JP2018528261A5 - - Google Patents
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- Publication number
- JP2018528261A5 JP2018528261A5 JP2018525526A JP2018525526A JP2018528261A5 JP 2018528261 A5 JP2018528261 A5 JP 2018528261A5 JP 2018525526 A JP2018525526 A JP 2018525526A JP 2018525526 A JP2018525526 A JP 2018525526A JP 2018528261 A5 JP2018528261 A5 JP 2018528261A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- group
- compound
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 150000002772 monosaccharides Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- -1 N-substituted amino Chemical group 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562199566P | 2015-07-31 | 2015-07-31 | |
| US62/199,566 | 2015-07-31 | ||
| PCT/US2016/044767 WO2017023774A1 (en) | 2015-07-31 | 2016-07-29 | Prodrugs of glutamine analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018528261A JP2018528261A (ja) | 2018-09-27 |
| JP2018528261A5 true JP2018528261A5 (OSRAM) | 2019-09-05 |
| JP6863981B2 JP6863981B2 (ja) | 2021-04-21 |
Family
ID=57943518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525526A Active JP6863981B2 (ja) | 2015-07-31 | 2016-07-29 | グルタミン類似体のプロドラッグ |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US10336778B2 (OSRAM) |
| EP (1) | EP3328827B1 (OSRAM) |
| JP (1) | JP6863981B2 (OSRAM) |
| KR (1) | KR102666477B1 (OSRAM) |
| CN (2) | CN108290827B (OSRAM) |
| AU (1) | AU2016302940B2 (OSRAM) |
| CA (1) | CA2994258C (OSRAM) |
| DK (1) | DK3328827T3 (OSRAM) |
| EA (1) | EA034571B1 (OSRAM) |
| ES (1) | ES2957583T3 (OSRAM) |
| FI (1) | FI3328827T3 (OSRAM) |
| HR (1) | HRP20231163T1 (OSRAM) |
| HU (1) | HUE063399T2 (OSRAM) |
| IL (1) | IL257219B (OSRAM) |
| LT (1) | LT3328827T (OSRAM) |
| MX (1) | MX384906B (OSRAM) |
| PL (1) | PL3328827T3 (OSRAM) |
| PT (1) | PT3328827T (OSRAM) |
| RS (1) | RS64597B1 (OSRAM) |
| SI (1) | SI3328827T1 (OSRAM) |
| SM (1) | SMT202300320T1 (OSRAM) |
| WO (1) | WO2017023774A1 (OSRAM) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX384906B (es) | 2015-07-31 | 2025-03-14 | Univ Johns Hopkins | Profármacos de análogos de glutamina. |
| WO2017023787A1 (en) | 2015-07-31 | 2017-02-09 | The Johns Hopkins University | Methods and compositions for treating metabolic reprogramming disorders |
| CA2994162A1 (en) * | 2015-07-31 | 2017-02-09 | The Johns Hopkins University | Glutamine antagonists for the treatment of cognitive deficits |
| US10842763B2 (en) | 2015-07-31 | 2020-11-24 | The Johns Hopkins University | Methods for cancer and immunotherapy using prodrugs of glutamine analogs |
| CN110520118A (zh) | 2017-02-01 | 2019-11-29 | 约翰斯霍普金斯大学 | 谷氨酰胺类似物的前药 |
| ES2930258T3 (es) * | 2017-10-06 | 2022-12-09 | Univ Johns Hopkins | Nuevos antagonistas de glutamina y usos de los mismos |
| BR112021014112A2 (pt) * | 2019-01-18 | 2021-10-13 | Dracen Pharmaceuticals, Inc. | Usos de composto pró-fármaco de don e inibidor de ponto de controle imunológico para tratar câncer, bem como composto e composição farmacêutica compreendendo o mesmo |
