JP2018527912A5 - - Google Patents
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- Publication number
- JP2018527912A5 JP2018527912A5 JP2018506135A JP2018506135A JP2018527912A5 JP 2018527912 A5 JP2018527912 A5 JP 2018527912A5 JP 2018506135 A JP2018506135 A JP 2018506135A JP 2018506135 A JP2018506135 A JP 2018506135A JP 2018527912 A5 JP2018527912 A5 JP 2018527912A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- binding fragment
- antibody
- chain variable
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000427 antigen Substances 0.000 claims description 114
- 102000036639 antigens Human genes 0.000 claims description 114
- 108091007433 antigens Proteins 0.000 claims description 114
- 239000012634 fragment Substances 0.000 claims description 113
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 61
- 210000004027 cell Anatomy 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 22
- 102000018682 Interleukin Receptor Common gamma Subunit Human genes 0.000 claims description 19
- 108010066719 Interleukin Receptor Common gamma Subunit Proteins 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 16
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 10
- 238000000338 in vitro Methods 0.000 claims description 10
- 208000035473 Communicable disease Diseases 0.000 claims description 9
- 206010028980 Neoplasm Diseases 0.000 claims description 9
- 201000011510 cancer Diseases 0.000 claims description 9
- 210000000822 natural killer cell Anatomy 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 238000013160 medical therapy Methods 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 108010038453 Interleukin-2 Receptors Proteins 0.000 claims 1
- 102000010789 Interleukin-2 Receptors Human genes 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 239000000018 receptor agonist Substances 0.000 claims 1
- 229940044601 receptor agonist Drugs 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 description 11
- 108090000765 processed proteins & peptides Proteins 0.000 description 11
- 102000004196 processed proteins & peptides Human genes 0.000 description 11
- 125000003275 alpha amino acid group Chemical group 0.000 description 10
- 208000015181 infectious disease Diseases 0.000 description 8
- 102000025171 antigen binding proteins Human genes 0.000 description 6
- 108091000831 antigen binding proteins Proteins 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 4
- 238000012217 deletion Methods 0.000 description 4
- 230000037430 deletion Effects 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 108040006849 interleukin-2 receptor activity proteins Proteins 0.000 description 4
- 238000006467 substitution reaction Methods 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 108010002350 Interleukin-2 Proteins 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000004879 dioscorea Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG10201506227V | 2015-08-06 | ||
| SG10201506227V | 2015-08-06 | ||
| PCT/EP2016/068780 WO2017021540A1 (en) | 2015-08-06 | 2016-08-05 | Il2rbeta/common gamma chain antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018527912A JP2018527912A (ja) | 2018-09-27 |
| JP2018527912A5 true JP2018527912A5 (https=) | 2019-09-19 |
| JP6908591B2 JP6908591B2 (ja) | 2021-07-28 |
Family
ID=56889037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506135A Active JP6908591B2 (ja) | 2015-08-06 | 2016-08-05 | Ｉｌ２ｒベータ／共通ガンマ鎖抗体 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US10167338B2 (https=) |
| EP (2) | EP3328894B1 (https=) |
| JP (1) | JP6908591B2 (https=) |
| KR (1) | KR102753399B1 (https=) |
| CN (2) | CN107922496B (https=) |
| AU (1) | AU2016301970A1 (https=) |
| CA (1) | CA2994906A1 (https=) |
| CY (1) | CY1121197T1 (https=) |
| DK (1) | DK3328894T3 (https=) |
| ES (2) | ES2710618T3 (https=) |
| HU (1) | HUE043421T2 (https=) |
| PL (1) | PL3328894T3 (https=) |
| PT (1) | PT3328894T (https=) |
