSSA-N 0.000 claims 1
YXKRBSHHVJRXPO-QZTJIDSGSA-N N-[(1R,2R)-2-aminocyclohexyl]-6-oxo-7-(6-phenoxypyridin-3-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1)OC1=CC=CC=C1 YXKRBSHHVJRXPO-QZTJIDSGSA-N 0.000 claims 1
QJTFLTQNFXMDAR-WOJBJXKFSA-N N-[(1R,2R)-2-aminocyclohexyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C QJTFLTQNFXMDAR-WOJBJXKFSA-N 0.000 claims 1
PUZXOEYNXATBLP-ZIAGYGMSSA-N N-[(1R,2R)-2-aminocyclopentyl]-6-oxo-7-(2-propan-2-ylpyridin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C(C)C PUZXOEYNXATBLP-ZIAGYGMSSA-N 0.000 claims 1
VOFQMEUQEBMKBJ-IAGOWNOFSA-N N-[(1R,2R)-2-aminocyclopentyl]-6-oxo-7-(6-phenoxypyridin-3-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1)OC1=CC=CC=C1 VOFQMEUQEBMKBJ-IAGOWNOFSA-N 0.000 claims 1
MYMWOOGETWIZGF-RTBURBONSA-N N-[(1R,2R)-2-aminocyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C MYMWOOGETWIZGF-RTBURBONSA-N 0.000 claims 1
DQYUXLADHUMPNW-IAGOWNOFSA-N N-[(1R,2R)-2-aminocyclopentyl]-7-(4-methyl-6-phenoxypyridin-3-yl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1C)OC1=CC=CC=C1 DQYUXLADHUMPNW-IAGOWNOFSA-N 0.000 claims 1
XMJBYWMGKCAFQS-VQIMIIECSA-N N-[(1R,2R)-2-hydroxycyclopentyl]-6-oxo-7-(2-phenylpyridin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound O[C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 XMJBYWMGKCAFQS-VQIMIIECSA-N 0.000 claims 1
SWRCMICAZULUNE-UYAOXDASSA-N N-[(1R,2R)-2-hydroxycyclopentyl]-6-oxo-7-(3-phenylphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1(=CC(=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1[C@@H](CCC1)O)=O)C1=CC=CC=C1 SWRCMICAZULUNE-UYAOXDASSA-N 0.000 claims 1
QPEWQLTUJTWGHH-WIYYLYMNSA-N N-[(1R,2R)-2-hydroxycyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound O[C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C QPEWQLTUJTWGHH-WIYYLYMNSA-N 0.000 claims 1
KUVJOKBTRIPUPB-CRAIPNDOSA-N N-[(1R,2R)-2-hydroxycyclopentyl]-7-(2-methyl-4-propan-2-yloxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound O[C@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC(C)C)C KUVJOKBTRIPUPB-CRAIPNDOSA-N 0.000 claims 1
TVHWNFSRMOKWOU-GGAORHGYSA-N N-[(1R,2S)-2-(dimethylamino)cyclohexyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CN([C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C)C TVHWNFSRMOKWOU-GGAORHGYSA-N 0.000 claims 1
HIECXPCJFDWTBC-IRLDBZIGSA-N N-[(1R,2S)-2-(dimethylamino)cyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CN([C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C)C HIECXPCJFDWTBC-IRLDBZIGSA-N 0.000 claims 1
JTOYEYNFXIKFEC-FCHUYYIVSA-N N-[(1R,2S)-2-acetamidocyclohexyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C)(=O)N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C JTOYEYNFXIKFEC-FCHUYYIVSA-N 0.000 claims 1
WRUWXCKMYSTGSE-RBUKOAKNSA-N N-[(1R,2S)-2-acetamidocyclopentyl]-6-oxo-7-(2-phenylpyridin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 WRUWXCKMYSTGSE-RBUKOAKNSA-N 0.000 claims 1
WCGZILVSWSLCFZ-LEWJYISDSA-N N-[(1R,2S)-2-acetamidocyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C)(=O)N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C WCGZILVSWSLCFZ-LEWJYISDSA-N 0.000 claims 1
