JP2013523708A5 - - Google Patents
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- Publication number
- JP2013523708A5 JP2013523708A5 JP2013501945A JP2013501945A JP2013523708A5 JP 2013523708 A5 JP2013523708 A5 JP 2013523708A5 JP 2013501945 A JP2013501945 A JP 2013501945A JP 2013501945 A JP2013501945 A JP 2013501945A JP 2013523708 A5 JP2013523708 A5 JP 2013523708A5
- Authority
- JP
- Japan
- Prior art keywords
- cbdv
- therapeutically effective
- phytocannabinoid
- effective amount
- thcv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- REOZWEGFPHTFEI-JKSUJKDBSA-N Cannabidivarin Chemical compound OC1=CC(CCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 REOZWEGFPHTFEI-JKSUJKDBSA-N 0.000 claims 28
- 241001471082 Colocasia bobone disease-associated cytorhabdovirus Species 0.000 claims 28
- REOZWEGFPHTFEI-UHFFFAOYSA-N cannabidivarine Natural products OC1=CC(CCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 REOZWEGFPHTFEI-UHFFFAOYSA-N 0.000 claims 28
- 241000218236 Cannabis Species 0.000 claims 13
- 239000000419 plant extract Substances 0.000 claims 13
- ZROLHBHDLIHEMS-HUUCEWRRSA-N (6ar,10ar)-6,6,9-trimethyl-3-propyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCC)=CC(O)=C3[C@@H]21 ZROLHBHDLIHEMS-HUUCEWRRSA-N 0.000 claims 12
- ZROLHBHDLIHEMS-UHFFFAOYSA-N Delta9 tetrahydrocannabivarin Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCC)=CC(O)=C3C21 ZROLHBHDLIHEMS-UHFFFAOYSA-N 0.000 claims 12
- 241001483078 Phyto Species 0.000 claims 6
- 239000001961 anticonvulsive agent Substances 0.000 claims 6
- 229930003827 cannabinoid Natural products 0.000 claims 6
- 239000003557 cannabinoid Substances 0.000 claims 6
- QHMBSVQNZZTUGM-UHFFFAOYSA-N Trans-Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-UHFFFAOYSA-N 0.000 claims 5
- QHMBSVQNZZTUGM-ZWKOTPCHSA-N cannabidiol Chemical compound OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-ZWKOTPCHSA-N 0.000 claims 5
- 229950011318 cannabidiol Drugs 0.000 claims 5
- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 claims 5
- 206010010904 Convulsion Diseases 0.000 claims 4
- 230000001773 anti-convulsant effect Effects 0.000 claims 3
- 229960003965 antiepileptics Drugs 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 108090000312 Calcium Channels Proteins 0.000 claims 2
- 102000003922 Calcium Channels Human genes 0.000 claims 2
- 108010052164 Sodium Channels Proteins 0.000 claims 2
- 102000018674 Sodium Channels Human genes 0.000 claims 2
- PCXRACLQFPRCBB-ZWKOTPCHSA-N dihydrocannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)C)CCC(C)=C1 PCXRACLQFPRCBB-ZWKOTPCHSA-N 0.000 claims 2
- 230000010534 mechanism of action Effects 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- AERBNCYCJBRYDG-UHFFFAOYSA-N D-ribo-phytosphingosine Natural products CCCCCCCCCCCCCCC(O)C(O)C(N)CO AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 230000036982 action potential Effects 0.000 claims 1
- 239000008186 active pharmaceutical agent Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 229940088679 drug related substance Drugs 0.000 claims 1
- 238000010304 firing Methods 0.000 claims 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 230000007246 mechanism Effects 0.000 claims 1
- 229930003658 monoterpene Natural products 0.000 claims 1
- 150000002773 monoterpene derivatives Chemical class 0.000 claims 1
- 235000002577 monoterpenes Nutrition 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- AERBNCYCJBRYDG-KSZLIROESA-N phytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO AERBNCYCJBRYDG-KSZLIROESA-N 0.000 claims 1
- 229940033329 phytosphingosine Drugs 0.000 claims 1
