JP2018535693A5 - - Google Patents
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- Publication number
- JP2018535693A5 JP2018535693A5 JP2018535237A JP2018535237A JP2018535693A5 JP 2018535693 A5 JP2018535693 A5 JP 2018535693A5 JP 2018535237 A JP2018535237 A JP 2018535237A JP 2018535237 A JP2018535237 A JP 2018535237A JP 2018535693 A5 JP2018535693 A5 JP 2018535693A5
- Authority
- JP
- Japan
- Prior art keywords
- sucrose phosphorylase
- sucrose
- range
- incubation
- phosphorylase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 20
- 108020000005 Sucrose phosphorylase Proteins 0.000 claims 16
- 238000011534 incubation Methods 0.000 claims 6
- 229930006000 Sucrose Natural products 0.000 claims 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 5
- 230000001580 bacterial effect Effects 0.000 claims 5
- 239000005720 sucrose Substances 0.000 claims 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 3
- 241000186000 Bifidobacterium Species 0.000 claims 2
- 241001608472 Bifidobacterium longum Species 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 claims 2
- 241000194019 Streptococcus mutans Species 0.000 claims 2
- 239000011668 ascorbic acid Substances 0.000 claims 2
- 229960005070 ascorbic acid Drugs 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- 229940009291 bifidobacterium longum Drugs 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 241000589176 Agrobacterium vitis Species 0.000 claims 1
- 241000328900 Candidatus Solibacter Species 0.000 claims 1
- 241000186660 Lactobacillus Species 0.000 claims 1
- 240000001046 Lactobacillus acidophilus Species 0.000 claims 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims 1
- 241000186779 Listeria monocytogenes Species 0.000 claims 1
- 241000589779 Pelomonas saccharophila Species 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 241000878021 Shewanella baltica Species 0.000 claims 1
- 241000557287 Shewanella frigidimarina Species 0.000 claims 1
- 241000192707 Synechococcus Species 0.000 claims 1
- HXXFSFRBOHSIMQ-VFUOTHLCSA-N alpha-D-glucose 1-phosphate Chemical group OC[C@H]1O[C@H](OP(O)(O)=O)[C@H](O)[C@@H](O)[C@@H]1O HXXFSFRBOHSIMQ-VFUOTHLCSA-N 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 229950010772 glucose-1-phosphate Drugs 0.000 claims 1
- 125000003147 glycosyl group Chemical group 0.000 claims 1
- 229940039696 lactobacillus Drugs 0.000 claims 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15186888.2 | 2015-09-25 | ||
| EP15186888 | 2015-09-25 | ||
| PCT/EP2016/072586 WO2017050920A1 (en) | 2015-09-25 | 2016-09-22 | Method for small molecule glycosylation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535693A JP2018535693A (ja) | 2018-12-06 |
| JP2018535693A5 true JP2018535693A5 (cg-RX-API-DMAC7.html) | 2019-10-24 |
| JP7000327B2 JP7000327B2 (ja) | 2022-02-04 |
Family
ID=54251987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018535237A Active JP7000327B2 (ja) | 2015-09-25 | 2016-09-22 | 小分子グリコシル化のための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20180291410A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3353311B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7000327B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20180072705A (cg-RX-API-DMAC7.html) |
| CN (1) | CN108350474B (cg-RX-API-DMAC7.html) |
| ES (1) | ES2886572T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017050920A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108913641B (zh) * | 2018-06-29 | 2021-02-02 | 浙江工业大学 | 一种重组大肠杆菌及其应用 |
| CN109988778B (zh) * | 2019-05-14 | 2020-10-27 | 南京工业大学 | 一种蔗糖磷酸化酶基因及其应用 |
| CN111172128A (zh) * | 2020-01-21 | 2020-05-19 | 浙江工业大学 | 一种蔗糖磷酸化酶在制备2-O-α-D-葡萄糖基-L-抗坏血酸中的应用 |
| CN113980932B (zh) * | 2021-07-15 | 2023-08-01 | 暨南大学 | 一种定点突变的α-葡萄糖苷酶 |
| CN115786388B (zh) * | 2022-12-26 | 2025-01-14 | 暨南大学 | 生产2-O-α-D-吡喃葡萄糖基-L-抗坏血酸的基因工程菌及其构建方法与应用 |
| CN116144625A (zh) * | 2023-02-24 | 2023-05-23 | 杭州佳嘉乐生物技术有限公司 | 重组蔗糖磷酸化酶及其催化糖基化反应的方法 |
| CN120230742B (zh) * | 2025-06-03 | 2025-07-29 | 山东三元生物科技股份有限公司 | 一种固定化细胞及其制备方法和2-O-α-D-吡喃葡萄糖基-L-抗坏血酸的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2832848B2 (ja) | 1989-10-21 | 1998-12-09 | 株式会社林原生物化学研究所 | 結晶２―Ｏ―α―Ｄ―グルコピラノシル―Ｌ―アスコルビン酸とその製造方法並びに用途 |
| JP3134235B2 (ja) | 1991-10-23 | 2001-02-13 | 株式会社林原生物化学研究所 | ２−Ｏ−α−Ｄ−グルコピラノシル−Ｌ−アスコルビン酸高含有物の製造方法 |
| US20020006418A1 (en) * | 1998-10-13 | 2002-01-17 | John Kung | Composition to enhance permeation of topical skin agents |
| JP4043312B2 (ja) | 2002-08-06 | 2008-02-06 | 株式会社林原生物化学研究所 | ２−Ｏ−α−Ｄ−グルコピラノシル−Ｌ−アスコルビン酸の製造方法 |
| JP2014518611A (ja) * | 2011-03-25 | 2014-08-07 | プロテロ インコーポレイテッド | 調節された遺伝子発現系およびその構築物 |
| WO2014060452A1 (en) * | 2012-10-18 | 2014-04-24 | Universiteit Gent | A thermostable sucrose and sucrose-6'-phosphate phosphorylase |
| CN103122341B (zh) * | 2013-01-08 | 2015-05-13 | 江南大学 | 一种麦芽糊精底物特异性提高的环糊精糖基转移酶及其制备方法 |
| CN104531629B (zh) * | 2014-12-16 | 2017-07-21 | 江南大学 | 一种提高aa‑2g转化率的环糊精葡萄糖基转移酶突变体 |
-
2016
- 2016-09-22 WO PCT/EP2016/072586 patent/WO2017050920A1/en not_active Ceased
- 2016-09-22 US US15/762,082 patent/US20180291410A1/en not_active Abandoned
- 2016-09-22 JP JP2018535237A patent/JP7000327B2/ja active Active
- 2016-09-22 EP EP16775588.3A patent/EP3353311B1/en active Active
- 2016-09-22 ES ES16775588T patent/ES2886572T3/es active Active
- 2016-09-22 KR KR1020187011643A patent/KR20180072705A/ko not_active Withdrawn
- 2016-09-22 CN CN201680062080.0A patent/CN108350474B/zh active Active
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