JP6893208B2 - Ｐｈ測定装置の較正ずれの特定 - Google Patents

Ｐｈ測定装置の較正ずれの特定 Download PDF

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Publication number
JP6893208B2
JP6893208B2 JP2018517832A JP2018517832A JP6893208B2 JP 6893208 B2 JP6893208 B2 JP 6893208B2 JP 2018517832 A JP2018517832 A JP 2018517832A JP 2018517832 A JP2018517832 A JP 2018517832A JP 6893208 B2 JP6893208 B2 JP 6893208B2
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medium
value
tank
measuring device
concentration
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JP2018534560A5 (enExample
JP2018534560A (ja
Inventor
クリスティアン クリンガー
クリスティアン クリンガー
カトリン クレップマイア
カトリン クレップマイア
デトレフ アイゼンクラッツァー
デトレフ アイゼンクラッツァー
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
    • G01D18/00—Testing or calibrating apparatus or arrangements provided for in groups G01D1/00 - G01D15/00
    • G01D18/008—Testing or calibrating apparatus or arrangements provided for in groups G01D1/00 - G01D15/00 with calibration coefficients stored in memory
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/4163—Systems checking the operation of, or calibrating, the measuring apparatus
    • G01N27/4165—Systems checking the operation of, or calibrating, the measuring apparatus for pH meters
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D21/00—Control of chemical or physico-chemical variables, e.g. pH value
    • G05D21/02—Control of chemical or physico-chemical variables, e.g. pH value characterised by the use of electric means

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Automation & Control Theory (AREA)
  • Computer Hardware Design (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Testing Or Calibration Of Command Recording Devices (AREA)
JP2018517832A 2015-10-30 2016-10-28 Ｐｈ測定装置の較正ずれの特定 Active JP6893208B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15192389 2015-10-30
EP15192389.3 2015-10-30
PCT/EP2016/076173 WO2017072346A1 (en) 2015-10-30 2016-10-28 Identification of calibration deviations of ph-measuring devices

Publications (3)

Publication Number Publication Date
JP2018534560A JP2018534560A (ja) 2018-11-22
JP2018534560A5 JP2018534560A5 (enExample) 2019-11-21
JP6893208B2 true JP6893208B2 (ja) 2021-06-23

Family

ID=54364192

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018517832A Active JP6893208B2 (ja) 2015-10-30 2016-10-28 Ｐｈ測定装置の較正ずれの特定

Country Status (15)

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US (3) US11371006B2 (enExample)
EP (2) EP3786278B1 (enExample)
JP (1) JP6893208B2 (enExample)
KR (1) KR102612135B1 (enExample)
CN (1) CN108368471B (enExample)
AU (1) AU2016345668B2 (enExample)
BR (1) BR112018003852B1 (enExample)
CA (1) CA2996468A1 (enExample)
ES (2) ES2808923T3 (enExample)
HR (2) HRP20221081T1 (enExample)
IL (1) IL258080B (enExample)
MX (1) MX2018004248A (enExample)
PL (2) PL3368653T3 (enExample)
SI (2) SI3786278T1 (enExample)
WO (1) WO2017072346A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102019107625A1 (de) * 2018-12-20 2020-06-25 Endress+Hauser Conducta Gmbh+Co. Kg Verfahren zur In-Prozess-Justage eines potentiometrischen Sensors einer Messanordnung
CN109856220B (zh) * 2019-03-07 2020-06-05 中南大学 一种pH值在线检测装置及其控制和校准预判方法
CN110057990B (zh) * 2019-03-08 2021-09-14 天津大学 一种多参数水质剖面仪的pH校正方法
US12031941B2 (en) * 2019-08-12 2024-07-09 Emd Millipore Corporation Methods to automatically calibrate pH sensors without sampling
IL305067A (en) * 2021-02-12 2023-10-01 Bayer Healthcare Llc Methods for adjusting the pH of cell culture medium
EP4612312A1 (en) 2022-11-02 2025-09-10 F. Hoffmann-La Roche AG Method for producing glycoprotein compositions
CN115753948B (zh) * 2022-11-28 2025-07-25 新疆大学 一种高温高压条件下饱和酸性气体的溶液pH获取系统、方法及预测方法
US20240248104A1 (en) * 2023-01-24 2024-07-25 Culture Biosciences, Inc. Methods and systems for tracking performance characteristics of probes for a biomanufacturing system
WO2025224236A1 (en) 2024-04-25 2025-10-30 F. Hoffmann-La Roche Ag Methods and systems for determining an actual ph in a liquid phase of a tank

