CN103025325B - 植物大麻素次大麻二酚(cbdv)在治疗癫痫中的用途 - Google Patents
植物大麻素次大麻二酚(cbdv)在治疗癫痫中的用途 Download PDFInfo
- Publication number
- CN103025325B CN103025325B CN201180026947.4A CN201180026947A CN103025325B CN 103025325 B CN103025325 B CN 103025325B CN 201180026947 A CN201180026947 A CN 201180026947A CN 103025325 B CN103025325 B CN 103025325B
- Authority
- CN
- China
- Prior art keywords
- cbdv
- seizures
- phytocannabinoid
- thcv
- seizure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/348—Cannabaceae
- A61K36/3482—Cannabis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1005364.3A GB2479153B (en) | 2010-03-30 | 2010-03-30 | The phytocannabinoid cannabidivarin (CBDV) for use in the treatment of epilepsy |
| GB1005364.3 | 2010-03-30 | ||
| GB1100042.9A GB2487183B (en) | 2011-01-04 | 2011-01-04 | Use of the phytocannabinoid cannabidivarin (CBDV) in the treatment of epilepsy |
| GB1100042.9 | 2011-01-04 | ||
| PCT/GB2011/050649 WO2011121351A1 (en) | 2010-03-30 | 2011-03-30 | Use of the phytocannabinoid cannabidivarin (cbdv) in the treatment of epilepsy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103025325A CN103025325A (zh) | 2013-04-03 |
| CN103025325B true CN103025325B (zh) | 2016-03-16 |
Family
ID=43983229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180026947.4A Active CN103025325B (zh) | 2010-03-30 | 2011-03-30 | 植物大麻素次大麻二酚(cbdv)在治疗癫痫中的用途 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9125859B2 (enExample) |
| EP (2) | EP3763361B1 (enExample) |
| JP (1) | JP5918748B2 (enExample) |
| KR (1) | KR101849703B1 (enExample) |
| CN (1) | CN103025325B (enExample) |
| AR (1) | AR080730A1 (enExample) |
| AU (3) | AU2011234225B2 (enExample) |
| BR (1) | BR112012024480A8 (enExample) |
| CA (1) | CA2794620C (enExample) |
| EA (1) | EA036044B1 (enExample) |
| IL (1) | IL222132B (enExample) |
| MX (1) | MX2012011033A (enExample) |
| MY (1) | MY162129A (enExample) |
| NZ (1) | NZ602925A (enExample) |
| PH (1) | PH12012501902A1 (enExample) |
| SG (2) | SG10201502480XA (enExample) |
| TW (1) | TWI583374B (enExample) |
| WO (1) | WO2011121351A1 (enExample) |
| ZA (1) | ZA201208141B (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0425248D0 (en) | 2004-11-16 | 2004-12-15 | Gw Pharma Ltd | New use for cannabinoid |
| CA2586358C (en) * | 2004-11-16 | 2015-11-24 | Gw Pharma Limited | Use of tetrahydrocannabivarin (thcv) as neutral antagonist of the cb1 cannabinoid receptor |
| GB2471523A (en) | 2009-07-03 | 2011-01-05 | Gw Pharma Ltd | Use of tetrahydrocannibivarin (THCV) and optionally cannabidiol (CBD) in the treatment of epilepsy |
| TWI583374B (zh) | 2010-03-30 | 2017-05-21 | Ｇｗ伐瑪有限公司 | 使用植物大麻素次大麻二酚（ｃｂｄｖ）來治療癲癇之用途 |
| GB2487183B (en) * | 2011-01-04 | 2018-10-03 | Otsuka Pharma Co Ltd | Use of the phytocannabinoid cannabidivarin (CBDV) in the treatment of epilepsy |
| GB2487712B (en) | 2011-01-04 | 2015-10-28 | Otsuka Pharma Co Ltd | Use of the phytocannabinoid cannabidiol (CBD) in combination with a standard anti-epileptic drug (SAED) in the treatment of epilepsy |
| GB2495118B (en) * | 2011-09-29 | 2016-05-18 | Otsuka Pharma Co Ltd | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD) |
| US10774288B2 (en) | 2013-09-18 | 2020-09-15 | The Werc Shop, LLC | Terpene-based compositions, processes, methodologies for creation and products thereby |
| LT3062606T (lt) * | 2013-10-29 | 2019-07-10 | Biotech Institute, Llc | Specializuotų kanapių selekcija, gamyba, perdirbimas ir panaudojimas |