| TR (1) | TR201901445T4 (https=) |
| TW (1) | TW201713699A (https=) |
| WO (1) | WO2017021540A1 (https=) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2701699B1 (en) | 2011-04-28 | 2019-10-16 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| PT3328894T (pt) | 2015-08-06 | 2019-02-13 | Agency Science Tech & Res | Anticorpos de cadeia comum gama/il2rbeta |
| JP2019525898A (ja) | 2016-06-10 | 2019-09-12 | ガデタ・ベー・フェー | ヒト白血球抗原拘束ガンマデルタｔ細胞受容体及びその使用方法 |
| JP7486953B2 (ja) | 2017-05-18 | 2024-05-20 | ユーエムセー・ユトレヒト・ホールディング・ベー・フェー | 細胞標的化療法のための組成物および方法 |
| CN111954680B (zh) * | 2017-11-10 | 2024-03-15 | 新加坡科技研究局 | IL2Rβ/共同γ链抗体 |
| US20210017248A1 (en) * | 2018-03-16 | 2021-01-21 | The Regents Of The University Of California | Cellular signaling domain engineering in chimeric antigen receptor-modified regulatory t cells |
| CA3100349A1 (en) * | 2018-05-17 | 2019-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Receptor inhibition by phosphatase recruitment |
| MX2021001493A (es) | 2018-08-06 | 2021-07-15 | Medikine Inc | Compuestos de fijación al receptor de il-2. |
| US11518792B2 (en) | 2018-08-30 | 2022-12-06 | HCW Biologics, Inc. | Multi-chain chimeric polypeptides and uses thereof |
| CA3109361A1 (en) | 2018-08-30 | 2020-03-05 | HCW Biologics, Inc. | Single-chain and multi-chain chimeric polypeptides and uses thereof |
| US11401324B2 (en) | 2018-08-30 | 2022-08-02 | HCW Biologics, Inc. | Single-chain chimeric polypeptides and uses thereof |
| TWI897855B (zh) * | 2018-10-26 | 2025-09-21 | 美商免疫遺傳股份有限公司 | Ｅ ｐ Ｃ Ａ Ｍ 抗體、可活化抗體及免疫偶聯物以及其用途 |
| TW202031683A (zh) | 2018-11-09 | 2020-09-01 | 新加坡商優其洛伊生物私人有限公司 | 介白素2受體β(IL2Rβ)/共同γ鏈抗體 |
| TW202039557A (zh) | 2018-11-09 | 2020-11-01 | 新加坡商優其洛伊生物私人有限公司 | 介白素2受體β(IL2Rβ)/共同γ鏈抗體 |
| MX2021008958A (es) | 2019-02-01 | 2021-11-04 | Regeneron Pharma | Proteínas de unión a antígeno del receptor gamma anti-il2. |
| CN120924491A (zh) | 2019-06-21 | 2025-11-11 | 免疫生物公司 | 多链嵌合多肽和其用途 |
| KR20220110207A (ko) | 2019-11-05 | 2022-08-05 | 메디카인 인코포레이티드 | IL-2RβγC 결합 화합물 |
| MX2022005404A (es) | 2019-11-05 | 2022-09-09 | Medikine Inc | Compuestos de fijación a il-2r e il-7r dual. |
| EP4065605A4 (en) | 2019-11-26 | 2023-07-12 | Ramot at Tel-Aviv University Ltd. | Antibodies to carbohydrate antigens |
| US20230331858A1 (en) * | 2019-12-24 | 2023-10-19 | Neoleukin Therapeutics, Inc. | Combination therapy using an il-2 receptor agonist and an immune checkpoint inhibitor |
| JP2023512687A (ja) | 2020-02-03 | 2023-03-28 | メディカイン、インコーポレイテッド | ＩＬ－７Ｒα結合化合物 |
| IL295304A (en) | 2020-02-03 | 2022-10-01 | Medikine Inc | Il-7 receptor alpha gamma c binding compounds, compositions comprising same and uses thereof |
| WO2021163299A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Chromatography resin and uses thereof |
| AU2021220870A1 (en) | 2020-02-11 | 2022-08-04 | Immunitybio, Inc. | Methods of treating age-related and inflammatory diseases |
| CA3169243A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methods of activating regulatory t cells |
| AU2021221287B2 (en) | 2020-02-16 | 2023-10-05 | Aulos Bioscience, Inc | Engineered anti-IL-2 antibodies |
| CN115836087A (zh) | 2020-04-29 | 2023-03-21 | Hcw生物科技公司 | 抗cd26蛋白及其用途 |
| BR102020009679A2 (pt) | 2020-05-14 | 2021-11-23 | Fundação Universidade Federal Do Abc - Ufabc | Anticorpos recombinantes humanos para inibição da calicreína tecidual humana 7 (klk7) e uso em doenças relacionadas ao processo de descamação da pele |
| JP2023527869A (ja) | 2020-06-01 | 2023-06-30 | エイチシーダブリュー バイオロジックス インコーポレイテッド | 加齢関連障害の治療法 |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| WO2021247003A1 (en) | 2020-06-01 | 2021-12-09 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| BR112023001723A2 (pt) | 2020-08-05 | 2023-05-02 | Synthekine Inc | Moléculas de ligação à gp130 e métodos de uso |
| KR20230061394A (ko) | 2020-08-05 | 2023-05-08 | 신테카인, 인크. | IL10Ra 결합 분자 및 사용 방법 |
