JP2018529763A5 - - Google Patents
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- Publication number
- JP2018529763A5 JP2018529763A5 JP2018531303A JP2018531303A JP2018529763A5 JP 2018529763 A5 JP2018529763 A5 JP 2018529763A5 JP 2018531303 A JP2018531303 A JP 2018531303A JP 2018531303 A JP2018531303 A JP 2018531303A JP 2018529763 A5 JP2018529763 A5 JP 2018529763A5
- Authority
- JP
- Japan
- Prior art keywords
- extract
- composition
- luteolin
- rosemary
- ginger
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 86
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 60
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 claims description 60
- 235000009498 luteolin Nutrition 0.000 claims description 60
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 claims description 60
- 235000020748 rosemary extract Nutrition 0.000 claims description 44
- 229940092258 rosemary extract Drugs 0.000 claims description 44
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 claims description 44
- 235000020708 ginger extract Nutrition 0.000 claims description 28
- 229940002508 ginger extract Drugs 0.000 claims description 28
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 claims description 26
- 239000000284 extract Substances 0.000 claims description 24
- DBRXOUCRJQVYJQ-CKNDUULBSA-N withaferin A Chemical compound C([C@@H]1[C@H]([C@@H]2[C@]3(CC[C@@H]4[C@@]5(C)C(=O)C=C[C@H](O)[C@@]65O[C@@H]6C[C@H]4[C@@H]3CC2)C)C)C(C)=C(CO)C(=O)O1 DBRXOUCRJQVYJQ-CKNDUULBSA-N 0.000 claims description 18
- 235000017807 phytochemicals Nutrition 0.000 claims description 17
- 229930000223 plant secondary metabolite Natural products 0.000 claims description 17
- XUSYGBPHQBWGAD-PJSUUKDQSA-N Carnosol Chemical compound CC([C@@H]1C2)(C)CCC[C@@]11C(=O)O[C@@H]2C2=C1C(O)=C(O)C(C(C)C)=C2 XUSYGBPHQBWGAD-PJSUUKDQSA-N 0.000 claims description 14
- MMFRMKXYTWBMOM-UHFFFAOYSA-N Carnosol Natural products CCc1cc2C3CC4C(C)(C)CCCC4(C(=O)O3)c2c(O)c1O MMFRMKXYTWBMOM-UHFFFAOYSA-N 0.000 claims description 14
- 235000004654 carnosol Nutrition 0.000 claims description 14
- 239000009405 Ashwagandha Substances 0.000 claims description 13
- 235000001978 Withania somnifera Nutrition 0.000 claims description 13
- 240000004482 Withania somnifera Species 0.000 claims description 13
- 102100031701 Nuclear factor erythroid 2-related factor 2 Human genes 0.000 claims description 12
- JZLXEKNVCWMYHI-UHFFFAOYSA-N gingerol Natural products CCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 JZLXEKNVCWMYHI-UHFFFAOYSA-N 0.000 claims description 11
- NLDDIKRKFXEWBK-AWEZNQCLSA-N gingerol Chemical compound CCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 NLDDIKRKFXEWBK-AWEZNQCLSA-N 0.000 claims description 11
- 235000002780 gingerol Nutrition 0.000 claims description 11
- 235000015418 Bacopa monnieria Nutrition 0.000 claims description 10
- 101000588302 Homo sapiens Nuclear factor erythroid 2-related factor 2 Proteins 0.000 claims description 10
- 240000002999 Bacopa monnieri Species 0.000 claims description 8
- 235000020727 milk thistle extract Nutrition 0.000 claims description 8
- 229940096421 milk thistle extract Drugs 0.000 claims description 8
- 230000037361 pathway Effects 0.000 claims description 8
- 241000124008 Mammalia Species 0.000 claims description 6
