JP2018523655A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018523655A5 JP2018523655A5 JP2018504819A JP2018504819A JP2018523655A5 JP 2018523655 A5 JP2018523655 A5 JP 2018523655A5 JP 2018504819 A JP2018504819 A JP 2018504819A JP 2018504819 A JP2018504819 A JP 2018504819A JP 2018523655 A5 JP2018523655 A5 JP 2018523655A5
- Authority
- JP
- Japan
- Prior art keywords
- double
- rnai agent
- nucleotide
- stranded rnai
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021096344A JP7417559B2 (ja) | 2015-07-31 | 2021-06-09 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
| JP2023199064A JP7711150B2 (ja) | 2015-07-31 | 2023-11-24 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
| JP2025115513A JP2025165939A (ja) | 2015-07-31 | 2025-07-09 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562199563P | 2015-07-31 | 2015-07-31 | |
| US62/199,563 | 2015-07-31 | ||
| US201662287518P | 2016-01-27 | 2016-01-27 | |
| US62/287,518 | 2016-01-27 | ||
| PCT/US2016/044359 WO2017023660A1 (en) | 2015-07-31 | 2016-07-28 | TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021096344A Division JP7417559B2 (ja) | 2015-07-31 | 2021-06-09 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018523655A JP2018523655A (ja) | 2018-08-23 |
| JP2018523655A5 true JP2018523655A5 (OSRAM) | 2019-08-29 |
| JP6896703B2 JP6896703B2 (ja) | 2021-06-30 |
Family
ID=56682264
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018504819A Active JP6896703B2 (ja) | 2015-07-31 | 2016-07-28 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
| JP2021096344A Active JP7417559B2 (ja) | 2015-07-31 | 2021-06-09 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
| JP2023199064A Active JP7711150B2 (ja) | 2015-07-31 | 2023-11-24 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
| JP2025115513A Pending JP2025165939A (ja) | 2015-07-31 | 2025-07-09 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021096344A Active JP7417559B2 (ja) | 2015-07-31 | 2021-06-09 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
| JP2023199064A Active JP7711150B2 (ja) | 2015-07-31 | 2023-11-24 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
| JP2025115513A Pending JP2025165939A (ja) | 2015-07-31 | 2025-07-09 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
Country Status (35)
| Country | Link |
|---|---|
| US (5) | US10208307B2 (OSRAM) |
| EP (1) | EP3329002B1 (OSRAM) |
| JP (4) | JP6896703B2 (OSRAM) |
| KR (2) | KR20240074895A (OSRAM) |
| CN (2) | CN108138182B (OSRAM) |
| BR (1) | BR112018000542B1 (OSRAM) |
| CA (1) | CA2994285A1 (OSRAM) |
| CL (1) | CL2018000198A1 (OSRAM) |
| CY (1) | CY1124545T1 (OSRAM) |
| DK (1) | DK3329002T3 (OSRAM) |
| EA (1) | EA201890394A1 (OSRAM) |
| ES (1) | ES2842300T3 (OSRAM) |
| FI (1) | FIC20230006I1 (OSRAM) |
| FR (1) | FR23C1008I2 (OSRAM) |
| HK (1) | HK1256683A1 (OSRAM) |
| HR (1) | HRP20202082T1 (OSRAM) |
| HU (2) | HUE051998T2 (OSRAM) |
| IL (3) | IL313082A (OSRAM) |
| LT (2) | LT3329002T (OSRAM) |
| LU (1) | LUC00297I2 (OSRAM) |
| MA (1) | MA43335B1 (OSRAM) |
| MX (2) | MX2018000981A (OSRAM) |
| MY (1) | MY195720A (OSRAM) |
| NL (1) | NL301216I2 (OSRAM) |
| NO (1) | NO2023007I1 (OSRAM) |
| PL (1) | PL3329002T3 (OSRAM) |
| PT (1) | PT3329002T (OSRAM) |
| RS (1) | RS61297B1 (OSRAM) |
| SG (1) | SG10201912341SA (OSRAM) |
