JP2018524347A5 - - Google Patents
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- JP2018524347A5 JP2018524347A5 JP2017568243A JP2017568243A JP2018524347A5 JP 2018524347 A5 JP2018524347 A5 JP 2018524347A5 JP 2017568243 A JP2017568243 A JP 2017568243A JP 2017568243 A JP2017568243 A JP 2017568243A JP 2018524347 A5 JP2018524347 A5 JP 2018524347A5
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- 229940126062 Compound A Drugs 0.000 claims description 31
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims description 31
- 150000003839 salts Chemical class 0.000 claims description 26
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- 206010029461 Nodal marginal zone B-cell lymphomas Diseases 0.000 description 1
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- 206010041067 Small cell lung cancer Diseases 0.000 description 1
- 208000004346 Smoldering Multiple Myeloma Diseases 0.000 description 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 description 1
- 206010042971 T-cell lymphoma Diseases 0.000 description 1
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- 210000001744 T-lymphocyte Anatomy 0.000 description 1
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- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- GUWXKKAWLCENJA-WGWHJZDNSA-N [(2r,3s,5r)-5-(2-amino-6-oxo-3h-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl [(2r,3s,5r)-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Chemical group O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](OP(O)(=O)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=C(C(N=C(N)N3)=O)N=C2)O)C1 GUWXKKAWLCENJA-WGWHJZDNSA-N 0.000 description 1
- 201000006966 adult T-cell leukemia Diseases 0.000 description 1
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- 206010002022 amyloidosis Diseases 0.000 description 1
- 229960002756 azacitidine Drugs 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
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- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 1
- 230000001886 ciliary effect Effects 0.000 description 1
- 201000010897 colon adenocarcinoma Diseases 0.000 description 1
- 201000003444 follicular lymphoma Diseases 0.000 description 1
- GYQYAJJFPNQOOW-UHFFFAOYSA-N gilteritinib Chemical compound N1=C(NC2CCOCC2)C(CC)=NC(C(N)=O)=C1NC(C=C1OC)=CC=C1N(CC1)CCC1N1CCN(C)CC1 GYQYAJJFPNQOOW-UHFFFAOYSA-N 0.000 description 1
- 229950006304 gilteritinib Drugs 0.000 description 1
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- 230000002489 hematologic effect Effects 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 229950007752 isatuximab Drugs 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 208000008585 mastocytosis Diseases 0.000 description 1
- BMGQWWVMWDBQGC-IIFHNQTCSA-N midostaurin Chemical group CN([C@H]1[C@H]([C@]2(C)O[C@@H](N3C4=CC=CC=C4C4=C5C(=O)NCC5=C5C6=CC=CC=C6N2C5=C43)C1)OC)C(=O)C1=CC=CC=C1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 0.000 description 1
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562188404P | 2015-07-02 | 2015-07-02 | |
| US62/188,404 | 2015-07-02 | ||
| US201562245916P | 2015-10-23 | 2015-10-23 | |
| US62/245,916 | 2015-10-23 | ||
| US201662308055P | 2016-03-14 | 2016-03-14 | |
| US62/308,055 | 2016-03-14 | ||
| US201662340972P | 2016-05-24 | 2016-05-24 | |