NGWGZNHDNXXMBD-ZWKOTPCHSA-N N-[(1R,2S)-2-aminocyclohexyl]-6-oxo-7-(2-phenylpyridin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 NGWGZNHDNXXMBD-ZWKOTPCHSA-N 0.000 claims 1
AETMFQTWQRNOMK-VQTJNVASSA-N N-[(1R,2S)-2-aminocyclohexyl]-6-oxo-7-(3-phenylphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1(=CC(=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1[C@H](CCCC1)N)=O)C1=CC=CC=C1 AETMFQTWQRNOMK-VQTJNVASSA-N 0.000 claims 1
YXKRBSHHVJRXPO-ZWKOTPCHSA-N N-[(1R,2S)-2-aminocyclohexyl]-6-oxo-7-(6-phenoxypyridin-3-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1)OC1=CC=CC=C1 YXKRBSHHVJRXPO-ZWKOTPCHSA-N 0.000 claims 1
QJTFLTQNFXMDAR-VQTJNVASSA-N N-[(1R,2S)-2-aminocyclohexyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C QJTFLTQNFXMDAR-VQTJNVASSA-N 0.000 claims 1
BISPZPOXGBQRKF-DLBZAZTESA-N N-[(1R,2S)-2-aminocyclohexyl]-7-(2-methyl-4-propan-2-yloxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC(C)C)C BISPZPOXGBQRKF-DLBZAZTESA-N 0.000 claims 1
UAOMYRPARFKEHJ-RBUKOAKNSA-N N-[(1R,2S)-2-aminocyclohexyl]-7-(3-chloro-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=C(C=C1)OC1=CC=CC=C1)Cl UAOMYRPARFKEHJ-RBUKOAKNSA-N 0.000 claims 1
DRCJKARREHPPHK-DLBZAZTESA-N N-[(1R,2S)-2-aminocyclopentyl]-6-oxo-7-(2-phenylpyridin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 DRCJKARREHPPHK-DLBZAZTESA-N 0.000 claims 1
PUZXOEYNXATBLP-UONOGXRCSA-N N-[(1R,2S)-2-aminocyclopentyl]-6-oxo-7-(2-propan-2-ylpyridin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C(C)C PUZXOEYNXATBLP-UONOGXRCSA-N 0.000 claims 1
VYWPCABUKKZTRF-RBUKOAKNSA-N N-[(1R,2S)-2-aminocyclopentyl]-6-oxo-7-(3-phenylphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1(=CC(=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1[C@H](CCC1)N)=O)C1=CC=CC=C1 VYWPCABUKKZTRF-RBUKOAKNSA-N 0.000 claims 1
MTMKTNDMMOBQJQ-DLBZAZTESA-N N-[(1R,2S)-2-aminocyclopentyl]-6-oxo-7-(4-phenylpyridin-2-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=CC(=C1)C1=CC=CC=C1 MTMKTNDMMOBQJQ-DLBZAZTESA-N 0.000 claims 1
MRSNNUOSMKEUKC-JKSUJKDBSA-N N-[(1R,2S)-2-aminocyclopentyl]-6-oxo-7-(5-phenylpyridazin-3-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1N=NC=C(C=1)C1=CC=CC=C1 MRSNNUOSMKEUKC-JKSUJKDBSA-N 0.000 claims 1
KXKSZAWSLYVIQL-ZWKOTPCHSA-N N-[(1R,2S)-2-aminocyclopentyl]-6-oxo-7-(5-phenylpyridin-3-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC=C(C=1)C1=CC=CC=C1 KXKSZAWSLYVIQL-ZWKOTPCHSA-N 0.000 claims 1
VOFQMEUQEBMKBJ-DLBZAZTESA-N N-[(1R,2S)-2-aminocyclopentyl]-6-oxo-7-(6-phenoxypyridin-3-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1)OC1=CC=CC=C1 VOFQMEUQEBMKBJ-DLBZAZTESA-N 0.000 claims 1
NSMSDQLCXWDLCO-JKSUJKDBSA-N N-[(1R,2S)-2-aminocyclopentyl]-6-oxo-7-(6-phenylpyridazin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CN=NC(=C1)C1=CC=CC=C1 NSMSDQLCXWDLCO-JKSUJKDBSA-N 0.000 claims 1
YUGLIFZTPOZTDJ-LSDHHAIUSA-N N-[(1R,2S)-2-aminocyclopentyl]-6-oxo-7-(6-phenylpyrimidin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=NC=NC(=C1)C1=CC=CC=C1 YUGLIFZTPOZTDJ-LSDHHAIUSA-N 0.000 claims 1
MYMWOOGETWIZGF-RBUKOAKNSA-N N-[(1R,2S)-2-aminocyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C MYMWOOGETWIZGF-RBUKOAKNSA-N 0.000 claims 1