| SI (1) | SI3329002T1 (OSRAM) |
| SM (1) | SMT202100020T1 (OSRAM) |
| TW (4) | TW202532647A (OSRAM) |
| UA (1) | UA126276C2 (OSRAM) |
| WO (1) | WO2017023660A1 (OSRAM) |
| ZA (2) | ZA201800571B (OSRAM) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2937418T (pt) | 2008-10-20 | 2018-01-23 | Alnylam Pharmaceuticals Inc | Composições e métodos de inibição da expressão de transtirretina |
| SG171914A1 (en) | 2008-12-02 | 2011-07-28 | Chiralgen Ltd | Method for the synthesis of phosphorus atom modified nucleic acids |
| IN2012DN00720A (OSRAM) | 2009-07-06 | 2015-06-19 | Ontorii Inc | |
| MX343559B (es) | 2010-04-29 | 2016-11-10 | Ionis Pharmaceuticals Inc | Modulacion de la expresion de transtiretina. |
| WO2012039448A1 (ja) | 2010-09-24 | 2012-03-29 | 株式会社キラルジェン | 不斉補助基 |
| MX347361B (es) | 2011-07-19 | 2017-04-12 | Wave Life Sciences Ltd | Metodos para la sintesis de acidos nucleicos funcionalizados. |
| PE20142362A1 (es) | 2011-11-18 | 2015-01-30 | Alnylam Pharmaceuticals Inc | Agentes de iarn, composiciones y metodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (ttr) |
| DK3366775T4 (da) * | 2011-11-18 | 2025-10-27 | Alnylam Pharmaceuticals Inc | Modificerede rnai-midler |
| EP2872147B1 (en) | 2012-07-13 | 2022-12-21 | Wave Life Sciences Ltd. | Method for making chiral oligonucleotides |
| EP2872485B1 (en) | 2012-07-13 | 2020-12-16 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| US10144933B2 (en) | 2014-01-15 | 2018-12-04 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| CN106068325B (zh) | 2014-01-16 | 2021-07-09 | 波涛生命科学有限公司 | 手性设计 |
| ES2842300T3 (es) | 2015-07-31 | 2021-07-13 | Alnylam Pharmaceuticals Inc | Composiciones de ARNi de transtiretina (TTR) y métodos para su uso para el tratamiento o la prevención de enfermedades asociadas con TTR |
| JOP20210043A1 (ar) * | 2015-10-01 | 2017-06-16 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
| EP3555292A1 (en) * | 2016-12-16 | 2019-10-23 | Alnylam Pharmaceuticals, Inc. | Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions |
| US11806360B2 (en) | 2017-09-19 | 2023-11-07 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for treating transthyretin (TTR) mediated amyloidosis |
| AU2018374219C1 (en) * | 2017-12-01 | 2023-05-11 | Suzhou Ribo Life Science Co., Ltd. | Double-stranded oligonucleotide, composition and conjugate comprising double-stranded oligonucleotide, preparation method therefor and use thereof |
| CA3114396A1 (en) | 2018-09-28 | 2020-04-02 | Alnylam Pharmaceuticals, Inc. | Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases |
| EP4022062A1 (en) | 2019-08-30 | 2022-07-06 | Alnylam Pharmaceuticals, Inc. | Neurofilament light chain (nfl) as a biomarker for transthyretin amyloidosis polyneuropathy |
| AU2021232029A1 (en) * | 2020-03-06 | 2022-10-06 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of transthyretin (TTR) |
| EP4237005A4 (en) * | 2020-10-28 | 2024-10-09 | Novo Nordisk A/S | ANTI-TRANSTHYRETIN ANTIBODIES AND METHODS OF USE THEREOF |
| US20240182892A1 (en) * | 2021-03-24 | 2024-06-06 | Atalanta Therapeutics, Inc. | Double-stranded sirna having patterned chemical modifications |
| EP4351541A2 (en) | 2021-06-08 | 2024-04-17 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for treating or preventing stargardt's disease and/or retinal binding protein 4 (rbp4)-associated disorders |
