CA2996468A1 - Identification of calibration deviations of ph-measuring devices - Google Patents

Identification of calibration deviations of ph-measuring devices Download PDF

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Publication number
CA2996468A1
CA2996468A1 CA2996468A CA2996468A CA2996468A1 CA 2996468 A1 CA2996468 A1 CA 2996468A1 CA 2996468 A CA2996468 A CA 2996468A CA 2996468 A CA2996468 A CA 2996468A CA 2996468 A1 CA2996468 A1 CA 2996468A1
Authority
CA
Canada
Prior art keywords
medium
value
tank
measuring device
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2996468A
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English (en)
French (fr)
Inventor
Christian Klinger
Katrin GREPPMAIR
Detlef Eisenkraetzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2996468A1 publication Critical patent/CA2996468A1/en
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48Automatic or computerized control
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01DMEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
    • G01D18/00Testing or calibrating apparatus or arrangements provided for in groups G01D1/00 - G01D15/00
    • G01D18/008Testing or calibrating apparatus or arrangements provided for in groups G01D1/00 - G01D15/00 with calibration coefficients stored in memory
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/4163Systems checking the operation of, or calibrating, the measuring apparatus
    • G01N27/4165Systems checking the operation of, or calibrating, the measuring apparatus for pH meters
    • GPHYSICS
    • G05CONTROLLING; REGULATING
    • G05DSYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D21/00Control of chemical or physico-chemical variables, e.g. pH value
    • G05D21/02Control of chemical or physico-chemical variables, e.g. pH value characterised by the use of electric means

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Automation & Control Theory (AREA)
  • Computer Hardware Design (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Testing Or Calibration Of Command Recording Devices (AREA)
CA2996468A 2015-10-30 2016-10-28 Identification of calibration deviations of ph-measuring devices Pending CA2996468A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15192389 2015-10-30
EP15192389.3 2015-10-30
PCT/EP2016/076173 WO2017072346A1 (en) 2015-10-30 2016-10-28 Identification of calibration deviations of ph-measuring devices

Publications (1)

Publication Number Publication Date
CA2996468A1 true CA2996468A1 (en) 2017-05-04

Family

ID=54364192

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2996468A Pending CA2996468A1 (en) 2015-10-30 2016-10-28 Identification of calibration deviations of ph-measuring devices

Country Status (15)

Country Link
US (3) US11371006B2 (enExample)
EP (2) EP3786278B1 (enExample)
JP (1) JP6893208B2 (enExample)
KR (1) KR102612135B1 (enExample)
CN (1) CN108368471B (enExample)
AU (1) AU2016345668B2 (enExample)
BR (1) BR112018003852B1 (enExample)
CA (1) CA2996468A1 (enExample)
ES (2) ES2808923T3 (enExample)
HR (2) HRP20221081T1 (enExample)
IL (1) IL258080B (enExample)
MX (1) MX2018004248A (enExample)
PL (2) PL3368653T3 (enExample)
SI (2) SI3786278T1 (enExample)
WO (1) WO2017072346A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115753948A (zh) * 2022-11-28 2023-03-07 新疆大学 一种高温高压条件下饱和酸性气体的溶液pH获取系统、方法及预测方法

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DE102019107625A1 (de) * 2018-12-20 2020-06-25 Endress+Hauser Conducta Gmbh+Co. Kg Verfahren zur In-Prozess-Justage eines potentiometrischen Sensors einer Messanordnung
CN109856220B (zh) * 2019-03-07 2020-06-05 中南大学 一种pH值在线检测装置及其控制和校准预判方法
CN110057990B (zh) * 2019-03-08 2021-09-14 天津大学 一种多参数水质剖面仪的pH校正方法
US12031941B2 (en) * 2019-08-12 2024-07-09 Emd Millipore Corporation Methods to automatically calibrate pH sensors without sampling
IL305067A (en) * 2021-02-12 2023-10-01 Bayer Healthcare Llc Methods for adjusting the pH of cell culture medium
EP4612312A1 (en) 2022-11-02 2025-09-10 F. Hoffmann-La Roche AG Method for producing glycoprotein compositions
US20240248104A1 (en) * 2023-01-24 2024-07-25 Culture Biosciences, Inc. Methods and systems for tracking performance characteristics of probes for a biomanufacturing system
WO2025224236A1 (en) 2024-04-25 2025-10-30 F. Hoffmann-La Roche Ag Methods and systems for determining an actual ph in a liquid phase of a tank