JNODEEBHVYOKLR-JKSUJKDBSA-N N-[(1R,2S)-2-aminocyclopentyl]-7-(2-methyl-4-propan-2-yloxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC(C)C)C JNODEEBHVYOKLR-JKSUJKDBSA-N 0.000 claims 1
HCUQITXEGWKLRT-ZWKOTPCHSA-N N-[(1R,2S)-2-aminocyclopentyl]-7-[2-methyl-4-(oxan-4-yloxy)phenyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1CCOCC1)C HCUQITXEGWKLRT-ZWKOTPCHSA-N 0.000 claims 1
FVUXWDRNBBIXDR-ZWKOTPCHSA-N N-[(1R,2S)-2-aminocyclopentyl]-7-[4-(oxan-4-yloxy)phenyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC=C(C=C1)OC1CCOCC1 FVUXWDRNBBIXDR-ZWKOTPCHSA-N 0.000 claims 1
QPEWQLTUJTWGHH-NQIIRXRSSA-N N-[(1R,2S)-2-hydroxycyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound O[C@@H]1[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C QPEWQLTUJTWGHH-NQIIRXRSSA-N 0.000 claims 1
UMJICMCUYGGUAU-QZTJIDSGSA-N N-[(1R,3R)-3-[(2-aminoacetyl)amino]cyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound NCC(=O)N[C@H]1C[C@@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C UMJICMCUYGGUAU-QZTJIDSGSA-N 0.000 claims 1
OSUMLSRVTSSXLP-WOJBJXKFSA-N N-[(1R,3R)-3-[[2-(dimethylamino)acetyl]amino]cyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CN(CC(=O)N[C@H]1C[C@@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C)C OSUMLSRVTSSXLP-WOJBJXKFSA-N 0.000 claims 1
USMFSTVOXMVHFX-RTBURBONSA-N N-[(1R,3R)-3-[[2-(methylamino)acetyl]amino]cyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@H]1C[C@@H](CC1)NC(CNC)=O)=O USMFSTVOXMVHFX-RTBURBONSA-N 0.000 claims 1
QKDQQSPCWJSKKI-RTBURBONSA-N N-[(1R,3R)-3-acetamidocyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C)(=O)N[C@H]1C[C@@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C QKDQQSPCWJSKKI-RTBURBONSA-N 0.000 claims 1
RNQPBWKBJRDZHV-QZTJIDSGSA-N N-[(1R,3R)-3-aminocyclohexyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@H]1C[C@@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C RNQPBWKBJRDZHV-QZTJIDSGSA-N 0.000 claims 1
PFRKGWWVHOFTRB-IAGOWNOFSA-N N-[(1R,3R)-3-aminocyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@H]1C[C@@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C PFRKGWWVHOFTRB-IAGOWNOFSA-N 0.000 claims 1
CGUIMACFWLXECS-ZVAWYAOSSA-N N-[(1S)-3-(methylamino)cyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@@H]1CC(CC1)NC)=O CGUIMACFWLXECS-ZVAWYAOSSA-N 0.000 claims 1
TVHWNFSRMOKWOU-JTHBVZDNSA-N N-[(1S,2R)-2-(dimethylamino)cyclohexyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CN([C@H]1[C@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C)C TVHWNFSRMOKWOU-JTHBVZDNSA-N 0.000 claims 1
HIECXPCJFDWTBC-RBBKRZOGSA-N N-[(1S,2R)-2-(dimethylamino)cyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CN([C@H]1[C@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C)C HIECXPCJFDWTBC-RBBKRZOGSA-N 0.000 claims 1
TYVGREKRBPWXDB-RTWAWAEBSA-N N-[(1S,2R)-2-(methylamino)cyclohexyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@@H]1[C@@H](CCCC1)NC)=O TYVGREKRBPWXDB-RTWAWAEBSA-N 0.000 claims 1
BGYLRPUSLSNGJI-MOPGFXCFSA-N N-[(1S,2R)-2-[[2-(methylamino)acetyl]amino]cyclopentyl]-6-oxo-7-(2-phenylpyridin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CNCC(=O)N[C@H]1[C@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 BGYLRPUSLSNGJI-MOPGFXCFSA-N 0.000 claims 1