| GB2530001B (en) | 2014-06-17 | 2019-01-16 | Gw Pharma Ltd | Use of cannabidiol in the reduction of convulsive seizure frequency in treatment-resistant epilepsy |
| GB2527599A (en) * | 2014-06-27 | 2015-12-30 | Gw Pharma Ltd | Use of 7-OH-Cannabidiol (7-OH-CBD) and/or 7-OH-Cannabidivarin (7-OH-CBDV) in the treatment of epilepsy |
| US10117891B2 (en) | 2014-09-16 | 2018-11-06 | India Globalization Capital, Inc. | Cannabinoid composition for treating pain |
| GB2531282A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabinoids in the treatment of epilepsy |
| GB2531278A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
| GB2531281A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
| EP3247359A4 (en) * | 2015-01-25 | 2018-08-08 | India Globalization Capital, Inc. | Composition and method for treating seizure disorders |
| US10238745B2 (en) | 2015-01-31 | 2019-03-26 | Constance Therapeutics, Inc. | Cannabinoid composition and products including α-tocopherol |
| MX386351B (es) | 2015-01-31 | 2025-03-18 | Constance Therapeutics Inc | Métodos para la preparación de extractos y composiciones de aceite de cannabis. |
| CA2977802A1 (en) | 2015-02-27 | 2016-09-01 | Ebbu, LLC | Compositions comprising combinations of purified cannabinoids, with at least one flavonoid, terpene, or mineral |
| JP2018514540A (ja) * | 2015-04-28 | 2018-06-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 点頭てんかん治療へのカンナビジオールの使用 |
| GB2539472A (en) | 2015-06-17 | 2016-12-21 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
| GB2541191A (en) * | 2015-08-10 | 2017-02-15 | Gw Pharma Ltd | Use of cannabinoids in the treatment of epilepsy |
| US10596159B2 (en) | 2015-08-12 | 2020-03-24 | India Globalization Capital, Inc. | Method and composition for treating cachexia and eating disorders |
| IL299047A (en) | 2015-11-24 | 2023-02-01 | Constance Therapeutics Inc | Cannabis fat preparations and methods for their preparation |
| GB2548873B (en) | 2016-03-31 | 2020-12-02 | Gw Res Ltd | Use of Cannabidiol in the Treatment of SturgeWeber Syndrome |
| GB2549278B (en) | 2016-04-11 | 2021-02-17 | Gw Res Ltd | Use of cannabidivarin in the treatment of autism spectrum disorder |
| US10499584B2 (en) | 2016-05-27 | 2019-12-10 | New West Genetics | Industrial hemp Cannabis cultivars and seeds with stable cannabinoid profiles |
| US10399920B2 (en) | 2016-06-01 | 2019-09-03 | S&B Pharma, Inc. | Crystalline form of cannabidiol |
| US10053407B2 (en) | 2016-06-01 | 2018-08-21 | S&B Pharma, Inc. | Crystalline cannabidivarin |
| EP3471746A4 (en) | 2016-06-15 | 2020-02-26 | India Globalization Capital, Inc. | METHOD AND COMPOSITION FOR TREATING CRAMPING SEASONS |
| JP2019524655A (ja) | 2016-06-29 | 2019-09-05 | キャンサイエンス イノベーションズ インコーポレーテッドＣａｎｎｓｃｉｅｎｃｅ Ｉｎｎｏｖａｔｉｏｎｓ Ｉｎｃ． | 脱炭酸大麻樹脂、その使用、及びそれを製造する方法 |
| GB2551987A (en) | 2016-07-01 | 2018-01-10 | Gw Res Ltd | Oral cannabinoid formulations |
| GB2551986A (en) | 2016-07-01 | 2018-01-10 | Gw Res Ltd | Parenteral formulations |
| MX386620B (es) | 2016-08-03 | 2025-03-19 | Zelda Therapeutics Operations Pty Ltd | Composicion de cannabis |
| GB2553139A (en) | 2016-08-25 | 2018-02-28 | Gw Res Ltd | Use of cannabinoids in the treatment of multiple myeloma |
| US12485129B2 (en) | 2016-08-29 | 2025-12-02 | Canopy Growth Corporation | Water soluble compositions comprising purified cannabinoids |
| WO2018044953A1 (en) | 2016-08-29 | 2018-03-08 | Ebbu, LLC | Water soluble compositions comprising purified cannabinoids |
| GB2557921A (en) | 2016-12-16 | 2018-07-04 | Gw Res Ltd | Use of cannabinoids in the treatment of angelman syndrome |
| CN108236608B (zh) * | 2016-12-27 | 2020-05-08 | 汉义生物科技（北京）有限公司 | 大麻二酚与氨己烯酸的药物组合物及其用途 |
| CN108245510B (zh) * | 2016-12-29 | 2020-11-20 | 汉义生物科技（北京）有限公司 | 大麻二酚与乙丙酰脲类抗癫痫药物的组合物及其用途 |
| CN108245499B (zh) * | 2016-12-29 | 2020-11-20 | 汉义生物科技（北京）有限公司 | 大麻二酚与双链脂肪酸类抗癫痫药物的组合物及其用途 |
| CN108245517B (zh) * | 2016-12-29 | 2020-05-08 | 汉义生物科技（北京）有限公司 | 大麻二酚与拉莫三嗪的药物组合物及其用途 |
| GB2559774B (en) | 2017-02-17 | 2021-09-29 | Gw Res Ltd | Oral cannabinoid formulations |
| GB2560019A (en) | 2017-02-27 | 2018-08-29 | Gw Res Ltd | Use of cannabinoids in the treatment of leukaemia |
| EP3589129A4 (en) * | 2017-03-01 | 2020-11-25 | Canopy Growth Corporation | TARGETEDLY SELECTED COMPOSITIONS CONTAINING PURIFIED CANNABINOIDS AND / OR PURIFIED TERPENES |
| GB2564383B (en) | 2017-06-23 | 2021-04-21 | Gw Res Ltd | Use of cannabidiol in the treatment of tumours assoicated with Tuberous Sclerosis Complex |
| CN109106699A (zh) * | 2017-06-23 | 2019-01-01 | 汉义生物科技（北京）有限公司 | 一种用于治疗癫痫的药物组合物、其制备方法及用途 |
| CN109498606A (zh) | 2017-09-15 | 2019-03-22 | 汉义生物科技（北京）有限公司 | 一种含有大麻二酚和/或次大麻二酚的组合物及其在治疗痛经中的应用 |
| GB2568929A (en) | 2017-12-01 | 2019-06-05 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
| EP3720275A4 (en) * | 2017-12-08 | 2021-10-27 | Biotech Institute, LLC | PROPYL CANNABINOID HEMP PLANTS, METHOD OF MANUFACTURING AND METHOD OF USING THEREOF |
| GB2569961B (en) | 2018-01-03 | 2021-12-22 | Gw Res Ltd | Pharmaceutical |
| GB201806953D0 (en) | 2018-04-27 | 2018-06-13 | Gw Res Ltd | Cannabidiol Preparations |
| WO2020123383A1 (en) * | 2018-12-10 | 2020-06-18 | Natural Extraction Systems, LLC | Compositions with novel cannabinoid and terpene profiles |
| CN113874344B (zh) * | 2019-03-08 | 2025-05-27 | 加利福尼亚大学董事会 | 8,9-二氢大麻二酚化合物的用途 |
| GB201910389D0 (en) | 2019-07-19 | 2019-09-04 | Gw Pharma Ltd | Novel compounds, methods for their manufacture, and uses thereof |
| GB2588576A (en) | 2019-08-27 | 2021-05-05 | Gw Res Ltd | Use of cannabinoids in the treatment of dyskinesia associated with Parkinson's disease |
| GB201916849D0 (en) | 2019-11-19 | 2020-01-01 | Gw Res Ltd | Cannabidiol-type cannabinoid compound |
| GB201916846D0 (en) | 2019-11-19 | 2020-01-01 | Gw Res Ltd | Cannabidiol-type cannabinoid compound |
| GB201916974D0 (en) | 2019-11-21 | 2020-01-08 | Gw Res Ltd | Cannabidol-type cannabinoid compound |
| GB201916977D0 (en) * | 2019-11-21 | 2020-01-08 | Gw Res Ltd | Cannibidol-type cannabinoid compound |
| CA3163788A1 (en) | 2019-12-06 | 2021-06-10 | JLABS Beauty LLC | Topical compositions containing rose oil and cannabidiol and methods of making and using the same |
| GB202002754D0 (en) | 2020-02-27 | 2020-04-15 | Gw Res Ltd | Methods of treating tuberous sclerosis complex with cannabidiol and everolimus |
| KR102371269B1 (ko) | 2020-03-11 | 2022-03-07 | 연세대학교 산학협력단 | VEGFR-3 발현 조절을 통한 mTOR 관련 질환의 예방 또는 치료 방법 |
| EP4126800A1 (en) * | 2020-03-31 | 2023-02-08 | Phytotherapeutix Ltd | Terpenophenolic compounds and their use |
| EP4153306A4 (en) | 2020-05-22 | 2024-06-26 | Ilera Derm LLC | COMPOSITIONS FOR TREATING ACNE AND DERMATOLOGICAL DISEASES |
| EP4188090A4 (en) | 2020-07-28 | 2024-08-14 | Impello Biosciences, Inc. | METHODS AND COMPOSITIONS FOR MODIFYING SECONDARY METABOLITES IN PLANTS |
| GB202014250D0 (en) * | 2020-09-10 | 2020-10-28 | Gw Res Ltd | Use of cannabidivarin in the treatment of seizures associated with rare epilepsy syndromes related to genetic abnormalities |
| US11160757B1 (en) | 2020-10-12 | 2021-11-02 | GW Research Limited | pH dependent release coated microparticle cannabinoid formulations |
| US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
| WO2022103635A1 (en) | 2020-11-16 | 2022-05-19 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
| WO2022122904A1 (en) | 2020-12-09 | 2022-06-16 | Chanelle Mccoy Cbd Limited | A delayed-release capsule of cannabidiol |
| GB2606334A (en) | 2021-02-12 | 2022-11-09 | Gw Res Ltd | Use of cannabidivarin in the treatment of seizures associated with canine epilepsy |
| CN115583933B (zh) * | 2022-10-31 | 2024-02-06 | 暨明医药科技（苏州）有限公司 | 一种高纯度四氢大麻素同系物的制备方法 |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003099302A1 (en) * | 2002-05-24 | 2003-12-04 | Turispharma S.R.L. | A terpene-based composition of substances, a method for its preparation and a method for its dispersal into the atmosphere |
| CN1688290A (zh) * | 2002-08-14 | 2005-10-26 | Gw药品有限公司 | 粘膜给药的大麻素类液体制剂 |
| CN1886117A (zh) * | 2001-02-14 | 2006-12-27 | Gw药品有限公司 | 药物制剂 |
| WO2007083098A1 (en) * | 2006-01-18 | 2007-07-26 | Gw Pharma Limited | Cannabinoid-containing plant extracts as neuroprotective agents |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6403126B1 (en) | 1999-05-26 | 2002-06-11 | Websar Innovations Inc. | Cannabinoid extraction method |
| US6949582B1 (en) | 1999-05-27 | 2005-09-27 | Wallace Walter H | Method of relieving analgesia and reducing inflamation using a cannabinoid delivery topical liniment |
| JP4467883B2 (ja) | 2001-02-14 | 2010-05-26 | ジーダブリュー・ファーマ・リミテッド | 医薬製剤 |
| GB0202385D0 (en) | 2002-02-01 | 2002-03-20 | Gw Pharma Ltd | Compositions for the treatment of nausea,vomiting,emesis,motion sicknes or like conditions |
| DE10226494A1 (de) | 2002-06-14 | 2004-01-08 | Lts Lohmann Therapie-Systeme Ag | Filmförmige mucoadhäsive Darreichungsformen zur Verabreichung von Cannabis-Wirkstoffen |
| ES2377819T3 (es) * | 2002-08-14 | 2012-04-02 | Gw Pharma Limited | Formulaciones líquidas cannabinoides para administración mucosal |
| CA2994322A1 (en) | 2002-08-14 | 2004-02-14 | Gw Pharma Limited | Botanical drug substances comprising various proportions of thc and cbd |
| CA2586358C (en) | 2004-11-16 | 2015-11-24 | Gw Pharma Limited | Use of tetrahydrocannabivarin (thcv) as neutral antagonist of the cb1 cannabinoid receptor |
| GB0425248D0 (en) | 2004-11-16 | 2004-12-15 | Gw Pharma Ltd | New use for cannabinoid |
| TWI366460B (en) | 2005-06-16 | 2012-06-21 | Euro Celtique Sa | Cannabinoid active pharmaceutical ingredient for improved dosage forms |
| WO2007142957A2 (en) | 2006-05-30 | 2007-12-13 | Air Systems | Gear drive damper |
| GB2438682A (en) * | 2006-06-01 | 2007-12-05 | Gw Pharma Ltd | New use for cannabinoids |
| US20080188461A1 (en) | 2007-02-01 | 2008-08-07 | Regents Of The University Of Michigan | Compositions and methods for detecting, preventing and treating seizures and seizure related disorders |
| GB2448535A (en) | 2007-04-19 | 2008-10-22 | Gw Pharma Ltd | New use for cannabinoid-containing plant extracts |
| GB2449691A (en) | 2007-05-31 | 2008-12-03 | Gw Pharma Ltd | A reference plant lacking medicinal active compound expression |
| GB2450753B (en) | 2007-07-06 | 2012-07-18 | Gw Pharma Ltd | New Pharmaceutical formulation |
| GB2456183A (en) | 2008-01-04 | 2009-07-08 | Gw Pharma Ltd | Anti-psychotic composition comprising cannabinoids and anti-psychotic medicament |
| GB2459637B (en) | 2008-01-21 | 2012-06-06 | Gw Pharma Ltd | New use for cannabinoids |
| EP2280687B1 (en) | 2008-03-26 | 2019-02-27 | Stichting Sanammad | Chewing gum compositions comprising cannabinoids |
| GB2478074B (en) | 2008-06-04 | 2012-12-26 | Gw Pharma Ltd | Anti-tumoural effects of cannabinoid combinations |
| GB2478072B (en) | 2008-06-04 | 2012-12-26 | Gw Pharma Ltd | Anti-tumoural effects of cannabinoid combinations |
| GB2471523A (en) | 2009-07-03 | 2011-01-05 | Gw Pharma Ltd | Use of tetrahydrocannibivarin (THCV) and optionally cannabidiol (CBD) in the treatment of epilepsy |
| GB2478595B (en) | 2010-03-12 | 2018-04-04 | Gw Pharma Ltd | Phytocannabinoids in the treatment of glioma |
| GB2479153B (en) | 2010-03-30 | 2014-03-19 | Gw Pharma Ltd | The phytocannabinoid cannabidivarin (CBDV) for use in the treatment of epilepsy |
| TWI583374B (zh) * | 2010-03-30 | 2017-05-21 | Ｇｗ伐瑪有限公司 | 使用植物大麻素次大麻二酚（ｃｂｄｖ）來治療癲癇之用途 |
| US8895536B2 (en) | 2010-10-29 | 2014-11-25 | Infirst Healthcare Ltd. | Compositions and methods for treating chronic inflammation and inflammatory diseases |
| GB2487712B (en) | 2011-01-04 | 2015-10-28 | Otsuka Pharma Co Ltd | Use of the phytocannabinoid cannabidiol (CBD) in combination with a standard anti-epileptic drug (SAED) in the treatment of epilepsy |
| GB201111261D0 (en) | 2011-07-01 | 2011-08-17 | Gw Pharma Ltd | Cannabinoids for use in the treatment of neuro-degenerative diseases or disorders |
| CA2847235C (en) | 2011-08-26 | 2020-07-07 | Bial - Portela & Ca, S.A. | Treatments involving eslicarbazepine acetate or eslicarbazepine |
| GB2495118B (en) | 2011-09-29 | 2016-05-18 | Otsuka Pharma Co Ltd | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD) |
| GB2496687A (en) | 2011-11-21 | 2013-05-22 | Gw Pharma Ltd | Tetrahydrocannabivarin (THCV) in the protection of pancreatic islet cells |
| US20150181924A1 (en) | 2013-10-31 | 2015-07-02 | Michael R. Llamas | Cannabidiol liquid composition for smoking |
| US10052339B2 (en) | 2014-03-21 | 2018-08-21 | Bodybio Inc. | Methods and compositions for treating symptoms of diseases related to imbalance of essential fatty acids |
| CA2950424C (en) | 2014-05-29 | 2023-03-14 | Insys Pharma, Inc. | Stable cannabinoid formulations |
| GB2530001B (en) | 2014-06-17 | 2019-01-16 | Gw Pharma Ltd | Use of cannabidiol in the reduction of convulsive seizure frequency in treatment-resistant epilepsy |
| GB2531281A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
| GB2531278A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
| GB2531282A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabinoids in the treatment of epilepsy |
| GB2539472A (en) | 2015-06-17 | 2016-12-21 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
-
2011
- 2011-03-15 TW TW100108735A patent/TWI583374B/zh active
- 2011-03-28 AR ARP110101014 patent/AR080730A1/es unknown
- 2011-03-30 SG SG10201502480XA patent/SG10201502480XA/en unknown
- 2011-03-30 WO PCT/GB2011/050649 patent/WO2011121351A1/en not_active Ceased
- 2011-03-30 MY MYPI2012004222A patent/MY162129A/en unknown
- 2011-03-30 EP EP20194696.9A patent/EP3763361B1/en active Active
- 2011-03-30 NZ NZ60292511A patent/NZ602925A/en unknown
- 2011-03-30 MX MX2012011033A patent/MX2012011033A/es active IP Right Grant
- 2011-03-30 US US13/075,873 patent/US9125859B2/en active Active
- 2011-03-30 EA EA201290975A patent/EA036044B1/ru unknown
- 2011-03-30 BR BR112012024480A patent/BR112012024480A8/pt not_active Application Discontinuation
