JP2018500924A5 - - Google Patents
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- Publication number
- JP2018500924A5 JP2018500924A5 JP2017540959A JP2017540959A JP2018500924A5 JP 2018500924 A5 JP2018500924 A5 JP 2018500924A5 JP 2017540959 A JP2017540959 A JP 2017540959A JP 2017540959 A JP2017540959 A JP 2017540959A JP 2018500924 A5 JP2018500924 A5 JP 2018500924A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antibody
- binding fragment
- variable region
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000427 antigen Substances 0.000 claims description 102
- 102000036639 antigens Human genes 0.000 claims description 102
- 108091007433 antigens Proteins 0.000 claims description 102
- 239000012634 fragment Substances 0.000 claims description 97
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 30
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 15
- 238000000338 in vitro Methods 0.000 claims description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 230000004064 dysfunction Effects 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 208000035473 Communicable disease Diseases 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- 239000013598 vector Substances 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 4
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 230000003915 cell function Effects 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims description 2
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims description 2
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims description 2
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims description 2
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims description 2
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims description 2
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims description 2
- -1 ICOS Proteins 0.000 claims description 2
- 102000017578 LAG3 Human genes 0.000 claims description 2
- 230000017274 T cell anergy Effects 0.000 claims description 2
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000000032 diagnostic agent Substances 0.000 claims description 2
- 229940039227 diagnostic agent Drugs 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 230000001747 exhibiting effect Effects 0.000 claims description 2
- 230000008685 targeting Effects 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 description 25
- 108090000765 processed proteins & peptides Proteins 0.000 description 25
- 102000004196 processed proteins & peptides Human genes 0.000 description 25
- 101710089372 Programmed cell death protein 1 Proteins 0.000 description 13
- 102100037850 Interferon gamma Human genes 0.000 description 2
- 108010074328 Interferon-gamma Proteins 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000013160 medical therapy Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1419084.7 | 2014-10-27 | ||
| GBGB1419084.7A GB201419084D0 (en) | 2014-10-27 | 2014-10-27 | Anti-PD-1 antibodies |
| PCT/SG2015/050413 WO2016068801A1 (en) | 2014-10-27 | 2015-10-27 | Anti-pd-1 antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018500924A JP2018500924A (ja) | 2018-01-18 |
| JP2018500924A5 true JP2018500924A5 (https=) | 2018-12-13 |
| JP6701213B2 JP6701213B2 (ja) | 2020-05-27 |
Family
