CA2992692C - Injectable macroporous hydrogels - Google Patents

Injectable macroporous hydrogels Download PDF

Info

Publication number
CA2992692C
CA2992692C CA2992692A CA2992692A CA2992692C CA 2992692 C CA2992692 C CA 2992692C CA 2992692 A CA2992692 A CA 2992692A CA 2992692 A CA2992692 A CA 2992692A CA 2992692 C CA2992692 C CA 2992692C
Authority
CA
Canada
Prior art keywords
cross
peg
polyethylene glycol
aqueous solution
linkable polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2992692A
Other languages
English (en)
French (fr)
Other versions
CA2992692A1 (en
Inventor
Nicolas BROGUIERE
Marcy Zenobi-Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eidgenoessische Technische Hochschule Zurich ETHZ
Original Assignee
Eidgenoessische Technische Hochschule Zurich ETHZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eidgenoessische Technische Hochschule Zurich ETHZ filed Critical Eidgenoessische Technische Hochschule Zurich ETHZ
Publication of CA2992692A1 publication Critical patent/CA2992692A1/en
Application granted granted Critical
Publication of CA2992692C publication Critical patent/CA2992692C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/28—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
    • C08J9/286—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum the liquid phase being a solvent for the monomers but not for the resulting macromolecular composition, i.e. macroporous or macroreticular polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/02—Dextran; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/08—Polyethers derived from hydroxy compounds or from their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L79/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2371/00—Characterised by the use of polyethers obtained by reactions forming an ether link in the main chain; Derivatives of such polymers
    • C08J2371/02—Polyalkylene oxides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
    • C08J2405/02—Dextran; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
    • C08J2405/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00—Properties
    • C08L2201/54—Aqueous solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Materials Engineering (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
CA2992692A 2015-09-09 2016-09-08 Injectable macroporous hydrogels Active CA2992692C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15184552 2015-09-09
EP15184552.6 2015-09-09
PCT/EP2016/071238 WO2017042301A1 (en) 2015-09-09 2016-09-08 Injectable macroporous hydrogels

Publications (2)

Publication Number Publication Date
CA2992692A1 CA2992692A1 (en) 2017-03-16
CA2992692C true CA2992692C (en) 2021-12-21

Family

ID=54150245

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2992692A Active CA2992692C (en) 2015-09-09 2016-09-08 Injectable macroporous hydrogels

Country Status (19)

