|
JP6261500B2
(ja)
|
2011-07-22 |
2018-01-17 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ヌクレアーゼ切断特異性の評価および改善
|
|
US9950282B2
(en)
|
2012-03-15 |
2018-04-24 |
Flodesign Sonics, Inc. |
Electronic configuration and control for acoustic standing wave generation
|
|
US10704021B2
(en)
|
2012-03-15 |
2020-07-07 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
US10967298B2
(en)
|
2012-03-15 |
2021-04-06 |
Flodesign Sonics, Inc. |
Driver and control for variable impedence load
|
|
US9458450B2
(en)
|
2012-03-15 |
2016-10-04 |
Flodesign Sonics, Inc. |
Acoustophoretic separation technology using multi-dimensional standing waves
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
WO2015105955A1
(en)
|
2014-01-08 |
2015-07-16 |
Flodesign Sonics, Inc. |
Acoustophoresis device with dual acoustophoretic chamber
|
|
WO2016022363A2
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
US11021699B2
(en)
|
2015-04-29 |
2021-06-01 |
FioDesign Sonics, Inc. |
Separation using angled acoustic waves
|
|
US11377651B2
(en)
|
2016-10-19 |
2022-07-05 |
Flodesign Sonics, Inc. |
Cell therapy processes utilizing acoustophoresis
|
|
US11708572B2
(en)
|
2015-04-29 |
2023-07-25 |
Flodesign Sonics, Inc. |
Acoustic cell separation techniques and processes
|
|
US11459540B2
(en)
|
2015-07-28 |
2022-10-04 |
Flodesign Sonics, Inc. |
Expanded bed affinity selection
|
|
US11474085B2
(en)
|
2015-07-28 |
2022-10-18 |
Flodesign Sonics, Inc. |
Expanded bed affinity selection
|
|
GB2592821B
(en)
|
2015-07-31 |
2022-01-12 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
JP7109784B2
(ja)
|
2015-10-23 |
2022-08-01 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
遺伝子編集のための進化したCas9蛋白質
|
|
WO2017184674A1
(en)
*
|
2016-04-19 |
2017-10-26 |
President And Fellows Of Harvard College |
Methods for increasing efficiency of nuclease-mediated gene editing in stem cells
|
|
US11085035B2
(en)
|
2016-05-03 |
2021-08-10 |
Flodesign Sonics, Inc. |
Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
|
|
US11214789B2
(en)
|
2016-05-03 |
2022-01-04 |
Flodesign Sonics, Inc. |
Concentration and washing of particles with acoustics
|
|
KR102547316B1
(ko)
|
2016-08-03 |
2023-06-23 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
|
US11661590B2
(en)
|
2016-08-09 |
2023-05-30 |
President And Fellows Of Harvard College |
Programmable CAS9-recombinase fusion proteins and uses thereof
|
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
EP3526320A1
(en)
|
2016-10-14 |
2019-08-21 |
President and Fellows of Harvard College |
Aav delivery of nucleobase editors
|
|
JP7181862B2
(ja)
|
2016-10-18 |
2022-12-01 |
リージェンツ オブ ザ ユニバーシティ オブ ミネソタ |
腫瘍浸潤リンパ球および治療の方法
|
|
CA3041517A1
(en)
|
2016-10-19 |
2018-04-26 |
Flodesign Sonics, Inc. |
Affinity cell extraction by acoustics
|
|
CA3041831A1
(en)
*
|
2016-10-27 |
2018-05-03 |
Intima Bioscience, Inc. |
Viral methods of making genetically modified cells
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
CN107746845B
(zh)
*
|
2016-12-28 |
2021-03-26 |
北京微旋基因技术有限公司 |
特异性靶向LAG-3基因的sgRNA和特异性敲除LAG-3基因的方法
|
|
CN107760680B
(zh)
*
|
2016-12-28 |
2020-09-22 |
北京微旋基因技术有限公司 |
特异性靶向TIM-3基因的sgRNA和特异性敲除TIM-3基因的方法
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
JP2020510038A
(ja)
|
2017-03-09 |
2020-04-02 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
がんワクチン
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
CA3057192A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
|
CN108866100A
(zh)
*
|
2017-05-16 |
2018-11-23 |
中国科学院上海生命科学研究院 |
一种高效率的基因编辑方法
|
|
US12144825B2
(en)
|
2017-06-30 |
2024-11-19 |
Cellectis |
Cellular immunotherapy for repetitive administration
|
|
WO2019006418A2
(en)
|
2017-06-30 |
2019-01-03 |
Intima Bioscience, Inc. |
ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
|
|
WO2019023680A1
(en)
|
2017-07-28 |
2019-01-31 |
President And Fellows Of Harvard College |
METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE)
