JP2018523483A5 - - Google Patents

Info

Publication number

JP2018523483A5

JP2018523483A5 JP2018509494A JP2018509494A JP2018523483A5 JP 2018523483 A5 JP2018523483 A5 JP 2018523483A5 JP 2018509494 A JP2018509494 A JP 2018509494A JP 2018509494 A JP2018509494 A JP 2018509494A JP 2018523483 A5 JP2018523483 A5 JP 2018523483A5

Authority

JP

Japan

Prior art keywords

polypeptide

medicament

fusion polypeptide

amino acid

medicament according

Prior art date

2016-08-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 229920001184 polypeptide Polymers 0.000 claims description 51
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 51
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 51
• 230000004927 fusion Effects 0.000 claims description 26
• 239000003814 drug Substances 0.000 claims description 19
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 10
• 206010040047 Sepsis Diseases 0.000 claims description 8
• 108091033319 polynucleotide Proteins 0.000 claims description 7
• 102000040430 polynucleotide Human genes 0.000 claims description 7
• 239000002157 polynucleotide Substances 0.000 claims description 7
• 206010053159 Organ failure Diseases 0.000 claims description 6
• 108010084313 CD58 Antigens Proteins 0.000 claims description 4
• 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims description 4
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 4
• 108060003951 Immunoglobulin Proteins 0.000 claims description 4
• 102100030984 Lymphocyte function-associated antigen 3 Human genes 0.000 claims description 4
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 4
• 229940079593 drug Drugs 0.000 claims description 4
• 239000012634 fragment Substances 0.000 claims description 4
• 102000048776 human CD274 Human genes 0.000 claims description 4
• 102000018358 immunoglobulin Human genes 0.000 claims description 4
• 230000002265 prevention Effects 0.000 claims description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
• 101710187898 60S ribosomal protein L28 Proteins 0.000 claims description 2
• 102220470351 Charged multivesicular body protein 5_K62S_mutation Human genes 0.000 claims description 2
• 102000004127 Cytokines Human genes 0.000 claims description 2
• 108090000695 Cytokines Proteins 0.000 claims description 2
• 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims description 2
• 241000124008 Mammalia Species 0.000 claims description 2
• 208000034486 Multi-organ failure Diseases 0.000 claims description 2
• 208000010718 Multiple Organ Failure Diseases 0.000 claims description 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
• 102220539261 Programmed cell death 1 ligand 2_A98F_mutation Human genes 0.000 claims description 2
• 102220539294 Programmed cell death 1 ligand 2_D49S_mutation Human genes 0.000 claims description 2
• 102220539291 Programmed cell death 1 ligand 2_E58S_mutation Human genes 0.000 claims description 2
• 102220539286 Programmed cell death 1 ligand 2_E72S_mutation Human genes 0.000 claims description 2
• 102220539288 Programmed cell death 1 ligand 2_K75S_mutation Human genes 0.000 claims description 2
• 102220539262 Programmed cell death 1 ligand 2_K89S_mutation Human genes 0.000 claims description 2
• 102220539506 Programmed cell death 1 ligand 2_L27A_mutation Human genes 0.000 claims description 2
• 102220539264 Programmed cell death 1 ligand 2_Q100S_mutation Human genes 0.000 claims description 2
• 102220539292 Programmed cell death 1 ligand 2_S34Y_mutation Human genes 0.000 claims description 2
• 102220539289 Programmed cell death 1 ligand 2_Y56S_mutation Human genes 0.000 claims description 2
• 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims description 2
• 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims description 2
• 230000004913 activation Effects 0.000 claims description 2
• 239000003242 anti bacterial agent Substances 0.000 claims description 2
• 230000002785 anti-thrombosis Effects 0.000 claims description 2
• 229940088710 antibiotic agent Drugs 0.000 claims description 2
• 239000003146 anticoagulant agent Substances 0.000 claims description 2
• 229940127219 anticoagulant drug Drugs 0.000 claims description 2
• 229960004676 antithrombotic agent Drugs 0.000 claims description 2
• 230000001419 dependent effect Effects 0.000 claims description 2
• 230000002757 inflammatory effect Effects 0.000 claims description 2
• 239000003112 inhibitor Substances 0.000 claims description 2
• 230000005923 long-lasting effect Effects 0.000 claims description 2
• 208000029744 multiple organ dysfunction syndrome Diseases 0.000 claims description 2
• 150000007523 nucleic acids Chemical group 0.000 claims description 2
• 150000003431 steroids Chemical class 0.000 claims description 2
• 238000006467 substitution reaction Methods 0.000 claims description 2