| WO2020167831A1 (en) * | 2019-02-11 | 2020-08-20 | Dracen Pharmaceuticals, Inc. | Method of preparing a don prodrug from l-glutamic acid |
| JP2022519530A (ja) * | 2019-02-11 | 2022-03-24 | ドラセン ファーマシューティカルズ インコーポレイテッド | Ｌ－ピログルタミン酸からｄｏｎプロドラッグを調製する方法 |
| CN115461053A (zh) * | 2019-10-03 | 2022-12-09 | 羿尊生物医药股份有限公司 | 用于静脉内施用的包含(s)-2-((s)-2-乙酰氨基-3-(1h-吲哚-3-基)丙酰氨基)-6-重氮基-5-氧代己酸异丙酯的冻干组合物及其用途 |
| CN110763792A (zh) * | 2019-10-24 | 2020-02-07 | 湖北省宏源药业科技股份有限公司 | 一种鸟嘌呤有关物质检测方法 |
| WO2021239049A1 (en) * | 2020-05-27 | 2021-12-02 | Jacobio Pharmaceuticals Co., Ltd. | Novel glutamine analogs |
| WO2022022612A1 (en) * | 2020-07-29 | 2022-02-03 | Jacobio Pharmaceuticals Co., Ltd. | Novel glutamine analogs |
| EP4221842A4 (en) * | 2020-10-02 | 2024-11-20 | Dracen Pharmaceuticals, Inc. | LYOPHILIZED COMPOSITION CONTAINING (S)-ISOPROPYL 2-((S)-2-ACETAMIDO-3-(1H-INDOL-3-YL)PROPANAMIDO)-6-DIAZO-5-OXOHEXANOATE FOR SUBCUTANEOUS ADMINISTRATION AND ITS USE |
| WO2022078416A1 (en) * | 2020-10-15 | 2022-04-21 | Jacobio Pharmaceuticals Co., Ltd. | Novel glutamine analogs |
| WO2022078462A1 (en) * | 2020-10-15 | 2022-04-21 | Jacobio Pharmaceuticals Co., Ltd. | Novel glutamine analogs |
| CN114621120B (zh) * | 2020-12-10 | 2023-11-03 | 深圳先进技术研究院 | 一种don前药分子、前药激活化合物和前药激活体系 |
| US20240246902A1 (en) * | 2021-04-29 | 2024-07-25 | The Johns Hopkins University | Prodrugs of 6-diazo-5-oxo-l-norleucine |
| WO2022261117A1 (en) * | 2021-06-07 | 2022-12-15 | Dracen Pharmaceuticals, Inc. | Combination therapy with a don prodrug and a tigit inhibitor |
| CN113461563B (zh) * | 2021-07-27 | 2022-05-10 | 中国药科大学 | Nqo1激活型6-重氮基-5-氧代-l-正亮氨酸前药及其制备方法和应用 |
| CN114306620A (zh) * | 2021-12-07 | 2022-04-12 | 深圳先进技术研究院 | 基于代谢检查点的人血清白蛋白纳米药物及其制备方法和应用 |
| JP2025078888A (ja) * | 2022-01-28 | 2025-05-21 | 国立大学法人富山大学 | グルタミナーゼ阻害剤 |
| CN114917230B (zh) * | 2022-03-09 | 2023-03-24 | 山东第一医科大学附属眼科研究所(山东省眼科研究所、山东第一医科大学附属青岛眼科医院) | Cb-839在制备抑制角膜新生血管生成的药物中的应用 |
| TW202406539A (zh) * | 2022-04-21 | 2024-02-16 | 大陸商北京加科思新藥研發有限公司 | 藥物組合及其用途 |
| TW202404938A (zh) * | 2022-04-21 | 2024-02-01 | 大陸商北京加科思新藥研發有限公司 | 麩醯胺酸拮抗劑的多晶型及其用途 |
| CN114805138B (zh) * | 2022-05-12 | 2023-10-10 | 中国科学院长春应用化学研究所 | 6-重氮-5-氧代-l-正亮氨酸的前药、其制备方法及应用 |
| WO2024094526A1 (en) | 2022-11-02 | 2024-05-10 | Ecole Polytechnique Federale De Lausanne (Epfl) | 6-diazo-5-oxo-l-norleucine prodrugs |
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| US121179A (en) * | 1871-11-21 | Improvement in brick-kilns | ||
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| EP0102324A3 (de) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
| US4503044A (en) * | 1983-04-25 | 1985-03-05 | American Cyanamid Company | Antibiotic LL-D05139 β |
| US4568646A (en) * | 1983-04-25 | 1986-02-04 | American Cyanamid Company | Preparation of antibiotic LL-D05139β from cultures of Glycomyces harbinensis, gen. nov., sp. nov. |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| BR9708574A (pt) * | 1996-04-12 | 1999-08-03 | Searle & Co | Derivados benzeno sulfonamida substituídos como pródrogas de inibidores cox-2 |
| WO2001041707A2 (en) | 1999-12-08 | 2001-06-14 | Vanderbilt University | Modulation of in vivo glutamine and glycine levels in the treatment of autism |
| AU2001291579B2 (en) | 2000-09-29 | 2006-08-31 | Viron Therapeutics Inc. | Use of serp- 1 in combination with an immunosuppressant for influencing inflammatory and immune reactions |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| AU2003234597A1 (en) | 2002-05-14 | 2003-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| AU2003294221A1 (en) * | 2002-09-13 | 2004-04-19 | Kenneth E. Miller | Method of alleviating pain via inhibition of neurotransmitter synthesis |
| GB0314262D0 (en) * | 2003-06-19 | 2003-07-23 | Univ Nottingham Trent | Novel compounds and methods of using the same |
| WO2005019163A2 (en) | 2003-08-20 | 2005-03-03 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| US7579313B2 (en) | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
| EP1709030B1 (en) | 2004-01-19 | 2008-04-02 | Novartis AG | Indolylmaleimide derivatives |
| US20070232658A1 (en) | 2004-04-08 | 2007-10-04 | Jurgen Wagner | Protein Kinase C Inhibitors for the Treatment of Autoimmune Diseases and of Transplant Rejiction |
| US20060276438A1 (en) | 2004-10-04 | 2006-12-07 | Natarajan Sethuraman | Prevention and treatment of influenza with glutamine antagonist agents |
| CN101355928B (zh) | 2005-04-26 | 2013-05-22 | 卫材R&D管理株式会社 | 用于癌症免疫疗法的组合物和方法 |
| RU2008139599A (ru) | 2006-03-07 | 2010-04-20 | Эррэй Биофарма Инк. (Us) | Гетеробициклические производные пиразола и способы их применения |
| JP2009536173A (ja) | 2006-05-10 | 2009-10-08 | メディカル エンザイムズ アクチエンゲゼルシャフト | グルタドン |
| US7585996B2 (en) | 2006-09-15 | 2009-09-08 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| US20080107623A1 (en) | 2006-11-01 | 2008-05-08 | Bristol-Myers Squibb Company | Inhibitors of Hepatitis C Virus |
| US8343477B2 (en) | 2006-11-01 | 2013-01-01 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
| US20080160024A1 (en) | 2006-12-07 | 2008-07-03 | Board Of Trustees Of The University Of Arkansas | Inhibition of cancer metastasis |
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| CN102781472B (zh) | 2010-02-17 | 2014-07-02 | 国立大学法人神户大学 | 放射线治疗剂 |
| EP2585066B1 (en) | 2010-06-24 | 2018-09-26 | Alkermes Pharma Ireland Limited | Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
| CA2830349C (en) | 2011-03-17 | 2019-07-16 | The University Of Birmingham | Re-directed immunotherapy |
| KR101900478B1 (ko) | 2011-08-04 | 2018-09-20 | 한올바이오파마주식회사 | 암의 재발 또는 전이의 억제용 약제학적 조성물 |
| US20160008380A1 (en) * | 2013-03-06 | 2016-01-14 | The Johns Hopkins University | Targeting glutamine metabolism in brain tumors |
| US20160022708A1 (en) | 2013-03-14 | 2016-01-28 | St. Jude Children's Research Hospital | Methods and compositions for the treatment of glutamine-addicted cancers |
| WO2015035112A1 (en) | 2013-09-05 | 2015-03-12 | The Johns Hopkins University | Cancer therapy via a combination of epigenetic modulation and immune modulation |
