JP2018536635A5 - - Google Patents
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- Publication number
- JP2018536635A5 JP2018536635A5 JP2018519271A JP2018519271A JP2018536635A5 JP 2018536635 A5 JP2018536635 A5 JP 2018536635A5 JP 2018519271 A JP2018519271 A JP 2018519271A JP 2018519271 A JP2018519271 A JP 2018519271A JP 2018536635 A5 JP2018536635 A5 JP 2018536635A5
- Authority
- JP
- Japan
- Prior art keywords
- monocyclic
- alkyl
- bicyclic
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)(C)NC(C)=*C Chemical compound CC(C)(C)NC(C)=*C 0.000 description 11
- ZWGJMQYWUXPQLZ-DCCUJTHKSA-N CC(C)(C)NC(C[C@@H](C(NCCNC(c1cccc(N(CCN2)C2O)c1)=O)=O)NS(c1ccc(C)cc1)(OC)=O)=O Chemical compound CC(C)(C)NC(C[C@@H](C(NCCNC(c1cccc(N(CCN2)C2O)c1)=O)=O)NS(c1ccc(C)cc1)(OC)=O)=O ZWGJMQYWUXPQLZ-DCCUJTHKSA-N 0.000 description 1
- CUZZVRKUMNZZAY-UHFFFAOYSA-N CCNC(CCc1ccccc1)=O Chemical compound CCNC(CCc1ccccc1)=O CUZZVRKUMNZZAY-UHFFFAOYSA-N 0.000 description 1
- LWQOVYRRTZOORP-KRWDZBQOSA-N C[C@@H](C(NCCNC(c(cc(cc1)-c(cccc2)c2F)c1F)=O)=O)NS(c1ccc(C)cc1)(=O)=O Chemical compound C[C@@H](C(NCCNC(c(cc(cc1)-c(cccc2)c2F)c1F)=O)=O)NS(c1ccc(C)cc1)(=O)=O LWQOVYRRTZOORP-KRWDZBQOSA-N 0.000 description 1
- PLGIBZPNZIMODY-UHFFFAOYSA-N C[U](c1ccccc1)(=O)=O Chemical compound C[U](c1ccccc1)(=O)=O PLGIBZPNZIMODY-UHFFFAOYSA-N 0.000 description 1
- FMGKTESWMWOJSZ-UHFFFAOYSA-N Cc(cc1)ccc1S(NCC(NCCNC(c(cccc1)c1O)=O)=O)(=O)=O Chemical compound Cc(cc1)ccc1S(NCC(NCCNC(c(cccc1)c1O)=O)=O)(=O)=O FMGKTESWMWOJSZ-UHFFFAOYSA-N 0.000 description 1
- ZRYKTFJQWMHYMN-UHFFFAOYSA-N O=C(CNS(C1CC1)(=O)=O)NCCNC(c(cc(cc1)-c(cccc2)c2F)c1F)=O Chemical compound O=C(CNS(C1CC1)(=O)=O)NCCNC(c(cc(cc1)-c(cccc2)c2F)c1F)=O ZRYKTFJQWMHYMN-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021176164A JP7379441B2 (ja) | 2015-10-15 | 2021-10-28 | プロテアソーム阻害剤およびその用途 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562242139P | 2015-10-15 | 2015-10-15 | |
| US62/242,139 | 2015-10-15 | ||
| PCT/US2016/057346 WO2017066763A1 (en) | 2015-10-15 | 2016-10-17 | Proteasome inhibitors and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021176164A Division JP7379441B2 (ja) | 2015-10-15 | 2021-10-28 | プロテアソーム阻害剤およびその用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018536635A JP2018536635A (ja) | 2018-12-13 |
| JP2018536635A5 true JP2018536635A5 (https=) | 2019-11-21 |
| JP6970085B2 JP6970085B2 (ja) | 2021-11-24 |
Family
ID=58518357
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018519271A Active JP6970085B2 (ja) | 2015-10-15 | 2016-10-17 | プロテアソーム阻害剤およびその用途 |
| JP2021176164A Active JP7379441B2 (ja) | 2015-10-15 | 2021-10-28 | プロテアソーム阻害剤およびその用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021176164A Active JP7379441B2 (ja) | 2015-10-15 | 2021-10-28 | プロテアソーム阻害剤およびその用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11066397B2 (https=) |
| EP (2) | EP4006012A1 (https=) |
| JP (2) | JP6970085B2 (https=) |
| KR (1) | KR102764027B1 (https=) |
| CN (2) | CN114306297A (https=) |
| ES (1) | ES2905008T3 (https=) |
| WO (1) | WO2017066763A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2748434T3 (es) | 2014-01-10 | 2020-03-16 | Univ Cornell | Dipéptidos como inhibidores de inmunoproteasomas humanos |