| AR126675A1 (es) | 2021-08-03 | 2023-11-01 | Alnylam Pharmaceuticals Inc | COMPOSICIONES DE ARNi CONTRA LA TRANSTIRRETINA (TTR) Y SUS MÉTODOS DE USO |
| EP4634385A2 (en) * | 2022-12-16 | 2025-10-22 | Amgen Inc. | Rnai constructs for inhibiting ttr expression and methods of use thereof |
| TW202530408A (zh) | 2023-09-29 | 2025-08-01 | 美商英西特羅公司 | 用於治療非酒精性脂肪肝病的組合物與方法 |
| WO2025077916A1 (zh) * | 2023-10-13 | 2025-04-17 | 北京安龙生物医药有限公司 | 靶向转甲状腺素蛋白的寡核苷酸及其用途 |
| WO2025098117A1 (zh) * | 2023-11-06 | 2025-05-15 | 成都倍特药业股份有限公司 | 一种抑制甲状腺素转运蛋白(TTR)表达的RNAi试剂、组合物及应用 |
| WO2025113470A1 (en) * | 2023-11-27 | 2025-06-05 | Shanghai Argo Biopharmaceutical Co., Ltd. | Compositions and methods for inhibiting expression of transthyretin (ttr) |
| US20250333742A1 (en) | 2024-04-25 | 2025-10-30 | Insitro, Inc. | Compositions and methods for treating metabolic dysfunction-associated steatotic liver disease |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030027216A1 (en) | 2001-07-02 | 2003-02-06 | Kiernan Urban A. | Analysis of proteins from biological fluids using mass spectrometric immunoassay |
| WO2005121370A2 (en) | 2004-06-03 | 2005-12-22 | Isis Pharmaceuticals, Inc. | Oligomeric compounds that facilitate risc loading |
| AU2001247951A1 (en) | 2000-02-07 | 2001-08-14 | Roche Diagnostics Corporation | Novel cationic amphiphiles |
| WO2002081628A2 (en) | 2001-04-05 | 2002-10-17 | Ribozyme Pharmaceuticals, Incorporated | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
| US20030072794A1 (en) | 2000-06-09 | 2003-04-17 | Teni Boulikas | Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes |
| CZ302719B6 (cs) | 2000-12-01 | 2011-09-21 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití |
| WO2002059621A2 (en) | 2001-01-24 | 2002-08-01 | Bayer Corporation | Regulation of transthyretin to treat obesity |
| US20030170891A1 (en) | 2001-06-06 | 2003-09-11 | Mcswiggen James A. | RNA interference mediated inhibition of epidermal growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| WO2003001182A2 (en) | 2001-06-21 | 2003-01-03 | The Cleveland Clinic Foundation | Homocysteinylated transthyretin |
| US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
| DK1527176T4 (en) | 2002-08-05 | 2017-07-03 | Silence Therapeutics Gmbh | ADDITIONAL NEW FORMS OF INTERFERRING RNA MOLECULES |
| US7923547B2 (en) | 2002-09-05 | 2011-04-12 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| AU2003301882A1 (en) | 2002-11-01 | 2004-06-07 | The Regents Of The University Of Colorado, A Body Corporate | Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry |
| US9228186B2 (en) | 2002-11-14 | 2016-01-05 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
| US7250496B2 (en) | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| EP1560931B1 (en) | 2002-11-14 | 2011-07-27 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| EP2216407B1 (en) | 2003-03-07 | 2016-01-13 | Alnylam Pharmaceuticals, Inc. | Therapeutic compositions |
| CA2488224A1 (en) | 2003-04-03 | 2004-10-21 | Alnylam Pharmaceuticals, Inc. | Irna conjugates |
| ES2559828T3 (es) | 2003-07-16 | 2016-02-16 | Protiva Biotherapeutics Inc. | ARN de interferencia encapsulado en lípidos |