- 229930004725 sesquiterpene Natural products 0.000 claims 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 210000003478 temporal lobe Anatomy 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1005364.3A GB2479153B (en) | 2010-03-30 | 2010-03-30 | The phytocannabinoid cannabidivarin (CBDV) for use in the treatment of epilepsy |
| GB1005364.3 | 2010-03-30 | ||
| GB1100042.9 | 2011-01-04 | ||
| GB1100042.9A GB2487183B (en) | 2011-01-04 | 2011-01-04 | Use of the phytocannabinoid cannabidivarin (CBDV) in the treatment of epilepsy |
| PCT/GB2011/050649 WO2011121351A1 (en) | 2010-03-30 | 2011-03-30 | Use of the phytocannabinoid cannabidivarin (cbdv) in the treatment of epilepsy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013523708A JP2013523708A (ja) | 2013-06-17 |
| JP2013523708A5 true JP2013523708A5 (enExample) | 2014-05-08 |
| JP5918748B2 JP5918748B2 (ja) | 2016-05-18 |
Family
ID=43983229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013501945A Active JP5918748B2 (ja) | 2010-03-30 | 2011-03-30 | てんかんの治療におけるフィトカンナビノイドカンナビジバリン（ｃｂｄｖ）の使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9125859B2 (enExample) |
| EP (2) | EP2552430A1 (enExample) |
| JP (1) | JP5918748B2 (enExample) |
| KR (1) | KR101849703B1 (enExample) |
| CN (1) | CN103025325B (enExample) |
| AR (1) | AR080730A1 (enExample) |
| AU (3) | AU2011234225B2 (enExample) |
| BR (1) | BR112012024480A8 (enExample) |
| CA (1) | CA2794620C (enExample) |
| EA (1) | EA036044B1 (enExample) |
| IL (1) | IL222132B (enExample) |
| MX (1) | MX2012011033A (enExample) |
| MY (1) | MY162129A (enExample) |
| NZ (1) | NZ602925A (enExample) |
| PH (1) | PH12012501902A1 (enExample) |
| SG (2) | SG10201502480XA (enExample) |
| TW (1) | TWI583374B (enExample) |
| WO (1) | WO2011121351A1 (enExample) |
| ZA (1) | ZA201208141B (enExample) |
Families Citing this family (74)
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| KR20070089151A (ko) * | 2004-11-16 | 2007-08-30 | 지더블유 파마 리미티드 | 카나비노이드의 새로운 용도 |
| GB0425248D0 (en) | 2004-11-16 | 2004-12-15 | Gw Pharma Ltd | New use for cannabinoid |
| GB2471523A (en) | 2009-07-03 | 2011-01-05 | Gw Pharma Ltd | Use of tetrahydrocannibivarin (THCV) and optionally cannabidiol (CBD) in the treatment of epilepsy |
| GB2487183B (en) * | 2011-01-04 | 2018-10-03 | Otsuka Pharma Co Ltd | Use of the phytocannabinoid cannabidivarin (CBDV) in the treatment of epilepsy |
| TWI583374B (zh) | 2010-03-30 | 2017-05-21 | Ｇｗ伐瑪有限公司 | 使用植物大麻素次大麻二酚（ｃｂｄｖ）來治療癲癇之用途 |
| GB2487712B (en) | 2011-01-04 | 2015-10-28 | Otsuka Pharma Co Ltd | Use of the phytocannabinoid cannabidiol (CBD) in combination with a standard anti-epileptic drug (SAED) in the treatment of epilepsy |
| GB2495118B (en) | 2011-09-29 | 2016-05-18 | Otsuka Pharma Co Ltd | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD) |
| US10774288B2 (en) | 2013-09-18 | 2020-09-15 | The Werc Shop, LLC | Terpene-based compositions, processes, methodologies for creation and products thereby |
| PT3062606T (pt) * | 2013-10-29 | 2019-07-17 | Biotech Inst Llc | Reprodução, produção, transformação e uso de canábis especial |
| GB2530001B (en) | 2014-06-17 | 2019-01-16 | Gw Pharma Ltd | Use of cannabidiol in the reduction of convulsive seizure frequency in treatment-resistant epilepsy |
| GB2527599A (en) | 2014-06-27 | 2015-12-30 | Gw Pharma Ltd | Use of 7-OH-Cannabidiol (7-OH-CBD) and/or 7-OH-Cannabidivarin (7-OH-CBDV) in the treatment of epilepsy |
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| EP3288592A4 (en) * | 2015-04-28 | 2019-01-09 | The Regents of The University of California | USE OF CANNABIDIOL FOR THE TREATMENT OF CHILDREN'S SPAS |
