JP2013209351A - 抗酸化機能亢進剤 - Google Patents
抗酸化機能亢進剤 Download PDFInfo
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Abstract
【解決手段】ヤナギエキス、ニトベギクエキス、アカショウガエキス、ラフマエキス、カンゾウエキス、カミツレエキス、ノブドウエキス、オリーブエキス、セントジョーンズワートエキス、大豆エキス、ザクロエキス、アーティチョークエキス、マリアアザミエキス、ローズマリーエキス、ヤーコン葉エキス、イタドリ根エキス、イチョウ葉エキス、バレリアナエキス、セロリ種子エキス、レッドクローバーエキス、ニンニクエキスから選ばれる一種以上からなる体内抗酸化亢進剤を提供する。
【選択図】なし
Description
項1.ヤナギエキス、ニトベギクエキス、アカショウガエキス、ラフマエキス、カンゾウエキス、カミツレエキス、ノブドウエキス、オリーブエキス、セントジョーンズワートエキス、大豆エキス、ザクロエキス、アーティチョークエキス、マリアアザミエキス、ローズマリーエキス、ヤーコン葉エキス、イタドリ根エキス、イチョウ葉エキス、バレリアナエキス、セロリ種子エキス、レッドクローバーエキス、ニンニクエキスから選ばれる一種以上からなる体内抗酸化亢進剤。
られる。抽出に際しては、主に葉または果実を使用する。使用できる抽出溶媒は、特に水、エタノールの単独または混液が好ましく、混液の混合比は例えば水:エタノールの体積比で約100:1〜約1:200が好ましく、約20:1〜1:20がより好ましく、約1:9〜1:1が最も好ましい。また、抽出時の溶媒の温度は約−4℃〜約200℃の範囲であればよいが、約30℃〜約150℃が好ましく、約40℃〜約80℃がより好ましい。
各種エキスのNrf2の活性化評価
下記の被検体に対して、Nrf2の活性化の度合いを評価した。評価にはNrf2が重要な役割を果たしている血管内皮細胞として、ヒト臍帯静脈血管内皮細胞(HUVEC)を用いた。HUVECは、37℃、5%CO2存在下で、10%FBS、10 mMグルタミン(Gibco社製)、10 nMFGF(科研製薬社製)、100U/mlペニシリン、100μg/mlストレプトマイシン(Gibco社製)を含有するMCDB131培地(Sigma Aldrich社製)にて培養し継代を行った。継代数4のHUVECsをTypeIコラーゲンでコートした12well培養フラスコ(住友ベークライト社製)に3.4×104/wellの濃度で播種した。48時間培養後、Nrf2の応答配列であるAntioxidant response element (ARE)を組み込んだホタルルシフェラーゼ発現プラスミド(pGL4.27[NRF2-luc2P/minP/Hygro])0.2μgとウミシイタケルシフェラーゼ発現コントロールプラスミド(pRL-TK)0.05μgをSuperFect Transfection試薬(QIAGEN社製)を用いて遺伝子導入した。8時間後、細胞を各々の被験体で16時間処理後、ホタル、およびウミシイタケのルシフェラーゼ活性をDual-Luciferase Reporter Assay System(Promega社製)を用いてルミノメーター(GloMax 20/20n、Promega社製)にて測定した。各々の被験体のホタルルシフェラーゼ活性は、ウミシイタケのルシフェラーゼ活性により補正し、コントロールに対するAREルシフェラーゼ活性比を求めた。測定結果を、表1に示す。
なお、評価に供した資料は以下の通りである。なお、括弧内の記載は抽出溶媒の種類を意味する。
セイヨウヤナギエキス(水)
ニトベギクエキス(水)
アカショウガエキス(水/エタノール混合液)
ラフマエキス(水)
カンゾウエキス(水)
カミツレエキス(50%エタノール)
ノブドウエキス(水/エタノール混合液)
オリーブ葉抽出物(80%エタノール)
オリーブ果実ポリフェノール(水)
セントジョーンズワートエキス(水)
大豆エキス(大豆サポニン)(水)
イチョウ葉エキス:ギンコロン(水)
ザクロ果実エキス(60%エタノール)
アーティチョークエキス(水)
マリアアザミエキス(エタノール)
ローズマリーエキス(水)
ヤーコン葉エキス(水)
バレリアナ根エキス(70%エタノール)
セロリ種子エキス(水)
レッドクローバーエキス(エタノール)
生コーヒー豆エキス(水/エタノール混合液)
ルチン
杜仲エキス(水)
Claims (1)
- ヤナギエキス、ニトベギクエキス、アカショウガエキス、ラフマエキス、カンゾウエキス、カミツレエキス、ノブドウエキス、オリーブエキス、セントジョーンズワートエキス、大豆エキス、ザクロエキス、アーティチョークエキス、マリアアザミエキス、ローズマリーエキス、ヤーコン葉エキス、イタドリ根エキス、イチョウ葉エキス、バレリアナエキス、セロリ種子エキス、レッドクローバーエキス、ニンニクエキスから選ばれる一種以上からなる体内抗酸化亢進剤。
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