| US20050244869A1 (en) | 2004-04-05 | 2005-11-03 | Brown-Driver Vickie L | Modulation of transthyretin expression |
| EP1781593B1 (en) | 2004-06-07 | 2011-12-14 | Protiva Biotherapeutics Inc. | Cationic lipids and methods of use |
| EP1766035B1 (en) | 2004-06-07 | 2011-12-07 | Protiva Biotherapeutics Inc. | Lipid encapsulated interfering rna |
| US7838561B2 (en) | 2004-06-14 | 2010-11-23 | Wisconsin Alumni Research Foundation | Method for preventing or treating cardiac hypertrophy |
| CN101129344A (zh) | 2004-12-08 | 2008-02-27 | 西来昂诊疗公司 | 治疗与视黄醇有关的疾病的方法、分析和组合物 |
| WO2007086883A2 (en) | 2005-02-14 | 2007-08-02 | Sirna Therapeutics, Inc. | Cationic lipids and formulated molecular compositions containing them |
| ATE541928T1 (de) | 2005-03-31 | 2012-02-15 | Calando Pharmaceuticals Inc | Inhibitoren der untereinheit 2 der ribonukleotidreduktase und ihre verwendungen |
| US7915230B2 (en) | 2005-05-17 | 2011-03-29 | Molecular Transfer, Inc. | Reagents for transfection of eukaryotic cells |
| EP1937213B1 (en) | 2005-07-27 | 2017-10-25 | Protiva Biotherapeutics Inc. | Systems and methods for manufacturing liposomes |
| CA2628300C (en) | 2005-11-02 | 2018-04-17 | Protiva Biotherapeutics, Inc. | Modified sirna molecules and uses thereof |
| CN101448849B (zh) | 2006-03-31 | 2013-08-21 | 阿尔尼拉姆医药品有限公司 | 抑制Eg5基因表达的组合物和方法 |
| US8598333B2 (en) | 2006-05-26 | 2013-12-03 | Alnylam Pharmaceuticals, Inc. | SiRNA silencing of genes expressed in cancer |
| MX2009003548A (es) | 2006-10-03 | 2009-04-15 | Alnylam Pharmaceuticals Inc | Formulaciones que contienen lipidos. |
| GB0704764D0 (en) | 2007-03-12 | 2007-04-18 | Electrophoretics Ltd | Isobarically labelled reagents and methods of their use |
| US20110046206A1 (en) | 2007-06-22 | 2011-02-24 | Isis Pharmaceuticals, Inc. | Double strand compositions comprising differentially modified strands for use in gene modulation |
| EP4074344A1 (en) | 2007-12-04 | 2022-10-19 | Arbutus Biopharma Corporation | Targeting lipids |
| ES2535419T3 (es) | 2007-12-27 | 2015-05-11 | Protiva Biotherapeutics Inc. | Silenciamiento de expresión de quinasa tipo polo usando ARN interferente |
| WO2009086558A1 (en) | 2008-01-02 | 2009-07-09 | Tekmira Pharmaceuticals Corporation | Improved compositions and methods for the delivery of nucleic acids |
| JP2011511004A (ja) | 2008-01-31 | 2011-04-07 | アルナイラム ファーマシューティカルズ インコーポレイテッド | ＰＣＳＫ９遺伝子を標的とするｄｓＲＮＡを送達するための最適化された方法 |
| US20100323381A1 (en) | 2008-02-08 | 2010-12-23 | Bergen Iii Harold R | Classifying amyloidosis |
| ES2638448T3 (es) | 2008-04-15 | 2017-10-20 | Protiva Biotherapeutics Inc. | Novedosas formulaciones de lípidos para la administración de ácidos nucleicos |
| TWI455944B (zh) | 2008-07-01 | 2014-10-11 | Daiichi Sankyo Co Ltd | 雙股多核苷酸 |
| EP2323667A4 (en) | 2008-08-07 | 2012-07-25 | Isis Pharmaceuticals Inc | MODULATION OF TRANSTHYRETIN EXPRESSION BY TREATMENT OF CNS DISEASES |
| EP2743265B1 (en) | 2008-10-09 | 2017-03-15 | Arbutus Biopharma Corporation | Improved amino lipids and methods for the delivery of nucleic acids |
| PT2937418T (pt) | 2008-10-20 | 2018-01-23 | Alnylam Pharmaceuticals Inc | Composições e métodos de inibição da expressão de transtirretina |
| US8969353B2 (en) | 2008-11-07 | 2015-03-03 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| EA037404B1 (ru) | 2008-11-10 | 2021-03-24 | Арбутус Биофарма Корпорэйшн | Липиды и композиции для доставки лекарственных средств |
