JP2018524338A5 - - Google Patents

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JP2018524338A5
JP2018524338A5 JP2017567489A JP2017567489A JP2018524338A5 JP 2018524338 A5 JP2018524338 A5 JP 2018524338A5 JP 2017567489 A JP2017567489 A JP 2017567489A JP 2017567489 A JP2017567489 A JP 2017567489A JP 2018524338 A5 JP2018524338 A5 JP 2018524338A5
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substituted
ring
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salt
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JP2017567489A
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JP6745824B2 (ja
JP2018524338A (ja
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Priority claimed from PCT/JP2016/069189 external-priority patent/WO2016208775A1/en
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JP2017567489A 2015-06-26 2016-06-23 複素環化合物 Active JP6745824B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2015129043 2015-06-26
JP2015129043 2015-06-26
JP2015206797 2015-10-20
JP2015206797 2015-10-20
PCT/JP2016/069189 WO2016208775A1 (en) 2015-06-26 2016-06-23 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor

Publications (3)

Publication Number Publication Date
JP2018524338A JP2018524338A (ja) 2018-08-30
JP2018524338A5 true JP2018524338A5 (OSRAM) 2019-07-25
JP6745824B2 JP6745824B2 (ja) 2020-08-26

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JP2017567489A Active JP6745824B2 (ja) 2015-06-26 2016-06-23 複素環化合物

Country Status (23)

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US (5) US9878989B2 (OSRAM)
EP (1) EP3313836B1 (OSRAM)
JP (1) JP6745824B2 (OSRAM)
KR (1) KR20180019234A (OSRAM)
CN (1) CN107922403A (OSRAM)
AU (1) AU2016284654B9 (OSRAM)
CA (1) CA2988572A1 (OSRAM)
CL (1) CL2017003127A1 (OSRAM)
CO (1) CO2017012859A2 (OSRAM)
CR (1) CR20170568A (OSRAM)
DO (1) DOP2017000309A (OSRAM)
EA (1) EA201890152A1 (OSRAM)
HK (1) HK1248698A1 (OSRAM)
IL (1) IL256059A (OSRAM)
MX (1) MX2017016875A (OSRAM)
PE (1) PE20180500A1 (OSRAM)
PH (1) PH12017502351A1 (OSRAM)
TN (1) TN2017000508A1 (OSRAM)
TW (1) TW201710255A (OSRAM)
UA (1) UA121503C2 (OSRAM)
UY (1) UY36750A (OSRAM)
WO (1) WO2016208775A1 (OSRAM)
ZA (1) ZA201708387B (OSRAM)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TN2017000508A1 (en) * 2015-06-26 2019-04-12 Takeda Pharmaceuticals Co 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor
WO2016206101A1 (en) 2015-06-26 2016-12-29 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors
JP6787913B2 (ja) 2015-10-20 2020-11-18 武田薬品工業株式会社 複素環化合物
US10548877B2 (en) 2016-03-11 2020-02-04 Takeda Pharmaceutical Company Limited Aromatic ring compound
EP3590936B1 (en) * 2017-02-28 2021-09-01 Takeda Pharmaceutical Company Limited Method for producing heterocyclic compound
US11560372B2 (en) 2017-04-18 2023-01-24 Takeda Pharmaceutical Company Limited Heterocyclic compounds useful as modulators of acetylcholine receptors
US12298319B2 (en) 2017-05-19 2025-05-13 Takeda Pharmaceutical Company Limited Method for measuring alpha value of muscarinic M1 receptor positive allosteric modulators
HRP20231236T1 (hr) 2017-06-20 2024-02-16 Takeda Pharmaceutical Company Limited Heterociklički spoj i njegova uporaba kao pozitivnog alosteričnog modulatora kolinergičkog muskarinskog m1 receptora
JP7123042B2 (ja) 2017-06-20 2022-08-22 武田薬品工業株式会社 複素環化合物
WO2020067456A1 (ja) 2018-09-28 2020-04-02 武田薬品工業株式会社 複素環化合物
US12162864B2 (en) 2018-09-28 2024-12-10 Takeda Pharmaceutical Company Limited Condensed-cyclic compound
JP7416537B2 (ja) * 2018-09-28 2024-01-17 武田薬品工業株式会社 複素環化合物
KR102288434B1 (ko) * 2018-10-18 2021-08-12 에이치케이이노엔 주식회사 신규한 (이소프로필-트리아졸릴)피리디닐 치환된 벤조옥사지논 또는 벤조티아지논 유도체 및 이의 용도
EP3870173A4 (en) 2018-10-24 2022-06-22 Vanderbilt University WDR5 INHIBITORS AND MODULATORS
WO2020247679A1 (en) * 2019-06-04 2020-12-10 Vanderbilt University Wdr5 inhibitors and modulators
CN114539035B (zh) * 2021-03-10 2023-08-18 山东新时代药业有限公司 一种七氟烷的合成方法
WO2025231259A1 (en) * 2024-05-01 2025-11-06 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m1
WO2025231260A1 (en) * 2024-05-01 2025-11-06 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m1

