JP2018530517A5 - - Google Patents
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- JP2018530517A5 JP2018530517A5 JP2018503486A JP2018503486A JP2018530517A5 JP 2018530517 A5 JP2018530517 A5 JP 2018530517A5 JP 2018503486 A JP2018503486 A JP 2018503486A JP 2018503486 A JP2018503486 A JP 2018503486A JP 2018530517 A5 JP2018530517 A5 JP 2018530517A5
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- JP
- Japan
- Prior art keywords
- composition
- extract
- weight
- nitric oxide
- nos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 74
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 44
- 238000009472 formulation Methods 0.000 claims description 7
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 4
- 235000013824 polyphenols Nutrition 0.000 claims description 4
- 102000003896 Myeloperoxidases Human genes 0.000 claims description 3
- 108090000235 Myeloperoxidases Proteins 0.000 claims description 3
- 235000013305 food Nutrition 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims 47
- 235000013399 edible fruits Nutrition 0.000 claims 12
- 229940122159 Myeloperoxidase inhibitor Drugs 0.000 claims 8
- 240000007817 Olea europaea Species 0.000 claims 8
- 229940038487 grape extract Drugs 0.000 claims 8
- 229940094952 green tea extract Drugs 0.000 claims 8
- 235000020688 green tea extract Nutrition 0.000 claims 8
- 235000002568 Capsicum frutescens Nutrition 0.000 claims 6
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 6
- 230000001419 dependent effect Effects 0.000 claims 6
- 240000006053 Garcinia mangostana Species 0.000 claims 5
- 235000017048 Garcinia mangostana Nutrition 0.000 claims 5
- 240000000851 Vaccinium corymbosum Species 0.000 claims 5
- 235000003095 Vaccinium corymbosum Nutrition 0.000 claims 5
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims 5
- 235000021014 blueberries Nutrition 0.000 claims 5
- 239000002454 curcuma longa l. root extract Substances 0.000 claims 5
- 235000021537 Beetroot Nutrition 0.000 claims 4
- 244000163122 Curcuma domestica Species 0.000 claims 4
- 235000003392 Curcuma domestica Nutrition 0.000 claims 4
- 229930003451 Vitamin B1 Natural products 0.000 claims 4
- 229960002173 citrulline Drugs 0.000 claims 4
- 235000003373 curcuma longa Nutrition 0.000 claims 4
- 229940054168 pomegranate fruit extract Drugs 0.000 claims 4
- 229960003495 thiamine Drugs 0.000 claims 4
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims 4
- 235000013976 turmeric Nutrition 0.000 claims 4
- 235000010374 vitamin B1 Nutrition 0.000 claims 4
- 239000011691 vitamin B1 Substances 0.000 claims 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 3
- 244000179970 Monarda didyma Species 0.000 claims 3
- 235000010672 Monarda didyma Nutrition 0.000 claims 3
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims 3
- 241001593968 Vitis palmata Species 0.000 claims 3
- 235000012905 Brassica oleracea var viridis Nutrition 0.000 claims 2
- 229930064664 L-arginine Natural products 0.000 claims 2
- 235000014852 L-arginine Nutrition 0.000 claims 2
- 230000003902 lesion Effects 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 240000007087 Apium graveolens Species 0.000 claims 1
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 claims 1
- 235000010591 Appio Nutrition 0.000 claims 1
- 235000011332 Brassica juncea Nutrition 0.000 claims 1
- 244000178993 Brassica juncea Species 0.000 claims 1
- 240000007124 Brassica oleracea Species 0.000 claims 1
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 claims 1
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 claims 1
- 235000017647 Brassica oleracea var italica Nutrition 0.000 claims 1
- 244000064816 Brassica oleracea var. acephala Species 0.000 claims 1
- 240000003259 Brassica oleracea var. botrytis Species 0.000 claims 1
- 244000241235 Citrullus lanatus Species 0.000 claims 1
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 claims 1
- 244000000626 Daucus carota Species 0.000 claims 1
- 235000002767 Daucus carota Nutrition 0.000 claims 1
- 244000024675 Eruca sativa Species 0.000 claims 1
- 235000014755 Eruca sativa Nutrition 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- 240000008415 Lactuca sativa Species 0.000 claims 1
- 235000003228 Lactuca sativa Nutrition 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- 235000017879 Nasturtium officinale Nutrition 0.000 claims 1
- 240000005407 Nasturtium officinale Species 0.000 claims 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 claims 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims 1