| WO2010078536A1 (en) | 2009-01-05 | 2010-07-08 | Rxi Pharmaceuticals Corporation | Inhibition of pcsk9 through rnai |
| EP2391343B1 (en) | 2009-01-29 | 2017-03-01 | Arbutus Biopharma Corporation | Improved lipid formulation for the delivery of nucleic acids |
| CA3042927C (en) | 2009-05-05 | 2022-05-17 | Arbutus Biopharma Corporation | Lipid compositions for the delivery of therapeutic agents |
| HRP20211619T1 (hr) | 2009-06-10 | 2022-02-04 | Arbutus Biopharma Corporation | Poboljšana formulacija lipida |
| NZ597504A (en) | 2009-06-15 | 2013-10-25 | Alnylam Pharmaceuticals Inc | Lipid formulated dsrna targeting the pcsk9 gene |
| US9051567B2 (en) | 2009-06-15 | 2015-06-09 | Tekmira Pharmaceuticals Corporation | Methods for increasing efficacy of lipid formulated siRNA |
| EP2496238A4 (en) | 2009-11-03 | 2013-10-02 | Alnylam Pharmaceuticals Inc | FORMULATED LIPID COMPOSITIONS AND METHODS FOR INHIBITING TRANSTHYRETIN EXPRESSION (TTR) |
| ES2893199T3 (es) | 2010-03-29 | 2022-02-08 | Alnylam Pharmaceuticals Inc | Terapia de ARNbc para amiloidosis ocular relacionada con transtiretina (TTR) |
| US20230340473A1 (en) | 2010-03-29 | 2023-10-26 | Alnylam Pharmaceuticals, Inc. | Sirna therapy for transthyretin (ttr) related ocular amyloidosis |
| MX343559B (es) | 2010-04-29 | 2016-11-10 | Ionis Pharmaceuticals Inc | Modulacion de la expresion de transtiretina. |
| JP2013541334A (ja) | 2010-09-15 | 2013-11-14 | アルニラム ファーマスーティカルズ インコーポレイテッド | 修飾されたｉＲＮＡ剤 |
| EP3327125B1 (en) | 2010-10-29 | 2020-08-05 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina) |
| WO2012064824A1 (en) | 2010-11-09 | 2012-05-18 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of eg5 and vegf genes |
| AU2012272908A1 (en) | 2011-06-21 | 2013-12-19 | Alnylam Pharmaceuticals, Inc. | Assays and methods for determining activity of a therapeutic agent in a subject |
| PE20142362A1 (es) | 2011-11-18 | 2015-01-30 | Alnylam Pharmaceuticals Inc | Agentes de iarn, composiciones y metodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (ttr) |
| DK3366775T4 (da) * | 2011-11-18 | 2025-10-27 | Alnylam Pharmaceuticals Inc | Modificerede rnai-midler |
| WO2013166041A1 (en) | 2012-05-01 | 2013-11-07 | The Trustees Of Columbia University In The City Of New York | Transthyretin ligands capable of inhibiting retinol-dependent rbp4-ttr interaction for treatment of age-related macular |
| WO2014022739A2 (en) | 2012-08-03 | 2014-02-06 | Alnylam Pharmaceuticals, Inc. | Modified rnai agents |
| TW201610151A (zh) * | 2013-09-23 | 2016-03-16 | 阿尼拉製藥公司 | 治療或預防與甲狀腺素運載蛋白相關疾病之方法 |
| CA2932904A1 (en) | 2013-12-06 | 2015-06-11 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of transthyretin (ttr) by double-stranded rna |
| BR112016013148B1 (pt) * | 2013-12-12 | 2024-02-27 | Alnylam Pharmaceuticals, Inc | ÁCIDO RIBONUCLEICO DE FITA DUPLA (dsRNA) PARA INIBIÇÃO DA EXPRESSÃO DO FATOR B DO COMPLEMENTO (CFB) EM UMA CÉLULA, COMPOSIÇÃO FARMACÊUTICA PARA INIBIÇÃO DA EXPRESSÃO DE UM GENE DO FATOR B DO COMPLEMENTO, SEU USO, E MÉTODO IN VITRO DE INIBIÇÃO DA EXPRESSÃO DO FATOR B DO COMPLEMENTO (CFB) EM UMA CÉLULA |
| IL316808A (en) | 2014-08-20 | 2025-01-01 | Alnylam Pharmaceuticals Inc | Modified double-stranded RNA materials and their uses |
