|
CA149387A
(en)
|
1913-05-22 |
1913-07-22 |
Andrew Jackson Coppock |
Means of priming explosive engines
|
|
CA151652A
(en)
|
1913-08-23 |
1913-11-11 |
Per Erik Martin Norell |
Side bearing for cars
|
|
CA157738A
(en)
|
1914-07-30 |
1914-09-08 |
John Martin Davis |
Aeroplane
|
|
DK100664C
(da)
|
1960-05-11 |
1964-12-21 |
Friedrich Tonne |
Rørpostanlæg med automatisk styring af rørpostpatronernes bevægelse.
|
|
US5714166A
(en)
|
1986-08-18 |
1998-02-03 |
The Dow Chemical Company |
Bioactive and/or targeted dendrimer conjugates
|
|
US5436146A
(en)
|
1989-09-07 |
1995-07-25 |
The Trustees Of Princeton University |
Helper-free stocks of recombinant adeno-associated virus vectors
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
US5283185A
(en)
|
1991-08-28 |
1994-02-01 |
University Of Tennessee Research Corporation |
Method for delivering nucleic acids into cells
|
|
US5334761A
(en)
|
1992-08-28 |
1994-08-02 |
Life Technologies, Inc. |
Cationic lipids
|
|
US6133028A
(en)
|
1993-05-28 |
2000-10-17 |
Transgene S.A. |
Defective adenoviruses and corresponding complementation lines
|
|
JP3816518B2
(ja)
|
1994-06-10 |
2006-08-30 |
ジェンベク、インコーポレイティッド |
相補的なアデノウイルスベクター系と細胞系
|
|
US5908635A
(en)
|
1994-08-05 |
1999-06-01 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method for the liposomal delivery of nucleic acids
|
|
US20020168342A1
(en)
|
1994-11-03 |
2002-11-14 |
Cell Genesys, Inc. |
Novel adenoviral vectors, packaging cell lines, recombinant adenoviruses and methods
|
|
US5872005A
(en)
|
1994-11-03 |
1999-02-16 |
Cell Genesys Inc. |
Packaging cell lines for adeno-associated viral vectors
|
|
IL116816A
(en)
|
1995-01-20 |
2003-05-29 |
Rhone Poulenc Rorer Sa |
Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof
|
|
US5629184A
(en)
|
1995-01-25 |
1997-05-13 |
Amgen Inc. |
Cationic copolymers of vinylamine and vinyl alcohol for the delivery of oligonucleotides
|
|
FR2730637B1
(fr)
|
1995-02-17 |
1997-03-28 |
Rhone Poulenc Rorer Sa |
Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
|
|
US5830430A
(en)
|
1995-02-21 |
1998-11-03 |
Imarx Pharmaceutical Corp. |
Cationic lipids and the use thereof
|
|
US6040183A
(en)
|
1995-06-07 |
2000-03-21 |
University Of North Carloina At Chapel Hill |
Helper virus-free AAV production
|
|
US6093570A
(en)
|
1995-06-07 |
2000-07-25 |
The University Of North Carolina At Chapel Hill |
Helper virus-free AAV production
|
|
CA2226299A1
(en)
|
1995-08-11 |
1997-02-27 |
Dendritech, Inc. |
Hyper comb-branched polymer conjugates
|
|
NZ500546A
(en)
|
1997-04-14 |
2001-09-28 |
Cell Genesys Inc |
Methods for increasing the production of high titre stocks of recombinant adeno-associated virus (AAV)
|
|
US5948878A
(en)
|
1997-04-15 |
1999-09-07 |
Burgess; Stephen W. |
Cationic polymers for nucleic acid transfection and bioactive agent delivery
|
|
WO1999029303A1
(en)
|
1997-12-12 |
1999-06-17 |
Samyang Corporation |
Biodegradable mixed polymeric micelles for gene delivery
|
|
ZA9811377B
(en)
|
1997-12-12 |
1999-08-27 |
Expression Genetics Inc |
Positively charged poly[alpha-(omega-aminoalkyl) glycolic acid[ for the delivery of a bioactive agent via tissue and cellular uptake.
|
|
US6169078B1
(en)
|
1998-05-12 |
2001-01-02 |
University Of Florida |
Materials and methods for the intracellular delivery of substances
|
|
US6177274B1
(en)
|
1998-05-20 |
2001-01-23 |
Expression Genetics, Inc. |
Hepatocyte targeting polyethylene glyco-grafted poly-L-lysine polymeric gene carrier
|
|
US7030219B2
(en)
*
|
2000-04-28 |
2006-04-18 |
Johns Hopkins University |
B7-DC, Dendritic cell co-stimulatory molecules
|
|
US7595048B2
(en)
*
|
2002-07-03 |
2009-09-29 |
Ono Pharmaceutical Co., Ltd. |
Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1
|
|
WO2004033486A2
(en)
*
|
2002-10-11 |
2004-04-22 |
Zymogenetics, Inc. |
Production of homotrimeric fusion proteins
|
|
WO2004045525A2
(en)
*
|
2002-11-15 |
2004-06-03 |
Morehouse School Of Medicine |
Anti-chemokine and associated receptor antibodies and uses for inhibition of inflammation.