| US62/340,972 | 2016-05-24 | ||
| PCT/US2016/040718 WO2017004532A1 (en) | 2015-07-02 | 2016-07-01 | Combination therapy for treatment of hematological cancers and solid tumors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020112519A Division JP2020172502A (ja) | 2015-07-02 | 2020-06-30 | 血液がん及び固形腫瘍の治療のための併用療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524347A JP2018524347A (ja) | 2018-08-30 |
| JP2018524347A5 true JP2018524347A5 (enExample) | 2019-08-15 |
| JP6727237B2 JP6727237B2 (ja) | 2020-07-22 |
Family
ID=56418624
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017568243A Expired - Fee Related JP6727237B2 (ja) | 2015-07-02 | 2016-07-01 | 血液がん及び固形腫瘍の治療のための併用療法 |
| JP2020112519A Pending JP2020172502A (ja) | 2015-07-02 | 2020-06-30 | 血液がん及び固形腫瘍の治療のための併用療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020112519A Pending JP2020172502A (ja) | 2015-07-02 | 2020-06-30 | 血液がん及び固形腫瘍の治療のための併用療法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10973822B2 (enExample) |
| EP (1) | EP3316888A1 (enExample) |
| JP (2) | JP6727237B2 (enExample) |
| KR (1) | KR20180023968A (enExample) |
| AU (1) | AU2016288246A1 (enExample) |
| BR (1) | BR112017028530A2 (enExample) |
| CA (1) | CA2991164A1 (enExample) |
| EA (1) | EA201890199A1 (enExample) |
| MX (1) | MX2018000216A (enExample) |
| WO (1) | WO2017004532A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108472366B (zh) * | 2015-10-21 | 2023-03-17 | 泰克利森有限公司 | 用于免疫介导的癌症疗法的组合物和方法 |
| EA201891289A1 (ru) | 2015-12-02 | 2018-11-30 | Селджин Корпорейшн | Циклическая терапия с применением 3-(5-амино-2-метил-4-оксо-4h-хиназолин-3-ил)пиперидин-2,6-диона |
| KR20230028571A (ko) | 2016-10-28 | 2023-02-28 | 모르포시스 아게 | 항-cd19 항체 및 bcl-2 억제제의 조합 및 이의 용도 |
| KR102721137B1 (ko) | 2017-05-30 | 2024-10-25 | 브리스톨-마이어스 스큅 컴퍼니 | 항-lag-3 항체 또는 항-lag-3 항체 및 항-pd-1 또는 항-pd-l1 항체를 포함하는 조성물 |
| CN111163776A (zh) | 2017-06-12 | 2020-05-15 | 安吉奥斯医药品有限公司 | 使用组合疗法治疗脑肿瘤的方法 |
| MX393477B (es) | 2017-06-12 | 2025-03-24 | Servier Lab | Combinación de vorasidenib con radiación y/o agentes adicionales para tratar gliomas. |
| EP3694520A1 (en) * | 2017-10-13 | 2020-08-19 | Merck Sharp & Dohme Corp. | Compositions and methods for treating diffuse large b cell lymphoma |
| WO2019094931A1 (en) * | 2017-11-10 | 2019-05-16 | Actinium Pharmaceuticals, Inc. | Combination therapy for treatment of a hematological disease |
| CA3107186A1 (en) * | 2018-07-30 | 2020-02-06 | Amgen Research (Munich) Gmbh | Prolonged administration of a bispecific antibody construct binding to cd33 and cd3 |
| JP7455822B2 (ja) * | 2019-05-21 | 2024-03-26 | クラレノリタケデンタル株式会社 | 光学的立体造形用樹脂組成物 |
| US20220298580A1 (en) * | 2019-08-30 | 2022-09-22 | Dana-Farber Cancer Institute, Inc. | Immune signatures predictive of response to pd-1 blockade in richter's transformation |
| US11839619B2 (en) * | 2019-09-16 | 2023-12-12 | The Regents Of The University Of California | Methods for treatment of pediatric systemic mastocytosis |
| US12594271B2 (en) | 2019-11-05 | 2026-04-07 | Health Research, Inc. | Combination therapy for cancer |
| US20230042129A1 (en) * | 2019-12-11 | 2023-02-09 | Erasmus University Medical Center Rotterdam | Method for Monitoring of Deep Remissions in Multiple Myeloma and Other Plasma Cell Dyscrasias |