| EP3193904B1 (en) | 2014-08-18 | 2025-10-01 | Cornell University | Dipeptidomimetics as inhibitors of human immunoproteasomes |
| KR102764027B1 (ko) | 2015-10-15 | 2025-02-07 | 코넬 유니버시티 | 프로테아좀 억제제 및 이의 용도 |
| US11357817B2 (en) * | 2017-05-15 | 2022-06-14 | The Regents Of The University Of California | Immunoproteasome inhibitor |
| US11834515B2 (en) | 2017-10-11 | 2023-12-05 | Cornell University | Macrocyclic compounds as proteasome inhibitors |
| EP3694605A4 (en) | 2017-10-11 | 2021-10-27 | Cornell University | PEPTIDOMIMETIC PROTEASOME INHIBITORS |
| EP3674288A1 (en) * | 2018-12-31 | 2020-07-01 | MMV Medicines for Malaria Venture | Pantothenamide analogues |
| WO2022150962A1 (en) * | 2021-01-12 | 2022-07-21 | Westlake Pharmaceutical (Hangzhou) Co., Ltd. | Protease inhibitors, preparation, and uses thereof |
| US20240358735A1 (en) * | 2021-08-27 | 2024-10-31 | Boyce Thompson Institute For Plant Research, Inc. | Therapeutic compositions and related methods |
| EP4155296A1 (en) * | 2021-09-24 | 2023-03-29 | Lead Discovery Center GmbH | Macrocyclic compounds as proteasome subunit beta type-5 inhibitors |
| WO2024182664A1 (en) * | 2023-03-01 | 2024-09-06 | Boyce Thompson Institute For Plant Research, Inc. | Modified rna compositions and related methods |
| WO2026041079A1 (zh) * | 2024-08-23 | 2026-02-26 | 江苏正大清江制药有限公司 | 肽环氧酮类化合物及其制备方法和应用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW223629B (https=) | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
| US7001921B1 (en) | 1995-01-23 | 2006-02-21 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
| AR011515A1 (es) | 1996-12-25 | 2000-08-30 | Agrogene Ltd | Derivado del acido aminobutirico para la proteccion de plantas de enfermedades fungosas y un metodo para proteger un cultivo contra enfermedadesfungosas por ejemplo tomates y papas contra el tizon tardio o temprano, cereales contra el mildiu polvoroso, y pepino, vides, melones contra el mildiu |
| EP1335898B1 (en) | 2000-09-29 | 2005-11-23 | TopoTarget UK Limited | Carbamic acid compounds comprising an amide linkage as hdac inhibitors |
| US7244743B2 (en) | 2002-06-05 | 2007-07-17 | Solvay Pharmaceuticals Gmbh | Non-peptidic BRS-3 agonists |
| EP1547590A4 (en) | 2002-09-13 | 2008-07-30 | Oga Res Inc | MELANIN EXTINGUISHER |
| TWI334868B (en) | 2003-06-03 | 2010-12-21 | Nippon Kayaku Kk | [1,2,4] triazoro [1,5-a] pyrimidine-2-ylurea derivative and use thereof |
| US20070244153A1 (en) * | 2004-07-21 | 2007-10-18 | Mitsui Chemicals, Inc. | Diamine Derivative, Process of Preparation Thereof, and Fungicide Comprising Diamine Derivative as an Active Ingredient |
| UY29101A1 (es) | 2004-09-07 | 2006-03-31 | Smithkline Beecham Corp | 1,3-diaminas aceclicas y usos de las mismas |
| WO2006065826A2 (en) | 2004-12-15 | 2006-06-22 | Merck & Co., Inc. | Process to chiral beta amino acid derivatives by asymmetric hydrogenation |
| US7589066B2 (en) | 2005-03-11 | 2009-09-15 | The University Of North Carolina At Chapel Hill | Potent and specific immunoproteasome inhibitors |
| JP2006298785A (ja) * | 2005-04-18 | 2006-11-02 | Mitsui Chemicals Inc | ジアミン誘導体、その製造方法およびそれらを有効成分とする殺菌剤 |
| US20090227601A1 (en) | 2005-12-07 | 2009-09-10 | Amgen Inc. | Bradykinin 1 Receptor Antagonists |
| WO2007083394A1 (ja) * | 2006-01-19 | 2007-07-26 | Mitsui Chemicals, Inc. | ジアミン誘導体を含む有害生物防除組成物 |
