JP2018521628A5 - - Google Patents
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- JP2018521628A5 JP2018521628A5 JP2017556597A JP2017556597A JP2018521628A5 JP 2018521628 A5 JP2018521628 A5 JP 2018521628A5 JP 2017556597 A JP2017556597 A JP 2017556597A JP 2017556597 A JP2017556597 A JP 2017556597A JP 2018521628 A5 JP2018521628 A5 JP 2018521628A5
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- JP
- Japan
- Prior art keywords
- seq
- domain
- tag cassette
- amino acid
- natural killer
- Prior art date
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021109884A JP2021168667A (ja) | 2015-04-29 | 2021-07-01 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
| JP2022199333A JP2023036712A (ja) | 2015-04-29 | 2022-12-14 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562154565P | 2015-04-29 | 2015-04-29 | |
| US62/154,565 | 2015-04-29 | ||
| PCT/US2016/030281 WO2016176651A2 (en) | 2015-04-29 | 2016-04-29 | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021109884A Division JP2021168667A (ja) | 2015-04-29 | 2021-07-01 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521628A JP2018521628A (ja) | 2018-08-09 |
| JP2018521628A5 true JP2018521628A5 (https=) | 2019-11-07 |
| JP6985934B2 JP6985934B2 (ja) | 2021-12-22 |
Family
ID=57198772
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556597A Active JP6985934B2 (ja) | 2015-04-29 | 2016-04-29 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
| JP2021109884A Pending JP2021168667A (ja) | 2015-04-29 | 2021-07-01 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
| JP2022199333A Pending JP2023036712A (ja) | 2015-04-29 | 2022-12-14 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021109884A Pending JP2021168667A (ja) | 2015-04-29 | 2021-07-01 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
| JP2022199333A Pending JP2023036712A (ja) | 2015-04-29 | 2022-12-14 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20180355318A1 (https=) |
| EP (2) | EP3288569A4 (https=) |
| JP (3) | JP6985934B2 (https=) |
| WO (1) | WO2016176651A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150131208A (ko) | 2013-03-13 | 2015-11-24 | 이미지냅 인코포레이티드 | Cd8에의 항원 결합 구조체들 |
| NZ759969A (en) | 2013-12-20 | 2022-12-23 | Fred Hutchinson Cancer Center | Tagged chimeric effector molecules and receptors thereof |
| EP3288570A4 (en) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
| IL315940A (en) | 2015-07-28 | 2024-11-01 | Univ Pennsylvania | Altered monocytes/macrophages expressing chimeric antigen receptors and their uses |
| US11254744B2 (en) | 2015-08-07 | 2022-02-22 | Imaginab, Inc. | Antigen binding constructs to target molecules |
| AU2016337525B2 (en) | 2015-10-16 | 2022-01-20 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for inhibition of lineage specific antigens |
| CA3050085A1 (en) * | 2017-01-20 | 2018-07-26 | Juno Therapeutics Gmbh | Cell surface conjugates and related cell compositions and methods |
| CN108395482B (zh) | 2017-02-08 | 2021-02-05 | 西比曼生物科技(香港)有限公司 | 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定 |
| RU2019130504A (ru) * | 2017-02-28 | 2021-03-30 | Вор Байофарма, Инк. | Композиции и способы ингибирования линиеспецифических белков |
| CN111051349A (zh) * | 2017-09-06 | 2020-04-21 | 弗雷德哈钦森癌症研究中心 | Strep-tag特异性嵌合受体及其用途 |
| JP7517983B2 (ja) * | 2017-11-20 | 2024-07-17 | ユリウス-マクシミリアン-ウニヴェルシテート・ヴュルツブルク | 非常に低レベルのcd19を発現する骨髄腫細胞を除去するcd19cart細胞 |
| WO2020004337A1 (ja) * | 2018-06-27 | 2020-01-02 | 国立大学法人名古屋大学 | Cd37特異的キメラ抗原レセプター |
| CA3110837A1 (en) | 2018-08-28 | 2020-03-05 | Vor Biopharma Inc. | Genetically engineered hematopoietic stem cells and uses thereof |
| CN113039206A (zh) * | 2018-08-31 | 2021-06-25 | 西雅图儿童医院(Dba西雅图儿童研究所) | 包含b7h3嵌合抗原受体的方法和组合物 |
| CN113710796A (zh) * | 2019-02-09 | 2021-11-26 | 美国卫生和人力服务部 | 作为减少或预防转移、治疗自身免疫和炎性病症以及重新平衡免疫环境和失调的小生境的平台的基因修饰的造血干细胞和祖细胞(hspc)及间充质细胞 |
| CN113402612A (zh) | 2020-03-17 | 2021-09-17 | 西比曼生物科技(香港)有限公司 | 靶向cd19和cd20的联合嵌合抗原受体及其应用 |
| EP4161536A4 (en) | 2020-06-04 | 2024-08-14 | Carisma Therapeutics Inc. | Novel constructs for chimeric antigen receptors |
| KR20230152783A (ko) | 2020-07-07 | 2023-11-03 | 칸큐어 엘엘씨 | Mic 항체 및 결합제 및 이의 사용 방법 |
| US12144827B2 (en) | 2021-02-25 | 2024-11-19 | Lyell Immunopharma, Inc. | ROR1 targeting chimeric antigen receptor |
| CN114733455B (zh) * | 2022-04-15 | 2023-02-14 | 北京田园奥瑞生物科技有限公司 | 一种利用生物改性β-环糊精纳米磁颗粒进行快速哺乳动物精子分型的方法 |
| KR20250131823A (ko) | 2023-03-31 | 2025-09-03 | 아벨제타 인크. | Cd20 및 bcma를 표적화하는 이중특이적 키메라 항원 수용체 |
| CN118853562B (zh) * | 2024-07-11 | 2025-08-29 | 中国科学院广州生物医药与健康研究院 | 一种靶向cd19的car-nk细胞及其制备方法和应用 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3753357A (en) | 1970-12-14 | 1973-08-21 | Ovitron Res Corp | Method and apparatus for the preservation of cells and tissues |
