JP2018521628A5 - - Google Patents
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- JP2018521628A5 JP2018521628A5 JP2017556597A JP2017556597A JP2018521628A5 JP 2018521628 A5 JP2018521628 A5 JP 2018521628A5 JP 2017556597 A JP2017556597 A JP 2017556597A JP 2017556597 A JP2017556597 A JP 2017556597A JP 2018521628 A5 JP2018521628 A5 JP 2018521628A5
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- JP
- Japan
- Prior art keywords
- seq
- domain
- tag cassette
- amino acid
- natural killer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021109884A JP2021168667A (ja) | 2015-04-29 | 2021-07-01 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
| JP2022199333A JP2023036712A (ja) | 2015-04-29 | 2022-12-14 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562154565P | 2015-04-29 | 2015-04-29 | |
| US62/154,565 | 2015-04-29 | ||
| PCT/US2016/030281 WO2016176651A2 (en) | 2015-04-29 | 2016-04-29 | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021109884A Division JP2021168667A (ja) | 2015-04-29 | 2021-07-01 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521628A JP2018521628A (ja) | 2018-08-09 |
| JP2018521628A5 true JP2018521628A5 (https=) | 2019-11-07 |
| JP6985934B2 JP6985934B2 (ja) | 2021-12-22 |
Family
ID=57198772
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556597A Active JP6985934B2 (ja) | 2015-04-29 | 2016-04-29 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
| JP2021109884A Pending JP2021168667A (ja) | 2015-04-29 | 2021-07-01 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
| JP2022199333A Pending JP2023036712A (ja) | 2015-04-29 | 2022-12-14 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021109884A Pending JP2021168667A (ja) | 2015-04-29 | 2021-07-01 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
| JP2022199333A Pending JP2023036712A (ja) | 2015-04-29 | 2022-12-14 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20180355318A1 (https=) |
| EP (2) | EP3995142A3 (https=) |
| JP (3) | JP6985934B2 (https=) |
| WO (1) | WO2016176651A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2904969C (en) | 2013-03-13 | 2025-06-17 | Imaginab, Inc. | DIFFERENTIATION CLUSTER ANTIGEN-BINDING GENETIC CONSTRUCTIONS 8 |
| CN113354744A (zh) | 2013-12-20 | 2021-09-07 | 弗雷德哈钦森癌症研究中心 | 带标签的嵌合效应分子及其受体 |
| EP3288570A4 (en) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
| RU2766690C2 (ru) | 2015-07-28 | 2022-03-15 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Модифицированные моноциты/макрофаги, экспрессирующие химерные антигенные рецепторы, и их применения |
| WO2017027325A1 (en) | 2015-08-07 | 2017-02-16 | Imaginab, Inc. | Antigen binding constructs to target molecules |
| CN108290939B (zh) | 2015-10-16 | 2023-01-13 | 纽约市哥伦比亚大学理事会 | 用于抑制谱系特异性抗原的组合物和方法 |
| MX2019008538A (es) | 2017-01-20 | 2019-11-05 | Juno Therapeutics Gmbh | Conjugados de superficie celular y composiciones y métodos celulares relacionados. |
| CN108395482B (zh) | 2017-02-08 | 2021-02-05 | 西比曼生物科技(香港)有限公司 | 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定 |
| SG11201907870VA (en) | 2017-02-28 | 2019-09-27 | Vor Biopharma Inc | Compositions and methods for inhibition of lineage specific proteins |
| JP7407701B2 (ja) * | 2017-09-06 | 2024-01-04 | フレッド ハッチンソン キャンサー センター | strepタグ特異的キメラ受容体およびその使用 |
| JP7517983B2 (ja) * | 2017-11-20 | 2024-07-17 | ユリウス-マクシミリアン-ウニヴェルシテート・ヴュルツブルク | 非常に低レベルのcd19を発現する骨髄腫細胞を除去するcd19cart細胞 |
