CN113372579B - 可注射大孔水凝胶 - Google Patents

可注射大孔水凝胶 Download PDF

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CN113372579B
CN113372579B CN202110629796.7A CN202110629796A CN113372579B CN 113372579 B CN113372579 B CN 113372579B CN 202110629796 A CN202110629796 A CN 202110629796A CN 113372579 B CN113372579 B CN 113372579B
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gel
solute
gels
macroporous
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CN113372579A (zh
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N·布洛克里
M·泽诺比-黄
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Eidgenoessische Technische Hochschule Zurich ETHZ
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    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • C08J3/00Processes of treating or compounding macromolecular substances
    • C08J3/02Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
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    • C08J3/075Macromolecular gels
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    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
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CN202110629796.7A 2015-09-09 2016-09-08 可注射大孔水凝胶 Active CN113372579B (zh)

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EP15184552.6 2015-09-09
EP15184552 2015-09-09
CN202110629796.7A CN113372579B (zh) 2015-09-09 2016-09-08 可注射大孔水凝胶
CN201680051583.8A CN108025110B (zh) 2015-09-09 2016-09-08 可注射大孔水凝胶
PCT/EP2016/071238 WO2017042301A1 (en) 2015-09-09 2016-09-08 Injectable macroporous hydrogels

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US (1) US20180264176A1 (enExample)
EP (2) EP3868416B1 (enExample)
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AU (1) AU2016320395B2 (enExample)
CA (1) CA2992692C (enExample)
CY (1) CY1124571T1 (enExample)
DK (2) DK3347061T3 (enExample)
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PT (1) PT3347061T (enExample)
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Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2622594B1 (en) 2010-10-01 2018-08-22 Applied Medical Resources Corporation Portable laparoscopic trainer
AU2012325987B2 (en) 2011-10-21 2017-02-02 Applied Medical Resources Corporation Simulated tissue structure for surgical training
CA2859967A1 (en) 2011-12-20 2013-06-27 Applied Medical Resources Corporation Advanced surgical simulation
CA2885433C (en) 2012-09-26 2023-04-04 Applied Medical Resources Corporation Surgical training model for laparoscopic procedures
US10679520B2 (en) 2012-09-27 2020-06-09 Applied Medical Resources Corporation Surgical training model for laparoscopic procedures
JP6245531B2 (ja) 2012-09-27 2017-12-13 アプライド メディカル リソーシーズ コーポレイション 腹腔鏡下手技用の外科用訓練モデル
EP3660816B1 (en) 2013-03-01 2021-10-13 Applied Medical Resources Corporation Advanced surgical simulation constructions and methods
EP3011550B1 (en) 2013-06-18 2018-01-03 Applied Medical Resources Corporation Gallbladder model
US10198966B2 (en) 2013-07-24 2019-02-05 Applied Medical Resources Corporation Advanced first entry model for surgical simulation
JP6517201B2 (ja) 2013-07-24 2019-05-22 アプライド メディカル リソーシーズ コーポレイション ファーストエントリーモデル
KR102438168B1 (ko) 2014-03-26 2022-08-31 어플라이드 메디컬 리소시스 코포레이션 시뮬레이션된 절개가능 조직
KR102718882B1 (ko) 2014-11-13 2024-10-17 어플라이드 메디컬 리소시스 코포레이션 시뮬레이션된 조직 모델들 및 방법들
EP4620662A2 (en) 2015-02-19 2025-09-24 Applied Medical Resources Corporation Simulated tissue structures and methods
EP3253315B1 (en) 2015-05-14 2019-01-02 Applied Medical Resources Corporation Synthetic tissue structures for electrosurgical training and simulation
EP4057260A1 (en) 2015-06-09 2022-09-14 Applied Medical Resources Corporation Hysterectomy model
JP7009355B2 (ja) 2015-07-16 2022-01-25 アプライド メディカル リソーシーズ コーポレイション 模擬切開可能組織
KR102646090B1 (ko) 2015-07-22 2024-03-12 어플라이드 메디컬 리소시스 코포레이션 충수절제술 모델
KR102649261B1 (ko) 2015-10-02 2024-03-20 어플라이드 메디컬 리소시스 코포레이션 자궁 절제술 모델
ES2955662T3 (es) 2015-11-20 2023-12-05 Applied Med Resources Tejido diseccionable simulado
WO2017165389A2 (en) 2016-03-24 2017-09-28 Millennium Pharmaceuticals, Inc. Alginate hydrogel compositions
JP6925579B2 (ja) * 2016-03-31 2021-08-25 日油株式会社 環状ベンジリデンアセタール構造を有する生分解性ヒドロゲル
KR102405187B1 (ko) 2016-06-27 2022-06-07 어플라이드 메디컬 리소시스 코포레이션 시뮬레이션된 복벽
EA201991452A1 (ru) 2016-12-13 2020-01-16 Милленниум Фармасьютикалз, Инк. Конформное покрытие биологических поверхностей
ES3004046T3 (en) 2017-02-14 2025-03-11 Applied Med Resources Laparoscopic training system
US10847057B2 (en) 2017-02-23 2020-11-24 Applied Medical Resources Corporation Synthetic tissue structures for electrosurgical training and simulation
SG11202001914QA (en) * 2017-09-11 2020-04-29 Evorion Biotechnologies Gmbh Systems, methods and hydrogels for cell culture and analysis
CN108893445A (zh) * 2018-07-26 2018-11-27 南方医科大学 一种引导视网膜神经节细胞及其轴突生长延展的方法
CN109316628B (zh) * 2018-09-21 2021-04-20 广州远想生物科技有限公司 一种凝胶及其制备方法和应用
CN109731133B (zh) * 2019-02-01 2020-09-01 浙江大学 一种抗菌、抗粘附、可注射式温敏壳聚糖凝胶敷料及其制备方法
US11680107B2 (en) * 2019-03-22 2023-06-20 Taipei Medical University Hydrogel composition for drug delivery and uses thereof
WO2021041222A1 (en) 2019-08-28 2021-03-04 Boston Scientific Scimed, Inc. Multi-armed polyoxazolines and compositions, systems and methods pertaining to the same
US20230051239A1 (en) * 2020-01-03 2023-02-16 Repertoire Immune Medicines, Inc. Compositions of hydrogels and methods of use thereof
EP4100471A4 (en) * 2020-02-07 2024-03-13 The University of British Columbia MUCOADHESIVE POLYMER DRUG DELIVERY COMPOSITIONS AND METHODS
CN112898600B (zh) * 2021-02-07 2023-05-23 西安工业大学 一种聚多巴胺可逆粘附凝胶的分相制备方法
WO2023135155A1 (en) 2022-01-12 2023-07-20 Eth Zurich Photocurable phase-separating hydrogels
EP4536801A1 (en) 2022-06-13 2025-04-16 ETH Zurich Collagen visualization on microfluidic device
EP4616875A1 (en) 2024-03-12 2025-09-17 Novonexile AG Semi-interpenetrating polymer networks

