JP6976859B2 - ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療 - Google Patents

ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療 Download PDF

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Publication number
JP6976859B2
JP6976859B2 JP2017559025A JP2017559025A JP6976859B2 JP 6976859 B2 JP6976859 B2 JP 6976859B2 JP 2017559025 A JP2017559025 A JP 2017559025A JP 2017559025 A JP2017559025 A JP 2017559025A JP 6976859 B2 JP6976859 B2 JP 6976859B2
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certain embodiments
actriib
seq
polypeptide
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JP2018520094A (ja
JP2018520094A5 (enExample
Inventor
エム．アティエ ケネス
ラアデム アブデラーマン
チョプラ ラジェシュ
バックストロム ジェイ
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Celgene Corp
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Celgene Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2017559025A 2015-05-13 2016-05-12 ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療 Expired - Fee Related JP6976859B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021131870A JP2021191755A (ja) 2015-05-13 2021-08-13 ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562161136P 2015-05-13 2015-05-13
US62/161,136 2015-05-13
US201562173836P 2015-06-10 2015-06-10
US62/173,836 2015-06-10
US201562243457P 2015-10-19 2015-10-19
US62/243,457 2015-10-19
PCT/US2016/031999 WO2016183280A1 (en) 2015-05-13 2016-05-12 Treatment of beta-thalassemia using actrii ligand traps

Related Child Applications (1)

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JP2021131870A Division JP2021191755A (ja) 2015-05-13 2021-08-13 ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療

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JP2018520094A JP2018520094A (ja) 2018-07-26
JP2018520094A5 JP2018520094A5 (enExample) 2019-06-20
JP6976859B2 true JP6976859B2 (ja) 2021-12-08

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JP2017559025A Expired - Fee Related JP6976859B2 (ja) 2015-05-13 2016-05-12 ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療
JP2021131870A Pending JP2021191755A (ja) 2015-05-13 2021-08-13 ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療

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JP2021131870A Pending JP2021191755A (ja) 2015-05-13 2021-08-13 ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療

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Country Link
US (1) US20180125928A1 (enExample)
EP (1) EP3294320A4 (enExample)
JP (2) JP6976859B2 (enExample)
KR (1) KR102640198B1 (enExample)
CN (1) CN107847562A (enExample)
AU (2) AU2016261913B2 (enExample)
CA (1) CA2985777A1 (enExample)
HK (1) HK1251157A1 (enExample)
IL (2) IL284686B2 (enExample)
JO (1) JOP20160092B1 (enExample)
MY (1) MY189601A (enExample)
PH (1) PH12017502079A1 (enExample)
TN (1) TN2017000468A1 (enExample)
TW (2) TWI762444B (enExample)
WO (1) WO2016183280A1 (enExample)