| DK3185957T3 (da) | 2014-08-29 | 2022-08-29 | Alnylam Pharmaceuticals Inc | Patisiran til anvendelse ved behandlingen af transthyretin-medieret amyloidosis |
| US11117877B2 (en) | 2014-11-21 | 2021-09-14 | Bsim Therapeutics, S.A. | 2-thioxothiazolidin-4-one derivatives active as transthyretin ligands and uses thereof |
| ES2842300T3 (es) | 2015-07-31 | 2021-07-13 | Alnylam Pharmaceuticals Inc | Composiciones de ARNi de transtiretina (TTR) y métodos para su uso para el tratamiento o la prevención de enfermedades asociadas con TTR |
| EP3555292A1 (en) | 2016-12-16 | 2019-10-23 | Alnylam Pharmaceuticals, Inc. | Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions |
| US11806360B2 (en) | 2017-09-19 | 2023-11-07 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for treating transthyretin (TTR) mediated amyloidosis |
| CA3114396A1 (en) | 2018-09-28 | 2020-04-02 | Alnylam Pharmaceuticals, Inc. | Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases |
| EP4022062A1 (en) | 2019-08-30 | 2022-07-06 | Alnylam Pharmaceuticals, Inc. | Neurofilament light chain (nfl) as a biomarker for transthyretin amyloidosis polyneuropathy |
| WO2021092145A1 (en) | 2019-11-06 | 2021-05-14 | Alnylam Pharmaceuticals, Inc. | Transthyretin (ttr) irna composition and methods of use thereof for treating or preventing ttr-associated ocular diseases |
| AU2021232029A1 (en) | 2020-03-06 | 2022-10-06 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of transthyretin (TTR) |
| EP4334448A1 (en) | 2021-05-03 | 2024-03-13 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for treating transthyretin (ttr) mediated amyloidosis |
| EP4351541A2 (en) | 2021-06-08 | 2024-04-17 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for treating or preventing stargardt's disease and/or retinal binding protein 4 (rbp4)-associated disorders |
| AR126675A1 (es) | 2021-08-03 | 2023-11-01 | Alnylam Pharmaceuticals Inc | COMPOSICIONES DE ARNi CONTRA LA TRANSTIRRETINA (TTR) Y SUS MÉTODOS DE USO |
-
2016
- 2016-07-28 ES ES16750567T patent/ES2842300T3/es active Active
- 2016-07-28 KR KR1020247015927A patent/KR20240074895A/ko active Pending
- 2016-07-28 EP EP16750567.6A patent/EP3329002B1/en active Active
- 2016-07-28 MX MX2018000981A patent/MX2018000981A/es unknown
- 2016-07-28 HR HRP20202082TT patent/HRP20202082T1/hr unknown
- 2016-07-28 MY MYPI2018700351A patent/MY195720A/en unknown
- 2016-07-28 KR KR1020187005958A patent/KR102667020B1/ko active Active
- 2016-07-28 SI SI201631039T patent/SI3329002T1/sl unknown
- 2016-07-28 MA MA43335A patent/MA43335B1/fr unknown
- 2016-07-28 SM SM20210020T patent/SMT202100020T1/it unknown
- 2016-07-28 CN CN201680057293.4A patent/CN108138182B/zh active Active
- 2016-07-28 CA CA2994285A patent/CA2994285A1/en active Pending
- 2016-07-28 CN CN202210881662.9A patent/CN116064515A/zh active Pending
- 2016-07-28 UA UAA201802022A patent/UA126276C2/uk unknown
- 2016-07-28 WO PCT/US2016/044359 patent/WO2017023660A1/en not_active Ceased
- 2016-07-28 IL IL313082A patent/IL313082A/en unknown
- 2016-07-28 EA EA201890394A patent/EA201890394A1/ru unknown
- 2016-07-28 IL IL296476A patent/IL296476B2/en unknown
- 2016-07-28 LT LTEP16750567.6T patent/LT3329002T/lt unknown
- 2016-07-28 SG SG10201912341SA patent/SG10201912341SA/en unknown
