AU2016345668B2 - Identification of calibration deviations of pH-measuring devices - Google Patents

Identification of calibration deviations of pH-measuring devices Download PDF

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Publication number
AU2016345668B2
AU2016345668B2 AU2016345668A AU2016345668A AU2016345668B2 AU 2016345668 B2 AU2016345668 B2 AU 2016345668B2 AU 2016345668 A AU2016345668 A AU 2016345668A AU 2016345668 A AU2016345668 A AU 2016345668A AU 2016345668 B2 AU2016345668 B2 AU 2016345668B2
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medium
value
tank
measuring device
concentration
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AU2016345668A1 (en
Inventor
Detlef Eisenkraetzer
Katrin GREPPMAIR
Christian Klinger
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
    • G01D18/00—Testing or calibrating apparatus or arrangements provided for in groups G01D1/00 - G01D15/00
    • G01D18/008—Testing or calibrating apparatus or arrangements provided for in groups G01D1/00 - G01D15/00 with calibration coefficients stored in memory
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/4163—Systems checking the operation of, or calibrating, the measuring apparatus
    • G01N27/4165—Systems checking the operation of, or calibrating, the measuring apparatus for pH meters
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D21/00—Control of chemical or physico-chemical variables, e.g. pH value
    • G05D21/02—Control of chemical or physico-chemical variables, e.g. pH value characterised by the use of electric means

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Automation & Control Theory (AREA)
  • Computer Hardware Design (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Testing Or Calibration Of Command Recording Devices (AREA)
AU2016345668A 2015-10-30 2016-10-28 Identification of calibration deviations of pH-measuring devices Active AU2016345668B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15192389 2015-10-30
EP15192389.3 2015-10-30
PCT/EP2016/076173 WO2017072346A1 (en) 2015-10-30 2016-10-28 Identification of calibration deviations of ph-measuring devices

Publications (2)

Publication Number Publication Date
AU2016345668A1 AU2016345668A1 (en) 2018-03-08
AU2016345668B2 true AU2016345668B2 (en) 2021-07-08

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Family Applications (1)

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AU2016345668A Active AU2016345668B2 (en) 2015-10-30 2016-10-28 Identification of calibration deviations of pH-measuring devices

Country Status (15)

Country Link
US (3) US11371006B2 (enExample)
EP (2) EP3786278B1 (enExample)
JP (1) JP6893208B2 (enExample)
KR (1) KR102612135B1 (enExample)
CN (1) CN108368471B (enExample)
AU (1) AU2016345668B2 (enExample)
BR (1) BR112018003852B1 (enExample)
CA (1) CA2996468A1 (enExample)
ES (2) ES2808923T3 (enExample)
HR (2) HRP20221081T1 (enExample)
IL (1) IL258080B (enExample)
MX (1) MX2018004248A (enExample)
PL (2) PL3368653T3 (enExample)
SI (2) SI3786278T1 (enExample)
WO (1) WO2017072346A1 (enExample)

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DE102019107625A1 (de) * 2018-12-20 2020-06-25 Endress+Hauser Conducta Gmbh+Co. Kg Verfahren zur In-Prozess-Justage eines potentiometrischen Sensors einer Messanordnung
CN109856220B (zh) * 2019-03-07 2020-06-05 中南大学 一种pH值在线检测装置及其控制和校准预判方法
CN110057990B (zh) * 2019-03-08 2021-09-14 天津大学 一种多参数水质剖面仪的pH校正方法
US12031941B2 (en) * 2019-08-12 2024-07-09 Emd Millipore Corporation Methods to automatically calibrate pH sensors without sampling
IL305067A (en) * 2021-02-12 2023-10-01 Bayer Healthcare Llc Methods for adjusting the pH of cell culture medium
EP4612312A1 (en) 2022-11-02 2025-09-10 F. Hoffmann-La Roche AG Method for producing glycoprotein compositions
CN115753948B (zh) * 2022-11-28 2025-07-25 新疆大学 一种高温高压条件下饱和酸性气体的溶液pH获取系统、方法及预测方法
US20240248104A1 (en) * 2023-01-24 2024-07-25 Culture Biosciences, Inc. Methods and systems for tracking performance characteristics of probes for a biomanufacturing system
WO2025224236A1 (en) 2024-04-25 2025-10-30 F. Hoffmann-La Roche Ag Methods and systems for determining an actual ph in a liquid phase of a tank

