JP2018535704A5 - - Google Patents
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- Publication number
- JP2018535704A5 JP2018535704A5 JP2018511412A JP2018511412A JP2018535704A5 JP 2018535704 A5 JP2018535704 A5 JP 2018535704A5 JP 2018511412 A JP2018511412 A JP 2018511412A JP 2018511412 A JP2018511412 A JP 2018511412A JP 2018535704 A5 JP2018535704 A5 JP 2018535704A5
- Authority
- JP
- Japan
- Prior art keywords
- polyethylene glycol
- group
- oxazoline
- aqueous solution
- reagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 16
- 239000002202 Polyethylene glycol Substances 0.000 claims 12
- 229920001223 polyethylene glycol Polymers 0.000 claims 12
- 229920000642 polymer Polymers 0.000 claims 9
- 239000007864 aqueous solution Substances 0.000 claims 8
- 150000004676 glycans Chemical class 0.000 claims 7
- 229920001282 polysaccharide Polymers 0.000 claims 7
- 239000005017 polysaccharide Substances 0.000 claims 7
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 239000003431 cross linking reagent Substances 0.000 claims 4
- 229920000765 poly(2-oxazolines) Polymers 0.000 claims 4
- 150000003573 thiols Chemical group 0.000 claims 4
- IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical compound C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 claims 3
- 229920002307 Dextran Polymers 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims 3
- 229920002674 hyaluronan Polymers 0.000 claims 3
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 3
- 229940099552 hyaluronan Drugs 0.000 claims 3
- -1 mannuronane Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 2
- 229920002148 Gellan gum Polymers 0.000 claims 2
- 239000004698 Polyethylene Substances 0.000 claims 2
- 229940072056 alginate Drugs 0.000 claims 2
- 235000010443 alginic acid Nutrition 0.000 claims 2
- 229920000615 alginic acid Polymers 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 229920006187 aquazol Polymers 0.000 claims 2
- 229920001400 block copolymer Polymers 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 235000010980 cellulose Nutrition 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 238000004132 cross linking Methods 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 235000010492 gellan gum Nutrition 0.000 claims 2
- 239000000216 gellan gum Substances 0.000 claims 2
- 239000000017 hydrogel Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 229920001277 pectin Polymers 0.000 claims 2
- 239000001814 pectin Substances 0.000 claims 2
- 235000010987 pectin Nutrition 0.000 claims 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 2
- 229920001610 polycaprolactone Polymers 0.000 claims 2
- 229920000573 polyethylene Polymers 0.000 claims 2
- 229920001451 polypropylene glycol Polymers 0.000 claims 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
- GUXJXWKCUUWCLX-UHFFFAOYSA-N 2-methyl-2-oxazoline Chemical compound CC1=NCCO1 GUXJXWKCUUWCLX-UHFFFAOYSA-N 0.000 claims 1
- GXCJLVVUIVSLOQ-UHFFFAOYSA-N 2-propyl-4,5-dihydro-1,3-oxazole Chemical compound CCCC1=NCCO1 GXCJLVVUIVSLOQ-UHFFFAOYSA-N 0.000 claims 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- 102000005741 Metalloproteases Human genes 0.000 claims 1