ID=52103452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017540959A Active JP6701213B2 (ja) | 2014-10-27 | 2015-10-27 | 抗ｐｄ−１抗体 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10280224B2 (https=) |
| EP (1) | EP3212671A4 (https=) |
| JP (1) | JP6701213B2 (https=) |
| KR (1) | KR20170070243A (https=) |
| CN (1) | CN107438621B (https=) |
| AU (1) | AU2015340054A1 (https=) |
| CA (1) | CA2965623A1 (https=) |
| GB (1) | GB201419084D0 (https=) |
| IL (1) | IL251963A0 (https=) |
| MY (1) | MY191581A (https=) |
| PH (1) | PH12017500803A1 (https=) |
| RU (1) | RU2715628C2 (https=) |
| SG (1) | SG11201703344WA (https=) |
| WO (1) | WO2016068801A1 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201804945WA (en) | 2013-12-12 | 2018-07-30 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
| TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
| GB201419084D0 (en) | 2014-10-27 | 2014-12-10 | Agency Science Tech & Res | Anti-PD-1 antibodies |
| TWI773646B (zh) | 2015-06-08 | 2022-08-11 | 美商宏觀基因股份有限公司 | 結合lag-3的分子和其使用方法 |
| HUE068868T2 (hu) | 2015-07-30 | 2025-02-28 | Macrogenics Inc | PD-1-hez kötõdõ molekulák és alkalmazásukra szolgáló eljárások |
| AU2016317915B2 (en) | 2015-09-01 | 2021-02-18 | Agenus Inc. | Anti-PD-1 antibodies and methods of use thereof |
| BR112018006237A2 (pt) | 2015-09-29 | 2018-10-09 | Celgene Corp | proteínas de ligação a pd-1 e métodos de uso das mesmas |
| WO2017055404A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific antibodies specific for pd1 and tim3 |
| PE20181326A1 (es) | 2015-11-03 | 2018-08-20 | Janssen Biotech Inc | Anticuerpos que se unen especificamente a pd-1 y sus usos |
| IL260021B (en) | 2015-12-14 | 2022-09-01 | Macrogenics Inc | Bispecific molecules that are immunoreactive for pd1 and ctla4 and methods for using them |
| RU2769282C2 (ru) | 2016-06-20 | 2022-03-30 | Кимаб Лимитед | Анти-PD-L1 и IL-2 цитокины |
| RU2656181C1 (ru) | 2016-07-13 | 2018-05-31 | Закрытое Акционерное Общество "Биокад" | Анти-pd-1-антитела, способ их получения и способ применения |
| US11858996B2 (en) | 2016-08-09 | 2024-01-02 | Kymab Limited | Anti-ICOS antibodies |
| JP6993812B2 (ja) * | 2016-08-17 | 2022-01-14 | 治範 小田 | 細胞傷害活性を向上させたリンパ球の培養方法及び該方法で得られた細胞傷害活性を向上させたリンパ球を含む細胞免疫治療剤 |
| JP2019534859A (ja) | 2016-09-19 | 2019-12-05 | セルジーン コーポレイション | Ｐｄ−１結合タンパク質を使用して白斑を治療する方法 |
| MX2019002867A (es) | 2016-09-19 | 2019-11-12 | Celgene Corp | Metodos de tratamiento de trastornos inmunologicos usando proteinas de union a pd-1. |
| CN110300599B (zh) | 2016-12-07 | 2024-07-02 | 艾吉纳斯公司 | 抗体和其使用方法 |
| US11161905B2 (en) | 2017-03-04 | 2021-11-02 | Xiangtan Tenghua Bioscience | Recombinant antibodies to programmed death 1 (PD-1) and uses thereof |
| EP4516809A3 (en) | 2017-04-05 | 2025-09-03 | F. Hoffmann-La Roche AG | Bispecific antibodies specifically binding to pd1 and lag3 |
| MX2019012295A (es) | 2017-04-14 | 2020-02-07 | Tollnine Inc | Polinucleotidos inmunomoduladores, conjugados de anticuerpos de los mismos y metodos para su uso. |
| WO2019083971A1 (en) | 2017-10-23 | 2019-05-02 | Children's Medical Center Corporation | METHODS OF TREATING CANCER USING LSD1 INHIBITORS IN COMBINATION WITH IMMUNOTHERAPY |
| EP3707162A1 (en) | 2017-11-10 | 2020-09-16 | Agency for Science, Technology and Research | Il2rbeta/common gamma chain antibodies |
