JP2019509735A5 - - Google Patents

Info

Publication number

JP2019509735A5

JP2019509735A5 JP2018546471A JP2018546471A JP2019509735A5 JP 2019509735 A5 JP2019509735 A5 JP 2019509735A5 JP 2018546471 A JP2018546471 A JP 2018546471A JP 2018546471 A JP2018546471 A JP 2018546471A JP 2019509735 A5 JP2019509735 A5 JP 2019509735A5

Authority

JP

Japan

Prior art keywords

seq

recombinant follistatin

amino acid

composition

fusion protein

Prior art date

2017-03-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

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• 102000016970 Follistatin Human genes 0.000 claims description 129
• 108010014612 Follistatin Proteins 0.000 claims description 129
• 229920001184 polypeptide Polymers 0.000 claims description 64
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 64
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 64
• 102000037865 fusion proteins Human genes 0.000 claims description 63
• 108020001507 fusion proteins Proteins 0.000 claims description 63
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 44
• 239000000203 mixture Substances 0.000 claims description 35
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 30
• 150000001413 amino acids Chemical class 0.000 claims description 28
• 238000000034 method Methods 0.000 claims description 26
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• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims description 2
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• 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 2
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