JP2018531622A5 - - Google Patents
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- JP2018531622A5 JP2018531622A5 JP2018531307A JP2018531307A JP2018531622A5 JP 2018531622 A5 JP2018531622 A5 JP 2018531622A5 JP 2018531307 A JP2018531307 A JP 2018531307A JP 2018531307 A JP2018531307 A JP 2018531307A JP 2018531622 A5 JP2018531622 A5 JP 2018531622A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 188
- 229920001184 polypeptide Polymers 0.000 claims description 187
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 187
- 230000004927 fusion Effects 0.000 claims description 152
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 44
- 125000000539 amino acid group Chemical group 0.000 claims description 43
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 18
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 15
- 102000004169 proteins and genes Human genes 0.000 claims description 14
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 102000006382 Ribonucleases Human genes 0.000 claims description 11
- 108010083644 Ribonucleases Proteins 0.000 claims description 11
- 238000006467 substitution reaction Methods 0.000 claims description 11
- 210000004027 cell Anatomy 0.000 claims description 10
- 102000006996 Aryldialkylphosphatase Human genes 0.000 claims description 9
- 108010008184 Aryldialkylphosphatase Proteins 0.000 claims description 9
- 102000012336 Cholesterol Ester Transfer Proteins Human genes 0.000 claims description 8
- 108010061846 Cholesterol Ester Transfer Proteins Proteins 0.000 claims description 8
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 8
- 239000013604 expression vector Substances 0.000 claims description 8
- 102000003896 Myeloperoxidases Human genes 0.000 claims description 6
- 108090000235 Myeloperoxidases Proteins 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 5
- 238000006471 dimerization reaction Methods 0.000 claims description 5
- 235000012000 cholesterol Nutrition 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
- 101710126783 Acetyl-hydrolase Proteins 0.000 claims description 3
- 108060003951 Immunoglobulin Proteins 0.000 claims description 3
- 239000012190 activator Substances 0.000 claims description 3
- 102000018358 immunoglobulin Human genes 0.000 claims description 3
- 239000003112 inhibitor Substances 0.000 claims description 3
- 102000004157 Hydrolases Human genes 0.000 claims description 2
- 108090000604 Hydrolases Proteins 0.000 claims description 2
- 108010003541 Platelet Activating Factor Proteins 0.000 claims description 2
- 210000004748 cultured cell Anatomy 0.000 claims description 2
- 102000040430 polynucleotide Human genes 0.000 claims description 2
- 108091033319 polynucleotide Proteins 0.000 claims description 2
- 239000002157 polynucleotide Substances 0.000 claims description 2
- 238000013518 transcription Methods 0.000 claims description 2
- 230000035897 transcription Effects 0.000 claims description 2
- 230000002103 transcriptional effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 35
- 108020001507 fusion proteins Proteins 0.000 description 8
- 102000037865 fusion proteins Human genes 0.000 description 8
- 230000007423 decrease Effects 0.000 description 6
- 238000002648 combination therapy Methods 0.000 description 5
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 description 4
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 4
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 208000027866 inflammatory disease Diseases 0.000 description 4
- 230000004770 neurodegeneration Effects 0.000 description 4
- 208000015122 neurodegenerative disease Diseases 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 108010024976 Asparaginase Proteins 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 3
- 208000035473 Communicable disease Diseases 0.000 description 3
- 102100031538 Phosphatidylcholine-sterol acyltransferase Human genes 0.000 description 3
- 208000029078 coronary artery disease Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 201000006417 multiple sclerosis Diseases 0.000 description 3
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 208000037259 Amyloid Plaque Diseases 0.000 description 2
- 108010087819 Fc receptors Proteins 0.000 description 2
- 102000009109 Fc receptors Human genes 0.000 description 2
- 108010073807 IgG Receptors Proteins 0.000 description 2
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 description 2
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 description 2
- 208000019693 Lung disease Diseases 0.000 description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 2
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 description 2
- 230000013595 glycosylation Effects 0.000 description 2
- 238000006206 glycosylation reaction Methods 0.000 description 2
- 230000002519 immonomodulatory effect Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 108010068617 neonatal Fc receptor Proteins 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 2
- 208000004476 Acute Coronary Syndrome Diseases 0.000 description 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 102000008096 B7-H1 Antigen Human genes 0.000 description 1
- 108010074708 B7-H1 Antigen Proteins 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 229940045513 CTLA4 antagonist Drugs 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 206010058490 Hyperoxia Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- 208000033749 Small cell carcinoma of the bladder Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 201000009267 bronchiectasis Diseases 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 1
