JP2018534560A5 - - Google Patents
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- Publication number
- JP2018534560A5 JP2018534560A5 JP2018517832A JP2018517832A JP2018534560A5 JP 2018534560 A5 JP2018534560 A5 JP 2018534560A5 JP 2018517832 A JP2018517832 A JP 2018517832A JP 2018517832 A JP2018517832 A JP 2018517832A JP 2018534560 A5 JP2018534560 A5 JP 2018534560A5
- Authority
- JP
- Japan
- Prior art keywords
- tank
- value
- medium
- concentration
- measuring device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002609 medium Substances 0.000 description 61
- 238000000034 method Methods 0.000 description 46
- 238000001139 pH measurement Methods 0.000 description 45
- 239000007789 gas Substances 0.000 description 38
- 238000004113 cell culture Methods 0.000 description 23
- 238000005259 measurement Methods 0.000 description 14
- 239000001963 growth medium Substances 0.000 description 10
- 230000004060 metabolic process Effects 0.000 description 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000001301 oxygen Substances 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 238000005070 sampling Methods 0.000 description 3
- 230000000977 initiatory effect Effects 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 239000012080 ambient air Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15192389 | 2015-10-30 | ||
| EP15192389.3 | 2015-10-30 | ||
| PCT/EP2016/076173 WO2017072346A1 (en) | 2015-10-30 | 2016-10-28 | Identification of calibration deviations of ph-measuring devices |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018534560A JP2018534560A (ja) | 2018-11-22 |
| JP2018534560A5 true JP2018534560A5 (enExample) | 2019-11-21 |
| JP6893208B2 JP6893208B2 (ja) | 2021-06-23 |
Family
ID=54364192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018517832A Active JP6893208B2 (ja) | 2015-10-30 | 2016-10-28 | Ｐｈ測定装置の較正ずれの特定 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11371006B2 (enExample) |
| EP (2) | EP3786278B1 (enExample) |
| JP (1) | JP6893208B2 (enExample) |
| KR (1) | KR102612135B1 (enExample) |
| CN (1) | CN108368471B (enExample) |
| AU (1) | AU2016345668B2 (enExample) |
| BR (1) | BR112018003852B1 (enExample) |
| CA (1) | CA2996468A1 (enExample) |
| ES (2) | ES2808923T3 (enExample) |
| HR (2) | HRP20221081T1 (enExample) |
| IL (1) | IL258080B (enExample) |
| MX (1) | MX2018004248A (enExample) |
| PL (2) | PL3368653T3 (enExample) |
| SI (2) | SI3786278T1 (enExample) |
| WO (1) | WO2017072346A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102019107625A1 (de) * | 2018-12-20 | 2020-06-25 | Endress+Hauser Conducta Gmbh+Co. Kg | Verfahren zur In-Prozess-Justage eines potentiometrischen Sensors einer Messanordnung |
| CN109856220B (zh) * | 2019-03-07 | 2020-06-05 | 中南大学 | 一种pH值在线检测装置及其控制和校准预判方法 |
| CN110057990B (zh) * | 2019-03-08 | 2021-09-14 | 天津大学 | 一种多参数水质剖面仪的pH校正方法 |
| US12031941B2 (en) * | 2019-08-12 | 2024-07-09 | Emd Millipore Corporation | Methods to automatically calibrate pH sensors without sampling |
| IL305067A (en) * | 2021-02-12 | 2023-10-01 | Bayer Healthcare Llc | Methods for adjusting the pH of cell culture medium |
| EP4612312A1 (en) | 2022-11-02 | 2025-09-10 | F. Hoffmann-La Roche AG | Method for producing glycoprotein compositions |
| CN115753948B (zh) * | 2022-11-28 | 2025-07-25 | 新疆大学 | 一种高温高压条件下饱和酸性气体的溶液pH获取系统、方法及预测方法 |
| US20240248104A1 (en) * | 2023-01-24 | 2024-07-25 | Culture Biosciences, Inc. | Methods and systems for tracking performance characteristics of probes for a biomanufacturing system |
| WO2025224236A1 (en) | 2024-04-25 | 2025-10-30 | F. Hoffmann-La Roche Ag | Methods and systems for determining an actual ph in a liquid phase of a tank |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60141286A (ja) | 1983-12-28 | 1985-07-26 | Ajinomoto Co Inc | 動物細胞の培養方法および装置 |
| US4513280A (en) | 1984-10-04 | 1985-04-23 | The United States Of America As Represented By The Secretary Of The Navy | Method and apparatus for the detection of toxicants |
| JPH06174677A (ja) * | 1992-12-08 | 1994-06-24 | Meidensha Corp | 酸−アルカリ滴定法におけるｐＨ計の誤差検出方法及び装置 |