- 230000004913 activation Effects 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- OQWKEEOHDMUXEO-UHFFFAOYSA-N (6)-shogaol Natural products CCCCCC=CC(=O)CCC1=CC=C(O)C(OC)=C1 OQWKEEOHDMUXEO-UHFFFAOYSA-N 0.000 claims description 5
- OQWKEEOHDMUXEO-BQYQJAHWSA-N [6]-Shogaol Chemical compound CCCCC\C=C\C(=O)CCC1=CC=C(O)C(OC)=C1 OQWKEEOHDMUXEO-BQYQJAHWSA-N 0.000 claims description 5
- YCGBUPXEBUFYFV-UHFFFAOYSA-N withaferin A Natural products CC(C1CC(=C(CO)C(=O)O1)C)C2CCC3C4CC5OC56C(O)C=CC(O)C6(C)C4CCC23C YCGBUPXEBUFYFV-UHFFFAOYSA-N 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 4
- 239000000499 gel Substances 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 3
- 241000295198 Bacopa Species 0.000 claims description 2
- 108010061414 Hepatocyte Nuclear Factor 1-beta Proteins 0.000 claims description 2
- 102100022123 Hepatocyte nuclear factor 1-beta Human genes 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 claims description 2
- 108010071382 NF-E2-Related Factor 2 Proteins 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 244000178231 Rosmarinus officinalis Species 0.000 claims description 2
- 241000320380 Silybum Species 0.000 claims description 2
- 235000010841 Silybum marianum Nutrition 0.000 claims description 2
- 241000234314 Zingiber Species 0.000 claims description 2
- 235000006886 Zingiber officinale Nutrition 0.000 claims description 2
- 239000000443 aerosol Substances 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 238000001784 detoxification Methods 0.000 claims description 2
- 235000015872 dietary supplement Nutrition 0.000 claims description 2
- 230000000925 erythroid effect Effects 0.000 claims description 2
- 235000008397 ginger Nutrition 0.000 claims description 2
- 230000004054 inflammatory process Effects 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 230000036542 oxidative stress Effects 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 230000002195 synergetic effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 6
- 230000007111 proteostasis Effects 0.000 description 2
- 241000282412 Homo Species 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000004900 autophagic degradation Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562214175P | 2015-09-03 | 2015-09-03 | |
| US62/214,175 | 2015-09-03 | ||
| US201662355810P | 2016-06-28 | 2016-06-28 | |
| US62/355,810 | 2016-06-28 | ||
| PCT/US2016/050292 WO2017041054A1 (en) | 2015-09-03 | 2016-09-02 | Compositions for improved nrf2 activation and methods of their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529763A JP2018529763A (ja) | 2018-10-11 |
| JP2018529763A5 true JP2018529763A5 (enExample) | 2019-10-10 |
| JP6901787B2 JP6901787B2 (ja) | 2021-07-14 |
Family
ID=58188643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018531303A Active JP6901787B2 (ja) | 2015-09-03 | 2016-09-02 | 改善されたｎｒｆ２活性化のための組成物及びその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11413269B2 (enExample) |
| JP (1) | JP6901787B2 (enExample) |
| CN (2) | CN120754114A (enExample) |
| CL (1) | CL2018000573A1 (enExample) |
| CO (1) | CO2018003454A2 (enExample) |
| HK (1) | HK1256480A1 (enExample) |
| MX (2) | MX394479B (enExample) |
| PE (1) | PE20190380A1 (enExample) |
| WO (1) | WO2017041054A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220354916A1 (en) * | 2015-09-03 | 2022-11-10 | Pathways Bioscience, Llc | Compositions for improved nrf2 activation and methods of their use |