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60141286A (ja) 1983-12-28 1985-07-26 Ajinomoto Co Inc 動物細胞の培養方法および装置
US4513280A (en) 1984-10-04 1985-04-23 The United States Of America As Represented By The Secretary Of The Navy Method and apparatus for the detection of toxicants
JPH06174677A (ja) * 1992-12-08 1994-06-24 Meidensha Corp 酸−アルカリ滴定法におけるｐＨ計の誤差検出方法及び装置
AT401111B (de) * 1995-02-01 1996-06-25 Avl Verbrennungskraft Messtech Verfahren zur kalibrierung eines ph-messelementes
US5578194A (en) * 1995-03-10 1996-11-26 Nova Biomedical Corporation Calibration of electrodes
CH690251A5 (de) * 1995-11-10 2000-06-15 Hamilton Bonaduz Ag Luftstabile pH-Standardlösungen.
DE69807042T2 (de) * 1997-01-17 2003-02-06 Metracor Technologies Inc., San Diego Verfahren zum kalibrieren von sensoren in diagnostischen testverfahren
US6865407B2 (en) 2002-07-11 2005-03-08 Optical Sensors, Inc. Calibration technique for non-invasive medical devices
DE10239610B3 (de) 2002-08-29 2004-06-24 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Verfahren zur Funktionsüberwachung von Sensoren
CN1238498C (zh) 2004-02-12 2006-01-25 陈志南 动物细胞无血清悬浮培养工艺过程控制参数的方法
US7771988B2 (en) 2005-03-24 2010-08-10 Hitachi, Ltd. Control device for fermenter
EP2001991A4 (en) 2006-01-28 2013-03-20 Abb Research Ltd METHOD FOR ON-LINE PREDICTION OF THE FUTURE EFFICIENCY OF A FERMENTATION UNIT
JP2008220235A (ja) * 2007-03-12 2008-09-25 Sanyo Electric Co Ltd 培養装置
JP5136280B2 (ja) * 2007-08-24 2013-02-06 Ｔｏｔｏ株式会社 腸内状態測定装置および測定方法
US8178318B2 (en) 2008-08-06 2012-05-15 Praxair Technology, Inc. Method for controlling pH, osmolality and dissolved carbon dioxide levels in a mammalian cell culture process to enhance cell viability and biologic product yield
PL2451936T3 (pl) 2009-07-06 2020-02-28 F. Hoffmann-La Roche Ag Sposób hodowli komórek eukariotycznych
US20130115588A1 (en) * 2010-04-15 2013-05-09 G & G Technologies, Inc. Integrated bioreactor and separation system and methods of use therof
WO2012171030A2 (en) * 2011-06-10 2012-12-13 Biovest International, Inc. Method and apparatus for antibody production and purification
JP5896105B2 (ja) * 2011-07-12 2016-03-30 横河電機株式会社 ｐＨ測定装置
WO2013016672A2 (en) * 2011-07-28 2013-01-31 Board Of Regents, The University Of Texas System Methods of producing human hemoglobin in a bioreactor
SG2014008809A (en) * 2011-09-21 2014-04-28 Hoffmann La Roche Co2 profile cultivation
EP2772529A4 (en) * 2011-10-28 2015-07-01 Siemens Ag SYSTEM FOR MONITORING A PRODUCTION PROCESS AND CONTROL METHOD THEREFOR
JP6164753B2 (ja) * 2015-03-30 2017-07-19 国立大学法人高知大学 被検溶液のｐＨ測定方法及びｐＨ測定装置

Also Published As

Publication number Publication date
HK1258706A1 (zh) 2019-11-15
BR112018003852B1 (pt) 2021-12-14
SI3368653T1 (sl) 2020-08-31
IL258080B (en) 2021-05-31
PL3368653T3 (pl) 2020-10-19
HRP20221081T1 (hr) 2022-11-25
HRP20201130T1 (hr) 2020-10-30
PL3786278T3 (pl) 2022-09-19
MX2018004248A (es) 2018-05-15
US11866686B2 (en) 2024-01-09
AU2016345668A1 (en) 2018-03-08
ES2808923T3 (es) 2021-03-02
EP3786278A1 (en) 2021-03-03
EP3786278B1 (en) 2022-07-13
BR112018003852A2 (pt) 2018-10-02
AU2016345668B2 (en) 2021-07-08
CA2996468A1 (en) 2017-05-04
CN108368471A (zh) 2018-08-03
ES2926594T3 (es) 2022-10-27
CN108368471B (zh) 2022-07-15
US20220325223A1 (en) 2022-10-13
KR102612135B1 (ko) 2023-12-08
WO2017072346A1 (en) 2017-05-04
KR20180077161A (ko) 2018-07-06
EP3368653B1 (en) 2020-05-27
US20240132829A1 (en) 2024-04-25
SI3786278T1 (sl) 2022-10-28
IL258080A (en) 2018-05-31
US20180216059A1 (en) 2018-08-02
JP2018534560A (ja) 2018-11-22
EP3368653A1 (en) 2018-09-05
US11371006B2 (en) 2022-06-28

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