| US20220117929A1 (en) * | 2020-10-21 | 2022-04-21 | Buddhist Tzu Chi Medical Foundation | Method for preventing or treating high-grade serous carcinoma |
| US12523658B2 (en) * | 2021-08-27 | 2026-01-13 | The Board Of Regents Of The University Of Texas System | Methods for the assessment of risk and treatments for liver cancers and lethal liver disease complications |
| US20240417473A1 (en) * | 2021-10-29 | 2024-12-19 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hematological cancer |
| CA3242316A1 (en) | 2021-12-30 | 2023-07-06 | Biomea Fusion, Inc. | Pyrazine compounds as inhibitors of flt3 |
| CN115137731B (zh) * | 2022-05-19 | 2023-11-21 | 上海交通大学医学院附属新华医院 | Flt3抑制剂及其药学上可接受的盐在制备治疗皮肤t细胞淋巴瘤药物中的应用 |
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| RS56770B1 (sr) | 2011-03-11 | 2018-04-30 | Celgene Corp | Čvrste forme 3-(5-amino-2-metil-4-okso-4h-hinazolin-3-il)-piperidin-2,6-diona i njihove farmaceutske smeše i upotrebe |
| EP2683383B1 (en) | 2011-03-11 | 2017-11-29 | Celgene Corporation | Use of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2-6-dione in treatment of immune-related and inflammatory diseases |
| CN104755472A (zh) | 2012-09-04 | 2015-07-01 | 细胞基因公司 | 3-(5-氨基-2-甲基-4-氧代喹唑啉-3(4h)-基)哌啶-2,6-二酮的同位素体及其制备方法 |
| US9694015B2 (en) * | 2012-09-10 | 2017-07-04 | Celgene Corporation | Methods for the treatment of locally advanced breast cancer |
| CA2935495C (en) | 2013-01-14 | 2021-04-20 | Deuterx, Llc | 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives |
| SG11201508836XA (en) | 2013-05-01 | 2015-11-27 | Celgene Corp | Synthesis of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl) piperidine-2,6-dione |
| EP2991651A1 (en) | 2013-05-03 | 2016-03-09 | Celgene Corporation | Methods for treating cancer using combination therapy |
| IL292510A (en) * | 2013-11-05 | 2022-06-01 | Cognate Bioservices Inc | Combinations of checkpoint inhibitors and therapeutics to treat cancer |
| WO2015108889A1 (en) | 2014-01-15 | 2015-07-23 | Celgene Corporation | Formulations of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione |
| CA2954652A1 (en) | 2014-07-11 | 2016-01-14 | Celgene Corporation | Combination therapy for cancer |
| CN107921004A (zh) | 2015-08-27 | 2018-04-17 | 细胞基因公司 | 包含3‑(5‑氨基‑2‑甲基‑4‑氧代基‑4h‑喹唑啉‑3‑基)‑哌啶‑2,6‑二酮的药物组合物 |
| EA201891289A1 (ru) | 2015-12-02 | 2018-11-30 | Селджин Корпорейшн | Циклическая терапия с применением 3-(5-амино-2-метил-4-оксо-4h-хиназолин-3-ил)пиперидин-2,6-диона |
-
2016
- 2016-07-01 WO PCT/US2016/040718 patent/WO2017004532A1/en not_active Ceased
- 2016-07-01 MX MX2018000216A patent/MX2018000216A/es unknown
- 2016-07-01 JP JP2017568243A patent/JP6727237B2/ja not_active Expired - Fee Related
- 2016-07-01 AU AU2016288246A patent/AU2016288246A1/en not_active Abandoned
- 2016-07-01 KR KR1020187002705A patent/KR20180023968A/ko not_active Withdrawn
- 2016-07-01 CA CA2991164A patent/CA2991164A1/en not_active Abandoned
- 2016-07-01 EA EA201890199A patent/EA201890199A1/ru unknown
- 2016-07-01 US US15/741,130 patent/US10973822B2/en not_active Expired - Fee Related
- 2016-07-01 EP EP16739642.3A patent/EP3316888A1/en not_active Withdrawn
- 2016-07-01 BR BR112017028530A patent/BR112017028530A2/pt not_active Application Discontinuation
-
2020
- 2020-06-30 JP JP2020112519A patent/JP2020172502A/ja active Pending
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