BR112012026768A2 - composições compreendendo pró-farmacos de opioides cliváveis de modo enzimático e seus inibidores. - Google Patents
composições compreendendo pró-farmacos de opioides cliváveis de modo enzimático e seus inibidores.Info
- Publication number
- BR112012026768A2 BR112012026768A2 BR112012026768A BR112012026768A BR112012026768A2 BR 112012026768 A2 BR112012026768 A2 BR 112012026768A2 BR 112012026768 A BR112012026768 A BR 112012026768A BR 112012026768 A BR112012026768 A BR 112012026768A BR 112012026768 A2 BR112012026768 A2 BR 112012026768A2
- Authority
- BR
- Brazil
- Prior art keywords
- prodrug
- compositions
- inhibitors
- enzymatically cleavable
- enzymatically
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Abstract
composições compreendendo pró-farmacos de opioides cliváveis de modo enzimático e seus inibidores. a presente revelação provê composições farmacêuticas e seus métodos de utilização, em que as composições farmacêuticas compreendem um pró-fármaco que provê a liberação controlada de modo enzimático de um pró-fármaco e um inibidor enzimático que interage com a(s) enzima(s) que medeia(m) a liberação controlada de modo enzimático do pró-fármaco a partir do pró-fármaco, de modo atenuar a clivagem enzimática do pró-fármaco. a revelação provê composições farmacêuticas que compreendem um inibidor enzimático e um pró-fármaco que contém uma fração clivável de modo enzimático que, quando clivada, facilita a liberação do pró-fármaco.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2010/031953 WO2011133149A1 (en) | 2010-04-21 | 2010-04-21 | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012026768A2 true BR112012026768A2 (pt) | 2015-09-29 |
Family
ID=44834413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012026768A BR112012026768A2 (pt) | 2010-04-21 | 2010-04-21 | composições compreendendo pró-farmacos de opioides cliváveis de modo enzimático e seus inibidores. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP2560489A4 (pt) |
JP (1) | JP2013525348A (pt) |
CN (1) | CN102917589A (pt) |
AU (1) | AU2010351605C1 (pt) |
BR (1) | BR112012026768A2 (pt) |
CA (1) | CA2795222A1 (pt) |
IL (1) | IL222354A0 (pt) |
RU (1) | RU2012149438A (pt) |
WO (1) | WO2011133149A1 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011031350A1 (en) * | 2009-09-08 | 2011-03-17 | Pharmacofore, Inc. | Compositions comprising enzyme-cleavable ketone-modified opioid prodrugs and optional inhibitors thereof |
ES2584634T3 (es) * | 2011-01-11 | 2016-09-28 | Signature Therapeutics, Inc. | Composiciones que comprenden un profármaco de oxicodona escindible enzimáticamente |
US11634384B2 (en) | 2014-11-25 | 2023-04-25 | Concentric Analgesics, Inc. | Prodrugs of phenolic TRPV1 agonists |
US20170056352A1 (en) | 2015-08-25 | 2017-03-02 | Rgenix, Inc. | PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF |
EP3463576A4 (en) | 2016-05-25 | 2020-01-15 | Concentric Analgesics, Inc. | PRODRUGS BY PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETIC AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA |
WO2018160178A1 (en) | 2017-03-01 | 2018-09-07 | Rgenix, Inc. | Pharmaceutically acceptable salts of b-guanidinopropionic acid with improved properties and uses thereof |
EP3684417A1 (en) * | 2017-09-19 | 2020-07-29 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | Lipophilic peptide prodrugs |
EP3684785A1 (en) | 2017-09-19 | 2020-07-29 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | N-methylated cyclic peptides and their prodrugs |
US10717712B2 (en) | 2018-07-27 | 2020-07-21 | Concentric Analgesics, Inc. | Pegylated prodrugs of phenolic TRPV1 agonists |
US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4668418B2 (ja) * | 1998-12-15 | 2011-04-13 | アプライド バイオシステムズ リミテッド ライアビリティー カンパニー | 多種酵素アッセイ |
US7060708B2 (en) * | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
US8163701B2 (en) * | 2005-08-19 | 2012-04-24 | Signature Therapeutics, Inc. | Prodrugs of active agents |
CA2624179A1 (en) * | 2005-10-06 | 2007-04-12 | Auspex Pharmaceuticals, Inc. | Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties |
CN101528264B (zh) * | 2006-05-26 | 2014-02-26 | 特色疗法股份有限公司 | 酚类阿片样物质的受控释放 |
MX2008014794A (es) * | 2006-05-26 | 2009-04-08 | Pharmacofore Inc | Liberacion controlada de opioides fenolicos. |
WO2008101187A2 (en) * | 2007-02-16 | 2008-08-21 | Pharmacofore, Inc. | Pro-drugs of peripheral phenolic opioid antagonists |
BRPI0919711A2 (pt) * | 2008-10-17 | 2015-12-08 | Pharmacofore Inc | composições farmacêuticas com liberação atenuada de opióides fenólicos |
WO2011031350A1 (en) * | 2009-09-08 | 2011-03-17 | Pharmacofore, Inc. | Compositions comprising enzyme-cleavable ketone-modified opioid prodrugs and optional inhibitors thereof |
-
2010
- 2010-04-21 EP EP20100850371 patent/EP2560489A4/en not_active Withdrawn
- 2010-04-21 WO PCT/US2010/031953 patent/WO2011133149A1/en active Application Filing
- 2010-04-21 CA CA2795222A patent/CA2795222A1/en not_active Abandoned
- 2010-04-21 JP JP2013506120A patent/JP2013525348A/ja active Pending
- 2010-04-21 BR BR112012026768A patent/BR112012026768A2/pt not_active IP Right Cessation
- 2010-04-21 AU AU2010351605A patent/AU2010351605C1/en not_active Ceased
- 2010-04-21 CN CN2010800671025A patent/CN102917589A/zh active Pending
- 2010-04-21 RU RU2012149438/15A patent/RU2012149438A/ru not_active Application Discontinuation
-
2012
- 2012-10-11 IL IL222354A patent/IL222354A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2010351605A1 (en) | 2012-11-22 |
WO2011133149A1 (en) | 2011-10-27 |
AU2010351605C1 (en) | 2015-08-06 |
EP2560489A1 (en) | 2013-02-27 |
JP2013525348A (ja) | 2013-06-20 |
CN102917589A (zh) | 2013-02-06 |
RU2012149438A (ru) | 2014-05-27 |
CA2795222A1 (en) | 2011-10-27 |
IL222354A0 (en) | 2012-12-31 |
AU2010351605B2 (en) | 2015-01-29 |
EP2560489A4 (en) | 2014-01-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |