JP2018522008A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018522008A5 JP2018522008A5 JP2018501178A JP2018501178A JP2018522008A5 JP 2018522008 A5 JP2018522008 A5 JP 2018522008A5 JP 2018501178 A JP2018501178 A JP 2018501178A JP 2018501178 A JP2018501178 A JP 2018501178A JP 2018522008 A5 JP2018522008 A5 JP 2018522008A5
- Authority
- JP
- Japan
- Prior art keywords
- phe
- pen
- nal
- seq
- aminoethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| USPCT/US2015/040658 | 2015-07-15 | ||
| US14/800,627 US9624268B2 (en) | 2014-07-17 | 2015-07-15 | Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases |
| US14/800,627 | 2015-07-15 | ||
| PCT/US2015/040658 WO2016011208A1 (en) | 2014-07-17 | 2015-07-15 | Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases |
| US201562264820P | 2015-12-08 | 2015-12-08 | |
| US62/264,820 | 2015-12-08 | ||
| US201662281123P | 2016-01-20 | 2016-01-20 | |
| US62/281,123 | 2016-01-20 | ||
| PCT/US2016/042680 WO2017011820A2 (en) | 2015-07-15 | 2016-07-15 | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522008A JP2018522008A (ja) | 2018-08-09 |
| JP2018522008A5 true JP2018522008A5 (https=) | 2020-07-30 |
| JP6858174B2 JP6858174B2 (ja) | 2021-04-14 |
Family
ID=57757647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018501178A Active JP6858174B2 (ja) | 2015-07-15 | 2016-07-15 | インターロイキン２３受容体のペプチド阻害剤、および炎症性疾患を処置するためのそれらの使用 |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP3341011A4 (https=) |
| JP (1) | JP6858174B2 (https=) |
| KR (1) | KR102513978B1 (https=) |
| CN (1) | CN108348580B (https=) |
| AU (1) | AU2016293619B2 (https=) |
| BR (1) | BR112018000691A2 (https=) |
| CA (1) | CA2991984A1 (https=) |
| CL (3) | CL2018000128A1 (https=) |
| CO (1) | CO2018000349A2 (https=) |
| CR (1) | CR20180029A (https=) |
| DO (1) | DOP2018000010A (https=) |
| EA (1) | EA035733B9 (https=) |
| EC (1) | ECSP18002929A (https=) |
| HK (1) | HK1257747A1 (https=) |
| IL (1) | IL256827A (https=) |
| MX (1) | MX384213B (https=) |
| NI (1) | NI201800008A (https=) |
| PE (1) | PE20180571A1 (https=) |
| PH (1) | PH12018500086A1 (https=) |
| SG (1) | SG10201912066SA (https=) |
| SV (1) | SV2018005614A (https=) |
| UA (1) | UA123772C2 (https=) |
| WO (1) | WO2017011820A2 (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2704744T3 (es) | 2012-06-13 | 2019-03-19 | Incyte Holdings Corp | Compuestos tricíclicos sustituidos como inhibidores de FGFR |
| DK2968443T3 (da) | 2013-03-15 | 2021-12-06 | Protagonist Therapeutics Inc | Hepcidinanaloger og anvendelser deraf |
| EA035095B1 (ru) | 2013-04-19 | 2020-04-27 | Инсайт Холдингс Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
| PT3143037T (pt) | 2014-05-16 | 2021-09-24 | Protagonist Therapeutics Inc | Antagonistas peptídicos tioéter de integrina alfa4beta7 |
| US9624268B2 (en) | 2014-07-17 | 2017-04-18 | Protagonist Therapeutics, Inc. | Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases |
| KR20170108936A (ko) | 2014-10-01 | 2017-09-27 | 프로타고니스트 테라퓨틱스, 인코포레이티드 | 신규한 α4β7 펩타이드 단량체 및 이량체 길항제 |
| EP3201217A4 (en) | 2014-10-01 | 2018-07-18 | Protagonist Therapeutics Inc. | Novel cyclic monomer and dimer peptides having integrin antagonist activity |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| MX373169B (es) | 2015-02-20 | 2020-04-24 | Incyte Holdings Corp | Heterociclos bicíclicos como inhibidores de receptores del factor de crecimiento fibroblástico (fgfr). |