- 108010006035 Metalloproteases Proteins 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- SMEGJBVQLJJKKX-HOTMZDKISA-N [(2R,3S,4S,5R,6R)-5-acetyloxy-3,4,6-trihydroxyoxan-2-yl]methyl acetate Chemical compound CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)OC(=O)C)O)O SMEGJBVQLJJKKX-HOTMZDKISA-N 0.000 claims 1
- 229940081735 acetylcellulose Drugs 0.000 claims 1
- 150000001345 alkine derivatives Chemical class 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 235000010418 carrageenan Nutrition 0.000 claims 1
- 239000000679 carrageenan Substances 0.000 claims 1
- 229920001525 carrageenan Polymers 0.000 claims 1
- 229940113118 carrageenan Drugs 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 229940059329 chondroitin sulfate Drugs 0.000 claims 1
- 229960002086 dextran Drugs 0.000 claims 1
- 229920000359 diblock copolymer Polymers 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 238000001879 gelation Methods 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 239000001341 hydroxy propyl starch Substances 0.000 claims 1
- 235000013828 hydroxypropyl starch Nutrition 0.000 claims 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 238000005191 phase separation Methods 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 229920000428 triblock copolymer Polymers 0.000 claims 1
- 229920001567 vinyl ester resin Polymers 0.000 claims 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15184552.6 | 2015-09-09 | ||
| EP15184552 | 2015-09-09 | ||
| PCT/EP2016/071238 WO2017042301A1 (en) | 2015-09-09 | 2016-09-08 | Injectable macroporous hydrogels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535704A JP2018535704A (ja) | 2018-12-06 |
| JP2018535704A5 true JP2018535704A5 (enExample) | 2019-08-22 |
| JP6829898B2 JP6829898B2 (ja) | 2021-02-17 |
Family
ID=54150245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018511412A Active JP6829898B2 (ja) | 2015-09-09 | 2016-09-08 | 注入可能なマクロ多孔質ハイドロゲル |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20180264176A1 (enExample) |
| EP (2) | EP3868416B1 (enExample) |
| JP (1) | JP6829898B2 (enExample) |
| CN (2) | CN113372579B (enExample) |
| AU (1) | AU2016320395B2 (enExample) |
| CA (1) | CA2992692C (enExample) |
| CY (1) | CY1124571T1 (enExample) |
| DK (2) | DK3347061T3 (enExample) |
| ES (1) | ES2883235T3 (enExample) |
| HR (1) | HRP20211306T1 (enExample) |
| HU (1) | HUE055937T2 (enExample) |
| IL (1) | IL257024B (enExample) |
| LT (1) | LT3347061T (enExample) |
| PL (1) | PL3347061T3 (enExample) |
| PT (1) | PT3347061T (enExample) |
| RS (1) | RS62239B1 (enExample) |
| SI (1) | SI3347061T1 (enExample) |
| SM (1) | SMT202100470T1 (enExample) |
| WO (1) | WO2017042301A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2622594B1 (en) | 2010-10-01 | 2018-08-22 | Applied Medical Resources Corporation | Portable laparoscopic trainer |
| AU2012325987B2 (en) | 2011-10-21 | 2017-02-02 | Applied Medical Resources Corporation | Simulated tissue structure for surgical training |
| CA2859967A1 (en) | 2011-12-20 | 2013-06-27 | Applied Medical Resources Corporation | Advanced surgical simulation |
| CA2885433C (en) | 2012-09-26 | 2023-04-04 | Applied Medical Resources Corporation | Surgical training model for laparoscopic procedures |
| US10679520B2 (en) | 2012-09-27 | 2020-06-09 | Applied Medical Resources Corporation | Surgical training model for laparoscopic procedures |