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5538983A (en) 1990-05-16 1996-07-23 The Rockefeller University Method of treating amyloidosis by modulation of calcium
AU665207B2 (en) 1991-07-29 1995-12-21 Warner-Lambert Company Quinazoline derivatives as acetylcholinesterase inhibitors
IT1255179B (it) 1992-06-26 1995-10-20 Enzo Cereda Azaciclo e azabiciclo alchiliden idrossilamine
US5744476A (en) 1994-06-27 1998-04-28 Interneuron Pharmaceuticals, Inc. Dopamine D1 agonists for the treatment of dementia
JP2992677B2 (ja) 1995-06-05 1999-12-20 武田薬品工業株式会社 骨形成促進医薬組成物
AU5716898A (en) 1997-01-08 1998-08-03 Warner-Lambert Company Acetylcholinesterase inhibitors in combination with muscarinic agonists for the treatment of alzheimer's disease
US6569897B1 (en) 1998-01-16 2003-05-27 Purdue Research Foundation Alkenyldiarylmethane non-nucleoside HIV-1 reverse transcriptase inhibitors
HUP0101810A3 (en) 1998-01-27 2002-05-28 Aventis Pharm Prod Inc Substituted oxoazaheterocyclyl factor xa inhibitors and pharmaceutical compositions containing them
WO2000032590A1 (en) 1998-11-25 2000-06-08 Aventis Pharmaceuticals Products Inc. SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS
HUP0203375A3 (en) 1999-07-28 2005-03-29 Aventis Pharm Prod Inc Substituted oxoazaheterocyclyl compounds
JP2001131173A (ja) 1999-08-23 2001-05-15 Kyorin Pharmaceut Co Ltd 二環式複素環誘導体
JP2005231995A (ja) 1999-12-22 2005-09-02 Meiji Seika Kaisha Ltd オピオイドδ受容体アゴニスト/アンタゴニストとして有用なスピロ化合物
US7084126B1 (en) 2000-05-01 2006-08-01 Healthpartners Research Foundation Methods and compositions for enhancing cellular function through protection of tissue components
EP1316203A2 (en) 2000-06-30 2003-06-04 Eli Lilly And Company Combination for treating psychoses, comprising an antipsychotic and a muscarinic agonist
CA2442717A1 (en) 2001-03-15 2002-09-26 Saegis Pharmaceuticals, Inc. Methods for restoring cognitive function following systemic stress
US20040023951A1 (en) 2001-06-18 2004-02-05 Bymaster Franklin Porter Combination therapy for treatment of psychoses
US20030004913A1 (en) 2001-07-02 2003-01-02 Koninklijke Philips Electronics N.V. Vision-based method and apparatus for detecting an event requiring assistance or documentation
EP1448537A4 (en) 2001-11-26 2005-05-04 Cortex Pharma Inc CARBONYLBENZOXAZINIC COMPOUNDS ENHANCING SYNAPTIC GLUTAMATERGIC RESPONSES
US20040044023A1 (en) 2002-08-30 2004-03-04 Marc Cantillon Compositions and methods for treating or preventing memory impairment
EP1596867A4 (en) 2003-02-19 2006-03-22 Merck & Co Inc TREATMENT OF PSYCHOSIS WITH A MUSCARIN M1 RECEPTOR ECTOPIC ACTIVATOR
JP2006521399A (ja) 2003-03-28 2006-09-21 アカディア ファーマシューティカルズ,インコーポレーテッド 疼痛管理用ムスカリンm1受容体アゴニスト
US20040266659A1 (en) 2003-06-27 2004-12-30 Stephen LaBerge Substances that enhance recall and lucidity during dreaming
GB0504019D0 (en) 2005-02-26 2005-04-06 Astrazeneca Ab Amide derivatives
JP2008537961A (ja) 2005-04-15 2008-10-02 ボード、オブ、トラスティーズ、オブ、ミシガン、ステイト、ユニバーシティ Gpcrモジュレーター
GB0516570D0 (en) 2005-08-12 2005-09-21 Astrazeneca Ab Amide derivatives
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