| US4199022A (en) | 1978-12-08 | 1980-04-22 | The United States Of America As Represented By The Department Of Energy | Method of freezing living cells and tissues with improved subsequent survival |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US6291161B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertiore |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| IE913929A1 (en) | 1990-11-13 | 1992-05-20 | Immunex Corp | Bifunctional selectable fusion genes |
| IE20030749A1 (en) | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| IL101728A (en) | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
| US5856441A (en) | 1991-05-03 | 1999-01-05 | Yale University | Serrate fragments and derivatives |
| WO1993012141A1 (en) | 1991-12-11 | 1993-06-24 | Yale University | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US5869282A (en) | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| AU6953394A (en) | 1993-05-21 | 1994-12-20 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| ATE277081T1 (de) | 1994-01-11 | 2004-10-15 | Dyax Corp | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| US5877299A (en) | 1995-06-16 | 1999-03-02 | Stemcell Technologies Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| DE69638023D1 (de) | 1995-06-28 | 2009-10-22 | Univ Yale | Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden |
| US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
| ES2327382T3 (es) * | 1999-07-20 | 2009-10-29 | Morphosys Ag | Metodos para presentar (poli)peptidos/proteinas en particulas de bacteriofagos a traves de enlaces disulfuro. |
| WO2002059285A1 (en) | 2000-10-27 | 2002-08-01 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
| DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
| EP1400534B1 (en) * | 2002-09-10 | 2015-10-28 | Affimed GmbH | Human CD3-specific antibody with immunosuppressive properties |
| ATE475669T1 (de) | 2004-06-29 | 2010-08-15 | Immunocore Ltd | Einen modifizierten t-zellen-rezeptor exprimierende zellen |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| ZA200704252B (en) | 2004-10-25 | 2009-09-30 | Cellerant Therapeutics Inc | Methods of expanding myeloid cell populations and uses thereof |
| EP1699826B1 (en) | 2005-01-05 | 2009-03-11 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions |
| GB0504767D0 (en) | 2005-03-08 | 2005-04-13 | Ares Trading Sa | Lipocalin protein |
| US20090220501A1 (en) * | 2006-01-30 | 2009-09-03 | Fey Georg H | Anti-CD19 Antibody, Immunotoxin and Treatment Method |
| CN101421393B (zh) | 2006-02-14 | 2013-08-14 | 塞勒兰特治疗公司 | 提高造血干细胞植入的方法和组合物 |
| EP1829895A1 (en) | 2006-03-03 | 2007-09-05 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies |
| WO2007145227A1 (ja) | 2006-06-14 | 2007-12-21 | Chugai Seiyaku Kabushiki Kaisha | 造血幹細胞増加促進剤 |
| US8119772B2 (en) | 2006-09-29 | 2012-02-21 | California Institute Of Technology | MART-1 T cell receptors |
| US9365629B2 (en) | 2007-09-24 | 2016-06-14 | University Of Zurich | Designed armadillo repeat proteins |
| PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
| ES2621181T3 (es) * | 2008-11-21 | 2017-07-03 | Lallemand Hungary Liquidity Management Llc | Levaduras que expresan celulasas para la sacarificación y fermentación simultáneas utilizando celulosa |
| CN102421800A (zh) * | 2009-02-23 | 2012-04-18 | 格兰马克药品股份有限公司 | 结合cd19的人源化抗体及其用途 |
| JP2013523842A (ja) | 2010-04-09 | 2013-06-17 | フレッド ハッチンソン キャンサー リサーチ センター | 造血機能を提供するための組成物および方法 |
| CA2795627C (en) | 2010-04-09 | 2023-03-14 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function without hla matching |
| WO2012136231A1 (en) * | 2010-09-08 | 2012-10-11 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Interleukin 15 as selectable marker for gene transfer in lymphocytes |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| EP2788476B1 (en) | 2011-12-08 | 2019-05-22 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| EP2970985A1 (en) * | 2013-03-14 | 2016-01-20 | Fred Hutchinson Cancer Research Center | Compositions and methods to modify cells for therapeutic objectives |
| CN105873952A (zh) * | 2013-10-31 | 2016-08-17 | 弗莱德哈钦森癌症研究中心 | 经修饰的造血干细胞/祖细胞和非t效应细胞及其用途 |
| NZ759969A (en) * | 2013-12-20 | 2022-12-23 | Fred Hutchinson Cancer Center | Tagged chimeric effector molecules and receptors thereof |
-
2016
- 2016-04-29 EP EP16787279.5A patent/EP3288569A4/en not_active Withdrawn
- 2016-04-29 JP JP2017556597A patent/JP6985934B2/ja active Active
- 2016-04-29 WO PCT/US2016/030281 patent/WO2016176651A2/en not_active Ceased
- 2016-04-29 US US15/570,191 patent/US20180355318A1/en not_active Abandoned
- 2016-04-29 EP EP21199232.6A patent/EP3995142A3/en not_active Withdrawn
-
2021
- 2021-07-01 JP JP2021109884A patent/JP2021168667A/ja active Pending
- 2021-11-11 US US17/524,592 patent/US20220204935A1/en not_active Abandoned
-
2022
- 2022-12-14 JP JP2022199333A patent/JP2023036712A/ja active Pending
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