| RU2450016C2 (ru) * | 2006-06-19 | 2012-05-10 | Протеоликс, Инк. | Пептидные эпоксикетоны для ингибирования протеасомы |
| DE102007025718A1 (de) | 2007-06-01 | 2008-12-04 | Merck Patent Gmbh | Pyridazinonderivate |
| JP5565667B2 (ja) | 2007-09-11 | 2014-08-06 | 学校法人東京理科大学 | 新規ジヒドロナフタレン化合物及びその用途 |
| WO2009051581A1 (en) | 2007-10-16 | 2009-04-23 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
| CN102015673B (zh) * | 2008-02-21 | 2014-10-29 | 昂科协同公司 | 用作治疗剂的大环前药化合物 |
| AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| WO2010038200A1 (en) | 2008-10-01 | 2010-04-08 | Actelion Pharmaceuticals Ltd | Oxazolidine compounds as orexin receptor antagonists |
| CA2791651C (en) | 2010-03-01 | 2019-08-20 | Onyx Therapeutics, Inc. | Compounds for immunoproteasome inhibition |
| US8513218B2 (en) | 2010-03-31 | 2013-08-20 | Millennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclopropylethylboronic acid |
| EP2487152A1 (en) | 2010-11-17 | 2012-08-15 | UCB Pharma GmbH | Process for the preparation of Lacosamide including resolution of O-methyl-DL-serine |
| EP2681200A4 (en) | 2011-03-03 | 2015-05-27 | Zalicus Pharmaceuticals Ltd | INHIBITORS OF BENZIMIDAZOLE TYPE OF SODIUM CHANNEL |
| US20140315786A1 (en) * | 2011-03-18 | 2014-10-23 | Catabasis Pharmaceuticals, Inc. | Use of intracellular enzymes for the release of covalently linked bioactives |
| CN102807601B (zh) | 2011-06-03 | 2014-02-26 | 首都医科大学 | 氨基酰-色氨酰-5-甲氧色胺及其制备方法和应用 |
| GB2494851A (en) | 2011-07-07 | 2013-03-27 | Kalvista Pharmaceuticals Ltd | Plasma kallikrein inhibitors |
| SG11201403254QA (en) | 2011-12-22 | 2014-07-30 | Ares Trading Sa | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
| JP2014091731A (ja) | 2012-11-06 | 2014-05-19 | Kobe Gakuin | 新規ソマトスタチン由来ペプチド化合物並びに該化合物を含むｄｎａポリメラーゼ阻害剤、抗癌剤及びアポトーシス誘導剤。 |
| EP2935312B1 (en) | 2012-12-21 | 2018-08-08 | F.Hoffmann-La Roche Ag | Peptides as oxytocin agonists |
| WO2015076359A1 (ja) | 2013-11-21 | 2015-05-28 | 国立大学法人北海道大学 | プロテアソーム阻害性化合物 |
| ES2748434T3 (es) | 2014-01-10 | 2020-03-16 | Univ Cornell | Dipéptidos como inhibidores de inmunoproteasomas humanos |
| EP3193904B1 (en) | 2014-08-18 | 2025-10-01 | Cornell University | Dipeptidomimetics as inhibitors of human immunoproteasomes |
| KR102764027B1 (ko) | 2015-10-15 | 2025-02-07 | 코넬 유니버시티 | 프로테아좀 억제제 및 이의 용도 |
| EP3694605A4 (en) | 2017-10-11 | 2021-10-27 | Cornell University | PEPTIDOMIMETIC PROTEASOME INHIBITORS |
-
2016
- 2016-10-17 KR KR1020187011464A patent/KR102764027B1/ko active Active
- 2016-10-17 ES ES16856412T patent/ES2905008T3/es active Active
- 2016-10-17 CN CN202210020990.XA patent/CN114306297A/zh active Pending
- 2016-10-17 CN CN201680065296.2A patent/CN108351169B/zh active Active
- 2016-10-17 JP JP2018519271A patent/JP6970085B2/ja active Active
- 2016-10-17 EP EP21216660.7A patent/EP4006012A1/en active Pending
- 2016-10-17 WO PCT/US2016/057346 patent/WO2017066763A1/en not_active Ceased
- 2016-10-17 US US15/768,628 patent/US11066397B2/en active Active
- 2016-10-17 EP EP16856412.8A patent/EP3362754B1/en active Active
-
2021
- 2021-02-17 US US17/177,729 patent/US11629141B2/en active Active
- 2021-10-28 JP JP2021176164A patent/JP7379441B2/ja active Active
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