JP2014525926A5 - - Google Patents
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- JP2014525926A5 JP2014525926A5 JP2014525434A JP2014525434A JP2014525926A5 JP 2014525926 A5 JP2014525926 A5 JP 2014525926A5 JP 2014525434 A JP2014525434 A JP 2014525434A JP 2014525434 A JP2014525434 A JP 2014525434A JP 2014525926 A5 JP2014525926 A5 JP 2014525926A5
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- JP
- Japan
- Prior art keywords
- sequence
- seq
- region
- combination
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *CCN(CCCl)c1ccc(CCCC(O)=O)cc1 Chemical compound *CCN(CCCl)c1ccc(CCCC(O)=O)cc1 0.000 description 2
- WAMNGGHTLRINPS-UHFFFAOYSA-N CCCN(CCCO1)P1(NCCCl)=O Chemical compound CCCN(CCCO1)P1(NCCCl)=O WAMNGGHTLRINPS-UHFFFAOYSA-N 0.000 description 1
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N N[C@@H](Cc(cc1)ccc1N(CCCl)CCCl)C(O)=O Chemical compound N[C@@H](Cc(cc1)ccc1N(CCCl)CCCl)C(O)=O SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 1
- IDPUKCWIGUEADI-UHFFFAOYSA-N O=C(C(N(CCCl)CCCl)=CN1)NC1=O Chemical compound O=C(C(N(CCCl)CCCl)=CN1)NC1=O IDPUKCWIGUEADI-UHFFFAOYSA-N 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N O=P1(N(CCCl)CCCl)OCCCN1 Chemical compound O=P1(N(CCCl)CCCl)OCCCN1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
Images
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161523861P | 2011-08-16 | 2011-08-16 | |
| US61/523,861 | 2011-08-16 | ||
| EP11177658 | 2011-08-16 | ||
| EP11177658.9 | 2011-08-16 | ||
| US201261647539P | 2012-05-16 | 2012-05-16 | |
| US61/647,539 | 2012-05-16 | ||
| US201261654097P | 2012-06-01 | 2012-06-01 | |
| US61/654,097 | 2012-06-01 | ||
| PCT/EP2012/065906 WO2013024097A1 (en) | 2011-08-16 | 2012-08-14 | Combination therapy with an anti - cd19 antibody and a nitrogen mustard |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014525926A JP2014525926A (ja) | 2014-10-02 |
| JP2014525926A5 true JP2014525926A5 (enExample) | 2015-10-01 |
| JP6184952B2 JP6184952B2 (ja) | 2017-08-23 |
Family
ID=47714801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014525434A Active JP6184952B2 (ja) | 2011-08-16 | 2012-08-14 | 抗ｃｄ１９抗体とナイトロゲンマスタードとの併用療法 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US20140255427A1 (enExample) |
| EP (2) | EP2744515B1 (enExample) |
| JP (1) | JP6184952B2 (enExample) |
| KR (3) | KR20200058583A (enExample) |
| CN (1) | CN103732252B (enExample) |
| AU (1) | AU2012296907B2 (enExample) |
| BR (1) | BR112013033919B1 (enExample) |
| CA (2) | CA3137321A1 (enExample) |
| CY (1) | CY1125122T1 (enExample) |
| DK (1) | DK2744515T3 (enExample) |
| ES (1) | ES2909722T3 (enExample) |
| HR (1) | HRP20220228T1 (enExample) |
| HU (1) | HUE058350T2 (enExample) |
| IL (1) | IL230293B (enExample) |
| LT (1) | LT2744515T (enExample) |
| MX (1) | MX354479B (enExample) |
| PL (1) | PL2744515T3 (enExample) |
| PT (1) | PT2744515T (enExample) |
| RS (1) | RS63238B1 (enExample) |
| RU (1) | RU2625222C2 (enExample) |
| SG (1) | SG10201606785UA (enExample) |
| SI (1) | SI2744515T1 (enExample) |
| SM (1) | SMT202200159T1 (enExample) |