| EP3728314A1 (en) | 2017-12-19 | 2020-10-28 | Kymab Limited | Bispecific antibody for icos and pd-l1 |
| CN111699200B (zh) * | 2018-01-15 | 2023-05-26 | 南京传奇生物科技有限公司 | 针对pd-1的单域抗体和其变体 |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| EP3755716A4 (en) * | 2018-02-23 | 2021-08-04 | Eucure (Beijing) Biopharma Co., Ltd | ANTI-PD-1 ANTIBODIES AND USES THEREOF |
| US12448448B2 (en) | 2018-06-20 | 2025-10-21 | Incyte Corporation | Anti-PD-1 antibodies and uses thereof |
| CN110790839B (zh) * | 2018-08-03 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | 抗pd-1抗体、其抗原结合片段及医药用途 |
| TW202039557A (zh) | 2018-11-09 | 2020-11-01 | 新加坡商優其洛伊生物私人有限公司 | 介白素2受體β(IL2Rβ)/共同γ鏈抗體 |
| TW202031683A (zh) | 2018-11-09 | 2020-09-01 | 新加坡商優其洛伊生物私人有限公司 | 介白素2受體β(IL2Rβ)/共同γ鏈抗體 |
| BR112021010634A2 (pt) * | 2018-12-14 | 2021-11-16 | Boehringer Ingelheim Io Canada Inc | Anticorpos antiperiostina e usos dos mesmos |
| EA202191929A1 (ru) * | 2019-01-11 | 2021-09-23 | Дзе Уистар Инститьют Оф Энэтоми Энд Байолоджи | Днк-кодируемые моноклональные антитела, нацеленные на pd-1, для лечения и профилактики злокачественного заболевания |
| WO2020227431A1 (en) | 2019-05-06 | 2020-11-12 | Brown University | Bispecific antibodies against chi3l1 and pd1 with enhanced t cell-mediated cytotoxic effects on tumor cells |
| JP6881658B2 (ja) | 2019-07-05 | 2021-06-02 | 小野薬品工業株式会社 | Ｐｄ−１／ｃｄ３二重特異性タンパク質による血液がん治療 |
| US20220332825A1 (en) | 2019-08-08 | 2022-10-20 | Ono Pharmaceutical Co., Ltd. | Bispecific protein |
| EP4079763A4 (en) * | 2019-12-20 | 2023-10-11 | Guangdong Feipeng Pharmaceutical Co., Ltd | MONOCLONAL ANTIBODY AGAINST HUMAN PROGRAMMED DEATH-1 (PD-1) |
| CA3169523A1 (en) | 2020-02-28 | 2021-09-02 | Jaume Pons | Transglutaminase-mediated conjugation |
| EP4288455A1 (en) | 2021-02-03 | 2023-12-13 | Mozart Therapeutics, Inc. | Binding agents and methods of using the same |
| GB202107994D0 (en) | 2021-06-04 | 2021-07-21 | Kymab Ltd | Treatment of cancer |
| WO2023076876A1 (en) | 2021-10-26 | 2023-05-04 | Mozart Therapeutics, Inc. | Modulation of immune responses to viral vectors |
| CN120813375A (zh) | 2023-01-30 | 2025-10-17 | 凯玛布有限公司 | 抗体 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101899114A (zh) * | 2002-12-23 | 2010-12-01 | 惠氏公司 | 抗pd-1抗体及其用途 |
| WO2004084823A2 (en) | 2003-03-19 | 2004-10-07 | Abgenix, Inc. | Antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen and uses thereof |
| DK2439273T3 (da) * | 2005-05-09 | 2019-06-03 | Ono Pharmaceutical Co | Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika |
| CA2612449A1 (en) | 2005-06-17 | 2006-12-28 | Imclone Systems Incorporated | Receptor antagonists for treatment of metastatic bone cancer |
| GB0615662D0 (en) | 2006-08-07 | 2006-09-13 | Affitech As | Antibody |
| BR122017025062B8 (pt) * | 2007-06-18 | 2021-07-27 | Merck Sharp & Dohme | anticorpo monoclonal ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotídeo e composição compreendendo o referido anticorpo ou fragmento |
| MX2010000970A (es) | 2007-07-31 | 2010-03-09 | Regeneron Pharma | Anticuerpos humanos contra cd20 humano y metodo para utilizarlos. |
| AU2013204861B2 (en) * | 2008-09-26 | 2016-05-12 | Dana-Farber Cancer Institute, Inc. | Human anti-PD-1, PD-L1, and PD-L2 antibodies and uses therefor |
