JP2013539369A5 - - Google Patents
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- Publication number
- JP2013539369A5 JP2013539369A5 JP2013527309A JP2013527309A JP2013539369A5 JP 2013539369 A5 JP2013539369 A5 JP 2013539369A5 JP 2013527309 A JP2013527309 A JP 2013527309A JP 2013527309 A JP2013527309 A JP 2013527309A JP 2013539369 A5 JP2013539369 A5 JP 2013539369A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- antibody
- antigen
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 71
- 239000012634 fragment Substances 0.000 claims 49
- 239000000427 antigen Substances 0.000 claims 37
- 102000036639 antigens Human genes 0.000 claims 37
- 108091007433 antigens Proteins 0.000 claims 37
- 102000039446 nucleic acids Human genes 0.000 claims 28
- 108020004707 nucleic acids Proteins 0.000 claims 28
- 150000007523 nucleic acids Chemical class 0.000 claims 28
- 229920001184 polypeptide Polymers 0.000 claims 28
- 102000004196 processed proteins & peptides Human genes 0.000 claims 28
- 108090000765 processed proteins & peptides Proteins 0.000 claims 28
- 102000040430 polynucleotide Human genes 0.000 claims 23
- 108091033319 polynucleotide Proteins 0.000 claims 23
- 239000002157 polynucleotide Substances 0.000 claims 23
- 238000006467 substitution reaction Methods 0.000 claims 20
- 239000013598 vector Substances 0.000 claims 14
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 13
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 11
- 101000858064 Homo sapiens C-X-C motif chemokine 13 Proteins 0.000 claims 10
- 102100025277 C-X-C motif chemokine 13 Human genes 0.000 claims 9
- 239000003937 drug carrier Substances 0.000 claims 5
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 241000589989 Helicobacter Species 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 101100222384 Mus musculus Cxcl13 gene Proteins 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000007107 Stomach Ulcer Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000000718 duodenal ulcer Diseases 0.000 claims 1
- 201000005917 gastric ulcer Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000005004 lymphoid follicle Anatomy 0.000 claims 1
- 210000003563 lymphoid tissue Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37967210P | 2010-09-02 | 2010-09-02 | |
| US61/379,672 | 2010-09-02 | ||
| US201161481645P | 2011-05-02 | 2011-05-02 | |
| US61/481,645 | 2011-05-02 | ||
| PCT/US2011/050177 WO2012031099A2 (en) | 2010-09-02 | 2011-09-01 | Anti-cxcl13 antibodies and methods of using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016218182A Division JP2017099379A (ja) | 2010-09-02 | 2016-11-08 | 抗ｃｘｃｌ１３抗体およびそれを用いる方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013539369A JP2013539369A (ja) | 2013-10-24 |
| JP2013539369A5 true JP2013539369A5 (https=) | 2014-10-16 |
| JP6097690B2 JP6097690B2 (ja) | 2017-03-15 |
Family
ID=45773520
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013527309A Active JP6097690B2 (ja) | 2010-09-02 | 2011-09-01 | 抗ｃｘｃｌ１３抗体およびそれを用いる方法 |
| JP2016218182A Withdrawn JP2017099379A (ja) | 2010-09-02 | 2016-11-08 | 抗ｃｘｃｌ１３抗体およびそれを用いる方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016218182A Withdrawn JP2017099379A (ja) | 2010-09-02 | 2016-11-08 | 抗ｃｘｃｌ１３抗体およびそれを用いる方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9963504B2 (https=) |
| EP (1) | EP2611832B1 (https=) |
| JP (2) | JP6097690B2 (https=) |
| KR (1) | KR101862236B1 (https=) |
| CN (1) | CN103347896B (https=) |
| AU (1) | AU2011295902B2 (https=) |
| BR (1) | BR112013005145B1 (https=) |
| CA (1) | CA2810217C (https=) |
| DK (1) | DK2611832T3 (https=) |
| MX (1) | MX353476B (https=) |
| NZ (1) | NZ608318A (https=) |
| SG (1) | SG188285A1 (https=) |
| WO (1) | WO2012031099A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010129917A2 (en) | 2009-05-08 | 2010-11-11 | Vaccinex, Inc. | Anti-cd100 antibodies and methods for using the same |