| AU2021322238A1 (en) | 2020-08-05 | 2023-03-23 | Synthekine, Inc. | Compositions and methods related to IL27 receptor binding |
| US12122839B2 (en) | 2020-08-05 | 2024-10-22 | Synthekine, Inc. | IFNGR binding synthetic cytokines and methods of use |
| WO2022032045A1 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | IL10Rα/IL2Rγ SYNTHETIC CYTOKINES |
| JP7743500B2 (ja) | 2020-08-05 | 2025-09-24 | シンセカイン インコーポレイテッド | Ｉｌ１０受容体結合性分子および使用方法 |
| US20230272094A1 (en) * | 2020-08-05 | 2023-08-31 | Synthekine, Inc. | Il2rb/il2rg synthetic cytokines |
| KR102846963B1 (ko) | 2020-08-05 | 2025-08-18 | 신테카인, 인크. | IL27Rα 결합 분자 및 사용 방법 |
| US12291572B2 (en) | 2020-08-05 | 2025-05-06 | Synthekine, Inc. | IL12 receptor synthetic cytokines and methods of use |
| WO2022032006A2 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Il2rb binding molecules and methods of use |
| JP7819178B2 (ja) | 2020-08-05 | 2026-02-24 | シンセカイン インコーポレイテッド | ＩＬ１０Ｒｂ結合分子および使用方法 |
| WO2022031884A2 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Il2rg binding molecules and methods of use |
| US11859001B2 (en) | 2020-08-05 | 2024-01-02 | Synthekine, Inc. | IL12RB1-Binding molecules and methods of use |
| US12018085B2 (en) | 2020-08-05 | 2024-06-25 | Synthekine, Inc. | Interferon-gamma R2 (IFNGR2) binding molecules comprising single-domain antibodies and method of use thereof to treat autoimmune and inflammatory diseases |
| US12012457B1 (en) | 2020-08-05 | 2024-06-18 | Synthekine, Inc. | IL23R binding molecules and methods of use |
| US20250333520A1 (en) * | 2021-01-11 | 2025-10-30 | Synthekine, Inc. | Compositions and methods related to il2 receptor binding |
| WO2022150791A2 (en) * | 2021-01-11 | 2022-07-14 | Synthekine, Inc. | Compositions and methods related to il2 receptor binding |
| US20240101673A1 (en) | 2021-02-03 | 2024-03-28 | Mozart Therapeutics, Inc. | Binding agents and methods of using the same |
| US12162945B2 (en) | 2021-03-05 | 2024-12-10 | Immunome, Inc. | EPHA2 antibodies |
| CN117222667A (zh) * | 2021-03-16 | 2023-12-12 | Jn生物科学有限责任公司 | 用于治疗免疫失调的双功能分子 |
| TW202304994A (zh) | 2021-04-02 | 2023-02-01 | 美商泰尼歐生物公司 | 促效性抗ｉｌ－２ｒ抗體及使用方法 |
| CA3229748A1 (en) | 2021-08-26 | 2023-03-02 | Akifumi Kato | Bispecific antibody that binds to cd116 and cd131 |
| WO2023044457A1 (en) | 2021-09-17 | 2023-03-23 | Parker Institute For Cancer Immunotherapy | Switch receptors using il-9 signaling domains |
| WO2023076876A1 (en) | 2021-10-26 | 2023-05-04 | Mozart Therapeutics, Inc. | Modulation of immune responses to viral vectors |
| CN118251416A (zh) * | 2021-11-02 | 2024-06-25 | 上海岸迈生物科技有限公司 | 抗cd122抗体、抗cd132抗体及相关的双特异性结合蛋白 |
| CN118715024A (zh) | 2022-01-24 | 2024-09-27 | 诺夫免疫股份有限公司 | 用于细胞因子信号传导通路的选择性激活的组合物和方法 |
| AU2023215393A1 (en) * | 2022-02-04 | 2024-08-15 | The Board Of Trustees Of The Leland Stanford Junior University | Surrogate cytokine polypeptides |
| JP2025508939A (ja) | 2022-03-02 | 2025-04-10 | イミュニティーバイオ インコーポレイテッド | 膵臓癌の治療方法 |
| US11999771B2 (en) | 2022-04-07 | 2024-06-04 | Medikine, Inc. | IL-7Rαγc ligand immunoglobulin fusion proteins |
| WO2023201311A1 (en) | 2022-04-13 | 2023-10-19 | HCW Biologics, Inc. | Multi-chain chimeric polypeptide for use in the treatment of treating neuroinflammatory disorder |
| WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| IL319931A (en) * | 2022-09-30 | 2025-05-01 | Forte Subsidiary Inc | Anti-CD122 antibodies and their uses |
| WO2024086754A2 (en) * | 2022-10-19 | 2024-04-25 | Tentarix Biotherapeutics, Inc. | Multi variable domain therapeutic immunoglobulin |
| WO2024146955A1 (en) | 2023-01-06 | 2024-07-11 | Twain Therapeutics Pte. Ltd. | Antigen-binding molecules |
| EP4646225A1 (en) | 2023-01-06 | 2025-11-12 | Twain Therapeutics Pte. Ltd. | Antigen-binding molecules |
| EP4669671A1 (en) * | 2023-02-22 | 2025-12-31 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | ANTI-IL2RA ANTIBODIES AND THEIR USES |