|
|
US8512701B2
(en)
*
|
2002-11-15 |
2013-08-20 |
Morehouse School Of Medicine |
Anti-CXCL13 and anti-CXCR5 antibodies for the prevention and treatment of cancer and cancer cell migration
|
|
WO2006066066A2
(en)
*
|
2004-12-15 |
2006-06-22 |
University Of North Carolina At Chapel Hill |
Chimeric vectors
|
|
NZ597168A
(en)
*
|
2005-08-19 |
2013-07-26 |
Abbott Lab |
Dual variable domain immunoglobin and uses thereof
|
|
ES2657801T3
(es)
|
2007-07-10 |
2018-03-06 |
Apogenix Ag |
Proteínas de fusión de colectina de la superfamilia de TNF
|
|
WO2010037042A2
(en)
*
|
2008-09-26 |
2010-04-01 |
The General Hospital Corporation |
Methods for detecting and treating cancer
|
|
JP5677972B2
(ja)
*
|
2008-11-18 |
2015-02-25 |
メリマック ファーマシューティカルズ インコーポレーティッド |
ヒト血清アルブミンリンカーおよびそのコンジュゲート
|
|
EP2504028A4
(en)
*
|
2009-11-24 |
2014-04-09 |
Amplimmune Inc |
SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2
|
|
CN102250254A
(zh)
|
2010-05-19 |
2011-11-23 |
江苏先声药物研究有限公司 |
肿瘤坏死因子相关凋亡诱导配体融合蛋白及其制备和应用
|
|
WO2012162426A1
(en)
*
|
2011-05-23 |
2012-11-29 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for heptameric targeting ligands
|
|
WO2012162561A2
(en)
|
2011-05-24 |
2012-11-29 |
Zyngenia, Inc. |
Multivalent and monovalent multispecific complexes and their uses
|
|
EP2765997A4
(en)
*
|
2011-10-14 |
2015-06-24 |
Stc Unm |
POROUS NANOPARTICLE-SUPPORTED LIPID DOUBLE LAYERS (PROTOCOLS) FOR THE TARGETED RELEASE BY TRANSDERMAL RELEASE AND USE METHOD THEREFOR
|
|
RS58102B1
(sr)
*
|
2011-11-09 |
2019-02-28 |
Bristol Myers Squibb Co |
Lečenje hematoloških maligniteta sa anti-cxcr4 antitelom
|
|
SG10201601747XA
(en)
*
|
2012-01-18 |
2016-04-28 |
Genentech Inc |
Anti-LRP5 Antibodies And Methods Of Use
|
|
EP2950814A4
(en)
|
2013-01-31 |
2016-06-08 |
Univ Jefferson |
FUSION PROTEINS BASED ON PD-L1 AND PD-L2 AND USES THEREOF
|
|
JP2016527303A
(ja)
*
|
2013-08-05 |
2016-09-08 |
ケンブリッジ エンタープライズ リミテッド |
がん免疫療法におけるcxcr4シグナル伝達の阻害
|
|
JP6707445B2
(ja)
*
|
2013-10-21 |
2020-06-10 |
ジェネンテック, インコーポレイテッド |
抗Ly6E抗体及び使用方法
|
|
TWI681969B
(zh)
*
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
針對pd-1的人類抗體
|
|
JP6731346B2
(ja)
*
|
2014-02-10 |
2020-07-29 |
メルク パテント ゲーエムベーハー |
標的TGFβ阻害
|
|
CN105085677B
(zh)
*
|
2014-05-05 |
2019-01-18 |
中国科学院上海药物研究所 |
抗vegfr2人源纳米抗体ntv1及其制备方法和用途
|
|
WO2016004389A2
(en)
*
|
2014-07-03 |
2016-01-07 |
Abbvie Inc. |
Monovalent binding proteins
|
|
PT3177640T
(pt)
|
2014-08-08 |
2020-08-31 |
Univ Leland Stanford Junior |
Agentes pd-1 de alta afinidade e métodos de utilização
|
|
KR20180063885A
(ko)
*
|
2015-09-24 |
2018-06-12 |
더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 |
전이 감소를 위한 방법 및 조성물
|
|
CN108079301B
(zh)
|
2016-11-23 |
2021-03-02 |
四川大学 |
减少cxcl13蛋白活性或表达量的活性物质在制备治疗恶性肿瘤转移药物中的用途
|
|
WO2018160572A1
(en)
|
2017-02-28 |
2018-09-07 |
Oncomed Pharmaceuticals, Inc. |
Methods for treatment of cancer comprising gitr-binding agents
|
|
AU2019231191A1
(en)
*
|
2018-03-05 |
2020-09-03 |
Institute Of Biophysics, Chinese Academy Of Sciences |
Methods of use of soluble CD24 for treating acquired immune deficiency syndrome (HIV/AIDS)
|
|
CN110357960A
(zh)
*
|
2018-04-10 |
2019-10-22 |
广州爱思迈生物医药科技有限公司 |
抗体及抗体改造方法
|
|
CN112870362B
(zh)
*
|
2021-02-08 |
2023-06-27 |
中山大学附属第一医院 |
Circ-MET-1214和/或Circ-M50作为靶点在制备抗肿瘤药物中的用途
|
|
CN113234165B
(zh)
*
|
2021-05-07 |
2023-02-28 |
暨南大学 |
EpCAM的改造的结合蛋白及其应用
|
|
CN113402618B
(zh)
*
|
2021-06-30 |
2022-06-10 |
徐州医科大学 |
Ski在制备增效型CAR-T细胞中的应用
|
|
CN113512115B
(zh)
*
|
2021-08-09 |
2023-09-15 |
江苏省农业科学院 |
一种广谱识别小菜蛾中肠受体的抗Cry2Aa独特型单域抗体及其应用
|