| US10993981B2 (en) * | 2016-07-11 | 2021-05-04 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organiation (Aro), (Volcani Center) | Compositions for treatment of follicular tonsillitis using an emulsion based on rosemary extract and oregano essential oil |
| CN110545831A (zh) * | 2017-04-27 | 2019-12-06 | 帝斯曼知识产权资产管理有限公司 | Withania somnifera提取物提供针对空气污染相关疾病的保护的用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5888514A (en) * | 1997-05-23 | 1999-03-30 | Weisman; Bernard | Natural composition for treating bone or joint inflammation |
| US9265808B2 (en) * | 2004-03-23 | 2016-02-23 | Lifeline Nutraceuticals Corporation | Compositions for alleviating inflammation and oxidative stress in a mammal |
| WO2006073042A1 (ja) * | 2005-01-05 | 2006-07-13 | Toagosei Co., Ltd. | Ｎｒｆ２依存遺伝子の活性化剤 |
| CN101460185A (zh) * | 2006-04-03 | 2009-06-17 | 雀巢产品技术援助有限公司 | 用于促进骨生长和维持骨健康的营养组合物及与其有关的方法 |
| US8142806B2 (en) | 2008-03-10 | 2012-03-27 | University Of Louisville Research Foundation, Inc. | Methods and compositions for controlled delivery of phytochemical agents |
| CN102164508B (zh) | 2008-07-31 | 2015-04-01 | 嘉康利公司 | 具有增加的抗氧化活性的麝香葡萄组合物 |
| JP2011057654A (ja) * | 2009-09-14 | 2011-03-24 | Iwate Univ | メタボリックシンドローム治療又は予防薬、及び脂肪細胞分化抑制方法 |
| CA2785581A1 (en) | 2009-12-24 | 2011-06-30 | Stanley Kubow | Compositions and methods for preventing and treating diseases and environmentally induced health disorders |
| KR101254847B1 (ko) * | 2010-05-27 | 2013-04-15 | 한림대학교 산학협력단 | 실리비닌(silibinin)을 포함하는 골다공증 치료 및 예방용 조성물 |
| WO2012142511A2 (en) | 2011-04-15 | 2012-10-18 | Md Matrix Health Llc Dba Md Matrix Health Inc | Orthomolecular compositions and their use in stabilizing the extracellular matrix |
| CN104540513B (zh) * | 2012-01-16 | 2019-04-05 | 赫克托·德·杰休斯·维莱斯-里韦拉 | 用于治疗与关节疾病相关疼痛的植物组合物 |
| JP2013209351A (ja) | 2012-03-30 | 2013-10-10 | Sunstar Inc | 抗酸化機能亢進剤 |
| US20140287071A1 (en) * | 2013-01-17 | 2014-09-25 | Lifevantage Corporation | Veterinary supplements |
| WO2014151891A1 (en) * | 2013-03-14 | 2014-09-25 | Walley Darlene | Topical products |
| AU2014291615B2 (en) * | 2013-07-17 | 2019-09-26 | Council Of Scientific & Industrial Research | Pharmaceutical composition for the treatment of diminution of bone tissue |
| WO2016037971A1 (en) * | 2014-09-08 | 2016-03-17 | Bios Line S.P.A. | Compositions comprising glucosinolates precursors of sulforaphane in combination with extracts of rosemary |
-
2016
- 2016-09-02 PE PE2018000340A patent/PE20190380A1/es unknown
- 2016-09-02 WO PCT/US2016/050292 patent/WO2017041054A1/en not_active Ceased
- 2016-09-02 HK HK18115518.1A patent/HK1256480A1/zh unknown
- 2016-09-02 MX MX2018002743A patent/MX394479B/es unknown
- 2016-09-02 US US15/757,270 patent/US11413269B2/en active Active
- 2016-09-02 CN CN202510745791.9A patent/CN120754114A/zh active Pending
- 2016-09-02 JP JP2018531303A patent/JP6901787B2/ja active Active
- 2016-09-02 CN CN201680050947.0A patent/CN108136209A/zh active Pending
-
2018
- 2018-03-02 MX MX2022009446A patent/MX2022009446A/es unknown
- 2018-03-02 CL CL2018000573A patent/CL2018000573A1/es unknown
- 2018-03-27 CO CONC2018/0003454A patent/CO2018003454A2/es unknown
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