| US10787490B2 (en) | 2015-07-15 | 2020-09-29 | Protaganist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| GB2545898B (en) | 2015-12-21 | 2019-10-09 | Sutura Therapeutics Ltd | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| US20190002503A1 (en) | 2015-12-30 | 2019-01-03 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
| WO2017165676A1 (en) | 2016-03-23 | 2017-09-28 | Protagonist Therapeutics, Inc. | METHODS FOR SYNTHESIZING α4β7 PEPTIDE ANTAGONISTS |
| WO2018136646A1 (en) | 2017-01-18 | 2018-07-26 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| GB2563875B (en) * | 2017-06-28 | 2020-08-19 | Sutura Therapeutics Ltd | Improvements in drug delivery |
| EP3681900A4 (en) | 2017-09-11 | 2021-09-08 | Protagonist Therapeutics, Inc. | OPIOID AGONIST PEPTIDES AND THEIR USES |
| EP3749345A4 (en) | 2018-02-08 | 2022-04-06 | Protagonist Therapeutics, Inc. | CONJUGATED HEPCIDIN MIMETICS |
| CR20200590A (es) | 2018-05-04 | 2021-04-26 | Incyte Corp | Formas sólidas de un inhibidor de fgfr y procesos para prepararlas |
| MA52493A (fr) | 2018-05-04 | 2021-03-10 | Incyte Corp | Sels d'un inhibiteur de fgfr |
| TW202019948A (zh) * | 2018-07-12 | 2020-06-01 | 美商領導醫療有限公司 | 介白素-23受體之肽抑制劑及其治療發炎疾病之用途 |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| CN110015978B (zh) * | 2019-04-29 | 2021-03-19 | 康化（上海）新药研发有限公司 | O-[2-[[叔丁氧羰基]氨基]乙基]-n-[芴甲氧羰基]-l-酪氨酸的合成方法 |
| AU2020300527B2 (en) * | 2019-07-01 | 2026-02-05 | Valitor, Inc. | Hydrophilic linkers for multivalent peptide conjugates |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CN114341161A (zh) * | 2019-07-10 | 2022-04-12 | 领导医疗有限公司 | 白细胞介素-23受体的肽抑制剂及其用于治疗炎症性疾病的用途 |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| TWI891666B (zh) | 2019-10-14 | 2025-08-01 | 美商英塞特公司 | 作為ｆｇｆｒ抑制劑之雙環雜環 |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| EP3819307A1 (en) | 2019-11-07 | 2021-05-12 | CytoKi Pharma ApS | Therapeutic derivatives of interleukin-22 |
| BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
| EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| AU2021209086A1 (en) | 2020-01-15 | 2022-08-04 | Janssen Biotech, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| HRP20250769T1 (hr) * | 2020-01-15 | 2025-08-29 | Janssen Biotech, Inc. | Peptidni inhibitori receptora za interleukin-23 i njihova uporaba u liječenju upalnih bolesti |
| BR112022026700A2 (pt) * | 2020-06-29 | 2023-01-24 | Univ Washington | Polipeptídeos de ligação de receptor de il23 humano |
| EP4211468A4 (en) | 2020-09-11 | 2024-10-09 | Glympse Bio, Inc. | DETECTION OF EX VIVO PROTEASE ACTIVITY FOR DETECTION/DIAGNOSTIC, STAGING, MONITORING AND TREATMENT OF DISEASES |
| JP2023145581A (ja) * | 2020-11-20 | 2023-10-11 | ヤンセン ファーマシューティカ エヌ．ベー． | インターロイキン－２３受容体のペプチド阻害剤の組成物 |
| AU2021383828A1 (en) * | 2020-11-20 | 2023-07-06 | Janssen Pharmaceutica Nv | Compositions of peptide inhibitors of interleukin-23 receptor |
| TW202304459A (zh) | 2021-04-12 | 2023-02-01 | 美商英塞特公司 | 包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法 |