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1668697A (zh) * 2001-11-07 2005-09-14 苏黎世大学 用于控制细胞向内生长和组织再生的合成基质
CN1835792A (zh) * 2003-01-17 2006-09-20 康乃尔研究基金会有限公司 含水两相体系的可注射水凝胶微球
CN1918219A (zh) * 2004-02-03 2007-02-21 安特易斯有限公司 生物相容性交联凝胶
CN102573941A (zh) * 2009-07-30 2012-07-11 卡比兰生物外科公司 改性透明质酸聚合物组合物和相关的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070264227A1 (en) * 2001-11-07 2007-11-15 Eidgenossische Technische Hochschule Zurich Synthetic Matrix for Controlled Cell Ingrowth and Tissue Regeneration
JP4560291B2 (ja) * 2001-12-18 2010-10-13 イジュノシッヒ テクニッヒ ホッフシューラ チューリッヒ 組織操作のための成長因子改変タンパク質マトリクス
KR100699278B1 (ko) * 2005-05-12 2007-03-23 학교법인 포항공과대학교 수화젤레이터로 유용한 바이오틴-아미노산 결합체 및이로부터 제조된 수화젤
US20070212385A1 (en) * 2006-03-13 2007-09-13 David Nathaniel E Fluidic Tissue Augmentation Compositions and Methods
CN106913902A (zh) * 2009-11-09 2017-07-04 聚光灯技术合伙有限责任公司 多糖基水凝胶
CN107648668B (zh) * 2010-10-06 2021-06-18 哈佛学院董事会 用于基于材料的细胞疗法的可注射的成孔水凝胶
CN104271638B (zh) * 2012-03-16 2016-11-02 本德尔分析控股公司 源于亲核活性聚噁唑啉的交联聚合物和医用品
RS60057B1 (sr) * 2012-11-07 2020-04-30 Eth Zuerich Hidrogelovi sulfatnog alginata za kulturu ćelije i terapiju

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1668697A (zh) * 2001-11-07 2005-09-14 苏黎世大学 用于控制细胞向内生长和组织再生的合成基质
CN1835792A (zh) * 2003-01-17 2006-09-20 康乃尔研究基金会有限公司 含水两相体系的可注射水凝胶微球
CN1918219A (zh) * 2004-02-03 2007-02-21 安特易斯有限公司 生物相容性交联凝胶
CN102573941A (zh) * 2009-07-30 2012-07-11 卡比兰生物外科公司 改性透明质酸聚合物组合物和相关的方法

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