| EP3255060A1 (en) | 2008-12-09 | 2017-12-13 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| EP2366714A1 (en) | 2010-03-03 | 2011-09-21 | Dr. Rentschler Holding GmbH & Co. KG | Naturally occuring autoantibodies against alpha-synuclein that inhibit the aggregation and cytotoxicity of alpha-synuclein |
| TW201134488A (en) | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
| WO2011159877A2 (en) * | 2010-06-18 | 2011-12-22 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions |
| US8828390B2 (en) | 2010-07-09 | 2014-09-09 | Universitat Zurich | Uses of NOGO-A inhibitors and related methods |
| EP2663331A4 (en) | 2011-01-10 | 2015-07-15 | Glaxosmithkline Intellectual Property Man Ltd | NEW USES |
| PT2691112T (pt) | 2011-03-31 | 2018-07-10 | Merck Sharp & Dohme | Formulações estáveis de anticorpos para o recetor pd-1 humano de morte programada e tratamentos relacionados |
| JP6072771B2 (ja) | 2011-04-20 | 2017-02-01 | メディミューン，エルエルシー | Ｂ７−ｈ１およびｐｄ−１に結合する抗体およびその他の分子 |
| CN102898528B (zh) | 2012-08-18 | 2015-06-10 | 三峡大学 | 钙网蛋白-可溶性程序性死亡受体1的融合蛋白及其制备方法和用途 |
| PL2904011T3 (pl) | 2012-10-02 | 2018-01-31 | Bristol Myers Squibb Co | Połączenie przeciwciał anty-kir i przeciwciał anty-pd-1 w leczeniu raka |
| HK1213788A1 (zh) | 2012-10-12 | 2016-07-15 | 布里格姆及妇女医院股份有限公司 | 免疫應答的增强 |
| CA2889182A1 (en) | 2012-10-26 | 2014-05-01 | The University Of Chicago | Synergistic combination of immunologic inhibitors for the treatment of cancer |
| WO2014159562A1 (en) | 2013-03-14 | 2014-10-02 | Bristol-Myers Squibb Company | Combination of dr5 agonist and anti-pd-1 antagonist and methods of use |
| WO2014194302A2 (en) * | 2013-05-31 | 2014-12-04 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind pd-1 |
| US20160145355A1 (en) | 2013-06-24 | 2016-05-26 | Biomed Valley Discoveries, Inc. | Bispecific antibodies |
| AU2014296887A1 (en) | 2013-08-02 | 2016-01-28 | Aduro Biotech Holdings, Europe B.V. | Combining CD27 agonists and immune checkpoint inhibition for immune stimulation |
| GB201419084D0 (en) | 2014-10-27 | 2014-12-10 | Agency Science Tech & Res | Anti-PD-1 antibodies |
-
2014
- 2014-10-27 GB GBGB1419084.7A patent/GB201419084D0/en not_active Ceased
-
2015
- 2015-10-27 SG SG11201703344WA patent/SG11201703344WA/en unknown
- 2015-10-27 MY MYPI2017701430A patent/MY191581A/en unknown
- 2015-10-27 US US15/521,434 patent/US10280224B2/en active Active
- 2015-10-27 RU RU2017116847A patent/RU2715628C2/ru active
- 2015-10-27 EP EP15855595.3A patent/EP3212671A4/en active Pending
- 2015-10-27 JP JP2017540959A patent/JP6701213B2/ja active Active
- 2015-10-27 KR KR1020177014305A patent/KR20170070243A/ko not_active Withdrawn
- 2015-10-27 CA CA2965623A patent/CA2965623A1/en not_active Abandoned
- 2015-10-27 CN CN201580071389.1A patent/CN107438621B/zh active Active
- 2015-10-27 AU AU2015340054A patent/AU2015340054A1/en not_active Abandoned
- 2015-10-27 WO PCT/SG2015/050413 patent/WO2016068801A1/en not_active Ceased
-
2017
- 2017-04-24 US US15/495,048 patent/US9771425B2/en active Active
- 2017-04-27 PH PH12017500803A patent/PH12017500803A1/en unknown
- 2017-04-27 IL IL251963A patent/IL251963A0/en unknown
-
2019
- 2019-03-21 US US16/360,445 patent/US11072659B2/en active Active
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