- 235000009337 Spinacia oleracea Nutrition 0.000 claims 1
- 244000300264 Spinacia oleracea Species 0.000 claims 1
- 235000000183 arugula Nutrition 0.000 claims 1
- 235000013361 beverage Nutrition 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229940055416 blueberry extract Drugs 0.000 claims 1
- 235000019216 blueberry extract Nutrition 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 235000013477 citrulline Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000008753 endothelial function Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 230000007505 plaque formation Effects 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 description 2
- 230000008265 DNA repair mechanism Effects 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000002715 bioenergetic effect Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 229940099898 chlorophyllin Drugs 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000005095 gastrointestinal system Anatomy 0.000 description 1
- 231100000025 genetic toxicology Toxicity 0.000 description 1
- 230000001738 genotoxic effect Effects 0.000 description 1
- 230000007407 health benefit Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000007886 mutagenicity Effects 0.000 description 1
- 231100000299 mutagenicity Toxicity 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000007372 neural signaling Effects 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 230000003711 photoprotective effect Effects 0.000 description 1
- 239000001575 punica granatum l. bark extract Substances 0.000 description 1
- 210000005227 renal system Anatomy 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 230000016160 smooth muscle contraction Effects 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562211673P | 2015-08-28 | 2015-08-28 | |
| US62/211,673 | 2015-08-28 | ||
| PCT/US2016/049306 WO2017040421A1 (en) | 2015-08-28 | 2016-08-29 | Compositions and methods for acutely raising nitic oxide levels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018530517A JP2018530517A (ja) | 2018-10-18 |
| JP2018530517A5 true JP2018530517A5 (enExample) | 2019-10-03 |
Family
ID=58188359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018503486A Pending JP2018530517A (ja) | 2015-08-28 | 2016-08-29 | 一酸化窒素レベルを急激に上昇させるための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11241406B2 (enExample) |
| EP (1) | EP3341003A4 (enExample) |
| JP (1) | JP2018530517A (enExample) |
| KR (1) | KR20180043251A (enExample) |
| CN (1) | CN108778306A (enExample) |
| CA (1) | CA2996627A1 (enExample) |
| WO (1) | WO2017040421A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10624921B2 (en) | 2016-11-15 | 2020-04-21 | Berkeley Nox Limited | Dietary supplements |
| KR102705858B1 (ko) | 2017-07-17 | 2024-09-10 | 아스트라제네카 아베 | 의약에서의 사용을 위한 mpo 억제제 |
| WO2019055704A1 (en) * | 2017-09-13 | 2019-03-21 | Thermolife International, Llc | ENRICHED ROOT POWDER PRODUCTS AND METHODS OF MAKING SAME |
| WO2019099003A2 (en) * | 2017-11-15 | 2019-05-23 | Berkeley Nox Limited | Novel dietary supplements |
| JP7047440B2 (ja) * | 2018-02-15 | 2022-04-05 | 三菱ケミカル株式会社 | 海綿体内圧上昇の増強剤並びにこれを含有する医薬組成物及び食品組成物 |
| US10792320B2 (en) * | 2018-03-28 | 2020-10-06 | Michael Alan Beller | Methods for treatment of bladder dysfunction |
| IT201800007747A1 (it) * | 2018-08-01 | 2020-02-01 | Pharmanutrition R&D Srl | Formulazione nutraceutica per il controllo dell’ipertensione arteriosa da lieve a moderata |
| CN108936667A (zh) * | 2018-08-29 | 2018-12-07 | 福建千叶百肽生物科技有限公司 | 一种多功能复合果蔬一氧化氮供体营养素及其制备方法 |
| US12295981B2 (en) * | 2018-10-01 | 2025-05-13 | Astrogenesis Co., Ltd. | Pharmaceutical composition for preventing or treating neurodegenerative diseases, containing Angelica gigas Nakai extract or mixed extract of Angelica gigas Nakai and broccoli |
| DK180173B1 (en) | 2018-12-07 | 2020-07-14 | Inxo Ivs | Compositions for improving sexual function |
| US11571405B2 (en) | 2018-12-07 | 2023-02-07 | Inxo A/S | Compositions for improving sexual function |
| JP2020182384A (ja) * | 2019-04-26 | 2020-11-12 | 健商株式会社 | 経口組成物およびこれを含有する食品 |
| WO2020231906A1 (en) * | 2019-05-10 | 2020-11-19 | Bgs Holdings Llc | Sports and nutritional supplement formulations |
| US20220288149A1 (en) * | 2019-08-14 | 2022-09-15 | Innovus Pharmaceuticals, Inc. | Sensitization cream comprising l-arginine and l-citrulline and therapeutic uses thereof |
| CA3052863C (en) | 2019-08-23 | 2023-11-07 | Spinal Relief Contres Of Canada Inc. | Composition and method for forming a composition for increasing dermal nitric oxide |