- 2011-03-30 CN CN201180026947.4A patent/CN103025325B/zh active Active
- 2011-03-30 AU AU2011234225A patent/AU2011234225B2/en active Active
- 2011-03-30 KR KR1020127028091A patent/KR101849703B1/ko active Active
- 2011-03-30 EP EP11712658A patent/EP2552430A1/en not_active Withdrawn
- 2011-03-30 JP JP2013501945A patent/JP5918748B2/ja active Active
- 2011-03-30 PH PH1/2012/501902A patent/PH12012501902A1/en unknown
- 2011-03-30 SG SG2012070793A patent/SG184236A1/en unknown
- 2011-03-30 CA CA2794620A patent/CA2794620C/en active Active
-
2012
- 2012-09-24 IL IL222132A patent/IL222132B/en active IP Right Grant
- 2012-10-29 ZA ZA2012/08141A patent/ZA201208141B/en unknown
-
2015
- 2015-04-14 US US14/685,753 patent/US10799467B2/en active Active
-
2016
- 2016-10-11 AU AU2016244223A patent/AU2016244223A1/en not_active Abandoned
-
2018
- 2018-08-17 AU AU2018217303A patent/AU2018217303A1/en not_active Abandoned
-
2020
- 2020-09-04 US US17/012,448 patent/US12023305B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1886117A (zh) * | 2001-02-14 | 2006-12-27 | Gw药品有限公司 | 药物制剂 |
| WO2003099302A1 (en) * | 2002-05-24 | 2003-12-04 | Turispharma S.R.L. | A terpene-based composition of substances, a method for its preparation and a method for its dispersal into the atmosphere |
| CN1688290A (zh) * | 2002-08-14 | 2005-10-26 | Gw药品有限公司 | 粘膜给药的大麻素类液体制剂 |
| WO2007083098A1 (en) * | 2006-01-18 | 2007-07-26 | Gw Pharma Limited | Cannabinoid-containing plant extracts as neuroprotective agents |
Non-Patent Citations (1)
| Title |
|---|
| Indigenous plants in traditional healthcare system in Kedarnath valley of western Himalaya;VP Bhatt等;《Indian journal of traditional knowledge》;20080430;第7卷(第2期);300-310 * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103025325B (zh) | 植物大麻素次大麻二酚(cbdv)在治疗癫痫中的用途 | |
| AU2012314129B2 (en) | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD) | |
| CN106236744A (zh) | 植物大麻素中的一种或组合在治疗癫痫中的用途 | |
| GB2479153A (en) | Use of the phytocannabinoid cannabidivarin (CBDV) in the treatment of epilepsy | |
| HK40043526A (en) | Cannabidivarin (cbdv) for use in the treatment of epilepsy | |
| HK40041471A (en) | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (cbdv) and cannabidiol (cbd) | |
| NZ622424B2 (en) | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (cbdv) and cannabidiol (cbd) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: B. Benefit Inventor after: C. Williams Inventor after: G. Stephens Inventor after: T. Futamra Inventor after: T. Hill Inventor before: B. Benefit Inventor before: C. Williams Inventor before: G. Stephens Inventor before: T. Futamra |
|
| COR | Change of bibliographic data | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230414 Address after: Britain's Tejun Patentee after: GW PHARMA Ltd. Address before: Britain's Tejun Patentee before: GW PHARMA Ltd. Patentee before: OTSUKA PHARMACEUTICAL Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| CP02 | Change in the address of a patent holder |
Address after: Cambridge County, England Patentee after: GW PHARMA Ltd. Address before: Britain's Tejun Patentee before: GW PHARMA Ltd. |
|
| CP02 | Change in the address of a patent holder | ||
| CP03 | Change of name, title or address |
Address after: Sheffield, Kent, UK Patentee after: Jazz Pharmaceutical Operations UK Ltd. Country or region after: Britain Address before: Cambridge County, England Patentee before: GW PHARMA Ltd. Country or region before: Britain |
|
| CP03 | Change of name, title or address |