JP2018524347A5 - - Google Patents
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- JP2018524347A5 JP2018524347A5 JP2017568243A JP2017568243A JP2018524347A5 JP 2018524347 A5 JP2018524347 A5 JP 2018524347A5 JP 2017568243 A JP2017568243 A JP 2017568243A JP 2017568243 A JP2017568243 A JP 2017568243A JP 2018524347 A5 JP2018524347 A5 JP 2018524347A5
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- 229940126062 Compound A Drugs 0.000 claims description 31
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims description 31
- 150000003839 salts Chemical class 0.000 claims description 26
- 239000012453 solvate Substances 0.000 claims description 26
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- 238000002560 therapeutic procedure Methods 0.000 claims description 5
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- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
- 208000014767 Myeloproliferative disease Diseases 0.000 description 1
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- 206010052399 Neuroendocrine tumour Diseases 0.000 description 1
- 206010029461 Nodal marginal zone B-cell lymphomas Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
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- 206010039710 Scleroderma Diseases 0.000 description 1
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- 206010041067 Small cell lung cancer Diseases 0.000 description 1
- 208000004346 Smoldering Multiple Myeloma Diseases 0.000 description 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 description 1
- 206010042971 T-cell lymphoma Diseases 0.000 description 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 208000024770 Thyroid neoplasm Diseases 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- GUWXKKAWLCENJA-WGWHJZDNSA-N [(2r,3s,5r)-5-(2-amino-6-oxo-3h-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl [(2r,3s,5r)-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Chemical group O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](OP(O)(=O)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=C(C(N=C(N)N3)=O)N=C2)O)C1 GUWXKKAWLCENJA-WGWHJZDNSA-N 0.000 description 1
- 201000006966 adult T-cell leukemia Diseases 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 206010002022 amyloidosis Diseases 0.000 description 1
- 229960002756 azacitidine Drugs 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 229960003008 blinatumomab Drugs 0.000 description 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 1
- 230000001886 ciliary effect Effects 0.000 description 1
- 201000010897 colon adenocarcinoma Diseases 0.000 description 1
- 201000003444 follicular lymphoma Diseases 0.000 description 1
- GYQYAJJFPNQOOW-UHFFFAOYSA-N gilteritinib Chemical compound N1=C(NC2CCOCC2)C(CC)=NC(C(N)=O)=C1NC(C=C1OC)=CC=C1N(CC1)CCC1N1CCN(C)CC1 GYQYAJJFPNQOOW-UHFFFAOYSA-N 0.000 description 1
- 229950006304 gilteritinib Drugs 0.000 description 1
- 208000005017 glioblastoma Diseases 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 229950007752 isatuximab Drugs 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 208000008585 mastocytosis Diseases 0.000 description 1
- BMGQWWVMWDBQGC-IIFHNQTCSA-N midostaurin Chemical group CN([C@H]1[C@H]([C@]2(C)O[C@@H](N3C4=CC=CC=C4C4=C5C(=O)NCC5=C5C6=CC=CC=C6N2C5=C43)C1)OC)C(=O)C1=CC=CC=C1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 0.000 description 1
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- 208000010721 smoldering plasma cell myeloma Diseases 0.000 description 1