- 2016-07-28 BR BR112018000542-8A patent/BR112018000542B1/pt active IP Right Grant
- 2016-07-28 US US15/221,651 patent/US10208307B2/en active Active
- 2016-07-28 HK HK18115667.0A patent/HK1256683A1/zh unknown
- 2016-07-28 JP JP2018504819A patent/JP6896703B2/ja active Active
- 2016-07-28 HU HUE16750567A patent/HUE051998T2/hu unknown
- 2016-07-28 PL PL16750567T patent/PL3329002T3/pl unknown
- 2016-07-28 PT PT167505676T patent/PT3329002T/pt unknown
- 2016-07-28 DK DK16750567.6T patent/DK3329002T3/da active
- 2016-07-28 RS RS20210015A patent/RS61297B1/sr unknown
- 2016-07-29 TW TW114112856A patent/TW202532647A/zh unknown
- 2016-07-29 TW TW112123223A patent/TWI883468B/zh active
- 2016-07-29 TW TW105124065A patent/TWI727963B/zh active
- 2016-07-29 TW TW110113415A patent/TWI807302B/zh active
-
2017
- 2017-12-27 IL IL256614A patent/IL256614B2/en unknown
-
2018
- 2018-01-23 MX MX2023012080A patent/MX2023012080A/es unknown
- 2018-01-24 CL CL2018000198A patent/CL2018000198A1/es unknown
- 2018-01-26 ZA ZA2018/00571A patent/ZA201800571B/en unknown
- 2018-12-18 US US16/223,362 patent/US10683501B2/en active Active
-
2019
- 2019-04-17 ZA ZA2019/02447A patent/ZA201902447B/en unknown
-
2020
- 2020-05-01 US US16/864,226 patent/US11286486B2/en active Active
-
2021
- 2021-01-07 CY CY20211100010T patent/CY1124545T1/el unknown
- 2021-06-09 JP JP2021096344A patent/JP7417559B2/ja active Active
-
2022
- 2022-01-26 US US17/584,463 patent/US12049628B2/en active Active
-
2023
- 2023-02-06 NL NL301216C patent/NL301216I2/nl unknown
- 2023-02-06 FI FIC20230006C patent/FIC20230006I1/fi unknown
- 2023-02-06 LU LU00297C patent/LUC00297I2/fr unknown
- 2023-02-07 NO NO2023007C patent/NO2023007I1/no unknown
- 2023-02-08 LT LTPA2023505C patent/LTC3329002I2/lt unknown
- 2023-02-08 FR FR23C1008C patent/FR23C1008I2/fr active Active
- 2023-02-09 HU HUS2300007C patent/HUS2300007I1/hu unknown
- 2023-11-24 JP JP2023199064A patent/JP7711150B2/ja active Active
-
2024
- 2024-06-17 US US18/744,959 patent/US20250075211A1/en active Pending
-
2025
- 2025-07-09 JP JP2025115513A patent/JP2025165939A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018523655A5 (OSRAM) | ||
| JP2024028749A5 (OSRAM) | ||
| HRP20202082T1 (hr) | Transtiretin (ttr) irna pripravci i postupci njihove upotrebe za liječenje ili sprječavanje bolesti povezanih s ttr | |
| JP7625637B2 (ja) | Ｂ型肝炎ウイルス感染のためのＲＮＡｉ薬 | |
| JP2023103244A5 (OSRAM) | ||
| JP2020502142A5 (OSRAM) | ||
| TWI880645B (zh) | 抑制lpa之基因表現之組合物及方法 | |
| JP2018530529A5 (OSRAM) | ||
| JP2016506240A5 (OSRAM) | ||
| CN110268060B (zh) | α-1抗胰蛋白酶(AAT)RNAi物质、包含AAT RNAi物质的组合物和使用方法 | |
| HRP20200672T1 (hr) | RNAi SREDSTVA, PRIPRAVCI I POSTUPCI NJIHOVE UPOTREBE ZA LIJEČENJE BOLESTI POVEZANIH S TRANSTIRETINOM (TTZ) | |
| JP2017532038A5 (OSRAM) | ||
| JP6752151B2 (ja) | 遺伝子サイレンシングにおいて低下したｏｆｆ−ｔａｒｇｅｔ効果を有するｕｎａオリゴマー | |
| JP2018512155A5 (OSRAM) | ||
| TW202045723A (zh) | 用於Ｂ型肝炎病毒感染之ＲＮＡｉ劑 | |
| JP2018525416A5 (OSRAM) | ||
| JP2018510621A5 (OSRAM) | ||
| JPWO2021081026A5 (OSRAM) | ||
| KR20220158011A (ko) | PNPLA3의 발현을 억제하기 위한 RNAi 작용제, 이의 약제학적 조성물, 및 사용 방법 | |
| JPWO2021257782A5 (OSRAM) | ||
| JPWO2021167841A5 (OSRAM) | ||
| JPWO2021252649A5 (OSRAM) | ||
| JPWO2022218941A5 (OSRAM) | ||
| JPWO2023014677A5 (OSRAM) | ||
| JPWO2021126734A5 (OSRAM) |