JP2018520094A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018520094A5 JP2018520094A5 JP2017559025A JP2017559025A JP2018520094A5 JP 2018520094 A5 JP2018520094 A5 JP 2018520094A5 JP 2017559025 A JP2017559025 A JP 2017559025A JP 2017559025 A JP2017559025 A JP 2017559025A JP 2018520094 A5 JP2018520094 A5 JP 2018520094A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- seq
- pharmaceutical composition
- composition according
- signaling inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021131870A JP2021191755A (ja) | 2015-05-13 | 2021-08-13 | ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562161136P | 2015-05-13 | 2015-05-13 | |
| US62/161,136 | 2015-05-13 | ||
| US201562173836P | 2015-06-10 | 2015-06-10 | |
| US62/173,836 | 2015-06-10 | ||
| US201562243457P | 2015-10-19 | 2015-10-19 | |
| US62/243,457 | 2015-10-19 | ||
| PCT/US2016/031999 WO2016183280A1 (en) | 2015-05-13 | 2016-05-12 | Treatment of beta-thalassemia using actrii ligand traps |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021131870A Division JP2021191755A (ja) | 2015-05-13 | 2021-08-13 | ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018520094A JP2018520094A (ja) | 2018-07-26 |
| JP2018520094A5 true JP2018520094A5 (enExample) | 2019-06-20 |
| JP6976859B2 JP6976859B2 (ja) | 2021-12-08 |
Family
ID=57248528
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559025A Expired - Fee Related JP6976859B2 (ja) | 2015-05-13 | 2016-05-12 | ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療 |
| JP2021131870A Pending JP2021191755A (ja) | 2015-05-13 | 2021-08-13 | ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021131870A Pending JP2021191755A (ja) | 2015-05-13 | 2021-08-13 | ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20180125928A1 (enExample) |
| EP (1) | EP3294320A4 (enExample) |
| JP (2) | JP6976859B2 (enExample) |
| KR (1) | KR102640198B1 (enExample) |
| CN (1) | CN107847562A (enExample) |
| AU (2) | AU2016261913B2 (enExample) |
| CA (1) | CA2985777A1 (enExample) |
| HK (1) | HK1251157A1 (enExample) |
| IL (2) | IL284686B2 (enExample) |
| JO (1) | JOP20160092B1 (enExample) |
| MY (1) | MY189601A (enExample) |
| PH (1) | PH12017502079A1 (enExample) |
| TN (1) | TN2017000468A1 (enExample) |
| TW (2) | TWI762444B (enExample) |
| WO (1) | WO2016183280A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS58231B1 (sr) | 2005-11-23 | 2019-03-29 | Acceleron Pharma Inc | Antagonisti aktivin-actriia i primene za stimulaciju rasta kostiju |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| HUE063136T2 (hu) | 2008-08-14 | 2023-12-28 | Acceleron Pharma Inc | GDF-Csapdák |
| KR20120049214A (ko) | 2009-06-08 | 2012-05-16 | 악셀레론 파마 인코포레이티드 | 발열성 지방세포를 증가시키는 방법 |
| US8293881B2 (en) | 2009-06-12 | 2012-10-23 | Acceleron Pharma Inc. | Isolated nucleic acid encoding a truncated ActRIIB fusion protein |
| WO2011063018A1 (en) | 2009-11-17 | 2011-05-26 | Acceleron Pharma Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| US9809636B2 (en) | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
| MX366336B (es) | 2012-11-02 | 2019-07-05 | Celgene Corp | Antagonistas de activina - actrii y usos para el tratar trastornos oseos y otros. |
| TN2016000553A1 (en) | 2014-06-13 | 2018-04-04 | Acceleron Pharma Inc | Methods and compositions for treating ulcers |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| IL252631B2 (en) | 2014-12-03 | 2024-06-01 | Celgene Corp | ACTIVIN-ACTRII antagonists and uses for the treatment of anemia |
| MA41119A (fr) | 2014-12-03 | 2017-10-10 | Acceleron Pharma Inc | Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique |
| EP3298034A4 (en) | 2015-05-20 | 2019-02-13 | Celgene Corporation | IN VITRO CELL CULTURE PROCEDURE FOR BETA THALASSEMIA BY MEANS OF ACTIVIN TYPE II RECEPTOR LIGANDS |