| WO2020004337A1 (ja) * | 2018-06-27 | 2020-01-02 | 国立大学法人名古屋大学 | Cd37特異的キメラ抗原レセプター |
| CA3110837A1 (en) | 2018-08-28 | 2020-03-05 | Vor Biopharma Inc. | Genetically engineered hematopoietic stem cells and uses thereof |
| JP7627080B2 (ja) * | 2018-08-31 | 2025-02-05 | シアトル チルドレンズ ホスピタル ディー/ビー/エイ シアトル チルドレンズ リサーチ インスティテュート | B7h3キメラ抗原受容体を含む方法および組成物 |
| CN118240767A (zh) * | 2019-02-09 | 2024-06-25 | 美国卫生和人力服务部 | 作为减少或预防转移、治疗自身免疫和炎性病症以及重新平衡免疫环境和失调的小生境的平台的基因修饰的hspc及间充质细胞 |
| CN113402612A (zh) | 2020-03-17 | 2021-09-17 | 西比曼生物科技(香港)有限公司 | 靶向cd19和cd20的联合嵌合抗原受体及其应用 |
| CN115867294A (zh) | 2020-06-04 | 2023-03-28 | 凯瑞斯马治疗公司 | 嵌合抗原受体的新型构建体 |
| CA3184940A1 (en) | 2020-07-07 | 2022-01-13 | Jennifer Donglan WU | Mic antibodies and binding agents and methods of using the same |
| AU2022227686A1 (en) | 2021-02-25 | 2023-07-27 | Lyell Immunopharma, Inc. | Ror1 targeting chimeric antigen receptor |
| CN114733455B (zh) * | 2022-04-15 | 2023-02-14 | 北京田园奥瑞生物科技有限公司 | 一种利用生物改性β-环糊精纳米磁颗粒进行快速哺乳动物精子分型的方法 |
| CA3278900A1 (en) | 2023-03-31 | 2024-10-03 | AbelZeta Inc. | BISPECIFIC CHIMERIC ANTIGENIC RECEPTORS TARGETING CD20 AND BCMA |
| CN118853562B (zh) * | 2024-07-11 | 2025-08-29 | 中国科学院广州生物医药与健康研究院 | 一种靶向cd19的car-nk细胞及其制备方法和应用 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3753357A (en) | 1970-12-14 | 1973-08-21 | Ovitron Res Corp | Method and apparatus for the preservation of cells and tissues |
| US4199022A (en) | 1978-12-08 | 1980-04-22 | The United States Of America As Represented By The Department Of Energy | Method of freezing living cells and tissues with improved subsequent survival |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US6291161B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertiore |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| CA2096222C (en) | 1990-11-13 | 1998-12-29 | Stephen D. Lupton | Bifunctional selectable fusion genes |
| US5856441A (en) | 1991-05-03 | 1999-01-05 | Yale University | Serrate fragments and derivatives |
| IE20030749A1 (en) | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| IL101728A (en) | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
| US5869282A (en) | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| WO1993012141A1 (en) | 1991-12-11 | 1993-06-24 | Yale University | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| WO1994028143A1 (en) | 1993-05-21 | 1994-12-08 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| ES2229236T3 (es) | 1994-01-11 | 2005-04-16 | Dyax Corporation | Inhibidores de la plasmina humana derivados de los dominios de kunitz. |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| US5877299A (en) | 1995-06-16 | 1999-03-02 | Stemcell Technologies Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| EP0861261B9 (en) | 1995-06-28 | 2010-02-24 | Imperial Cancer Research Technology Limited | Nucleotide and protein sequences of vertebrate delta genes and methods based thereon |
| US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
| ES2327382T3 (es) * | 1999-07-20 | 2009-10-29 | Morphosys Ag | Metodos para presentar (poli)peptidos/proteinas en particulas de bacteriofagos a traves de enlaces disulfuro. |
| US7399633B2 (en) | 2000-10-27 | 2008-07-15 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
| DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