| AT401111B (de) * | 1995-02-01 | 1996-06-25 | Avl Verbrennungskraft Messtech | Verfahren zur kalibrierung eines ph-messelementes |
| US5578194A (en) * | 1995-03-10 | 1996-11-26 | Nova Biomedical Corporation | Calibration of electrodes |
| CH690251A5 (de) * | 1995-11-10 | 2000-06-15 | Hamilton Bonaduz Ag | Luftstabile pH-Standardlösungen. |
| DE69807042T2 (de) * | 1997-01-17 | 2003-02-06 | Metracor Technologies Inc., San Diego | Verfahren zum kalibrieren von sensoren in diagnostischen testverfahren |
| US6865407B2 (en) | 2002-07-11 | 2005-03-08 | Optical Sensors, Inc. | Calibration technique for non-invasive medical devices |
| DE10239610B3 (de) | 2002-08-29 | 2004-06-24 | Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG | Verfahren zur Funktionsüberwachung von Sensoren |
| CN1238498C (zh) | 2004-02-12 | 2006-01-25 | 陈志南 | 动物细胞无血清悬浮培养工艺过程控制参数的方法 |
| US7771988B2 (en) | 2005-03-24 | 2010-08-10 | Hitachi, Ltd. | Control device for fermenter |
| EP2001991A4 (en) | 2006-01-28 | 2013-03-20 | Abb Research Ltd | METHOD FOR ON-LINE PREDICTION OF THE FUTURE EFFICIENCY OF A FERMENTATION UNIT |
| JP2008220235A (ja) * | 2007-03-12 | 2008-09-25 | Sanyo Electric Co Ltd | 培養装置 |
| JP5136280B2 (ja) * | 2007-08-24 | 2013-02-06 | Ｔｏｔｏ株式会社 | 腸内状態測定装置および測定方法 |
| US8178318B2 (en) | 2008-08-06 | 2012-05-15 | Praxair Technology, Inc. | Method for controlling pH, osmolality and dissolved carbon dioxide levels in a mammalian cell culture process to enhance cell viability and biologic product yield |
| PL2451936T3 (pl) | 2009-07-06 | 2020-02-28 | F. Hoffmann-La Roche Ag | Sposób hodowli komórek eukariotycznych |
| US20130115588A1 (en) * | 2010-04-15 | 2013-05-09 | G & G Technologies, Inc. | Integrated bioreactor and separation system and methods of use therof |
| WO2012171030A2 (en) * | 2011-06-10 | 2012-12-13 | Biovest International, Inc. | Method and apparatus for antibody production and purification |
| JP5896105B2 (ja) * | 2011-07-12 | 2016-03-30 | 横河電機株式会社 | ｐＨ測定装置 |
| WO2013016672A2 (en) * | 2011-07-28 | 2013-01-31 | Board Of Regents, The University Of Texas System | Methods of producing human hemoglobin in a bioreactor |
| SG2014008809A (en) * | 2011-09-21 | 2014-04-28 | Hoffmann La Roche | Co2 profile cultivation |
| EP2772529A4 (en) * | 2011-10-28 | 2015-07-01 | Siemens Ag | SYSTEM FOR MONITORING A PRODUCTION PROCESS AND CONTROL METHOD THEREFOR |
| JP6164753B2 (ja) * | 2015-03-30 | 2017-07-19 | 国立大学法人高知大学 | 被検溶液のｐＨ測定方法及びｐＨ測定装置 |
-
2016
- 2016-10-28 ES ES16790330T patent/ES2808923T3/es active Active
- 2016-10-28 HR HRP20221081TT patent/HRP20221081T1/hr unknown
- 2016-10-28 PL PL16790330T patent/PL3368653T3/pl unknown
- 2016-10-28 CA CA2996468A patent/CA2996468A1/en active Pending
- 2016-10-28 ES ES20176613T patent/ES2926594T3/es active Active
- 2016-10-28 EP EP20176613.6A patent/EP3786278B1/en active Active
- 2016-10-28 JP JP2018517832A patent/JP6893208B2/ja active Active
- 2016-10-28 CN CN201680058528.1A patent/CN108368471B/zh active Active
- 2016-10-28 SI SI201631595T patent/SI3786278T1/sl unknown
- 2016-10-28 EP EP16790330.1A patent/EP3368653B1/en active Active
- 2016-10-28 MX MX2018004248A patent/MX2018004248A/es unknown
- 2016-10-28 PL PL20176613.6T patent/PL3786278T3/pl unknown
- 2016-10-28 KR KR1020187009525A patent/KR102612135B1/ko active Active
- 2016-10-28 AU AU2016345668A patent/AU2016345668B2/en active Active
- 2016-10-28 SI SI201630858T patent/SI3368653T1/sl unknown
- 2016-10-28 HR HRP20201130TT patent/HRP20201130T1/hr unknown
- 2016-10-28 WO PCT/EP2016/076173 patent/WO2017072346A1/en not_active Ceased
- 2016-10-28 US US15/765,222 patent/US11371006B2/en active Active
- 2016-10-28 BR BR112018003852-0A patent/BR112018003852B1/pt active IP Right Grant
-
2018
- 2018-03-13 IL IL258080A patent/IL258080B/en active IP Right Grant
-
2022
- 2022-01-13 US US17/575,008 patent/US11866686B2/en active Active
-
2023
- 2023-12-01 US US18/526,338 patent/US20240132829A1/en active Pending
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