AU2016261913B2 - Treatment of beta-thalassemia using ActRII ligand traps - Google Patents

Treatment of beta-thalassemia using ActRII ligand traps Download PDF

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Publication number
AU2016261913B2
AU2016261913B2 AU2016261913A AU2016261913A AU2016261913B2 AU 2016261913 B2 AU2016261913 B2 AU 2016261913B2 AU 2016261913 A AU2016261913 A AU 2016261913A AU 2016261913 A AU2016261913 A AU 2016261913A AU 2016261913 B2 AU2016261913 B2 AU 2016261913B2
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Australia
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subject
certain embodiments
seq
actriib
signaling inhibitor
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AU2016261913A
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AU2016261913A1 (en
Inventor
Kenneth M. Attie
Jay BACKSTROM
Rajesh Chopra
Abderrahmane LAADEM
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Celgene Corp
Acceleron Pharma Inc
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Celgene Corp
Acceleron Pharma Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2016261913A 2015-05-13 2016-05-12 Treatment of beta-thalassemia using ActRII ligand traps Active AU2016261913B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021258087A AU2021258087B2 (en) 2015-05-13 2021-10-29 Treatment of beta-thalassemia using ActRII ligand traps

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562161136P 2015-05-13 2015-05-13
US62/161,136 2015-05-13
US201562173836P 2015-06-10 2015-06-10
US62/173,836 2015-06-10
US201562243457P 2015-10-19 2015-10-19
US62/243,457 2015-10-19
PCT/US2016/031999 WO2016183280A1 (en) 2015-05-13 2016-05-12 Treatment of beta-thalassemia using actrii ligand traps

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021258087A Division AU2021258087B2 (en) 2015-05-13 2021-10-29 Treatment of beta-thalassemia using ActRII ligand traps

Publications (2)

Publication Number Publication Date
AU2016261913A1 AU2016261913A1 (en) 2017-11-30
AU2016261913B2 true AU2016261913B2 (en) 2021-08-12

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AU2016261913A Active AU2016261913B2 (en) 2015-05-13 2016-05-12 Treatment of beta-thalassemia using ActRII ligand traps
AU2021258087A Active AU2021258087B2 (en) 2015-05-13 2021-10-29 Treatment of beta-thalassemia using ActRII ligand traps

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AU2021258087A Active AU2021258087B2 (en) 2015-05-13 2021-10-29 Treatment of beta-thalassemia using ActRII ligand traps

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US (1) US20180125928A1 (enExample)
EP (1) EP3294320A4 (enExample)
JP (2) JP6976859B2 (enExample)
KR (1) KR102640198B1 (enExample)
CN (1) CN107847562A (enExample)
AU (2) AU2016261913B2 (enExample)
CA (1) CA2985777A1 (enExample)
HK (1) HK1251157A1 (enExample)
IL (2) IL284686B2 (enExample)
JO (1) JOP20160092B1 (enExample)
MY (1) MY189601A (enExample)
PH (1) PH12017502079A1 (enExample)
TN (1) TN2017000468A1 (enExample)
TW (2) TWI814187B (enExample)
WO (1) WO2016183280A1 (enExample)