| JP2022151714A (ja) * | 2021-03-23 | 2022-10-07 | 花王株式会社 | 口腔内ナイセリア・ムコサ増加剤 |
| KR102578902B1 (ko) * | 2021-04-20 | 2023-09-13 | 단국대학교 천안캠퍼스 산학협력단 | 루꼴라 추출물을 함유하는 노인성 황반 변성 예방, 개선 및 치료용 조성물 |
| EP4362955A1 (en) * | 2021-06-28 | 2024-05-08 | ASC REGENITY Limited | Skin care nutraceutical composition |
| IT202100018509A1 (it) * | 2021-07-14 | 2023-01-14 | Biofficina Srls | Bevanda funzionale con effetti benefici sulla sindrome metabolica |
| FR3127395B1 (fr) * | 2021-09-27 | 2023-12-29 | Nexira | Composition orale antioxidante à base de plantes |
| US20250090729A1 (en) * | 2022-01-20 | 2025-03-20 | Cell and Molecular Tissue Engineering, LLC | Methods and Products to Detect, Minimize and Treat TRAP-Related Tissue Reactions and Tissue Injury Associated With Medical Devices |
| US20250325611A1 (en) * | 2024-04-23 | 2025-10-23 | 4Life Patents, Llc | Immune modulation with enhanced endothelial nitric oxide synthetase activity |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6063432A (en) | 1998-05-19 | 2000-05-16 | Cooke Pharma | Arginine or lysine containing fruit healthbar formulation |
| US6706756B1 (en) * | 2001-11-16 | 2004-03-16 | University Of South Florida | Vasodilating compound and method of use |
| US6743449B2 (en) | 2002-02-13 | 2004-06-01 | Skinceuticals, Inc. | Topical composition comprising olive leaf extract |
| US20040001817A1 (en) | 2002-05-14 | 2004-01-01 | Giampapa Vincent C. | Anti-aging nutritional supplement |
| US20060115555A1 (en) | 2004-12-01 | 2006-06-01 | Foulger Sidney W | Nutritional supplements containing xanthone extracts |
| US10835555B2 (en) | 2007-02-26 | 2020-11-17 | Heartbeet Ltd | Compositions of nitrates and methods of use thereof |
| JP2010519336A (ja) | 2007-02-26 | 2010-06-03 | ルンドベルク，ヨン | 亜硝酸塩及び硝酸塩及びこれらを含む組成物の新規使用 |
| US10821132B2 (en) | 2007-02-26 | 2020-11-03 | Heartbeet Ltd | Compositions of nitrates and methods of use thereof |
| HUE031982T2 (en) | 2007-02-26 | 2017-08-28 | Heartbeet Ltd | Performance enhancing composition and use thereof |
| US10842813B2 (en) | 2007-02-26 | 2020-11-24 | Heartbeet Ltd | Compositions of nitrates and methods of use thereof |
| US10426792B1 (en) | 2007-09-18 | 2019-10-01 | Thermolife International, Llc | Amino acid compositions |
| US8455531B2 (en) | 2007-09-18 | 2013-06-04 | Thermolife International, Llc | Amino acid compositions |
| US8569368B2 (en) | 2007-09-18 | 2013-10-29 | Thermolife International, Llc | Amino acid compounds |
| US8048921B2 (en) | 2007-09-18 | 2011-11-01 | Ronald Kramer | Amino acid compounds |
| US10426750B1 (en) | 2007-09-18 | 2019-10-01 | Thermolife International, Llc | Amino acid supplement formulations |
| US8466187B2 (en) | 2007-09-18 | 2013-06-18 | Thermolife International, Llc | Amino acid compositions |
| US7777074B2 (en) | 2007-09-18 | 2010-08-17 | Thermolife International, Llc | Amino acid compounds |
| US8569369B2 (en) | 2007-09-18 | 2013-10-29 | Thermolife International, Llc | Amino acid compounds |
| US10435356B1 (en) | 2007-09-18 | 2019-10-08 | Thermolife International, Llc | Amino acid compositions |
| US20100227925A1 (en) | 2009-03-09 | 2010-09-09 | Ruth Chatfield | Sensitizing compound and method for increasing sexual sensitivity |
| WO2010124201A2 (en) | 2009-04-23 | 2010-10-28 | Invasc Therapeutics, Inc. | Compositions and methods for treatment of cardiovascular disease |
| US8173837B1 (en) | 2009-12-03 | 2012-05-08 | The United States of America, as represented by the Secretary of Agriculure | Process for the production of L-citrulline from watermelon flesh and rind |
| KR20140053342A (ko) | 2011-08-17 | 2014-05-07 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 경구 전달 시스템을 통해 생리학적 및 치료학적 수준의 일산화질소를 생산하는 방법 |
| WO2014083438A2 (en) | 2012-11-09 | 2014-06-05 | Abattis Bioceuticals Corp | Nitric oxide increasing nutritional supplements and methods |
| US20150065943A1 (en) * | 2013-08-27 | 2015-03-05 | Matthew DeBow | Method to Accelerate Healing |
-
2016
- 2016-08-28 US US15/756,548 patent/US11241406B2/en active Active
- 2016-08-29 KR KR1020187002380A patent/KR20180043251A/ko not_active Withdrawn
- 2016-08-29 CN CN201680061891.9A patent/CN108778306A/zh active Pending
- 2016-08-29 CA CA2996627A patent/CA2996627A1/en not_active Abandoned
- 2016-08-29 JP JP2018503486A patent/JP2018530517A/ja active Pending
- 2016-08-29 WO PCT/US2016/049306 patent/WO2017040421A1/en not_active Ceased
- 2016-08-29 EP EP16842766.4A patent/EP3341003A4/en not_active Withdrawn
-
2022
- 2022-02-07 US US17/666,305 patent/US20220296552A1/en not_active Abandoned
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