US20110319386A1 (en) 2005-08-26 2011-12-29 Braincells Inc. Neurogenesis by muscarinic receptor modulation
WO2007044937A2 (en) 2005-10-13 2007-04-19 President And Fellows Of Harvard College Compositions and methods to modulate memory
AU2006331912B2 (en) 2005-12-21 2012-08-30 Janssen Pharmaceutica, N.V. Triazolopyridazines as tyrosine kinase modulators
GB0607946D0 (en) 2006-04-21 2006-05-31 Minster Res The Ltd Mono and combination therapy
GB0607952D0 (en) 2006-04-21 2006-05-31 Minster Res Ltd Novel treatment
GB0607949D0 (en) 2006-04-21 2006-05-31 Minster Res The Ltd Mono and combination therapy
PE20121506A1 (es) 2006-07-14 2012-11-26 Amgen Inc Compuestos triazolopiridinas como inhibidores de c-met
US8217177B2 (en) 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
US8198448B2 (en) 2006-07-14 2012-06-12 Amgen Inc. Fused heterocyclic derivatives and methods of use
US7834023B2 (en) 2006-09-20 2010-11-16 Portola Pharmaceuticals, Inc. Substituted dihydroquinazolines as platelet ADP receptor inhibitors
CN101616592B (zh) * 2007-01-03 2013-06-05 瑟维尔实验室 用于提高谷氨酸能突触响应的3-取代的-[1,2,3]-苯并三嗪酮化合物
US8618074B2 (en) 2007-03-15 2013-12-31 Board Of Regents Of The University Of Texas System GPCR enhanced neuroprotection to treat brain injury
PE20090995A1 (es) 2007-08-29 2009-08-03 Schering Corp Derivados indolicos 2,3-sustituidos como inhibidores del virus de la hepatitis c (vhc)
CN101821252A (zh) 2007-08-29 2010-09-01 先灵公司 取代的吲哚衍生物及其使用方法
PE20090994A1 (es) 2007-08-29 2009-08-03 Schering Corp Derivados de azaindol 2,3-sustituidos como agentes antivirales
SI2200610T1 (en) 2007-09-21 2018-06-29 Acadia Pharmaceuticals Inc. Co-administration of pimavanserin with other agents
WO2009039461A2 (en) 2007-09-21 2009-03-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
WO2009064848A1 (en) 2007-11-16 2009-05-22 Schering Corporation 3-heterocyclic substituted indole derivatives and methods of use thereof
WO2009064852A1 (en) 2007-11-16 2009-05-22 Schering Corporation 3-aminosulfonyl substituted indole derivatives and methods of use thereof
US20110024198A1 (en) 2008-02-19 2011-02-03 Baker Hughes Incorporated Bearing systems containing diamond enhanced materials and downhole applications for same
WO2010042603A1 (en) 2008-10-08 2010-04-15 Cingulate Neuro Therapeutics, Llc Amyloid and depression
CN102292323B (zh) 2008-11-20 2014-12-24 默沙东公司 芳基甲基苯并喹唑啉酮 m1受体正向变构调节剂
WO2010096338A1 (en) 2009-02-23 2010-08-26 Merck Sharp & Dohme Corp. PYRAZOLO [4,3-c] CINNOLIN-3-ONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
SG174220A1 (en) 2009-03-05 2011-10-28 Mithridion Inc Compounds and compositions for cognition-enhancement, methods of making, and methods of treating
WO2010123716A1 (en) 2009-04-20 2010-10-28 Merck Sharp & Dohme Corp. Heterocyclic fused cinnoline m1 receptor positive allosteric modulators
ES2353093B1 (es) 2009-05-20 2012-01-03 Consejo Superior De Investigaciones Científicas (Csic) Uso de derivados de quinazolinas y sus composiciones farmacéuticas en enfermedades neurodegenerativas.
PL3061821T3 (pl) 2009-07-22 2020-01-31 PureTech Health LLC Kompozycje do leczenia zaburzeń łagodzonych przez aktywację receptora muskarynowego