| KR20160093012A (ko) | 2013-11-05 | 2016-08-05 | 코그네이트 바이오서비시즈, 인코포레이티드 | 암 치료를 위한 체크포인트 억제제 및 치료제의 배합물 |
| JP2017500313A (ja) * | 2013-12-09 | 2017-01-05 | ブレット バイオテクノロジー， インコーポレーテッドＢｕｌｌｅｔ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， Ｉｎｃ． | 特異的ウイルス様粒子−ＣｐＧオリゴヌクレオチドワクチンおよびその使用 |
| EP3092235A2 (en) | 2014-01-06 | 2016-11-16 | Rhizen Pharmaceuticals S.A. | Novel inhibitors of glutaminase |
| WO2015138902A1 (en) | 2014-03-14 | 2015-09-17 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors |
| AU2015274361B2 (en) | 2014-06-13 | 2020-11-05 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors |
| US10864180B2 (en) | 2015-04-23 | 2020-12-15 | The Johns Hopkins University | Combination of immunotherapy with local chemotherapy for the treatment of malignancies |
| US10842763B2 (en) | 2015-07-31 | 2020-11-24 | The Johns Hopkins University | Methods for cancer and immunotherapy using prodrugs of glutamine analogs |
| MX384906B (es) | 2015-07-31 | 2025-03-14 | Univ Johns Hopkins | Profármacos de análogos de glutamina. |
| WO2017023787A1 (en) | 2015-07-31 | 2017-02-09 | The Johns Hopkins University | Methods and compositions for treating metabolic reprogramming disorders |
| CA2994162A1 (en) | 2015-07-31 | 2017-02-09 | The Johns Hopkins University | Glutamine antagonists for the treatment of cognitive deficits |
-
2016
- 2016-07-29 MX MX2018001300A patent/MX384906B/es unknown
- 2016-07-29 EP EP16833623.8A patent/EP3328827B1/en active Active
- 2016-07-29 LT LTEPPCT/US2016/044767T patent/LT3328827T/lt unknown
- 2016-07-29 SI SI201631748T patent/SI3328827T1/sl unknown
- 2016-07-29 RS RS20230850A patent/RS64597B1/sr unknown
- 2016-07-29 EA EA201890395A patent/EA034571B1/ru unknown
- 2016-07-29 HU HUE16833623A patent/HUE063399T2/hu unknown
- 2016-07-29 CA CA2994258A patent/CA2994258C/en active Active
- 2016-07-29 PT PT168336238T patent/PT3328827T/pt unknown
- 2016-07-29 CN CN201680057659.8A patent/CN108290827B/zh active Active
- 2016-07-29 CN CN202011474256.8A patent/CN112920092B/zh active Active
- 2016-07-29 AU AU2016302940A patent/AU2016302940B2/en active Active
- 2016-07-29 SM SM20230320T patent/SMT202300320T1/it unknown
- 2016-07-29 ES ES16833623T patent/ES2957583T3/es active Active
- 2016-07-29 JP JP2018525526A patent/JP6863981B2/ja active Active
- 2016-07-29 FI FIEP16833623.8T patent/FI3328827T3/fi active
- 2016-07-29 KR KR1020187006078A patent/KR102666477B1/ko active Active
- 2016-07-29 DK DK16833623.8T patent/DK3328827T3/da active
- 2016-07-29 HR HRP20231163TT patent/HRP20231163T1/hr unknown
- 2016-07-29 PL PL16833623.8T patent/PL3328827T3/pl unknown
- 2016-07-29 WO PCT/US2016/044767 patent/WO2017023774A1/en not_active Ceased
-
2018
- 2018-01-29 IL IL257219A patent/IL257219B/en active IP Right Grant
- 2018-01-31 US US15/885,258 patent/US10336778B2/en active Active
-
2019
- 2019-06-27 US US16/454,853 patent/US10954257B2/en active Active
- 2019-06-27 US US16/454,880 patent/US10738066B2/en active Active
-
2021
- 2021-03-19 US US17/207,388 patent/US11926640B2/en active Active
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