| US12311033B2 (en) | 2023-05-31 | 2025-05-27 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| WO2025076127A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025179294A2 (en) | 2024-02-22 | 2025-08-28 | Capstan Therapeutics, Inc. | Immune engineering amplification |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2026033134A1 (en) | 2024-08-09 | 2026-02-12 | Twain Therapeutics Pte. Ltd. | Antigen-binding molecules |
| WO2026033139A1 (en) | 2024-08-09 | 2026-02-12 | Twain Therapeutics Pte. Ltd. | Antigen-binding molecules |
| US20260049118A1 (en) | 2024-08-19 | 2026-02-19 | HCW Biologics, Inc. | Single-chain chimeric polypeptides and uses thereof |
| WO2026043906A1 (en) | 2024-08-19 | 2026-02-26 | HCW Biologics, Inc. | Multi-chain chimeric polypeptides and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0804578B1 (en) | 1995-01-09 | 2008-07-16 | Boehringer Ingelheim International GmbH | Il-2r-associated polypeptide and dna molecules coding therefor |
| EP0918858A1 (en) * | 1996-05-10 | 1999-06-02 | Biogen, Inc. | Common gamma chain blocking agents |
| DZ2788A1 (fr) * | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
| US20070098685A1 (en) | 2005-01-19 | 2007-05-03 | Brand Stephen J | Methods and kits to treat chronic inflammatory immune diseases by administering a proteasome inhibitor and an interleukin 2 receptor agonist |
| CA2656700A1 (en) | 2006-07-06 | 2008-01-10 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Compositions and methods for enhancing the efficacy of il-2 mediated immune responses |
| JP2010513245A (ja) * | 2006-12-14 | 2010-04-30 | アクトジェニックス・エヌブイ | 免疫調節を誘起するための結合分子の送達 |
| WO2011127324A2 (en) * | 2010-04-08 | 2011-10-13 | JN Biosciences, LLC | Antibodies to cd122 |
| WO2013168150A1 (en) * | 2012-05-07 | 2013-11-14 | Immune Pharmaceuticals Ltd. | Method of generating human monoclonal antibodies |
| US20140044675A1 (en) * | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| AU2013302696B9 (en) * | 2012-08-14 | 2018-08-09 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
| US9682143B2 (en) * | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| US20150093399A1 (en) * | 2013-08-28 | 2015-04-02 | Bioasis Technologies, Inc. | Cns-targeted conjugates having modified fc regions and methods of use thereof |
| PT3328894T (pt) | 2015-08-06 | 2019-02-13 | Agency Science Tech & Res | Anticorpos de cadeia comum gama/il2rbeta |
-
2016
- 2016-08-05 PT PT16762975T patent/PT3328894T/pt unknown
- 2016-08-05 HU HUE16762975A patent/HUE043421T2/hu unknown
- 2016-08-05 WO PCT/EP2016/068780 patent/WO2017021540A1/en not_active Ceased
- 2016-08-05 CN CN201680046297.2A patent/CN107922496B/zh active Active
- 2016-08-05 US US15/229,336 patent/US10167338B2/en active Active
- 2016-08-05 EP EP16762975.7A patent/EP3328894B1/en active Active
- 2016-08-05 TW TW105124993A patent/TW201713699A/zh unknown
- 2016-08-05 CN CN202210993771.XA patent/CN115925939A/zh active Pending
- 2016-08-05 DK DK16762975.7T patent/DK3328894T3/en active
- 2016-08-05 KR KR1020187006234A patent/KR102753399B1/ko active Active
- 2016-08-05 TR TR2019/01445T patent/TR201901445T4/tr unknown
- 2016-08-05 JP JP2018506135A patent/JP6908591B2/ja active Active
- 2016-08-05 US US15/750,425 patent/US10472421B2/en active Active
- 2016-08-05 ES ES16762975T patent/ES2710618T3/es active Active
- 2016-08-05 CA CA2994906A patent/CA2994906A1/en active Pending
- 2016-08-05 PL PL16762975T patent/PL3328894T3/pl unknown
- 2016-08-05 EP EP18187373.8A patent/EP3428193B1/en active Active
- 2016-08-05 ES ES18187373T patent/ES2841799T3/es active Active
- 2016-08-05 AU AU2016301970A patent/AU2016301970A1/en not_active Abandoned
-
2018
- 2018-02-28 US US15/908,218 patent/US10472423B2/en active Active
- 2018-03-16 US US15/922,921 patent/US10246512B2/en active Active
- 2018-08-24 US US16/112,008 patent/US10696747B2/en active Active
-
2019
- 2019-01-29 CY CY20191100118T patent/CY1121197T1/el unknown
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