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
NZ598462A (en) 2009-08-31 2012-12-21 Merck Sharp & Dohme Pyranyl aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators
EP2490692B1 (en) 2009-10-21 2016-11-16 Merck Sharp & Dohme Corp. Quinolinone-pyrazolone m1 receptor positive allosteric modulators
EP2512245B1 (en) 2009-12-14 2014-07-23 Merck Sharp & Dohme Corp. Pyridoquinazolinone m1 receptor positive allosteric modulators
US8383638B2 (en) 2009-12-21 2013-02-26 Merck Sharp & Dohme Aminobenzoquinazolinone M1 receptor positive allosteric modulators
US8557992B2 (en) 2010-06-15 2013-10-15 Merck Sharp & Dohme Corp. Heterocyclic fused phenanthrolinone M1 receptor positive allosteric modulators
WO2012003147A1 (en) 2010-07-01 2012-01-05 Merck Sharp & Dohme Corp. Isoindolone m1 receptor positive allosteric modulators
US8664234B2 (en) 2010-10-04 2014-03-04 Merck Sharp & Dohme Corp. Dihydrobenzoquinazolinone M1 receptor positive allosteric modulators
WO2012149524A1 (en) 2011-04-29 2012-11-01 The University Of Toledo Muscarinic agonists as enhancers of working memory and cognitive flexibility
WO2012158473A1 (en) * 2011-05-17 2012-11-22 Merck Sharp & Dohme Corp. N-methyl tetrahydroquinoline m1 receptor positive allosteric modulators
WO2012170599A1 (en) 2011-06-10 2012-12-13 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
JP6211509B2 (ja) 2012-03-02 2017-10-11 武田薬品工業株式会社 複素環化合物およびその用途
CN104470909B (zh) 2012-03-23 2018-04-24 Ptc医疗公司 用于治疗脊髓性肌萎缩的化合物
US20130289019A1 (en) 2012-04-26 2013-10-31 Amazing Grace, Inc. Methods of treating behaviorial and/or mental disorders
US9777005B2 (en) 2012-11-19 2017-10-03 Takeda Pharmaceutical Company Limited Bicyclic heterocyclic compound containing a substituted pyrrole ring
JP6075408B2 (ja) 2012-11-22 2017-02-08 株式会社デンソー 物標検出装置
RU2642779C2 (ru) 2012-12-27 2018-01-26 Ф.Хоффманн-Ля Рош Аг Ингибиторы сомт
CN104955826B (zh) 2013-02-04 2019-05-31 默克专利股份公司 可用于治疗神经学疾病和病症的螺-喹唑酮衍生物
CA2947838A1 (en) 2013-05-06 2014-11-13 Indiana University Research & Technology Corporation Compounds for treatment of angiogenesis-mediated diseases
JP6063400B2 (ja) 2014-01-08 2017-01-18 株式会社日立ビルシステム エレベータの異常監視装置
PL3134386T3 (pl) 2014-04-23 2020-11-16 Takeda Pharmaceutical Company Limited Pochodne izoindolin-1-onu jako dodatnia aktywność allosterycznego modulatora cholinergicznego receptora muskarynowego m1 do leczenia choroby alzheimera
EP3144308B1 (en) 2014-05-16 2020-06-24 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound
JP6571077B2 (ja) 2014-06-13 2019-09-04 武田薬品工業株式会社 含窒素複素環化合物
TN2017000508A1 (en) * 2015-06-26 2019-04-12 Takeda Pharmaceuticals Co 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor
WO2017044693A1 (en) 2015-09-11 2017-03-16 Chase Pharmaceuticals Corporation Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
JP6787913B2 (ja) 2015-10-20 2020-11-18 武田薬品工業株式会社 複素環化合物
US10548877B2 (en) 2016-03-11 2020-02-04 Takeda Pharmaceutical Company Limited Aromatic ring compound
US20200188388A1 (en) 2016-12-29 2020-06-18 Rvx Therapeutics Ltd. Methods and compositions for potentiating cns drugs and reducing their side effects

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