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MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
TWI730949B (zh) 2014-12-03 2021-06-21 美商西建公司 活化素-ａｃｔｒｉｉ拮抗劑及治療貧血之用途
MA41119A (fr) 2014-12-03 2017-10-10 Acceleron Pharma Inc Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique
EP3298034A4 (en) 2015-05-20 2019-02-13 Celgene Corporation IN VITRO CELL CULTURE PROCEDURE FOR BETA THALASSEMIA BY MEANS OF ACTIVIN TYPE II RECEPTOR LIGANDS
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CN116531490A (zh) 2016-07-15 2023-08-04 阿塞勒隆制药公司 用于治疗肺高血压的组合物和方法
HUE067225T2 (hu) 2016-07-27 2024-10-28 Acceleron Pharma Inc Mielofibrózis kezelésére szolgáló készítmények
CN119241685A (zh) 2016-11-10 2025-01-03 科乐斯疗法公司 激活素受体iia型变体及其使用方法
HUE068733T2 (hu) * 2017-06-14 2025-01-28 Celgene Corp Eljárások mieloproliferatív neoplazma-asszociált mielofibrózis anémia kezelésére
CN111801112A (zh) 2017-11-09 2020-10-20 科乐斯疗法公司 激活素受体iia型变体及其使用方法
KR20200109330A (ko) 2018-01-12 2020-09-22 케로스 테라퓨틱스, 인크. 액티빈 수용체 유형 iib 변이체 및 그의 사용 방법
US12263205B2 (en) 2018-04-30 2025-04-01 The Children's Hospital Of Philadelphia Methods of improving anemias by combining agents
WO2019217715A1 (en) 2018-05-09 2019-11-14 Keros Therapeutics, Inc. Activin receptor type iia variants and methods of use thereof
EP3873501A4 (en) * 2018-10-31 2022-07-13 Celgene Corporation TREATMENT OF ANEMIA DUE TO VERY LOW, LOW, OR INTERMEDIATE RISK MYELODYSPLASTIC SYNDROMES IN PEOPLE WITH RING SIDEROBLASTS USING AKTIVIN ACTRLL LIGAND TRAPS
AU2020316632B2 (en) 2019-07-19 2025-09-18 Vifor (International) Ag Ferroportin-inhibitors for the use in the treatment of transfusion-dependent beta-thalassemia (TDT)
CN112924684B (zh) * 2019-12-05 2022-07-29 中国科学院大连化学物理研究所 用于区分抑郁症和非抑郁症的生物标志物和包括其的诊断试剂盒
CA3176735A1 (en) 2020-03-20 2021-09-23 Keros Therapeutics, Inc. Activin receptor type ii chimeras and methods of use thereof
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CN115427056A (zh) * 2020-04-13 2022-12-02 细胞基因公司 使用actriib配体陷阱和菲卓替尼治疗贫血的方法
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WO2022098877A1 (en) * 2020-11-06 2022-05-12 Acceleron Pharma Inc. Formulations comprising actrii polypeptide variants
WO2022150590A1 (en) * 2021-01-08 2022-07-14 Acceleron Pharma Inc. Compositions and methods for treating pulmonary hypertension
JP2024504349A (ja) 2021-01-20 2024-01-31 ビフォー （インターナショナル） エージー 骨髄異形成症候群（ｍｄｓ）の処置において使用するためのフェロポーチン阻害剤
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Also Published As

Publication number Publication date
CA2985777A1 (en) 2016-11-17
TW201709927A (zh) 2017-03-16
CN107847562A (zh) 2018-03-27
JP2021191755A (ja) 2021-12-16
AU2021258087A1 (en) 2021-11-25
EP3294320A4 (en) 2018-12-26
EP3294320A1 (en) 2018-03-21
TWI762444B (zh) 2022-05-01
KR102640198B1 (ko) 2024-02-23
IL255527B (en) 2021-07-29
IL284686B (en) 2023-01-01
MY189601A (en) 2022-02-18
TWI814187B (zh) 2023-09-01
NZ737043A (en) 2025-02-28
TN2017000468A1 (en) 2019-04-12
HK1251157A1 (zh) 2019-01-25
KR20180006437A (ko) 2018-01-17
IL284686A (en) 2021-08-31
JOP20160092B1 (ar) 2023-03-28
US20180125928A1 (en) 2018-05-10
WO2016183280A1 (en) 2016-11-17
JP6976859B2 (ja) 2021-12-08
IL284686B2 (en) 2023-05-01
AU2021258087B2 (en) 2023-04-27
JP2018520094A (ja) 2018-07-26
IL255527A (en) 2018-01-31
TW202231294A (zh) 2022-08-16
PH12017502079A1 (en) 2018-06-11
AU2016261913A1 (en) 2017-11-30

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