| WO (1) | WO2013024097A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3157553A4 (en) * | 2014-06-16 | 2018-02-28 | Xencor, Inc. | Treatment for chronic lymphocytic leukemia (cll) |
| EP3603672B1 (en) * | 2015-05-26 | 2026-04-22 | Incyte Corporation | Combination of an anti-cd19 antibody and a bruton's tyrosine kinase inhibitor and uses thereof |
| MX392561B (es) * | 2015-08-21 | 2025-03-24 | Morphosys Ag | Combinación sinérgica de un anticuerpo anti-cd19 y un inhibidor de fosfoinositida 3-quinasa para usarse en el tratamiento de linfoma no hodgkin, leucemia linfocítica crónica y/o leucemia linfoblástica aguda. |
| WO2017172981A2 (en) | 2016-03-29 | 2017-10-05 | University Of Southern California | Chimeric antigen receptors targeting cancer |
| CN115932265B (zh) * | 2016-05-30 | 2026-04-14 | 因塞特公司 | 预测cd19抗体治疗在患者中的治疗益处的方法 |
| KR20230028571A (ko) | 2016-10-28 | 2023-02-28 | 모르포시스 아게 | 항-cd19 항체 및 bcl-2 억제제의 조합 및 이의 용도 |
| JP7685735B2 (ja) | 2016-12-02 | 2025-05-30 | アンヘレス セラピューティクス インコーポレイテッド | 合成免疫受容体およびその使用方法 |
| IL297461B2 (en) * | 2017-05-31 | 2024-09-01 | Morphosys Ag | Treatment paradigm for an anti-cd19 antibody and venetoclax combination treatment |
| KR20200030337A (ko) | 2018-09-12 | 2020-03-20 | 주식회사 녹십자랩셀 | 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물 |
| CN119013293A (zh) * | 2021-12-22 | 2024-11-22 | 因赛特公司 | 抗cd19抗体疗法的治疗范例 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1247080A (en) | 1983-03-08 | 1988-12-20 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
| US5686072A (en) | 1992-06-17 | 1997-11-11 | Board Of Regents, The University Of Texas | Epitope-specific monoclonal antibodies and immunotoxins and uses thereof |
| KR100508289B1 (ko) * | 1998-04-21 | 2005-08-17 | 마이크로메트 에이지 | Ｃｄ１９×ｃｄ３ 특이 폴리펩티드 및 그의 용도 |
| ATE311199T1 (de) * | 1999-05-07 | 2005-12-15 | Genentech Inc | Behandlung von autoimmunkrankheiten mit antagonisten die oberflächenmarker von b zellen binden |
| US20020058029A1 (en) | 2000-09-18 | 2002-05-16 | Nabil Hanna | Combination therapy for treatment of autoimmune diseases using B cell depleting/immunoregulatory antibody combination |
| DE60226641D1 (de) | 2001-12-03 | 2008-06-26 | Amgen Fremont Inc | Antikörperkategorisierung auf der grundlage von bindungseigenschaften |
| US20080260731A1 (en) * | 2002-03-01 | 2008-10-23 | Bernett Matthew J | Optimized antibodies that target cd19 |
| US7109304B2 (en) | 2003-07-31 | 2006-09-19 | Immunomedics, Inc. | Humanized anti-CD19 antibodies |
| US7902338B2 (en) | 2003-07-31 | 2011-03-08 | Immunomedics, Inc. | Anti-CD19 antibodies |
| CN101933923A (zh) | 2004-11-05 | 2011-01-05 | 赛福伦公司 | 癌症治疗 |
| EP1899379B1 (en) | 2005-06-20 | 2018-04-11 | E. R. Squibb & Sons, L.L.C. | Cd19 antibodies and their uses |
| EP2270050B1 (en) | 2005-12-30 | 2013-06-05 | Merck Patent GmbH | Anti-CD19 antibodies with reduced immunogenicity |
| PL2383297T3 (pl) * | 2006-08-14 | 2013-06-28 | Xencor Inc | Zoptymalizowane przeciwciała ukierunkowane na CD19 |
| JP5401314B2 (ja) | 2006-09-08 | 2014-01-29 | メディミューン，エルエルシー | ヒト化抗ｃｄ１９抗体ならびに癌、移植および自己免疫疾患の治療におけるその使用 |
| AU2008260498B2 (en) | 2007-05-30 | 2012-11-29 | Xencor, Inc. | Methods and compositions for inhibiting CD32b expressing cells |