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- BNJNAEJASPUJTO-DUOHOMBCSA-N vadastuximab talirine Chemical group COc1ccc(cc1)C2=CN3[C@@H](C2)C=Nc4cc(OCCCOc5cc6N=C[C@@H]7CC(=CN7C(=O)c6cc5OC)c8ccc(NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)CCCCCN9C(=O)C[C@@H](SC[C@H](N)C(=O)O)C9=O)C(C)C)cc8)c(OC)cc4C3=O BNJNAEJASPUJTO-DUOHOMBCSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562188404P | 2015-07-02 | 2015-07-02 | |
| US62/188,404 | 2015-07-02 | ||
| US201562245916P | 2015-10-23 | 2015-10-23 | |
| US62/245,916 | 2015-10-23 | ||
| US201662308055P | 2016-03-14 | 2016-03-14 | |
| US62/308,055 | 2016-03-14 | ||
| US201662340972P | 2016-05-24 | 2016-05-24 | |
| US62/340,972 | 2016-05-24 | ||
| PCT/US2016/040718 WO2017004532A1 (en) | 2015-07-02 | 2016-07-01 | Combination therapy for treatment of hematological cancers and solid tumors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020112519A Division JP2020172502A (ja) | 2015-07-02 | 2020-06-30 | 血液がん及び固形腫瘍の治療のための併用療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524347A JP2018524347A (ja) | 2018-08-30 |
| JP2018524347A5 true JP2018524347A5 (enExample) | 2019-08-15 |
| JP6727237B2 JP6727237B2 (ja) | 2020-07-22 |
Family
ID=56418624
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017568243A Expired - Fee Related JP6727237B2 (ja) | 2015-07-02 | 2016-07-01 | 血液がん及び固形腫瘍の治療のための併用療法 |
| JP2020112519A Pending JP2020172502A (ja) | 2015-07-02 | 2020-06-30 | 血液がん及び固形腫瘍の治療のための併用療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020112519A Pending JP2020172502A (ja) | 2015-07-02 | 2020-06-30 | 血液がん及び固形腫瘍の治療のための併用療法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10973822B2 (enExample) |
| EP (1) | EP3316888A1 (enExample) |
| JP (2) | JP6727237B2 (enExample) |
| KR (1) | KR20180023968A (enExample) |
| AU (1) | AU2016288246A1 (enExample) |
| BR (1) | BR112017028530A2 (enExample) |
| CA (1) | CA2991164A1 (enExample) |
| EA (1) | EA201890199A1 (enExample) |
| MX (1) | MX2018000216A (enExample) |
| WO (1) | WO2017004532A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018007889A2 (en) * | 2015-10-21 | 2018-10-30 | Teclison Limited | compositions and methods for immune mediated cancer therapy |
| MX2018006779A (es) | 2015-12-02 | 2018-08-01 | Celgene Corp | Terapia ciclica con 3-(5-amino-2-metil-4-oxo-4h-quinazolin-3-il)-p iperidin-2,6-diona. |
| IL301786B2 (en) | 2016-10-28 | 2025-09-01 | Morphosys Ag | Combination of anti-CD19 antibody with BCL-2 inhibitor and their uses |
| CA3065304A1 (en) | 2017-05-30 | 2018-12-06 | Bristol-Myers Squibb Company | Compositions comprising an anti-lag-3 antibody or an anti-lag-3 antibody and an anti-pd-1 or anti-pd-l1 antibody |
| EP3638245A1 (en) * | 2017-06-12 | 2020-04-22 | Agios Pharmaceuticals, Inc. | Methods of treating brain tumors using combination therapy |
| EP3638236A1 (en) | 2017-06-12 | 2020-04-22 | Agios Pharmaceuticals, Inc. | Methods of treating brain tumors using combination therapy |
| JP2020536923A (ja) * | 2017-10-13 | 2020-12-17 | メルク・シャープ・エンド・ドーム・コーポレイション | びまん性大細胞型ｂ細胞リンパ腫を治療するための組成物及び方法 |
| EP3706785B1 (en) * | 2017-11-10 | 2025-08-06 | Actinium Pharmaceuticals, Inc. | Combination of radionuclide-conjugated antibodies for treatment of a hematological malignancies |
| AU2019313444A1 (en) * | 2018-07-30 | 2021-02-18 | Amgen Inc. | Prolonged administration of a bispecific antibody construct binding to CD33 and CD3 |
| EP3974455A4 (en) * | 2019-05-21 | 2023-06-14 | Kuraray Noritake Dental Inc. | RESIN COMPOSITION FOR OPTICAL THREE-DIMENSIONAL MODELING |
| US20220298580A1 (en) * | 2019-08-30 | 2022-09-22 | Dana-Farber Cancer Institute, Inc. | Immune signatures predictive of response to pd-1 blockade in richter's transformation |
| US11839619B2 (en) * | 2019-09-16 | 2023-12-12 | The Regents Of The University Of California | Methods for treatment of pediatric systemic mastocytosis |