| US11123430B2 (en) | 2015-11-04 | 2021-09-21 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels and treating ineffective erythropoiesis |
| CN108697793B (zh) | 2015-11-23 | 2023-08-01 | 阿塞勒隆制药公司 | 治疗眼睛疾病的方法 |
| RS62011B1 (sr) | 2016-07-15 | 2021-07-30 | Acceleron Pharma Inc | Kompozicije koje sadrže polipeptide actriia za upotrebu u lečenju plućne hipertenzije |
| HUE067225T2 (hu) | 2016-07-27 | 2024-10-28 | Acceleron Pharma Inc | Mielofibrózis kezelésére szolgáló készítmények |
| EP3538123A4 (en) | 2016-11-10 | 2020-10-14 | Keros Therapeutics, Inc. | ACTIVIN RECEPTOR TYPE IIA VARIANTS AND THEIR METHODS OF USE |
| HUE068733T2 (hu) * | 2017-06-14 | 2025-01-28 | Celgene Corp | Eljárások mieloproliferatív neoplazma-asszociált mielofibrózis anémia kezelésére |
| EP3706777B1 (en) | 2017-11-09 | 2024-05-22 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
| CN120399032A (zh) | 2018-01-12 | 2025-08-01 | 科乐斯疗法公司 | 激活素受体iib型变体及其使用方法 |
| WO2019213016A1 (en) | 2018-04-30 | 2019-11-07 | The Children's Hospital Of Philadelphia | Methods of improving anemias by combining agents |
| KR20250133994A (ko) | 2018-05-09 | 2025-09-09 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법 |
| US20210346464A1 (en) * | 2018-10-31 | 2021-11-11 | Celgene Corporation | TREATMENT OF ANEMIA DUE TO VERY LOW, LOW, OR INTERMEDIATE RISK MYELODYSPLASTIC SYNDROMES IN SUBJECTS WITH RING SIDEROBLASTS USING ACTIVIN-ACTRll LIGAND TRAPS |
| EP3999059A1 (en) | 2019-07-19 | 2022-05-25 | Vifor (International) Ag | Ferroportin-inhibitors for the use in the treatment of transfusion-dependent beta-thalassemia (tdt) |
| CN112924684B (zh) * | 2019-12-05 | 2022-07-29 | 中国科学院大连化学物理研究所 | 用于区分抑郁症和非抑郁症的生物标志物和包括其的诊断试剂盒 |
| JP2023518260A (ja) | 2020-03-20 | 2023-04-28 | ケロス セラピューティクス インコーポレイテッド | アクチビン受容体ｉｉ型キメラ及びその使用方法 |
| WO2021189010A1 (en) | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
| JP2023523568A (ja) * | 2020-04-13 | 2023-06-06 | セルジーン コーポレーション | ＡｃｔＲＩＩＢリガンドトラップ及びフェドラチニブを使用して貧血を治療するための方法 |
| US12186370B1 (en) | 2020-11-05 | 2025-01-07 | Celgene Corporation | ACTRIIB ligand trap compositions and uses thereof |
| WO2022098877A1 (en) * | 2020-11-06 | 2022-05-12 | Acceleron Pharma Inc. | Formulations comprising actrii polypeptide variants |
| WO2022150590A1 (en) * | 2021-01-08 | 2022-07-14 | Acceleron Pharma Inc. | Compositions and methods for treating pulmonary hypertension |
| US20250268878A1 (en) | 2021-01-20 | 2025-08-28 | Vifor (International) Ag | Ferroportin-inhibitors for the use in the treatment of myelodysplastic syndromes (mds) |
| AU2024310149A1 (en) | 2023-06-26 | 2025-11-20 | Vifor (International) Ag | Ferroportin-inhibitors for the use in the treatment of hereditary haemochromatosis (hh) |
| WO2025122830A1 (en) * | 2023-12-08 | 2025-06-12 | Keros Therapeutics, Inc. | Methods of using activin receptor type ii signaling inhibitors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247A (en) * | 1845-11-01 | Jordan l | ||
| US6231880B1 (en) * | 1997-05-30 | 2001-05-15 | Susan P. Perrine | Compositions and administration of compositions for the treatment of blood disorders |
| MX2009006651A (es) * | 2006-12-18 | 2009-08-26 | Acceleron Pharma Inc | Antagonistas de activina-actrii y usos para incrementar los niveles de globulos rojo. |
| EP3415161A1 (en) * | 2008-06-26 | 2018-12-19 | Acceleron Pharma Inc. | The use of an actriib antagonist for the treatment of anemia |
| HUE063136T2 (hu) * | 2008-08-14 | 2023-12-28 | Acceleron Pharma Inc | GDF-Csapdák |
| BR112012005225B8 (pt) * | 2009-09-09 | 2023-01-10 | Acceleron Pharma Inc | Uso de uma proteína de fusão actriib-fc para o tratamento de um transtorno relacionado ao osso ou associado à perda de músculo por crescimento muscular insuficiente |