JTOYEYNFXIKFEC-YADHBBJMSA-N N-[(1S,2R)-2-acetamidocyclohexyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C)(=O)N[C@H]1[C@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C JTOYEYNFXIKFEC-YADHBBJMSA-N 0.000 claims 1
WRUWXCKMYSTGSE-MOPGFXCFSA-N N-[(1S,2R)-2-acetamidocyclopentyl]-6-oxo-7-(2-phenylpyridin-4-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C)(=O)N[C@H]1[C@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC(=NC=C1)C1=CC=CC=C1 WRUWXCKMYSTGSE-MOPGFXCFSA-N 0.000 claims 1
WCGZILVSWSLCFZ-RTWAWAEBSA-N N-[(1S,2R)-2-acetamidocyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C)(=O)N[C@H]1[C@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C WCGZILVSWSLCFZ-RTWAWAEBSA-N 0.000 claims 1
QJTFLTQNFXMDAR-UXHICEINSA-N N-[(1S,2R)-2-aminocyclohexyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@H]1[C@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C QJTFLTQNFXMDAR-UXHICEINSA-N 0.000 claims 1
MYMWOOGETWIZGF-MOPGFXCFSA-N N-[(1S,2R)-2-aminocyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@H]1[C@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C MYMWOOGETWIZGF-MOPGFXCFSA-N 0.000 claims 1
QPEWQLTUJTWGHH-GHTZIAJQSA-N N-[(1S,2R)-2-hydroxycyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound O[C@H]1[C@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C QPEWQLTUJTWGHH-GHTZIAJQSA-N 0.000 claims 1
TVHWNFSRMOKWOU-GMAHTHKFSA-N N-[(1S,2S)-2-(dimethylamino)cyclohexyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CN([C@@H]1[C@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C)C TVHWNFSRMOKWOU-GMAHTHKFSA-N 0.000 claims 1
HIECXPCJFDWTBC-UNMCSNQZSA-N N-[(1S,2S)-2-(dimethylamino)cyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CN([C@@H]1[C@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C)C HIECXPCJFDWTBC-UNMCSNQZSA-N 0.000 claims 1
YYSNEJBUAMRHDX-PMACEKPBSA-N N-[(1S,2S)-2-(methylamino)cyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@@H]1[C@H](CCC1)NC)=O YYSNEJBUAMRHDX-PMACEKPBSA-N 0.000 claims 1
JTOYEYNFXIKFEC-VXKWHMMOSA-N N-[(1S,2S)-2-acetamidocyclohexyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C)(=O)N[C@@H]1[C@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C JTOYEYNFXIKFEC-VXKWHMMOSA-N 0.000 claims 1
WCGZILVSWSLCFZ-SFTDATJTSA-N N-[(1S,2S)-2-acetamidocyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C)(=O)N[C@@H]1[C@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C WCGZILVSWSLCFZ-SFTDATJTSA-N 0.000 claims 1
QJTFLTQNFXMDAR-PMACEKPBSA-N N-[(1S,2S)-2-aminocyclohexyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C QJTFLTQNFXMDAR-PMACEKPBSA-N 0.000 claims 1
MYMWOOGETWIZGF-OALUTQOASA-N N-[(1S,2S)-2-aminocyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1[C@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C MYMWOOGETWIZGF-OALUTQOASA-N 0.000 claims 1
UIMRCMQQPKWLNS-SFTDATJTSA-N N-[(1S,2S)-2-formamidocyclohexyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(=O)N[C@@H]1[C@H](CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C UIMRCMQQPKWLNS-SFTDATJTSA-N 0.000 claims 1
QPEWQLTUJTWGHH-RXVVDRJESA-N N-[(1S,2S)-2-hydroxycyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound O[C@@H]1[C@H](CCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C QPEWQLTUJTWGHH-RXVVDRJESA-N 0.000 claims 1