| EP1400534B1 (en) * | 2002-09-10 | 2015-10-28 | Affimed GmbH | Human CD3-specific antibody with immunosuppressive properties |
| US8361794B2 (en) | 2004-06-29 | 2013-01-29 | Immunocore Limited | Cells expressing a modified T cell receptor |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| CN105168250B (zh) | 2004-10-25 | 2019-02-05 | 塞勒兰特治疗公司 | 增殖骨髓细胞群体的方法及其应用 |
| CN103555733A (zh) | 2005-01-05 | 2014-02-05 | F-星生物技术研究与开发有限公司 | 分子中互补决定区以外的区域中工程改造了的具有结合特性的合成免疫球蛋白结构域 |
| GB0504767D0 (en) | 2005-03-08 | 2005-04-13 | Ares Trading Sa | Lipocalin protein |
| US20090220501A1 (en) * | 2006-01-30 | 2009-09-03 | Fey Georg H | Anti-CD19 Antibody, Immunotoxin and Treatment Method |
| US8383095B2 (en) | 2006-02-14 | 2013-02-26 | Cellerant Therapeutics, Inc. | Methods and compositions for enhancing engraftment of hematopoietic stem cells |
| EP1829895A1 (en) | 2006-03-03 | 2007-09-05 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies |
| KR20090021217A (ko) | 2006-06-14 | 2009-02-27 | 추가이 세이야쿠 가부시키가이샤 | 조혈 줄기세포 증가 촉진제 |
| WO2008042814A2 (en) | 2006-09-29 | 2008-04-10 | California Institute Of Technology | Mart-1 t cell receptors |
| CA2700391A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zuerich | Designed armadillo repeat proteins |
| PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
| CA2744495C (en) * | 2008-11-21 | 2017-05-30 | Mascoma Corporation | Yeast expressing cellulases for simultaneous saccharification and fermentation using cellulose |
| EP2398829A2 (en) * | 2009-02-23 | 2011-12-28 | Glenmark Pharmaceuticals S.A. | Humanized antibodies that bind to cd19 and their uses |
| US20130095079A1 (en) | 2010-04-09 | 2013-04-18 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function without hla matching |
| US20130095080A1 (en) | 2010-04-09 | 2013-04-18 | Fred Hutchinson Cancer Reserach Center | Compositions and methods for providing hematopoietic function |
| US9487800B2 (en) * | 2010-09-08 | 2016-11-08 | Chemotherapeutisches Forschunginstitut Georg-Speyer-Haus | Interleukin 15 as selectable marker for gene transfer in lymphocytes |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| CA2858069C (en) | 2011-12-08 | 2020-02-11 | Novartis Ag | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| WO2014153114A1 (en) * | 2013-03-14 | 2014-09-25 | Fred Hutchinson Cancer Research Center | Compositions and methods to modify cells for therapeutic objectives |
| MX389160B (es) * | 2013-10-31 | 2025-03-20 | Hutchinson Fred Cancer Res | Células no t efectoras y madre/progenitoras hematopoyéticas modificadas y usos de estas. |
| CN113354744A (zh) * | 2013-12-20 | 2021-09-07 | 弗雷德哈钦森癌症研究中心 | 带标签的嵌合效应分子及其受体 |
-
2016
- 2016-04-29 WO PCT/US2016/030281 patent/WO2016176651A2/en not_active Ceased
- 2016-04-29 EP EP21199232.6A patent/EP3995142A3/en not_active Withdrawn
- 2016-04-29 EP EP16787279.5A patent/EP3288569A4/en not_active Withdrawn
- 2016-04-29 US US15/570,191 patent/US20180355318A1/en not_active Abandoned
- 2016-04-29 JP JP2017556597A patent/JP6985934B2/ja active Active
-
2021
- 2021-07-01 JP JP2021109884A patent/JP2021168667A/ja active Pending
- 2021-11-11 US US17/524,592 patent/US20220204935A1/en not_active Abandoned
-
2022
- 2022-12-14 JP JP2022199333A patent/JP2023036712A/ja active Pending
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