| KR20220075438A (ko) * | 2011-10-17 | 2022-06-08 | 악셀레론 파마 인코포레이티드 | 비효율적 적혈구생성 치료를 위한 방법 및 조성물 |
| EP2830642B1 (en) * | 2012-03-30 | 2019-08-28 | Shire Human Genetic Therapies, Inc. | Subcutaneous administration of iduronate- 2-sulfatase |
| AU2013334660B2 (en) * | 2012-10-24 | 2018-08-09 | Celgene Corporation | Methods for treating anemia |
| WO2014066486A2 (en) * | 2012-10-24 | 2014-05-01 | Celgene Corporation | Biomarker for use in treating anemia |
| US9822355B2 (en) * | 2012-11-27 | 2017-11-21 | Children's Medical Center Corporation | Targeting BCL11A distal regulatory elements for fetal hemoglobin reinduction |
-
2016
- 2016-05-12 JO JOP/2016/0092A patent/JOP20160092B1/ar active
- 2016-05-12 WO PCT/US2016/031999 patent/WO2016183280A1/en not_active Ceased
- 2016-05-12 IL IL284686A patent/IL284686B2/en unknown
- 2016-05-12 HK HK18110608.3A patent/HK1251157A1/zh unknown
- 2016-05-12 JP JP2017559025A patent/JP6976859B2/ja not_active Expired - Fee Related
- 2016-05-12 TN TNP/2017/000468A patent/TN2017000468A1/en unknown
- 2016-05-12 CN CN201680041002.2A patent/CN107847562A/zh active Pending
- 2016-05-12 CA CA2985777A patent/CA2985777A1/en active Pending
- 2016-05-12 MY MYPI2017704290A patent/MY189601A/en unknown
- 2016-05-12 US US15/573,177 patent/US20180125928A1/en not_active Abandoned
- 2016-05-12 AU AU2016261913A patent/AU2016261913B2/en active Active
- 2016-05-12 TW TW105114763A patent/TWI762444B/zh active
- 2016-05-12 TW TW110148304A patent/TWI814187B/zh active
- 2016-05-12 EP EP16793499.1A patent/EP3294320A4/en active Pending
- 2016-05-12 KR KR1020177035838A patent/KR102640198B1/ko active Active
-
2017
- 2017-11-08 IL IL255527A patent/IL255527B/en unknown
- 2017-11-16 PH PH12017502079A patent/PH12017502079A1/en unknown
-
2021
- 2021-08-13 JP JP2021131870A patent/JP2021191755A/ja active Pending
- 2021-10-29 AU AU2021258087A patent/AU2021258087B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018520094A5 (enExample) | ||
| TWI658834B (zh) | 用於治療或預防ｃ５相關疾病的醫藥組合物以及治療或預防ｃ５相關疾病的方法 | |
| TWI754622B (zh) | Ctla4結合劑 | |
| JP2024009946A (ja) | 抗ｐｄ－１抗体と他の抗体の組み合わせを含む組成物 | |
| KR102560808B1 (ko) | 응고 제 ix 인자 및/또는 활성화 응고 제 ix 인자 및 응고 제 x 인자 및/또는 활성화 응고 제 x 인자를 인식하는 이중특이성 항체의 사용법 | |
| HRP20230504T1 (hr) | Antagonisti aktivin-actrii i upotreba u liječenju mijelodisplastičnog sindroma | |
| JP2016514132A5 (enExample) | ||
| FI3638243T3 (fi) | Menetelmiä myeloproliferatiivin neoplasma-assosioidun myelofibroosin ja anemian hoitamiseksi | |
| JP6672533B1 (ja) | Ｃ５関連疾患の治療または予防用の医薬組成物およびｃ５関連疾患を治療または予防するための方法 | |
| AU2019374363A1 (en) | TGF-β receptor fusion protein pharmaceutical composition and use thereof | |
| JP2016527286A5 (enExample) | ||
| US10471142B2 (en) | Combination therapy using immunoglobulin and C1-Inhibitor | |
| RU2017111228A (ru) | Композиции антитела против IL-7R | |
| RU2015116264A (ru) | Композиции и способы лечения сердечной недостаточности у пациентов с диабетом | |
| JP2015532293A5 (ja) | 糖尿病患者における心不全の治療用組成物 | |
| JP2017524675A5 (enExample) | ||
| TW202222823A (zh) | 投與治療劑量的雙特異性ｔ細胞接合分子治療癌症之方法 | |
| EP3976193A1 (en) | Dosing of bispecific t cell engager | |
| Ochi et al. | Bispecific antibodies for multiple myeloma: past, present and future | |
| JPWO2020085467A1 (ja) | 再生不良性貧血を治療するための医薬組成物 | |
| Hill et al. | Coversin, a novel C5 complement inhibitor, is safe and effective in the treatment of PNH: results of a phase II clinical trial | |
| WO2025184284A1 (en) | Methods of using activin receptor type ii signaling inhibitors | |
| NZ737043B2 (en) | Treatment of beta-thalassemia using actrii ligand traps | |
| TW201828984A (zh) | 使用介白素-17(il-17)拮抗劑治療痤瘡的方法 | |
| NZ737043A (en) | Treatment of beta-thalassemia using actrii ligand traps |