Country Link
US (1) US20180264176A1 (enExample)
EP (2) EP3868416B1 (enExample)
JP (1) JP6829898B2 (enExample)
CN (2) CN113372579B (enExample)
AU (1) AU2016320395B2 (enExample)
CA (1) CA2992692C (enExample)
CY (1) CY1124571T1 (enExample)
DK (2) DK3347061T3 (enExample)
ES (1) ES2883235T3 (enExample)
HR (1) HRP20211306T1 (enExample)
HU (1) HUE055937T2 (enExample)
IL (1) IL257024B (enExample)
LT (1) LT3347061T (enExample)
PL (1) PL3347061T3 (enExample)
PT (1) PT3347061T (enExample)
RS (1) RS62239B1 (enExample)
SI (1) SI3347061T1 (enExample)
SM (1) SMT202100470T1 (enExample)
WO (1) WO2017042301A1 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011308788B2 (en) 2010-10-01 2015-05-07 Applied Medical Resources Corporation Surgical training device
JP6169088B2 (ja) 2011-10-21 2017-07-26 アプライド メディカル リソーシーズ コーポレイション 外科訓練のための模擬組織構造
AU2012358851B2 (en) 2011-12-20 2016-08-11 Applied Medical Resources Corporation Advanced surgical simulation
EP2907125B1 (en) 2012-09-26 2017-08-02 Applied Medical Resources Corporation Surgical training model for laparoscopic procedures
US10679520B2 (en) 2012-09-27 2020-06-09 Applied Medical Resources Corporation Surgical training model for laparoscopic procedures
CA3159450A1 (en) 2012-09-27 2014-04-03 Applied Medical Resources Corporation Surgical training model for laparoscopic procedures
EP3660816B1 (en) 2013-03-01 2021-10-13 Applied Medical Resources Corporation Advanced surgical simulation constructions and methods
AU2014281483B2 (en) 2013-06-18 2018-04-12 Applied Medical Resources Corporation Gallbladder model for teaching and practicing surgical procedures
EP3410421A1 (en) 2013-07-24 2018-12-05 Applied Medical Resources Corporation First entry model
US10198966B2 (en) 2013-07-24 2019-02-05 Applied Medical Resources Corporation Advanced first entry model for surgical simulation
EP3913602B1 (en) 2014-03-26 2025-08-27 Applied Medical Resources Corporation Simulated dissectible tissue
KR102665331B1 (ko) 2014-11-13 2024-05-13 어플라이드 메디컬 리소시스 코포레이션 시뮬레이션된 조직 모델들 및 방법들
KR20250033336A (ko) 2015-02-19 2025-03-07 어플라이드 메디컬 리소시스 코포레이션 시뮬레이션된 조직 구조체들 및 방법들
KR20180008417A (ko) 2015-05-14 2018-01-24 어플라이드 메디컬 리소시스 코포레이션 전기수술 트레이닝 및 시뮬레이션을 위한 합성 조직 구조체
US12512017B2 (en) 2015-05-27 2025-12-30 Applied Medical Resources Corporation Surgical training model for laparoscopic procedures
WO2016201085A1 (en) 2015-06-09 2016-12-15 Applied Medical Resources Corporation Hysterectomy model
WO2017011436A1 (en) 2015-07-16 2017-01-19 Applied Medical Resources Corporation Simulated dissectable tissue
AU2016297579B2 (en) 2015-07-22 2022-03-17 Applied Medical Resources Corporation Appendectomy model
AU2016329211A1 (en) 2015-10-02 2018-04-26 Applied Medical Resources Corporation Hysterectomy model
EP3378053B1 (en) 2015-11-20 2023-08-16 Applied Medical Resources Corporation Simulated dissectible tissue
WO2017165389A2 (en) 2016-03-24 2017-09-28 Millennium Pharmaceuticals, Inc. Alginate hydrogel compositions
JP6925579B2 (ja) * 2016-03-31 2021-08-25 日油株式会社 環状ベンジリデンアセタール構造を有する生分解性ヒドロゲル
AU2017291422B2 (en) 2016-06-27 2023-04-06 Applied Medical Resources Corporation Simulated abdominal wall
EP3554569A1 (en) 2016-12-13 2019-10-23 Millennium Pharmaceuticals, Inc. Conformal coating of biological surfaces
ES3004046T3 (en) 2017-02-14 2025-03-11 Applied Med Resources Laparoscopic training system
US10847057B2 (en) 2017-02-23 2020-11-24 Applied Medical Resources Corporation Synthetic tissue structures for electrosurgical training and simulation
WO2019048713A1 (en) * 2017-09-11 2019-03-14 Evorion Biotechnologies Gmbh SYSTEMS, METHODS AND HYDROGELS FOR CULTURE AND CELL ANALYSIS
CN108893445A (zh) * 2018-07-26 2018-11-27 南方医科大学 一种引导视网膜神经节细胞及其轴突生长延展的方法
CN109316628B (zh) * 2018-09-21 2021-04-20 广州远想生物科技有限公司 一种凝胶及其制备方法和应用
CN109731133B (zh) * 2019-02-01 2020-09-01 浙江大学 一种抗菌、抗粘附、可注射式温敏壳聚糖凝胶敷料及其制备方法
US11680107B2 (en) * 2019-03-22 2023-06-20 Taipei Medical University Hydrogel composition for drug delivery and uses thereof
CN118325079A (zh) 2019-08-28 2024-07-12 波士顿科学国际有限公司 多臂聚恶唑啉和与其相关的组合物、系统和方法
US20230051239A1 (en) * 2020-01-03 2023-02-16 Repertoire Immune Medicines, Inc. Compositions of hydrogels and methods of use thereof
JP7679939B2 (ja) * 2020-01-28 2025-05-20 国立大学法人 東京大学 再生医療用ゲル材料
US12171833B2 (en) * 2020-02-07 2024-12-24 The University Of British Columbia Mucoadhesive polymeric drug delivery compositions and methods
CN112898600B (zh) * 2021-02-07 2023-05-23 西安工业大学 一种聚多巴胺可逆粘附凝胶的分相制备方法
JP2023020949A (ja) * 2021-07-28 2023-02-09 東ソー株式会社 細胞培養用表面処理剤
EP4463193A1 (en) 2022-01-12 2024-11-20 ETH Zurich Photocurable phase-separating hydrogels
WO2023242189A1 (en) 2022-06-13 2023-12-21 Eth Zurich Collagen visualization on microfluidic device
EP4616875A1 (en) 2024-03-12 2025-09-17 Novonexile AG Semi-interpenetrating polymer networks

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1446453A1 (en) * 2001-11-07 2004-08-18 Universität Zürich Synthetic matrix for controlled cell ingrowth and tissue regeneration and endometriosis
US20070264227A1 (en) * 2001-11-07 2007-11-15 Eidgenossische Technische Hochschule Zurich Synthetic Matrix for Controlled Cell Ingrowth and Tissue Regeneration
ES2301697T3 (es) * 2001-12-18 2008-07-01 Eidgenossisch Technische Hochschule Zurich Matrices de proteina modificada con factor de crecimiento para ingenieria de tejidos.
ATE531447T1 (de) * 2003-01-17 2011-11-15 Cornell Res Foundation Inc Injizierbare hydrogel-microsphären aus wässrigem zwei-phasen-system
FR2865737B1 (fr) * 2004-02-03 2006-03-31 Anteis Sa Gel reticule biocompatible
KR100699278B1 (ko) * 2005-05-12 2007-03-23 학교법인 포항공과대학교 수화젤레이터로 유용한 바이오틴-아미노산 결합체 및이로부터 제조된 수화젤
US20070212385A1 (en) * 2006-03-13 2007-09-13 David Nathaniel E Fluidic Tissue Augmentation Compositions and Methods
AU2010276574B2 (en) * 2009-07-30 2015-08-20 Carbylan Therapeutics, Inc. Modified hyaluronic acid polymer compositions and related methods
WO2011057131A1 (en) * 2009-11-09 2011-05-12 Spotlight Technology Partners Llc Polysaccharide based hydrogels
EP3620185A1 (en) * 2010-10-06 2020-03-11 President and Fellows of Harvard College Injectable, pore-forming hydrogels for materials-based cell therapies
JP6178399B2 (ja) * 2012-03-16 2017-08-09 ベンデル アナリティカル ホールディング ビー．ブイ．Ｂｅｎｄｅｒ Ａｎａｌｙｔｉｃａｌ Ｈｏｌｄｉｎｇ Ｂ．Ｖ． 求核的に活性化したポリオキサゾリンに由来する架橋ポリマー及び医療製品
PT2916881T (pt) * 2012-11-07 2020-03-17 Eth Zuerich Hidrogéis de alginato sulfatado para cultura e terapia celular