DIVYUVPAVPSHIL-RBUKOAKNSA-N N-[(1S,3R)-3-(dimethylamino)cyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CN([C@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C)C DIVYUVPAVPSHIL-RBUKOAKNSA-N 0.000 claims 1
UMJICMCUYGGUAU-MSOLQXFVSA-N N-[(1S,3R)-3-[(2-aminoacetyl)amino]cyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound NCC(=O)N[C@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C UMJICMCUYGGUAU-MSOLQXFVSA-N 0.000 claims 1
OSUMLSRVTSSXLP-UXHICEINSA-N N-[(1S,3R)-3-[[2-(dimethylamino)acetyl]amino]cyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CN(CC(=O)N[C@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C)C OSUMLSRVTSSXLP-UXHICEINSA-N 0.000 claims 1
KPIDYSBMPYQGHT-MSOLQXFVSA-N N-[(1S,3R)-3-[[2-(dimethylamino)acetyl]amino]cyclopentyl]-7-(2-methyl-4-propan-2-yloxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CN(CC(=O)N[C@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC(C)C)C)C KPIDYSBMPYQGHT-MSOLQXFVSA-N 0.000 claims 1
USMFSTVOXMVHFX-MOPGFXCFSA-N N-[(1S,3R)-3-[[2-(methylamino)acetyl]amino]cyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@@H]1C[C@@H](CC1)NC(CNC)=O)=O USMFSTVOXMVHFX-MOPGFXCFSA-N 0.000 claims 1
QCPHYNCAKBFILR-SJORKVTESA-N N-[(1S,3R)-3-[[2-(methylamino)acetyl]amino]cyclopentyl]-7-(2-methyl-4-propan-2-yloxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C)(C)OC1=CC(=C(C=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@@H]1C[C@@H](CC1)NC(CNC)=O)=O)C QCPHYNCAKBFILR-SJORKVTESA-N 0.000 claims 1
QKDQQSPCWJSKKI-MOPGFXCFSA-N N-[(1S,3R)-3-acetamidocyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C)(=O)N[C@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C QKDQQSPCWJSKKI-MOPGFXCFSA-N 0.000 claims 1
BQUWXSQUPDEQGK-SJORKVTESA-N N-[(1S,3R)-3-acetamidocyclopentyl]-7-(2-methyl-4-propan-2-yloxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C(C)(=O)N[C@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC(C)C)C BQUWXSQUPDEQGK-SJORKVTESA-N 0.000 claims 1
PFRKGWWVHOFTRB-SJORKVTESA-N N-[(1S,3R)-3-aminocyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C PFRKGWWVHOFTRB-SJORKVTESA-N 0.000 claims 1
UKXVVRFPXSAXMH-DLBZAZTESA-N N-[(1S,3R)-3-hydroxycyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound O[C@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C UKXVVRFPXSAXMH-DLBZAZTESA-N 0.000 claims 1
OSUMLSRVTSSXLP-PMACEKPBSA-N N-[(1S,3S)-3-[[2-(dimethylamino)acetyl]amino]cyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CN(CC(=O)N[C@@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C)C OSUMLSRVTSSXLP-PMACEKPBSA-N 0.000 claims 1
USMFSTVOXMVHFX-OALUTQOASA-N N-[(1S,3S)-3-[[2-(methylamino)acetyl]amino]cyclopentyl]-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N[C@@H]1C[C@H](CC1)NC(CNC)=O)=O USMFSTVOXMVHFX-OALUTQOASA-N 0.000 claims 1
JUCSVRAQCKHXFG-HOTGVXAUSA-N N-[(1S,3S)-3-aminocyclopentyl]-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC=C(C=C1)OC1=CC=CC=C1 JUCSVRAQCKHXFG-HOTGVXAUSA-N 0.000 claims 1
GAXQQEKGURKNTM-GJZGRUSLSA-N N-[(1S,3S)-3-aminocyclopentyl]-6-oxo-7-(6-phenoxypyridin-3-yl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound N[C@@H]1C[C@H](CC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C=1C=NC(=CC=1)OC1=CC=CC=C1 GAXQQEKGURKNTM-GJZGRUSLSA-N 0.000 claims 1
