JP2020511931A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020511931A5 JP2020511931A5 JP2018565824A JP2018565824A JP2020511931A5 JP 2020511931 A5 JP2020511931 A5 JP 2020511931A5 JP 2018565824 A JP2018565824 A JP 2018565824A JP 2018565824 A JP2018565824 A JP 2018565824A JP 2020511931 A5 JP2020511931 A5 JP 2020511931A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- recombinase
- double
- genome
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108090000623 proteins and genes Proteins 0.000 claims 22
- 150000007523 nucleic acids Chemical class 0.000 claims 21
- 230000005782 double-strand break Effects 0.000 claims 16
- 108010091086 Recombinases Proteins 0.000 claims 15
- 102000018120 Recombinases Human genes 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 14
- 239000013598 vector Substances 0.000 claims 12
- 101710163270 Nuclease Proteins 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 230000014509 gene expression Effects 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 8
- 102000004190 Enzymes Human genes 0.000 claims 7
- 108090000790 Enzymes Proteins 0.000 claims 7
- 210000003527 eukaryotic cell Anatomy 0.000 claims 6
- 239000013604 expression vector Substances 0.000 claims 6
- 108091033409 CRISPR Proteins 0.000 claims 4
- 108020005004 Guide RNA Proteins 0.000 claims 4
- 208000009869 Neu-Laxova syndrome Diseases 0.000 claims 4
- 108010077850 Nuclear Localization Signals Proteins 0.000 claims 4
- 230000006801 homologous recombination Effects 0.000 claims 4
- 238000002744 homologous recombination Methods 0.000 claims 4
- 210000004962 mammalian cell Anatomy 0.000 claims 4
- 230000003612 virological effect Effects 0.000 claims 4
- 230000001580 bacterial effect Effects 0.000 claims 3
- 238000010362 genome editing Methods 0.000 claims 3
- 108020004705 Codon Proteins 0.000 claims 2
- 241000702421 Dependoparvovirus Species 0.000 claims 2
- 241000713666 Lentivirus Species 0.000 claims 2
- 108010068097 Rad51 Recombinase Proteins 0.000 claims 2
- 102000002490 Rad51 Recombinase Human genes 0.000 claims 2
- 102000001218 Rec A Recombinases Human genes 0.000 claims 2
- 108010055016 Rec A Recombinases Proteins 0.000 claims 2
- 241000700584 Simplexvirus Species 0.000 claims 2
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- -1 meganuclease Proteins 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000002103 transcriptional effect Effects 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- 241001430294 unidentified retrovirus Species 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- 230000004186 co-expression Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662350941P | 2016-06-16 | 2016-06-16 | |
| PCT/IB2017/000967 WO2018229521A1 (en) | 2016-06-16 | 2017-06-16 | Improved gene editing |
| US62/350,941 | 2017-06-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020511931A JP2020511931A (ja) | 2020-04-23 |
| JP2020511931A5 true JP2020511931A5 (https=) | 2020-07-30 |
Family
ID=65019181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018565824A Abandoned JP2020511931A (ja) | 2016-06-16 | 2017-06-16 | 改良された遺伝子編集 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11708588B2 (https=) |
| EP (1) | EP3472329A1 (https=) |
| JP (1) | JP2020511931A (https=) |
| CN (1) | CN109790551A (https=) |
| CA (1) | CA3028074A1 (https=) |
| CL (1) | CL2018003649A1 (https=) |
| WO (1) | WO2018229521A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020284581A1 (en) * | 2019-05-29 | 2021-12-23 | Monsanto Technology Llc | Directed genome engineering using enhanced targeted editing technologies |
| CN112979821B (zh) * | 2019-12-18 | 2022-02-08 | 华东师范大学 | 一种提高基因编辑效率的融合蛋白及其应用 |
| CN111518220A (zh) * | 2020-05-14 | 2020-08-11 | 重庆英茂盛业生物科技有限公司 | 一种融合蛋白及其设计方法 |
| CN111909961B (zh) * | 2020-08-21 | 2022-04-19 | 华侨大学 | 一种CRISPR/Cas介导的ATL细胞基因编辑载体及其应用 |
| CN116471929A (zh) * | 2020-11-06 | 2023-07-21 | 香港大学 | 可转移的I-F型CRISPR-Cas基因组编辑系统 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4217344A (en) | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4186183A (en) | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
| US4261975A (en) | 1979-09-19 | 1981-04-14 | Merck & Co., Inc. | Viral liposome particle |
| US4485054A (en) | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US4774085A (en) | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