- 201000010536 head and neck cancer Diseases 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 230000000222 hyperoxic effect Effects 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 description 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000002626 targeted therapy Methods 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 201000007710 urinary bladder small cell neuroendocrine carcinoma Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562215256P | 2015-09-08 | 2015-09-08 | |
| US62/215,256 | 2015-09-08 | ||
| PCT/US2016/050405 WO2017044424A1 (en) | 2015-09-08 | 2016-09-06 | Apoa-1 fusion polypeptides and related compositions and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020202324A Division JP7233113B2 (ja) | 2015-09-08 | 2020-12-04 | ＡｐｏＡ－１融合ポリペプチドならびに関連する組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018531622A JP2018531622A (ja) | 2018-11-01 |
| JP2018531622A5 true JP2018531622A5 (https=) | 2019-10-10 |
| JP6953020B2 JP6953020B2 (ja) | 2021-10-27 |
Family
ID=56985674
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018531307A Active JP6953020B2 (ja) | 2015-09-08 | 2016-09-06 | ＡｐｏＡ−１融合ポリペプチドならびに関連する組成物および方法 |
| JP2020202324A Active JP7233113B2 (ja) | 2015-09-08 | 2020-12-04 | ＡｐｏＡ－１融合ポリペプチドならびに関連する組成物および方法 |
| JP2022078179A Pending JP2022105200A (ja) | 2015-09-08 | 2022-05-11 | ＡｐｏＡ－１融合ポリペプチドならびに関連する組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020202324A Active JP7233113B2 (ja) | 2015-09-08 | 2020-12-04 | ＡｐｏＡ－１融合ポリペプチドならびに関連する組成物および方法 |
| JP2022078179A Pending JP2022105200A (ja) | 2015-09-08 | 2022-05-11 | ＡｐｏＡ－１融合ポリペプチドならびに関連する組成物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US12331102B2 (https=) |
| EP (1) | EP3328881B1 (https=) |
| JP (3) | JP6953020B2 (https=) |
| KR (1) | KR102440820B1 (https=) |
| CN (1) | CN107969127B (https=) |
| AU (1) | AU2016321146C1 (https=) |
| CA (1) | CA2997263C (https=) |
| DK (1) | DK3328881T3 (https=) |
| IL (1) | IL257302B (https=) |
| WO (1) | WO2017044424A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017044424A1 (en) | 2015-09-08 | 2017-03-16 | Theripion, Inc. | Apoa-1 fusion polypeptides and related compositions and methods |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| AU2019240609B2 (en) * | 2018-10-29 | 2025-12-11 | Consejo Nacional de Investigaciones Científcas Y Técnicas (Conicet) | TGF- ß receptor II isoform, fusion peptide, methods of treatment and methods in vitro |
| EP4019641A4 (en) * | 2019-08-19 | 2022-12-21 | Nanjing Novel Biotechnology Co., Ltd. | REPLICATIVE ONCOLYTIC ADENOVIRUS TO REGULATE LIPID METABOLISM AND ITS UTILIZATION |
| CN110964119A (zh) * | 2019-12-05 | 2020-04-07 | 沣潮医药科技（上海）有限公司 | 抗疟二聚体免疫粘附素、药物组合物和用途 |
| US12180521B2 (en) | 2021-02-19 | 2024-12-31 | Theripion, Inc. | Paraoxonase fusion polypeptides and related compositions and methods |
| AU2023277740A1 (en) * | 2022-05-24 | 2024-11-07 | Bio-Trip B.V. | Modified apolipoproteins with a targeting body for lipid nanoparticles |
| WO2024158816A1 (en) * | 2023-01-23 | 2024-08-02 | The Board Of Trustees Of The Leland Stanford Junior University | Conjugates, compositions, and methods for brain delivery |
| WO2024251979A1 (en) * | 2023-06-07 | 2024-12-12 | Universidad Del País Vasco/Euskal Herriko Unibertsitatea | Backpacked-antibody constructs and their uses |
| WO2024259220A1 (en) | 2023-06-15 | 2024-12-19 | Theripion, Inc. | Pon3 and evolved pon1 fusion polypeptides |
| CN118077649B (zh) * | 2024-02-29 | 2024-09-10 | 复旦大学附属中山医院 | 一种免疫检查点抑制剂构建动脉粥样硬化小鼠模型的方法 |
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| US20140120091A1 (en) | 2012-10-31 | 2014-05-01 | University Of Washington Through Its Center For Commercialization | Fusion proteins for therapy of autoimmune and cardiovascular disease |
| CN105407909A (zh) * | 2013-01-25 | 2016-03-16 | J·拉格斯泰特 | 用于治疗高血糖症的载脂蛋白a-i源性肽 |
| US9873882B2 (en) * | 2013-05-14 | 2018-01-23 | Bayer Cropscience Nv | Enhanced selective expression of transgenes in fiber producing plants |
| PL3063275T3 (pl) | 2013-10-31 | 2020-03-31 | Resolve Therapeutics, Llc | Terapeutyczne fuzje nukleaza-albumina i sposoby |
| US20160009776A1 (en) | 2014-07-10 | 2016-01-14 | Bayer Pharma Aktiengesellschaft | Pdgfrbeta-fc fusion proteins and uses thereof |
| WO2017044424A1 (en) | 2015-09-08 | 2017-03-16 | Theripion, Inc. | Apoa-1 fusion polypeptides and related compositions and methods |
-
2016
- 2016-09-06 WO PCT/US2016/050405 patent/WO2017044424A1/en not_active Ceased
- 2016-09-06 CN CN201680051589.5A patent/CN107969127B/zh not_active Expired - Fee Related
- 2016-09-06 EP EP16770394.1A patent/EP3328881B1/en active Active
- 2016-09-06 CA CA2997263A patent/CA2997263C/en active Active
- 2016-09-06 JP JP2018531307A patent/JP6953020B2/ja active Active
- 2016-09-06 KR KR1020187009391A patent/KR102440820B1/ko active Active
- 2016-09-06 AU AU2016321146A patent/AU2016321146C1/en active Active
- 2016-09-06 DK DK16770394.1T patent/DK3328881T3/da active
-
2018
- 2018-02-01 IL IL257302A patent/IL257302B/en unknown
- 2018-03-01 US US15/909,314 patent/US12331102B2/en active Active
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2020
- 2020-12-04 JP JP2020202324A patent/JP7233113B2/ja active Active
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2021
- 2021-12-03 US US17/542,181 patent/US11472864B2/en active Active
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2022
- 2022-05-11 JP JP2022078179A patent/JP2022105200A/ja active Pending
- 2022-09-09 US US17/930,761 patent/US20230024372A1/en not_active Abandoned
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2025
- 2025-03-07 US US19/074,055 patent/US12509501B2/en active Active
- 2025-11-13 US US19/388,476 patent/US20260062460A1/en active Pending
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