QPCDBWBWHQWEAP-GOSISDBHSA-N N-[(3R)-1-[7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carbonyl]pyrrolidin-3-yl]prop-2-enamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N1C[C@@H](CC1)NC(C=C)=O)=O QPCDBWBWHQWEAP-GOSISDBHSA-N 0.000 claims 1
RXSMILWNUXLXDP-SFHVURJKSA-N N-[(3S)-1-[7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carbonyl]pyrrolidin-3-yl]acetamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N1C[C@H](CC1)NC(C)=O)=O RXSMILWNUXLXDP-SFHVURJKSA-N 0.000 claims 1
QPCDBWBWHQWEAP-SFHVURJKSA-N N-[(3S)-1-[7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carbonyl]pyrrolidin-3-yl]prop-2-enamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N1C[C@H](CC1)NC(C=C)=O)=O QPCDBWBWHQWEAP-SFHVURJKSA-N 0.000 claims 1
HWFKNHKOUFSXEN-SFHVURJKSA-N N-[(3S)-1-[7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carbonyl]pyrrolidin-3-yl]propanamide Chemical compound CC1=C(C=CC(=C1)OC1=CC=CC=C1)N1C(NC2=C(SC=3N=CC=C1C=32)C(=O)N1C[C@H](CC1)NC(CC)=O)=O HWFKNHKOUFSXEN-SFHVURJKSA-N 0.000 claims 1
GWSCLQUVDADIIX-UHFFFAOYSA-N N-[7-[4-[3-[(2-cyanophenoxy)methyl]phenoxy]-2-methylphenyl]-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraen-3-yl]cyclopropanecarboxamide Chemical compound C(#N)C1=C(OCC=2C=C(OC3=CC(=C(C=C3)N3C(NC4=C(SC=5N=CC=C3C=54)NC(=O)C3CC3)=O)C)C=CC=2)C=CC=C1 GWSCLQUVDADIIX-UHFFFAOYSA-N 0.000 claims 1
UGZXMZHPCOUFDZ-UHFFFAOYSA-N N-cyclohexyl-6-oxo-7-(4-phenoxyphenyl)-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1(CCCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=CC=C(C=C1)OC1=CC=CC=C1 UGZXMZHPCOUFDZ-UHFFFAOYSA-N 0.000 claims 1
TYIIQNFWTXASHR-UHFFFAOYSA-N N-cyclohexyl-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1(CCCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C TYIIQNFWTXASHR-UHFFFAOYSA-N 0.000 claims 1
WVMZGDFZTWXGNK-UHFFFAOYSA-N N-cyclopentyl-7-(2-methyl-4-phenoxyphenyl)-6-oxo-2-thia-5,7,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraene-3-carboxamide Chemical compound C1(CCCC1)NC(=O)C=1SC=2N=CC=C3N(C(NC=1C=23)=O)C1=C(C=C(C=C1)OC1=CC=CC=C1)C WVMZGDFZTWXGNK-UHFFFAOYSA-N 0.000 claims 1
102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 1
108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
229960002685 biotin Drugs 0.000 claims 1
239000011616 biotin Substances 0.000 claims 1
125000000753 cycloalkyl group Chemical group 0.000 claims 1
208000035475 disorder Diseases 0.000 claims 1
125000001188 haloalkyl group Chemical group 0.000 claims 1
125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
229910052757 nitrogen Inorganic materials 0.000 claims 1
125000004433 nitrogen atom Chemical group N* 0.000 claims 1
229910052760 oxygen Inorganic materials 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
239000000546 pharmaceutical excipient Substances 0.000 claims 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
125000003373 pyrazinyl group Chemical group 0.000 claims 1
125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
206010039073 rheumatoid arthritis Diseases 0.000 claims 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1

JP2018530000A 2015-12-10 2016-12-09 ブルトン型チロシンキナーゼの阻害剤としての多環式化合物 Active JP6835846B2 (ja)