| JP6245531B2 (ja) | 2012-09-27 | 2017-12-13 | アプライド メディカル リソーシーズ コーポレイション | 腹腔鏡下手技用の外科用訓練モデル |
| EP3660816B1 (en) | 2013-03-01 | 2021-10-13 | Applied Medical Resources Corporation | Advanced surgical simulation constructions and methods |
| EP3011550B1 (en) | 2013-06-18 | 2018-01-03 | Applied Medical Resources Corporation | Gallbladder model |
| US10198966B2 (en) | 2013-07-24 | 2019-02-05 | Applied Medical Resources Corporation | Advanced first entry model for surgical simulation |
| JP6517201B2 (ja) | 2013-07-24 | 2019-05-22 | アプライド メディカル リソーシーズ コーポレイション | ファーストエントリーモデル |
| KR102438168B1 (ko) | 2014-03-26 | 2022-08-31 | 어플라이드 메디컬 리소시스 코포레이션 | 시뮬레이션된 절개가능 조직 |
| KR102718882B1 (ko) | 2014-11-13 | 2024-10-17 | 어플라이드 메디컬 리소시스 코포레이션 | 시뮬레이션된 조직 모델들 및 방법들 |
| EP4620662A2 (en) | 2015-02-19 | 2025-09-24 | Applied Medical Resources Corporation | Simulated tissue structures and methods |
| EP3253315B1 (en) | 2015-05-14 | 2019-01-02 | Applied Medical Resources Corporation | Synthetic tissue structures for electrosurgical training and simulation |
| EP4057260A1 (en) | 2015-06-09 | 2022-09-14 | Applied Medical Resources Corporation | Hysterectomy model |
| JP7009355B2 (ja) | 2015-07-16 | 2022-01-25 | アプライド メディカル リソーシーズ コーポレイション | 模擬切開可能組織 |
| KR102646090B1 (ko) | 2015-07-22 | 2024-03-12 | 어플라이드 메디컬 리소시스 코포레이션 | 충수절제술 모델 |
| KR102649261B1 (ko) | 2015-10-02 | 2024-03-20 | 어플라이드 메디컬 리소시스 코포레이션 | 자궁 절제술 모델 |
| ES2955662T3 (es) | 2015-11-20 | 2023-12-05 | Applied Med Resources | Tejido diseccionable simulado |
| WO2017165389A2 (en) | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Alginate hydrogel compositions |
| JP6925579B2 (ja) * | 2016-03-31 | 2021-08-25 | 日油株式会社 | 環状ベンジリデンアセタール構造を有する生分解性ヒドロゲル |
| KR102405187B1 (ko) | 2016-06-27 | 2022-06-07 | 어플라이드 메디컬 리소시스 코포레이션 | 시뮬레이션된 복벽 |
| EA201991452A1 (ru) | 2016-12-13 | 2020-01-16 | Милленниум Фармасьютикалз, Инк. | Конформное покрытие биологических поверхностей |
| ES3004046T3 (en) | 2017-02-14 | 2025-03-11 | Applied Med Resources | Laparoscopic training system |
| US10847057B2 (en) | 2017-02-23 | 2020-11-24 | Applied Medical Resources Corporation | Synthetic tissue structures for electrosurgical training and simulation |
| SG11202001914QA (en) * | 2017-09-11 | 2020-04-29 | Evorion Biotechnologies Gmbh | Systems, methods and hydrogels for cell culture and analysis |
| CN108893445A (zh) * | 2018-07-26 | 2018-11-27 | 南方医科大学 | 一种引导视网膜神经节细胞及其轴突生长延展的方法 |
| CN109316628B (zh) * | 2018-09-21 | 2021-04-20 | 广州远想生物科技有限公司 | 一种凝胶及其制备方法和应用 |
| CN109731133B (zh) * | 2019-02-01 | 2020-09-01 | 浙江大学 | 一种抗菌、抗粘附、可注射式温敏壳聚糖凝胶敷料及其制备方法 |
| US11680107B2 (en) * | 2019-03-22 | 2023-06-20 | Taipei Medical University | Hydrogel composition for drug delivery and uses thereof |
| WO2021041222A1 (en) | 2019-08-28 | 2021-03-04 | Boston Scientific Scimed, Inc. | Multi-armed polyoxazolines and compositions, systems and methods pertaining to the same |
| US20230051239A1 (en) * | 2020-01-03 | 2023-02-16 | Repertoire Immune Medicines, Inc. | Compositions of hydrogels and methods of use thereof |
| EP4100471A4 (en) * | 2020-02-07 | 2024-03-13 | The University of British Columbia | MUCOADHESIVE POLYMER DRUG DELIVERY COMPOSITIONS AND METHODS |
| CN112898600B (zh) * | 2021-02-07 | 2023-05-23 | 西安工业大学 | 一种聚多巴胺可逆粘附凝胶的分相制备方法 |