| WO2022261159A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| EP4352059A1 (en) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| CA3226539A1 (en) * | 2021-07-14 | 2023-01-19 | Janssen Biotech, Inc. | Peptide inhibitors of interleukin-23 receptor |
| WO2023288019A2 (en) | 2021-07-14 | 2023-01-19 | Janssen Biotech, Inc. | Lipidated peptide inhibitors of interleukin-23 receptor |
| AR126457A1 (es) * | 2021-07-14 | 2023-10-11 | Janssen Biotech Inc | Inhibidores peptídicos bicíclicos del receptor de interleuquina-23 |
| CN118354781A (zh) | 2021-12-01 | 2024-07-16 | 西兰制药公司 | 白介素-23受体的肽抑制剂 |
| WO2023172648A2 (en) * | 2022-03-09 | 2023-09-14 | Glympse Bio, Inc. | Fluorogenic substrates for aminopeptidase detection in biofluids |
| CN114751962B (zh) * | 2022-03-17 | 2023-11-07 | 北京大学 | 订书肽、其制备方法及其制药用途 |
| CA3260606A1 (en) | 2022-06-30 | 2024-01-04 | Sanofi | NEW PEPTIDES FOR USE AS SELECTIVE IL-23 RECEPTOR ANTAGONISTS |
| AU2023386710A1 (en) * | 2022-11-21 | 2025-07-10 | Janssen Pharmaceutica Nv | Synthesis of a cyclic peptide |
| WO2024155551A1 (en) * | 2023-01-16 | 2024-07-25 | Janssen Pharmaceutica Nv | Polycyclic peptide inhibitors of interleukin-23 receptor |
| EP4652180A2 (en) * | 2023-01-16 | 2025-11-26 | Janssen Pharmaceutica NV | Peptide inhibitors of interleukin-23 receptor |
| KR20250139359A (ko) | 2023-01-31 | 2025-09-23 | 얀센 파마슈티카 엔브이 | 인터류킨-23 수용체의 결정질 펩티드 억제제의 제조 방법 |
| WO2024227437A1 (zh) * | 2023-05-04 | 2024-11-07 | 西藏海思科制药有限公司 | 白介素-23受体的肽抑制剂制备及其用途 |
| EP4471049A1 (en) | 2023-06-01 | 2024-12-04 | Zealand Pharma A/S | Peptide inhibitors of interleukin-23 receptor |
| EP4471048A1 (en) | 2023-06-01 | 2024-12-04 | Zealand Pharma A/S | Peptide inhibitors of interleukin-23 receptor |
| WO2025051920A1 (en) | 2023-09-08 | 2025-03-13 | Sanofi | New peptides as selective il-23 receptor inhibitors |
| CN121909205A (zh) | 2023-09-08 | 2026-04-21 | 赛诺菲 | 作为选择性il-23受体抑制剂的新型肽 |
| WO2026013260A1 (en) | 2024-07-12 | 2026-01-15 | Zealand Pharma A/S | Peptide inhibitors of interleukin-23 receptor |
| WO2026057052A1 (zh) * | 2024-09-14 | 2026-03-19 | 深圳信立泰药业股份有限公司 | 一种il-23受体抑制剂及其制备方法和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5942492A (en) * | 1996-11-12 | 1999-08-24 | Angstrom Pharmaceuticals, Inc. | Cyclic peptides that bind to urokinase-type plasminogen activator receptor |
| AU2008216265B2 (en) | 2007-02-15 | 2014-04-03 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
| CN101990547A (zh) * | 2007-07-06 | 2011-03-23 | 瓦勒瑞萨欣Hsj有限合伙公司 | Il-23受体拮抗剂以及其应用 |
| CA2707840A1 (en) | 2007-08-20 | 2009-02-26 | Allozyne, Inc. | Amino acid substituted molecules |
| US10416172B2 (en) | 2010-03-31 | 2019-09-17 | Medical Diagnostic Laboratories, Llc | Recombinant soluble truncated IL-23 receptor (IL-23R) capable of inhibiting IL-23R-mediated cell signaling |
| US8946150B2 (en) * | 2011-06-14 | 2015-02-03 | Medical Diagnostic Laboratories, LLC. | Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof |
| US9169292B2 (en) * | 2011-06-14 | 2015-10-27 | Medical Diagnostic Laboratories, Llc | Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof |
| WO2015054500A2 (en) * | 2013-10-09 | 2015-04-16 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for downregulation of pro-inflammatory cytokines |