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| GB2471523A (en) * | 2009-07-03 | 2011-01-05 | Gw Pharma Ltd | Use of tetrahydrocannibivarin (THCV) and optionally cannabidiol (CBD) in the treatment of epilepsy |
| GB2478595B (en) | 2010-03-12 | 2018-04-04 | Gw Pharma Ltd | Phytocannabinoids in the treatment of glioma |
| GB2479153B (en) | 2010-03-30 | 2014-03-19 | Gw Pharma Ltd | The phytocannabinoid cannabidivarin (CBDV) for use in the treatment of epilepsy |
| TWI583374B (zh) | 2010-03-30 | 2017-05-21 | Ｇｗ伐瑪有限公司 | 使用植物大麻素次大麻二酚（ｃｂｄｖ）來治療癲癇之用途 |
| US8895536B2 (en) | 2010-10-29 | 2014-11-25 | Infirst Healthcare Ltd. | Compositions and methods for treating chronic inflammation and inflammatory diseases |
| GB2487712B (en) | 2011-01-04 | 2015-10-28 | Otsuka Pharma Co Ltd | Use of the phytocannabinoid cannabidiol (CBD) in combination with a standard anti-epileptic drug (SAED) in the treatment of epilepsy |
| GB201111261D0 (en) | 2011-07-01 | 2011-08-17 | Gw Pharma Ltd | Cannabinoids for use in the treatment of neuro-degenerative diseases or disorders |
| RU2639120C2 (ru) | 2011-08-26 | 2017-12-19 | Биал-Портела Энд Ка, С.А. | Лечение с использованием ацетата эсликарбазепина или эсликарбазепина |
| GB2495118B (en) | 2011-09-29 | 2016-05-18 | Otsuka Pharma Co Ltd | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD) |
| GB2496687A (en) | 2011-11-21 | 2013-05-22 | Gw Pharma Ltd | Tetrahydrocannabivarin (THCV) in the protection of pancreatic islet cells |
| US20150181924A1 (en) | 2013-10-31 | 2015-07-02 | Michael R. Llamas | Cannabidiol liquid composition for smoking |
| WO2015142501A1 (en) | 2014-03-21 | 2015-09-24 | Bodybio Inc. | Methods and compositions for treating symptoms of diseases related to imbalance of essential fatty acids |
| MX387604B (es) | 2014-05-29 | 2025-03-18 | Insys Pharma Inc | Formulaciones cannabinoides estables. |
| GB2530001B (en) | 2014-06-17 | 2019-01-16 | Gw Pharma Ltd | Use of cannabidiol in the reduction of convulsive seizure frequency in treatment-resistant epilepsy |
| GB2531281A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
| GB2531282A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabinoids in the treatment of epilepsy |
| GB2531278A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
| GB2539472A (en) | 2015-06-17 | 2016-12-21 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
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2011
- 2011-03-15 TW TW100108735A patent/TWI583374B/zh active
- 2011-03-28 AR ARP110101014 patent/AR080730A1/es unknown
- 2011-03-30 CN CN201180026947.4A patent/CN103025325B/zh active Active
- 2011-03-30 EA EA201290975A patent/EA036044B1/ru unknown
- 2011-03-30 MY MYPI2012004222A patent/MY162129A/en unknown
- 2011-03-30 US US13/075,873 patent/US9125859B2/en active Active
- 2011-03-30 PH PH1/2012/501902A patent/PH12012501902A1/en unknown
- 2011-03-30 SG SG10201502480XA patent/SG10201502480XA/en unknown
- 2011-03-30 WO PCT/GB2011/050649 patent/WO2011121351A1/en not_active Ceased
- 2011-03-30 KR KR1020127028091A patent/KR101849703B1/ko active Active
- 2011-03-30 JP JP2013501945A patent/JP5918748B2/ja active Active
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- 2011-03-30 AU AU2011234225A patent/AU2011234225B2/en active Active
- 2011-03-30 SG SG2012070793A patent/SG184236A1/en unknown
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- 2011-03-30 EP EP20194696.9A patent/EP3763361B1/en active Active
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2012
- 2012-09-24 IL IL222132A patent/IL222132B/en active IP Right Grant
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2016
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2020
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