JP2018531280A5 - - Google Patents
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- Publication number
- JP2018531280A5 JP2018531280A5 JP2018529503A JP2018529503A JP2018531280A5 JP 2018531280 A5 JP2018531280 A5 JP 2018531280A5 JP 2018529503 A JP2018529503 A JP 2018529503A JP 2018529503 A JP2018529503 A JP 2018529503A JP 2018531280 A5 JP2018531280 A5 JP 2018531280A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- appendix
- salt
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000003839 salts Chemical class 0.000 claims description 49
- KMXXSJLYVJEBHI-UHFFFAOYSA-N 3-guanidinopropanoic acid Chemical compound NC(=[NH2+])NCCC([O-])=O KMXXSJLYVJEBHI-UHFFFAOYSA-N 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 7
- 238000000113 differential scanning calorimetry Methods 0.000 claims description 5
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 2
- 238000001802 infusion Methods 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 2
- 238000002411 thermogravimetry Methods 0.000 claims description 2
- 230000004580 weight loss Effects 0.000 claims description 2
- 238000002050 diffraction method Methods 0.000 claims 4
- 239000000843 powder Substances 0.000 claims 4
- 150000003890 succinate salts Chemical class 0.000 claims 2
- 238000001938 differential scanning calorimetry curve Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 18
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 13
- 206010028980 Neoplasm Diseases 0.000 description 5
- 201000011510 cancer Diseases 0.000 description 5
- 208000037819 metastatic cancer Diseases 0.000 description 4
- 208000011575 metastatic malignant neoplasm Diseases 0.000 description 4
- 238000001069 Raman spectroscopy Methods 0.000 description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 description 2
- 230000005757 colony formation Effects 0.000 description 2
- 239000001530 fumaric acid Substances 0.000 description 2
- 230000001394 metastastic effect Effects 0.000 description 2
- 206010061289 metastatic neoplasm Diseases 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021077099A JP7134294B2 (ja) | 2015-08-25 | 2021-04-30 | 改善された特性を有するβ－グアニジノプロピオン酸の薬学的に許容される塩及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562209624P | 2015-08-25 | 2015-08-25 | |
| US62/209,624 | 2015-08-25 | ||
| PCT/US2016/048643 WO2017035331A1 (en) | 2015-08-25 | 2016-08-25 | PHARMACEUTICALLY ACCEPTABLE SALTS OF β-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021077099A Division JP7134294B2 (ja) | 2015-08-25 | 2021-04-30 | 改善された特性を有するβ－グアニジノプロピオン酸の薬学的に許容される塩及びその使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2018531280A JP2018531280A (ja) | 2018-10-25 |
| JP2018531280A6 JP2018531280A6 (ja) | 2018-12-13 |
| JP2018531280A5 true JP2018531280A5 (cg-RX-API-DMAC7.html) | 2019-10-03 |
| JP6880023B2 JP6880023B2 (ja) | 2021-06-02 |
Family
ID=58100994
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018529503A Active JP6880023B2 (ja) | 2015-08-25 | 2016-08-25 | 改善された特性を有するβ−グアニジノプロピオン酸の薬学的に許容される塩及びその使用 |
| JP2021077099A Active JP7134294B2 (ja) | 2015-08-25 | 2021-04-30 | 改善された特性を有するβ－グアニジノプロピオン酸の薬学的に許容される塩及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021077099A Active JP7134294B2 (ja) | 2015-08-25 | 2021-04-30 | 改善された特性を有するβ－グアニジノプロピオン酸の薬学的に許容される塩及びその使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US20170056352A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3340973B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6880023B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102707964B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN114057611A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016311368B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2996520C (cg-RX-API-DMAC7.html) |
| DK (1) | DK3340973T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2843561T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20210044T1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE053963T2 (cg-RX-API-DMAC7.html) |
| PL (1) | PL3340973T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT3340973T (cg-RX-API-DMAC7.html) |
| RS (1) | RS61804B1 (cg-RX-API-DMAC7.html) |
| SI (1) | SI3340973T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017035331A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015168465A1 (en) | 2014-04-30 | 2015-11-05 | Rgenix, Inc. | Inhibitors of creatine transport and uses thereof |
| WO2016100619A2 (en) * | 2014-12-17 | 2016-06-23 | Rgenix, Inc. | Treatment and diagnosis of cancer |
| US20170056352A1 (en) | 2015-08-25 | 2017-03-02 | Rgenix, Inc. | PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| WO2018160178A1 (en) * | 2017-03-01 | 2018-09-07 | Rgenix, Inc. | Pharmaceutically acceptable salts of b-guanidinopropionic acid with improved properties and uses thereof |
| EP3713575A4 (en) | 2017-11-21 | 2021-08-25 | Rgenix, Inc. | POLYMORPHS AND THEIR USES |
| JP2023505687A (ja) * | 2019-12-11 | 2023-02-10 | インスピルナ，インコーポレーテッド | 癌の処置方法 |
| JP7689964B2 (ja) | 2019-12-13 | 2025-06-09 | インスピルナ，インコーポレーテッド | 金属塩及びその使用 |
| KR102615692B1 (ko) * | 2021-10-13 | 2023-12-19 | 주식회사 휴엔켐 | 베타-구아니디노프로피온산을 포함하는 간섬유화 예방 또는 치료용 조성물 |
| US20250270471A1 (en) * | 2022-04-21 | 2025-08-28 | Merck Sharp & Dohme Llc | Process for preparing agglomerated crystalline medium-chain fatty acid sodium salts |
| KR102822799B1 (ko) | 2022-11-09 | 2025-06-20 | 충남대학교산학협력단 | 베타-구아니디노프로피온산을 포함하는 장내 미생물 개선용 조성물 |
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-
2016
- 2016-08-24 US US15/245,750 patent/US20170056352A1/en not_active Abandoned
- 2016-08-25 PT PT168401040T patent/PT3340973T/pt unknown
- 2016-08-25 HR HRP20210044TT patent/HRP20210044T1/hr unknown
- 2016-08-25 CN CN202111189796.6A patent/CN114057611A/zh active Pending
- 2016-08-25 ES ES16840104T patent/ES2843561T3/es active Active
- 2016-08-25 PL PL16840104T patent/PL3340973T3/pl unknown
- 2016-08-25 RS RS20210023A patent/RS61804B1/sr unknown
- 2016-08-25 WO PCT/US2016/048643 patent/WO2017035331A1/en not_active Ceased
- 2016-08-25 DK DK16840104.0T patent/DK3340973T3/da active
- 2016-08-25 KR KR1020187008144A patent/KR102707964B1/ko active Active
- 2016-08-25 HU HUE16840104A patent/HUE053963T2/hu unknown
- 2016-08-25 SI SI201631048T patent/SI3340973T1/sl unknown
- 2016-08-25 CN CN201680057402.2A patent/CN108472269B/zh active Active
- 2016-08-25 CA CA2996520A patent/CA2996520C/en active Active
- 2016-08-25 AU AU2016311368A patent/AU2016311368B2/en active Active
- 2016-08-25 JP JP2018529503A patent/JP6880023B2/ja active Active
- 2016-08-25 EP EP16840104.0A patent/EP3340973B1/en active Active
- 2016-09-30 US US15/281,329 patent/US9827217B2/en active Active
-
2017
- 2017-10-27 US US15/795,540 patent/US10512623B2/en active Active
-
2019
- 2019-11-06 US US16/675,669 patent/US20200138759A1/en not_active Abandoned
-
2021
- 2021-04-30 JP JP2021077099A patent/JP7134294B2/ja active Active
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