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US8293881B2 (en) 2009-06-12 2012-10-23 Acceleron Pharma Inc. Isolated nucleic acid encoding a truncated ActRIIB fusion protein
WO2011063018A1 (en) 2009-11-17 2011-05-26 Acceleron Pharma Inc. Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy
US9809636B2 (en) 2012-04-06 2017-11-07 Acceleron Pharma Inc. Methods for increasing red blood cell levels comprising administering BMP9
MX366336B (es) 2012-11-02 2019-07-05 Celgene Corp Antagonistas de activina - actrii y usos para el tratar trastornos oseos y otros.
TN2016000553A1 (en) 2014-06-13 2018-04-04 Acceleron Pharma Inc Methods and compositions for treating ulcers
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
IL252631B2 (en) 2014-12-03 2024-06-01 Celgene Corp ACTIVIN-ACTRII antagonists and uses for the treatment of anemia
MA41119A (fr) 2014-12-03 2017-10-10 Acceleron Pharma Inc Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique
EP3298034A4 (en) 2015-05-20 2019-02-13 Celgene Corporation IN VITRO CELL CULTURE PROCEDURE FOR BETA THALASSEMIA BY MEANS OF ACTIVIN TYPE II RECEPTOR LIGANDS
US11123430B2 (en) 2015-11-04 2021-09-21 Acceleron Pharma Inc. Methods for increasing red blood cell levels and treating ineffective erythropoiesis
CN108697793B (zh) 2015-11-23 2023-08-01 阿塞勒隆制药公司 治疗眼睛疾病的方法
RS62011B1 (sr) 2016-07-15 2021-07-30 Acceleron Pharma Inc Kompozicije koje sadrže polipeptide actriia za upotrebu u lečenju plućne hipertenzije
HUE067225T2 (hu) 2016-07-27 2024-10-28 Acceleron Pharma Inc Mielofibrózis kezelésére szolgáló készítmények
EP3538123A4 (en) 2016-11-10 2020-10-14 Keros Therapeutics, Inc. ACTIVIN RECEPTOR TYPE IIA VARIANTS AND THEIR METHODS OF USE
HUE068733T2 (hu) * 2017-06-14 2025-01-28 Celgene Corp Eljárások mieloproliferatív neoplazma-asszociált mielofibrózis anémia kezelésére
EP3706777B1 (en) 2017-11-09 2024-05-22 Keros Therapeutics, Inc. Activin receptor type iia variants and methods of use thereof
CN120399032A (zh) 2018-01-12 2025-08-01 科乐斯疗法公司 激活素受体iib型变体及其使用方法
WO2019213016A1 (en) 2018-04-30 2019-11-07 The Children's Hospital Of Philadelphia Methods of improving anemias by combining agents
KR20250133994A (ko) 2018-05-09 2025-09-09 케로스 테라퓨틱스, 인크. 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법
US20210346464A1 (en) * 2018-10-31 2021-11-11 Celgene Corporation TREATMENT OF ANEMIA DUE TO VERY LOW, LOW, OR INTERMEDIATE RISK MYELODYSPLASTIC SYNDROMES IN SUBJECTS WITH RING SIDEROBLASTS USING ACTIVIN-ACTRll LIGAND TRAPS
EP3999059A1 (en) 2019-07-19 2022-05-25 Vifor (International) Ag Ferroportin-inhibitors for the use in the treatment of transfusion-dependent beta-thalassemia (tdt)
CN112924684B (zh) * 2019-12-05 2022-07-29 中国科学院大连化学物理研究所 用于区分抑郁症和非抑郁症的生物标志物和包括其的诊断试剂盒
JP2023518260A (ja) 2020-03-20 2023-04-28 ケロス セラピューティクス インコーポレイテッド アクチビン受容体ｉｉ型キメラ及びその使用方法
WO2021189010A1 (en) 2020-03-20 2021-09-23 Keros Therapeutics, Inc. Methods of using activin receptor type iib variants
JP2023523568A (ja) * 2020-04-13 2023-06-06 セルジーン コーポレーション ＡｃｔＲＩＩＢリガンドトラップ及びフェドラチニブを使用して貧血を治療するための方法
US12186370B1 (en) 2020-11-05 2025-01-07 Celgene Corporation ACTRIIB ligand trap compositions and uses thereof
WO2022098877A1 (en) * 2020-11-06 2022-05-12 Acceleron Pharma Inc. Formulations comprising actrii polypeptide variants
WO2022150590A1 (en) * 2021-01-08 2022-07-14 Acceleron Pharma Inc. Compositions and methods for treating pulmonary hypertension
US20250268878A1 (en) 2021-01-20 2025-08-28 Vifor (International) Ag Ferroportin-inhibitors for the use in the treatment of myelodysplastic syndromes (mds)
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Also Published As

Publication number Publication date
JOP20160092B1 (ar) 2023-03-28
WO2016183280A1 (en) 2016-11-17
JP2018520094A (ja) 2018-07-26
AU2016261913A1 (en) 2017-11-30
IL284686A (en) 2021-08-31
IL284686B2 (en) 2023-05-01
TWI814187B (zh) 2023-09-01
US20180125928A1 (en) 2018-05-10
CN107847562A (zh) 2018-03-27
AU2021258087B2 (en) 2023-04-27
TW202231294A (zh) 2022-08-16
CA2985777A1 (en) 2016-11-17
IL284686B (en) 2023-01-01
HK1251157A1 (zh) 2019-01-25
IL255527B (en) 2021-07-29
KR102640198B1 (ko) 2024-02-23
JP2021191755A (ja) 2021-12-16
EP3294320A4 (en) 2018-12-26
NZ737043A (en) 2025-02-28
AU2021258087A1 (en) 2021-11-25
IL255527A (en) 2018-01-31
TN2017000468A1 (en) 2019-04-12
MY189601A (en) 2022-02-18
KR20180006437A (ko) 2018-01-17
AU2016261913B2 (en) 2021-08-12
TW201709927A (zh) 2017-03-16
PH12017502079A1 (en) 2018-06-11
EP3294320A1 (en) 2018-03-21
TWI762444B (zh) 2022-05-01

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