| WO2021092190A1 (en) * | 2019-11-05 | 2021-05-14 | Health Research, Inc. | Combination therapy for cancer |
| EP4073517A1 (en) * | 2019-12-11 | 2022-10-19 | Erasmus University Rotterdam Medical Center | Method for monitoring of deep remissions in multiple myeloma and other plasma cell dyscrasias |
| US20220117929A1 (en) * | 2020-10-21 | 2022-04-21 | Buddhist Tzu Chi Medical Foundation | Method for preventing or treating high-grade serous carcinoma |
| US12523658B2 (en) * | 2021-08-27 | 2026-01-13 | The Board Of Regents Of The University Of Texas System | Methods for the assessment of risk and treatments for liver cancers and lethal liver disease complications |
| AU2022375806A1 (en) * | 2021-10-29 | 2023-12-14 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hematological cancer |
| AU2022426699A1 (en) | 2021-12-30 | 2024-07-11 | Biomea Fusion, Inc. | Pyrazine compounds as inhibitors of flt3 |
| CN115137731B (zh) * | 2022-05-19 | 2023-11-21 | 上海交通大学医学院附属新华医院 | Flt3抑制剂及其药学上可接受的盐在制备治疗皮肤t细胞淋巴瘤药物中的应用 |
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| EA026100B1 (ru) | 2011-03-11 | 2017-03-31 | Селджин Корпорейшн | Твердые формы 3-(5-амино-2-метил-4-оксо-4н-хиназолин-3-ил)пиперидин-2,6-диона и их фармацевтические композиции и применение |
| AU2012229316B2 (en) * | 2011-03-11 | 2017-05-11 | Celgene Corporation | Use of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2-6-dione in treatment of immune-related and inflammatory diseases |
| JP2015531776A (ja) | 2012-09-04 | 2015-11-05 | セルジーン コーポレイション | ３−（５−アミノ−２−メチル−４−オキソキナゾリン−３（４ｈ）−イル）ピペリジン−２，６−ジオンのアイソトポログ及びその製造方法 |
| US9694015B2 (en) * | 2012-09-10 | 2017-07-04 | Celgene Corporation | Methods for the treatment of locally advanced breast cancer |
| JP6359563B2 (ja) | 2013-01-14 | 2018-07-18 | デュートルクス・リミテッド・ライアビリティ・カンパニーＤｅｕｔｅＲｘ， ＬＬＣ | ３−（５置換−４−オキソキナゾリン−３（４ｈ）−イル）−３−ジュウテロピペリジン−２，６−ジオン誘導体 |
| SI2991976T1 (sl) | 2013-05-01 | 2017-11-30 | Celgene Corporation | Sintheza 3-(5-amino-2-metil-4-oksokvinazolin-3(4H)-il)piperidin-2,6- diona |
| TW201534305A (zh) * | 2013-05-03 | 2015-09-16 | Celgene Corp | 使用組合療法治療癌症之方法 |
| JP2016540042A (ja) * | 2013-11-05 | 2016-12-22 | コグネート バイオサービシズ， インコーポレイテッド | がんを処置するためのチェックポイント阻害剤および治療薬の組合せ |
| US20150196562A1 (en) | 2014-01-15 | 2015-07-16 | Celgene Corporation | Formulations of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione |
| US20170128448A1 (en) | 2014-07-11 | 2017-05-11 | Celgene Corporation | Combination therapy for cancer |
| KR20180039084A (ko) | 2015-08-27 | 2018-04-17 | 셀진 코포레이션 | 3-(5-아미노-2-메틸-4-옥소-4h-퀴나졸린-3-일)-피페리딘-2,6-다이온을 포함하는 약제학적 조성물 |
| MX2018006779A (es) | 2015-12-02 | 2018-08-01 | Celgene Corp | Terapia ciclica con 3-(5-amino-2-metil-4-oxo-4h-quinazolin-3-il)-p iperidin-2,6-diona. |
-
2016
- 2016-07-01 BR BR112017028530A patent/BR112017028530A2/pt not_active Application Discontinuation
- 2016-07-01 AU AU2016288246A patent/AU2016288246A1/en not_active Abandoned
- 2016-07-01 JP JP2017568243A patent/JP6727237B2/ja not_active Expired - Fee Related
- 2016-07-01 MX MX2018000216A patent/MX2018000216A/es unknown
- 2016-07-01 EA EA201890199A patent/EA201890199A1/ru unknown
- 2016-07-01 KR KR1020187002705A patent/KR20180023968A/ko not_active Withdrawn
- 2016-07-01 US US15/741,130 patent/US10973822B2/en not_active Expired - Fee Related
- 2016-07-01 CA CA2991164A patent/CA2991164A1/en not_active Abandoned
- 2016-07-01 EP EP16739642.3A patent/EP3316888A1/en not_active Withdrawn
- 2016-07-01 WO PCT/US2016/040718 patent/WO2017004532A1/en not_active Ceased
-
2020
- 2020-06-30 JP JP2020112519A patent/JP2020172502A/ja active Pending
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