Also Published As

Publication number Publication date
CA2992692A1 (en) 2017-03-16
JP2018535704A (ja) 2018-12-06
JP6829898B2 (ja) 2021-02-17
DK3347061T3 (da) 2021-08-23
IL257024A (en) 2018-03-29
LT3347061T (lt) 2021-09-10
AU2016320395A1 (en) 2018-02-22
RS62239B1 (sr) 2021-09-30
ES2883235T3 (es) 2021-12-07
EP3868416A1 (en) 2021-08-25
SI3347061T1 (sl) 2021-11-30
PL3347061T3 (pl) 2021-11-22
CN108025110B (zh) 2021-08-20
SMT202100470T1 (it) 2021-09-14
PT3347061T (pt) 2021-08-25
EP3868416B1 (en) 2022-08-10
IL257024B (en) 2022-02-01
DK3868416T3 (da) 2022-10-31
HRP20211306T1 (hr) 2021-11-26
EP3347061A1 (en) 2018-07-18
US20180264176A1 (en) 2018-09-20
EP3347061B1 (en) 2021-05-19
CN113372579A (zh) 2021-09-10
CY1124571T1 (el) 2022-07-22
WO2017042301A1 (en) 2017-03-16
CN113372579B (zh) 2023-07-14
CN108025110A (zh) 2018-05-11
AU2016320395B2 (en) 2020-09-17
HUE055937T2 (hu) 2022-01-28

Similar Documents

Publication Publication Date Title
AU2016320395B2 (en) Injectable macroporous hydrogels
Bhattacharya et al. Nanofibrillar cellulose hydrogel promotes three-dimensional liver cell culture
Santo et al. Chitosan–chondroitin sulphate nanoparticles for controlled delivery of platelet lysates in bone regenerative medicine
ES2759257T3 (es) Material de cultivo celular derivado de plantas
Farasatkia et al. Robust and double-layer micro-patterned bioadhesive based on silk nanofibril/GelMA-alginate for stroma tissue engineering
EP2125050B1 (en) Albumin fibers and fabrics and methods of generating and using same
US20170080123A1 (en) Method for Preparing Porous Scaffold for Tissue Engineering, Cell Culture and Cell Delivery
US20130142763A1 (en) Crosslinked cellulosic polymers
US20110280914A1 (en) Hydrogels crosslinked with gold nanoparticles and methods of making and using thereof
US10682309B2 (en) Hydrogel microparticle scaffold with gradients of degradability and methods thereof
CN104548200A (zh) 一种制备高支化多糖-丝素水凝胶支架的方法
Nara et al. Strategies for faster detachment of corneal cell sheet using micropatterned thermoresponsive matrices
US10576042B2 (en) Composition comprising polyelectrolyte complexes, methods and uses thereof
US20140170224A1 (en) Gelatin-based microgels
Kirwale et al. Chitosan, chondroitin sulfate, and hyaluronic acid based in-situ forming scaffold for efficient cell grafting
Zhang et al. Enzyme‐assisted activation technique for producing versatile hydrogel microparticle scaffolds with high surface chemical reactivity
CN106390206B (zh) 一种多肽水凝胶、其制备方法及应用
WO2024233707A1 (en) 3d printing of self-assembling multidomain peptide hydrogels and fabrication of aligned nanofibrous self-assembling peptide hydrogels
KR102262206B1 (ko) 망막색소상피세포를 포함하는 하이드로겔 조성물 및 이의 용도
Mitra et al. Eggshell Membrane Incorporated Gelatin‐Tannic Acid‐Alginate Composite Bioink with Tissue Adhesive and Antibacterial Properties for Skin Tissue Engineering
Mazumder et al. Synthetic reactive polyelectrolytes for cell encapsulation
WO2025101564A1 (en) Methods of preparing and using plodia interpunctella silk
WO2025099175A1 (de) Lebendes kompositmaterial für medizinische produkte
Smith Cellular hitchhiking via injectable microparticles

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210804

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 8TH ANNIV.) - STANDARD

Year of fee payment: 8

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20240828

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20240828

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20240828

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 9TH ANNIV.) - STANDARD

Year of fee payment: 9

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250828

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250828