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US4513280A (en) 1984-10-04 1985-04-23 The United States Of America As Represented By The Secretary Of The Navy Method and apparatus for the detection of toxicants
JPH06174677A (ja) * 1992-12-08 1994-06-24 Meidensha Corp 酸−アルカリ滴定法におけるpH計の誤差検出方法及び装置
AT401111B (de) * 1995-02-01 1996-06-25 Avl Verbrennungskraft Messtech Verfahren zur kalibrierung eines ph-messelementes
US5578194A (en) * 1995-03-10 1996-11-26 Nova Biomedical Corporation Calibration of electrodes
CH690251A5 (de) * 1995-11-10 2000-06-15 Hamilton Bonaduz Ag Luftstabile pH-Standardlösungen.
DE69807042T2 (de) * 1997-01-17 2003-02-06 Metracor Technologies Inc., San Diego Verfahren zum kalibrieren von sensoren in diagnostischen testverfahren
US6865407B2 (en) 2002-07-11 2005-03-08 Optical Sensors, Inc. Calibration technique for non-invasive medical devices
DE10239610B3 (de) 2002-08-29 2004-06-24 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Verfahren zur Funktionsüberwachung von Sensoren
CN1238498C (zh) 2004-02-12 2006-01-25 陈志南 动物细胞无血清悬浮培养工艺过程控制参数的方法
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JP2008220235A (ja) * 2007-03-12 2008-09-25 Sanyo Electric Co Ltd 培養装置
JP5136280B2 (ja) * 2007-08-24 2013-02-06 Toto株式会社 腸内状態測定装置および測定方法
US8178318B2 (en) 2008-08-06 2012-05-15 Praxair Technology, Inc. Method for controlling pH, osmolality and dissolved carbon dioxide levels in a mammalian cell culture process to enhance cell viability and biologic product yield
PL2451936T3 (pl) 2009-07-06 2020-02-28 F. Hoffmann-La Roche Ag Sposób hodowli komórek eukariotycznych
US20130115588A1 (en) * 2010-04-15 2013-05-09 G & G Technologies, Inc. Integrated bioreactor and separation system and methods of use therof
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115753948A (zh) * 2022-11-28 2023-03-07 新疆大学 一种高温高压条件下饱和酸性气体的溶液pH获取系统、方法及预测方法

Also Published As

Publication number Publication date
HK1258706A1 (zh) 2019-11-15
BR112018003852B1 (pt) 2021-12-14
SI3368653T1 (sl) 2020-08-31
IL258080B (en) 2021-05-31
JP6893208B2 (ja) 2021-06-23
PL3368653T3 (pl) 2020-10-19
HRP20221081T1 (hr) 2022-11-25
HRP20201130T1 (hr) 2020-10-30
PL3786278T3 (pl) 2022-09-19
MX2018004248A (es) 2018-05-15
US11866686B2 (en) 2024-01-09
AU2016345668A1 (en) 2018-03-08
ES2808923T3 (es) 2021-03-02
EP3786278A1 (en) 2021-03-03
EP3786278B1 (en) 2022-07-13
BR112018003852A2 (pt) 2018-10-02
AU2016345668B2 (en) 2021-07-08
CN108368471A (zh) 2018-08-03
ES2926594T3 (es) 2022-10-27
CN108368471B (zh) 2022-07-15
US20220325223A1 (en) 2022-10-13
KR102612135B1 (ko) 2023-12-08
WO2017072346A1 (en) 2017-05-04
KR20180077161A (ko) 2018-07-06
EP3368653B1 (en) 2020-05-27
US20240132829A1 (en) 2024-04-25
SI3786278T1 (sl) 2022-10-28
IL258080A (en) 2018-05-31
US20180216059A1 (en) 2018-08-02
JP2018534560A (ja) 2018-11-22
EP3368653A1 (en) 2018-09-05
US11371006B2 (en) 2022-06-28

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