| WO2009052431A2 (en) | 2007-10-19 | 2009-04-23 | Seattle Genetics, Inc. | Cd19 binding agents and uses thereof |
| EA201170940A1 (ru) * | 2009-01-16 | 2012-02-28 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Лечение рака с использованием комбинации бендамустина и анти-cd20-антитела |
| JP2012518404A (ja) | 2009-02-23 | 2012-08-16 | グレンマーク・ファーマシューティカルズ・エスエー | Ｃｄ１９に結合するヒト化抗体及びその使用 |
| EP2445530B1 (en) | 2009-06-24 | 2016-09-07 | The Feinstein Institute for Medical Research | Method for treating chronic lymphocytic leukemia |
| RU2012109451A (ru) * | 2009-08-14 | 2013-09-27 | Роше Гликарт Аг | Комбинированная терапия на основе афукозилированного антитела к cd20 в сочетании с флударабином и/или митоксантроном |
| TWI409079B (zh) * | 2009-08-14 | 2013-09-21 | Roche Glycart Ag | 非典型岩藻醣化ｃｄ２０抗體與苯達莫斯汀（ｂｅｎｄａｍｕｓｔｉｎｅ）之組合療法 |
| EP2501237A1 (en) * | 2009-11-06 | 2012-09-26 | Infinity Pharmaceuticals, Inc. | Oral formulations of a hedgehog pathway inhibitor |
-
2012
- 2012-08-14 EP EP12747923.6A patent/EP2744515B1/en active Active
- 2012-08-14 CA CA3137321A patent/CA3137321A1/en active Pending
- 2012-08-14 SI SI201231989T patent/SI2744515T1/sl unknown
- 2012-08-14 DK DK12747923.6T patent/DK2744515T3/da active
- 2012-08-14 KR KR1020207014299A patent/KR20200058583A/ko not_active Withdrawn
- 2012-08-14 PL PL12747923T patent/PL2744515T3/pl unknown
- 2012-08-14 KR KR1020147006936A patent/KR20140064873A/ko not_active Ceased
- 2012-08-14 SM SM20220159T patent/SMT202200159T1/it unknown
- 2012-08-14 KR KR1020197026462A patent/KR102115203B1/ko active Active
- 2012-08-14 US US14/126,928 patent/US20140255427A1/en not_active Abandoned
- 2012-08-14 HU HUE12747923A patent/HUE058350T2/hu unknown
- 2012-08-14 CA CA2841875A patent/CA2841875C/en active Active
- 2012-08-14 BR BR112013033919-5A patent/BR112013033919B1/pt active IP Right Grant
- 2012-08-14 MX MX2013014933A patent/MX354479B/es active IP Right Grant
- 2012-08-14 ES ES12747923T patent/ES2909722T3/es active Active
- 2012-08-14 SG SG10201606785UA patent/SG10201606785UA/en unknown
- 2012-08-14 EP EP22155572.5A patent/EP4062936A1/en active Pending
- 2012-08-14 CN CN201280036571.XA patent/CN103732252B/zh active Active
- 2012-08-14 PT PT127479236T patent/PT2744515T/pt unknown
- 2012-08-14 WO PCT/EP2012/065906 patent/WO2013024097A1/en not_active Ceased
- 2012-08-14 HR HRP20220228TT patent/HRP20220228T1/hr unknown
- 2012-08-14 JP JP2014525434A patent/JP6184952B2/ja active Active
- 2012-08-14 RU RU2014103492A patent/RU2625222C2/ru active
- 2012-08-14 RS RS20220412A patent/RS63238B1/sr unknown
- 2012-08-14 LT LTEPPCT/EP2012/065906T patent/LT2744515T/lt unknown
- 2012-08-14 AU AU2012296907A patent/AU2012296907B2/en active Active
-
2014
- 2014-01-02 IL IL230293A patent/IL230293B/en active IP Right Grant
-
2020
- 2020-04-03 US US16/839,777 patent/US20200353077A1/en not_active Abandoned
-
2022
- 2022-04-18 CY CY20221100289T patent/CY1125122T1/el unknown
-
2024
- 2024-01-12 US US18/411,350 patent/US20240366756A1/en active Pending
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