| WO2023135155A1 (en) | 2022-01-12 | 2023-07-20 | Eth Zurich | Photocurable phase-separating hydrogels |
| EP4536801A1 (en) | 2022-06-13 | 2025-04-16 | ETH Zurich | Collagen visualization on microfluidic device |
| EP4616875A1 (en) | 2024-03-12 | 2025-09-17 | Novonexile AG | Semi-interpenetrating polymer networks |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1446453A1 (en) * | 2001-11-07 | 2004-08-18 | Universität Zürich | Synthetic matrix for controlled cell ingrowth and tissue regeneration and endometriosis |
| US20070264227A1 (en) * | 2001-11-07 | 2007-11-15 | Eidgenossische Technische Hochschule Zurich | Synthetic Matrix for Controlled Cell Ingrowth and Tissue Regeneration |
| JP4560291B2 (ja) * | 2001-12-18 | 2010-10-13 | イジュノシッヒ テクニッヒ ホッフシューラ チューリッヒ | 組織操作のための成長因子改変タンパク質マトリクス |
| US7776240B2 (en) * | 2003-01-17 | 2010-08-17 | Cornell Research Foundation, Inc. | Injectable hydrogel microspheres from aqueous two-phase system |
| FR2865737B1 (fr) * | 2004-02-03 | 2006-03-31 | Anteis Sa | Gel reticule biocompatible |
| KR100699278B1 (ko) * | 2005-05-12 | 2007-03-23 | 학교법인 포항공과대학교 | 수화젤레이터로 유용한 바이오틴-아미노산 결합체 및이로부터 제조된 수화젤 |
| US20070212385A1 (en) * | 2006-03-13 | 2007-09-13 | David Nathaniel E | Fluidic Tissue Augmentation Compositions and Methods |
| US8790702B2 (en) * | 2009-07-30 | 2014-07-29 | Carbylan Therapeutics, Inc. | Modified hyaluronic acid polymer compositions and related methods |
| CN106913902A (zh) * | 2009-11-09 | 2017-07-04 | 聚光灯技术合伙有限责任公司 | 多糖基水凝胶 |
| CN107648668B (zh) * | 2010-10-06 | 2021-06-18 | 哈佛学院董事会 | 用于基于材料的细胞疗法的可注射的成孔水凝胶 |
| CN104271638B (zh) * | 2012-03-16 | 2016-11-02 | 本德尔分析控股公司 | 源于亲核活性聚噁唑啉的交联聚合物和医用品 |
| RS60057B1 (sr) * | 2012-11-07 | 2020-04-30 | Eth Zuerich | Hidrogelovi sulfatnog alginata za kulturu ćelije i terapiju |
-
2016
- 2016-09-08 LT LTEP16763035.9T patent/LT3347061T/lt unknown
- 2016-09-08 HR HRP20211306TT patent/HRP20211306T1/hr unknown
- 2016-09-08 SM SM20210470T patent/SMT202100470T1/it unknown
- 2016-09-08 JP JP2018511412A patent/JP6829898B2/ja active Active
- 2016-09-08 US US15/758,390 patent/US20180264176A1/en not_active Abandoned
- 2016-09-08 DK DK16763035.9T patent/DK3347061T3/da active
- 2016-09-08 AU AU2016320395A patent/AU2016320395B2/en active Active
- 2016-09-08 RS RS20211024A patent/RS62239B1/sr unknown
- 2016-09-08 CN CN202110629796.7A patent/CN113372579B/zh active Active
- 2016-09-08 PT PT167630359T patent/PT3347061T/pt unknown
- 2016-09-08 CN CN201680051583.8A patent/CN108025110B/zh active Active
- 2016-09-08 CA CA2992692A patent/CA2992692C/en active Active
- 2016-09-08 EP EP21168993.0A patent/EP3868416B1/en active Active
- 2016-09-08 SI SI201631296T patent/SI3347061T1/sl unknown
- 2016-09-08 WO PCT/EP2016/071238 patent/WO2017042301A1/en not_active Ceased
- 2016-09-08 DK DK21168993.0T patent/DK3868416T3/da active
- 2016-09-08 EP EP16763035.9A patent/EP3347061B1/en active Active
- 2016-09-08 PL PL16763035T patent/PL3347061T3/pl unknown
- 2016-09-08 HU HUE16763035A patent/HUE055937T2/hu unknown
- 2016-09-08 ES ES16763035T patent/ES2883235T3/es active Active
-
2018
- 2018-01-18 IL IL257024A patent/IL257024B/en unknown
-
2021
- 2021-08-18 CY CY20211100738T patent/CY1124571T1/el unknown
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