| DE122007000007I1 (de) | 1986-04-09 | 2007-05-16 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| WO1991017424A1 (en) | 1990-05-03 | 1991-11-14 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| US5587308A (en) | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US7868149B2 (en) | 1999-07-20 | 2011-01-11 | Monsanto Technology Llc | Plant genome sequence and uses thereof |
| US6603061B1 (en) | 1999-07-29 | 2003-08-05 | Monsanto Company | Agrobacterium-mediated plant transformation method |
| JP4551058B2 (ja) | 2001-01-10 | 2010-09-22 | ロンザ・ケルン・アーゲー | モジュラートランスフェクション系 |
| US20090100536A1 (en) | 2001-12-04 | 2009-04-16 | Monsanto Company | Transgenic plants with enhanced agronomic traits |
| US8889394B2 (en) | 2009-09-07 | 2014-11-18 | Empire Technology Development Llc | Multiple domain proteins |
| US9405700B2 (en) | 2010-11-04 | 2016-08-02 | Sonics, Inc. | Methods and apparatus for virtualization in an integrated circuit |
| BR112013021785A8 (pt) * | 2011-02-25 | 2018-07-03 | Recombinetics Inc | animais geneticamente modificados e métodos para fazer os mesmos |
| EP2895620B1 (en) * | 2012-09-11 | 2017-08-02 | Life Technologies Corporation | Nucleic acid amplification |
| CA2889502A1 (en) * | 2012-10-30 | 2014-05-08 | Recombinetics, Inc. | Control of sexual maturation in animals |
| WO2014093694A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes |
| US8697359B1 (en) * | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| EP3011030B1 (en) | 2013-06-17 | 2023-11-08 | The Broad Institute, Inc. | Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation |
| MX2016007325A (es) | 2013-12-12 | 2017-07-19 | Broad Inst Inc | Composiciones y metodos de uso de sistemas crispr-cas en desordenes debidos a repeticion de nucleotidos. |
| CN104946621A (zh) | 2014-03-28 | 2015-09-30 | 中国科学院上海生命科学研究院 | 基因敲入组合物及其使用方法和应用 |
| EP3686279B1 (en) * | 2014-08-17 | 2023-01-04 | The Broad Institute, Inc. | Genome editing using cas9 nickases |
| WO2016054326A1 (en) * | 2014-10-01 | 2016-04-07 | The General Hospital Corporation | Methods for increasing efficiency of nuclease-induced homology-directed repair |
| CA2963820A1 (en) * | 2014-11-07 | 2016-05-12 | Editas Medicine, Inc. | Methods for improving crispr/cas-mediated genome-editing |
| EP3851530A1 (en) * | 2015-03-26 | 2021-07-21 | Editas Medicine, Inc. | Crispr/cas-mediated gene conversion |
| US9988637B2 (en) * | 2015-10-26 | 2018-06-05 | National Tsing Hua Univeristy | Cas9 plasmid, genome editing system and method of Escherichia coli |
-
2017
- 2017-06-16 CA CA3028074A patent/CA3028074A1/en active Pending
- 2017-06-16 JP JP2018565824A patent/JP2020511931A/ja not_active Abandoned
- 2017-06-16 CN CN201780050339.4A patent/CN109790551A/zh active Pending
- 2017-06-16 US US16/310,664 patent/US11708588B2/en active Active
- 2017-06-16 WO PCT/IB2017/000967 patent/WO2018229521A1/en not_active Ceased
- 2017-06-16 EP EP17758941.3A patent/EP3472329A1/en not_active Withdrawn
-
2018
- 2018-12-17 CL CL2018003649A patent/CL2018003649A1/es unknown
-
2023
- 2023-06-30 US US18/345,653 patent/US20230416788A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7698828B2 (ja) | Ｒｎａを編集する方法および組成物 | |
| CN103224947B (zh) | 一种基因打靶系统 | |
| KR101785847B1 (ko) | 선형 이중가닥 ＤＮＡ를 활용한 ＣＲＩＳＰＲ／Ｃａｓ９ 시스템을 이용한 표적 유전체 교정 | |
| JP2016500262A5 (https=) | ||
| JP2016504026A5 (https=) | ||
| JP2016165307A5 (https=) | ||
| JP2020511931A5 (https=) | ||
| US20190119678A1 (en) | Means and methods for inactivating therapeutic dna in a cell | |
| JP2019115348A5 (https=) | ||
| Yuan et al. | A marker-free system for highly efficient construction of vaccinia virus vectors using CRISPR Cas9 | |
| Cao et al. | The multiplexed CRISPR targeting platforms | |
| AU2018222092A1 (en) | Genome editing system and method | |
| JP2015510778A5 (https=) | ||
| CN107794272A (zh) | 一种高特异性的crispr基因组编辑体系 | |
| Jo et al. | CRISPR/Cas9 system as an innovative genetic engineering tool: Enhancements in sequence specificity and delivery methods | |
| CN104805078A (zh) | 用于高效基因组编辑的rna分子的设计、合成及其应用 | |
| WO2017215648A1 (zh) | 基因敲除方法 | |
| EP3733842A1 (en) | System and method for genome editing | |
| JP2020519304A5 (https=) | ||
| CN107151677B (zh) | 基于CRISPR/Cas9多基因敲除低转染效率细胞系的方法 | |
| CN102703424B (zh) | 一种重组工程介导的大肠杆菌基因组点突变的方法 | |
| JP2020527938A (ja) | デザイナーｄｎａ組換え酵素を利用したゲノムを遺伝的に改変するための方法及び手段 | |
| Bayat et al. | The CRISPR growth spurt: from bench to clinic on versatile small RNAs | |
| KR20240107373A (ko) | C2c9 뉴클레아제 기반의 신규 게놈 편집 시스템 및 이의 응용 | |
| CN105543223A (zh) | 一种基于miRNA/shRNA转录加工机制转录sgRNA的方法 |