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
KR20250107288A
(ko)
|
2017-10-16 |
2025-07-11 |
더 브로드 인스티튜트, 인코퍼레이티드 |
아데노신 염기 편집제의 용도
|
|
DK3701028T3
(da)
|
2017-10-24 |
2024-11-11 |
Editas Medicine Inc |
Systemer og fremgangsmåder til behandling af hyper-igm-syndrom
|
|
WO2019118921A1
(en)
|
2017-12-14 |
2019-06-20 |
Flodesign Sonics, Inc. |
Acoustic transducer drive and controller
|
|
WO2019118949A1
(en)
|
2017-12-15 |
2019-06-20 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
US20190284553A1
(en)
|
2018-03-15 |
2019-09-19 |
KSQ Therapeutics, Inc. |
Gene-regulating compositions and methods for improved immunotherapy
|
|
JP7469806B2
(ja)
*
|
2018-03-29 |
2024-04-17 |
学校法人自治医科大学 |
ゲノム編集方法、組成物、細胞、細胞製剤、及び細胞製剤の製造方法
|
|
US20210324381A1
(en)
*
|
2018-04-27 |
2021-10-21 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Therapeutic genome editing in x-linked hyper igm syndrome
|
|
KR20210045360A
(ko)
|
2018-05-16 |
2021-04-26 |
신테고 코포레이션 |
가이드 rna 설계 및 사용을 위한 방법 및 시스템
|
|
EP3797160A1
(en)
|
2018-05-23 |
2021-03-31 |
The Broad Institute Inc. |
Base editors and uses thereof
|
|
EP3802802A4
(en)
*
|
2018-05-30 |
2023-04-19 |
Tune Therapeutics, Inc. |
CELLULAR THERAPY
|
|
SG11202012978VA
(en)
*
|
2018-06-25 |
2021-01-28 |
Ospedale San Raffaele Srl |
Gene therapy
|
|
US12522807B2
(en)
|
2018-07-09 |
2026-01-13 |
The Broad Institute, Inc. |
RNA programmable epigenetic RNA modifiers and uses thereof
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
CN109528653B
(zh)
*
|
2018-11-22 |
2020-07-31 |
北京大学 |
具有基因编辑功能的膜性囊泡及其制备方法、药物组合物和用途
|
|
CN109735516B
(zh)
*
|
2019-01-22 |
2021-09-03 |
自然资源部第一海洋研究所 |
受核苷酸片段引导具有特异核酸内切酶活性的piwi蛋白
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
JP7657726B2
(ja)
|
2019-03-19 |
2025-04-07 |
ザ ブロード インスティテュート,インコーポレーテッド |
編集ヌクレオチド配列を編集するための方法および組成物
|
|
CN111812066B
(zh)
*
|
2019-04-10 |
2023-04-28 |
华东理工大学 |
基于CRISPR/Cas12a系统的生物传感器、试剂盒及其在小分子检测中的用途
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
DE112021002672T5
(de)
|
2020-05-08 |
2023-04-13 |
President And Fellows Of Harvard College |
Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz
|
|
CN111909961B
(zh)
*
|
2020-08-21 |
2022-04-19 |
华侨大学 |
一种CRISPR/Cas介导的ATL细胞基因编辑载体及其应用
|
|
US20240336904A1
(en)
*
|
2020-12-21 |
2024-10-10 |
2Seventy Bio, Inc. |
Compositions and methods for site-directed mutagenesis
|
|
WO2022170194A2
(en)
*
|
2021-02-08 |
2022-08-11 |
Intellia Therapeutics, Inc. |
Lymphocyte activation gene 3 (lag3) compositions and methods for immunotherapy
|
|
JP2024506016A
(ja)
*
|
2021-02-08 |
2024-02-08 |
インテリア セラピューティクス,インコーポレイテッド |
免疫療法のためのt細胞免疫グロブリン及びムチンドメイン3(tim3)組成物及び方法
|
|
BR112023018948A2
(pt)
*
|
2021-03-19 |
2023-10-17 |
Metagenomi Inc |
Edição multiplex com enzimas cas
|
|
CN113481184A
(zh)
*
|
2021-08-06 |
2021-10-08 |
北京大学 |
融合蛋白以及其使用方法
|
|
EP4392060A1
(en)
*
|
2021-08-24 |
2024-07-03 |
Intellia Therapeutics, Inc. |
Programmed cell death protein 1 (pd1) compositions and methods for cell-based therapy
|
|
US20250122535A1
(en)
*
|
2021-12-03 |
2025-04-17 |
The General Hospital Corporation |
Crispr-associated transposases and methods of use thereof
|
|
WO2023122036A1
(en)
*
|
2021-12-20 |
2023-06-29 |
Sobol Robert E |
Methods and compositions for improved molecular therapies of multigenic diseases
|
|
IL319698A
(en)
*
|
2022-09-19 |
2025-05-01 |
Emendobio Inc |
Biallelic silencing of PDCD1
|
|
WO2024102954A1
(en)
|
2022-11-10 |
2024-05-16 |
Massachusetts Institute Of Technology |
Activation induced clipping system (aics)
|
|
WO2024107119A1
(en)
*
|
2022-11-17 |
2024-05-23 |
Agency For Science, Technology And Research |
T3 vectors for recombinant protein production in mammalian cells
|
|
CN117987436B
(zh)
*
|
2024-04-03 |
2024-06-25 |
南京鸿明生物科技有限公司 |
一种双链靶dna序列的制备方法
|
|
WO2025235862A1
(en)
|
2024-05-10 |
2025-11-13 |
Inndura Therapeutics Inc. |
A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a
|