| SG188285A1 (en) | 2010-09-02 | 2013-04-30 | Vaccinex Inc | Anti-cxcl13 antibodies and methods of using the same |
| CN103608680A (zh) * | 2010-12-14 | 2014-02-26 | 詹姆士·W·里拉尔德 | 抗cxcl13抗体和抗cxcr5抗体在恶性肿瘤的治疗或检测中的用途 |
| AU2012322721B2 (en) | 2011-10-11 | 2016-05-05 | Vaccinex, Inc. | Use of semaphorin-4D binding molecules for modulation of blood brain barrier permeability |
| NZ629828A (en) * | 2012-03-02 | 2017-05-26 | Vaccinex Inc | Methods for the treatment of b cell-mediated inflammatory diseases |
| US9708601B2 (en) | 2012-04-26 | 2017-07-18 | Vaccinex, Inc. | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus |
| HK1212628A1 (zh) * | 2012-06-27 | 2016-06-17 | 吉安特科技公司 | 用於抑制炎症的抗-cxcl9、抗-cxcl10、抗-cxcl11、抗-cxcl13、抗-cxcr3和抗-cxcr5试剂 |
| CN104884955B (zh) * | 2012-12-07 | 2017-06-27 | 巴克斯特国际公司 | 抗‑mif抗体的细胞迁移测定方法 |
| CN105408355A (zh) * | 2013-01-31 | 2016-03-16 | 瓦克纳斯有限公司 | 用于提高免疫球蛋白a水平的方法 |
| AU2013205589A1 (en) * | 2013-03-08 | 2014-09-25 | Vaccinex, Inc. | Anti-CXCL13 antibodies and associated epitope sequences |
| BR112015032690B1 (pt) | 2013-06-25 | 2020-03-10 | Vaccinex, Inc. | Uso de moléculas inibidoras de semaforina-4d em combinação com uma terapia imunomoduladora para inibir o crescimento tumoral e metástase |
| HK1258218A1 (zh) * | 2015-09-15 | 2019-11-08 | Board Of Regents, The University Of Texas System | T细胞受体(tcr)结合抗体及其应用 |
| US10577427B2 (en) | 2016-04-22 | 2020-03-03 | Vaccinex, Inc. | Integral membrane protein display on poxvirus extracellular enveloped virions |
| BR112019001944A2 (pt) | 2016-08-02 | 2019-05-07 | Vaccinex, Inc. | métodos aperfeiçoados para produção de bibiliotecas de polinucleotídeo em células eucarióticas/vírus de vaccínia |
| CN111615520A (zh) | 2017-12-01 | 2020-09-01 | 辉瑞大药厂 | 抗cxcr5抗体及其组合物和用途 |
| BR112021004553A2 (pt) * | 2018-09-17 | 2021-06-08 | Abcuro, Inc. | anticorpos anti-klrg1 |
| SG11202010499UA (en) * | 2018-09-18 | 2020-11-27 | I Mab Biopharma Us Ltd | Anti-cxcl13 antibodies for treating autoimmune diseases and cancer |
| AU2021286476A1 (en) * | 2020-06-11 | 2023-02-02 | Imperial College Innovations Limited | Use of CXCL13 binding molecules to promote peripheral nerve regeneration |
| CN115975946A (zh) * | 2022-12-01 | 2023-04-18 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 表达趋化因子cxcl10、cxcl13、ccl19的免疫细胞及其制备方法与应用 |
| CN121652269B (zh) * | 2026-02-05 | 2026-04-17 | 北京中杉金桥生物技术有限公司 | 一种抗人cxcl13兔单克隆抗体、制备方法及其应用 |
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| NZ629828A (en) | 2012-03-02 | 2017-05-26 | Vaccinex Inc | Methods for the treatment of b cell-mediated inflammatory diseases |
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| AU2013205589A1 (en) | 2013-03-08 | 2014-09-25 | Vaccinex, Inc. | Anti-CXCL13 antibodies and associated epitope sequences |
-
2011
- 2011-09-01 SG SG2013013735A patent/SG188285A1/en unknown
- 2011-09-01 DK DK11822655.4T patent/DK2611832T3/en active
- 2011-09-01 MX MX2013002495A patent/MX353476B/es active IP Right Grant
- 2011-09-01 EP EP11822655.4A patent/EP2611832B1/en active Active
- 2011-09-01 WO PCT/US2011/050177 patent/WO2012031099A2/en not_active Ceased
- 2011-09-01 NZ NZ60831811A patent/NZ608318A/en unknown
- 2011-09-01 AU AU2011295902A patent/AU2011295902B2/en active Active
- 2011-09-01 US US13/820,278 patent/US9963504B2/en active Active
- 2011-09-01 CN CN201180052932.5A patent/CN103347896B/zh active Active
- 2011-09-01 KR KR1020137008377A patent/KR101862236B1/ko active Active
- 2011-09-01 JP JP2013527309A patent/JP6097690B2/ja active Active
- 2011-09-01 BR BR112013005145-0A patent/BR112013005145B1/pt active IP Right Grant
- 2011-09-01 CA CA2810217A patent/CA2810217C/en active Active
-
2016
- 2016-11-08 JP JP2016218182A patent/JP2017099379A/ja not_active Withdrawn
-
2018
- 2018-04-13 US US15/953,139 patent/US10829550B2/en active Active
-
2020
- 2020-09-24 US US17/030,627 patent/US11981730B2/en active Active
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