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US20100120139A1 (en) * 2007-03-12 2010-05-13 Sanyo Electric Co., Ltd. Incubation apparatus
US20130115588A1 (en) * 2010-04-15 2013-05-09 G & G Technologies, Inc. Integrated bioreactor and separation system and methods of use therof
US20140141469A1 (en) * 2011-07-28 2014-05-22 Douglas P. Henderson Methods of producing human hemoglobin in a bioreactor
US20140330398A1 (en) * 2011-10-28 2014-11-06 Siemens Aktiengesellschaft Production Process Monitoring System And Control Method Therefor

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US4513280A (en) 1984-10-04 1985-04-23 The United States Of America As Represented By The Secretary Of The Navy Method and apparatus for the detection of toxicants
JPH06174677A (ja) * 1992-12-08 1994-06-24 Meidensha Corp 酸−アルカリ滴定法におけるｐＨ計の誤差検出方法及び装置
AT401111B (de) * 1995-02-01 1996-06-25 Avl Verbrennungskraft Messtech Verfahren zur kalibrierung eines ph-messelementes
US5578194A (en) * 1995-03-10 1996-11-26 Nova Biomedical Corporation Calibration of electrodes
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CN1238498C (zh) 2004-02-12 2006-01-25 陈志南 动物细胞无血清悬浮培养工艺过程控制参数的方法
US7771988B2 (en) 2005-03-24 2010-08-10 Hitachi, Ltd. Control device for fermenter
JP5136280B2 (ja) * 2007-08-24 2013-02-06 Ｔｏｔｏ株式会社 腸内状態測定装置および測定方法
US8178318B2 (en) 2008-08-06 2012-05-15 Praxair Technology, Inc. Method for controlling pH, osmolality and dissolved carbon dioxide levels in a mammalian cell culture process to enhance cell viability and biologic product yield
PL2451936T3 (pl) 2009-07-06 2020-02-28 F. Hoffmann-La Roche Ag Sposób hodowli komórek eukariotycznych
WO2012171030A2 (en) * 2011-06-10 2012-12-13 Biovest International, Inc. Method and apparatus for antibody production and purification
JP5896105B2 (ja) * 2011-07-12 2016-03-30 横河電機株式会社 ｐＨ測定装置
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Publication number Priority date Publication date Assignee Title
WO2007085880A1 (en) * 2006-01-28 2007-08-02 Abb Research Ltd A method for on-line prediction of future performance of a fermentation unit.
US20100120139A1 (en) * 2007-03-12 2010-05-13 Sanyo Electric Co., Ltd. Incubation apparatus
US20130115588A1 (en) * 2010-04-15 2013-05-09 G & G Technologies, Inc. Integrated bioreactor and separation system and methods of use therof
US20140141469A1 (en) * 2011-07-28 2014-05-22 Douglas P. Henderson Methods of producing human hemoglobin in a bioreactor
US20140330398A1 (en) * 2011-10-28 2014-11-06 Siemens Aktiengesellschaft Production Process Monitoring System And Control Method Therefor

Also Published As

Publication number Publication date
HK1258706A1 (zh) 2019-11-15
BR112018003852B1 (pt) 2021-12-14
SI3368653T1 (sl) 2020-08-31
IL258080B (en) 2021-05-31
JP6893208B2 (ja) 2021-06-23
PL3368653T3 (pl) 2020-10-19
HRP20221081T1 (hr) 2022-11-25
HRP20201130T1 (hr) 2020-10-30
PL3786278T3 (pl) 2022-09-19
MX2018004248A (es) 2018-05-15
US11866686B2 (en) 2024-01-09
AU2016345668A1 (en) 2018-03-08
ES2808923T3 (es) 2021-03-02
EP3786278A1 (en) 2021-03-03
EP3786278B1 (en) 2022-07-13
BR112018003852A2 (pt) 2018-10-02
CA2996468A1 (en) 2017-05-04
CN108368471A (zh) 2018-08-03
ES2926594T3 (es) 2022-10-27
CN108368471B (zh) 2022-07-15
US20220325223A1 (en) 2022-10-13
KR102612135B1 (ko) 2023-12-08
WO2017072346A1 (en) 2017-05-04
KR20180077161A (ko) 2018-07-06
EP3368653B1 (en) 2020-05-27
US20240132829A1 (en) 2024-04-25
SI3786278T1 (sl) 2022-10-28
IL258080A (en) 2018-05-31
US20180216059A1 (en) 2018-08-02
JP2018534560A (ja) 2018-11-22
EP3368653A1 (en) 2018-09-05
US11371006B2 (en) 2022-06-28

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