| US9624268B2 (en) * | 2014-07-17 | 2017-04-18 | Protagonist Therapeutics, Inc. | Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases |
-
2016
- 2016-07-15 HK HK19100122.0A patent/HK1257747A1/zh unknown
- 2016-07-15 AU AU2016293619A patent/AU2016293619B2/en active Active
- 2016-07-15 CA CA2991984A patent/CA2991984A1/en active Pending
- 2016-07-15 UA UAA201801482A patent/UA123772C2/uk unknown
- 2016-07-15 PE PE2018000053A patent/PE20180571A1/es unknown
- 2016-07-15 WO PCT/US2016/042680 patent/WO2017011820A2/en not_active Ceased
- 2016-07-15 EP EP16825301.1A patent/EP3341011A4/en not_active Withdrawn
- 2016-07-15 EA EA201890325A patent/EA035733B9/ru not_active IP Right Cessation
- 2016-07-15 KR KR1020187004612A patent/KR102513978B1/ko active Active
- 2016-07-15 CR CR20180029A patent/CR20180029A/es unknown
- 2016-07-15 JP JP2018501178A patent/JP6858174B2/ja active Active
- 2016-07-15 MX MX2018000542A patent/MX384213B/es unknown
- 2016-07-15 BR BR112018000691A patent/BR112018000691A2/pt not_active IP Right Cessation
- 2016-07-15 CN CN201680049562.2A patent/CN108348580B/zh active Active
- 2016-07-15 SG SG10201912066SA patent/SG10201912066SA/en unknown
-
2018
- 2018-01-09 PH PH12018500086A patent/PH12018500086A1/en unknown
- 2018-01-10 IL IL256827A patent/IL256827A/en unknown
- 2018-01-10 DO DO2018000010A patent/DOP2018000010A/es unknown
- 2018-01-11 NI NI201800008A patent/NI201800008A/es unknown
- 2018-01-15 CL CL2018000128A patent/CL2018000128A1/es unknown
- 2018-01-15 SV SV2018005614A patent/SV2018005614A/es unknown
- 2018-01-15 CO CONC2018/0000349A patent/CO2018000349A2/es unknown
- 2018-01-15 EC ECIEPI20182929A patent/ECSP18002929A/es unknown
- 2018-11-22 CL CL2018003322A patent/CL2018003322A1/es unknown
-
2021
- 2021-02-09 CL CL2021000343A patent/CL2021000343A1/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018522008A5 (https=) | ||
| US12478617B2 (en) | Lipidated peptide inhibitors of interleukin-23 receptor | |
| US20200199086A1 (en) | 1,2,4-Oxadiazole Derivatives as Immunomodulators | |
| US20240409598A1 (en) | Peptide inhibitors of interleukin-23 receptor | |
| US20240352073A1 (en) | Bicyclic peptide inhibitors of interleukin-23 receptor | |
| JP2020505352A5 (https=) | ||
| BR112020014576A2 (pt) | Ligantes peptídicos bicíclicos multiméricos | |
| US20240366538A1 (en) | Hepatitis B Antiviral Agents | |
| JP2017530090A5 (https=) | ||
| JP2016518351A5 (https=) | ||
| CN102548558B (zh) | 具有Aurora A选择性抑制作用的氨基吡啶衍生物 | |
| JP2019503340A5 (https=) | ||
| JP2021502980A5 (https=) | ||
| JP2013172743A5 (https=) | ||
| JP2012508698A5 (https=) | ||
| US8536116B2 (en) | Antagonists for diseases induced by cells with high-affinity ELR-CXC chemokine receptor proteins | |
| EP3154563B1 (en) | New polypeptide | |
| US20210269482A1 (en) | Peptoid-peptide macrocycles, pharmaceutical compositions and methods of using the same | |
| CN103173419A (zh) | 抗趋化因子4单克隆抗体、杂交瘤细胞系及应用 | |
| JP6438585B2 (ja) | ピロロ［２，３−ｄ］ピリミジン化合物又はその塩 | |
| WO2013129660A1 (ja) | オキシトシン受容体作動および／またはバソプレッシン受容体拮抗剤 | |
| WO2025137159A1 (en) | Human interleukin (il)-17 cytokine binding peptides | |
| CN121449688A (zh) | 白介素-23受体的肽抑制剂及其用途 | |
| EP4611787A1 (en) | Ccr2 inhibitors and methods of use | |
| CN106794219A (zh) | 趋化因子受体拮抗体及其联合疗法 |