JP2018515449A5 - - Google Patents

Download PDF

Info

Publication number
JP2018515449A5
JP2018515449A5 JP2017555223A JP2017555223A JP2018515449A5 JP 2018515449 A5 JP2018515449 A5 JP 2018515449A5 JP 2017555223 A JP2017555223 A JP 2017555223A JP 2017555223 A JP2017555223 A JP 2017555223A JP 2018515449 A5 JP2018515449 A5 JP 2018515449A5
Authority
JP
Japan
Prior art keywords
variable domain
chain variable
antibody
mercaptoethylamine
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017555223A
Other languages
English (en)
Japanese (ja)
Other versions
JP6898251B2 (ja
JP2018515449A (ja
Filing date
Publication date
Priority claimed from GBGB1506870.3A external-priority patent/GB201506870D0/en
Application filed filed Critical
Publication of JP2018515449A publication Critical patent/JP2018515449A/ja
Publication of JP2018515449A5 publication Critical patent/JP2018515449A5/ja
Application granted granted Critical
Publication of JP6898251B2 publication Critical patent/JP6898251B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017555223A 2015-04-22 2016-04-22 組換え抗体分子の単量体化方法 Expired - Fee Related JP6898251B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1506870.3 2015-04-22
GBGB1506870.3A GB201506870D0 (en) 2015-04-22 2015-04-22 Method
PCT/EP2016/059051 WO2016170138A1 (en) 2015-04-22 2016-04-22 Method of monomerisation of recombinant antibody molecules

Publications (3)

Publication Number Publication Date
JP2018515449A JP2018515449A (ja) 2018-06-14
JP2018515449A5 true JP2018515449A5 (enExample) 2019-05-23
JP6898251B2 JP6898251B2 (ja) 2021-07-07

Family

ID=53299019

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017555223A Expired - Fee Related JP6898251B2 (ja) 2015-04-22 2016-04-22 組換え抗体分子の単量体化方法

Country Status (17)

Country Link
US (2) US10828366B2 (enExample)
EP (1) EP3286204B1 (enExample)
JP (1) JP6898251B2 (enExample)
KR (1) KR20170138552A (enExample)
CN (1) CN108064230B (enExample)
AU (1) AU2016251620A1 (enExample)
BR (1) BR112017021812A2 (enExample)
CA (1) CA2981644C (enExample)
CL (1) CL2017002676A1 (enExample)
CO (1) CO2017010385A2 (enExample)
EA (1) EA201792329A1 (enExample)
ES (1) ES2846732T3 (enExample)
GB (1) GB201506870D0 (enExample)
IL (1) IL254765A0 (enExample)
MX (1) MX2017013376A (enExample)
SG (1) SG11201708151TA (enExample)
WO (1) WO2016170138A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201223276D0 (en) * 2012-12-21 2013-02-06 Ucb Pharma Sa Antibodies and methods of producing same
ES3046837T3 (en) 2014-12-22 2025-12-02 UCB Biopharma SRL Method of protein manufacture
GB201506869D0 (en) 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method
GB201506870D0 (en) 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method
GB201506868D0 (en) 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method for protein purification
MX2021003976A (es) 2018-10-11 2021-05-27 Amgen Inc Procesamiento posterior de constructos de anticuerpos biespecificos.
AU2019409132B2 (en) * 2018-12-21 2026-08-06 Novartis Ag Antibodies to PMEL17 and conjugates thereof
US20240067758A1 (en) * 2020-12-07 2024-02-29 UCB Biopharma SRL Multi-specific antibodies and antibody combinations

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4741900A (en) 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
DK336987D0 (da) 1987-07-01 1987-07-01 Novo Industri As Immobiliseringsmetode
US5453363A (en) 1985-10-23 1995-09-26 Boehringer Mannheim Gmbh Process for the activation of t-PA or Ing after genetic expression in prokaryotes
GB8719042D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
GB8720833D0 (en) 1987-09-04 1987-10-14 Celltech Ltd Recombinant dna product
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
DE68927933T2 (de) 1988-09-02 1997-08-14 Dyax Corp Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8907617D0 (en) 1989-04-05 1989-05-17 Celltech Ltd Drug delivery system
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
AU7247191A (en) 1990-01-11 1991-08-05 Molecular Affinities Corporation Production of antibodies using gene libraries
US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
CA2090126C (en) 1990-08-02 2002-10-22 John W. Schrader Methods for the production of proteins with a desired function
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
ES2246502T3 (es) 1990-08-29 2006-02-16 Genpharm International, Inc. Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5698426A (en) 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
DE69129154T2 (de) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
PT100379B (pt) 1991-04-10 1999-01-29 Scripps Research Inst Bibliotecas de receptores heterodimericos usando fagomideos
GB9112536D0 (en) 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
GB9120467D0 (en) 1991-09-26 1991-11-06 Celltech Ltd Anti-hmfg antibodies and process for their production
PT1024191E (pt) 1991-12-02 2008-12-22 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
CA2372813A1 (en) * 1992-02-06 1993-08-19 L.L. Houston Biosynthetic binding protein for cancer marker
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
JPH09506262A (ja) 1993-12-08 1997-06-24 ジェンザイム・コーポレイション 特異的抗体の製造方法
ES2201097T3 (es) 1994-01-31 2004-03-16 Trustees Of Boston University Bibliotecas de anticuerpos policlonales.
FR2716640B1 (fr) 1994-02-28 1996-05-03 Procedes Machines Speciales Dispositif de centrage et de blocage d'une pièce en vue de son rodage à l'aide d'un rodoir à expansion.
US5516637A (en) 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
JP2978435B2 (ja) 1996-01-24 1999-11-15 チッソ株式会社 アクリロキシプロピルシランの製造方法
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
GB9625640D0 (en) 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
AU3703100A (en) * 1999-02-22 2000-09-14 Georgetown University Antibody fragment-targeted immunoliposomes for systemic gene delivery
US6908963B2 (en) 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
BR122019027966B8 (pt) 2002-05-02 2021-07-27 Wyeth Corp conjugado monomérico de derivado de caliqueamicina/anti-corpo anti-cd22 e uso dos mesmos
AU2003223936A1 (en) * 2002-05-17 2003-12-02 Kobenhavns Universitet Method for purifying denatured proteins having a desired disulfide bond configuration
WO2004051268A1 (en) 2002-12-03 2004-06-17 Celltech R & D Limited Assay for identifying antibody producing cells
GB0312481D0 (en) 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315450D0 (en) * 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
PT1644412E (pt) 2003-07-01 2015-12-23 Ucb Biopharma Sprl Fragmentos de anticorpos fab modificados
NZ551180A (en) 2004-06-01 2009-10-30 Genentech Inc Antibody drug conjugates and methods
GB0412181D0 (en) 2004-06-01 2004-06-30 Celltech R&D Ltd Biological products
US20060051347A1 (en) 2004-09-09 2006-03-09 Winter Charles M Process for concentration of antibodies and therapeutic products thereof
EP1805320B1 (en) * 2004-10-22 2014-09-03 Amgen Inc. Methods for refolding of recombinant antibodies
US20070021591A1 (en) 2005-07-25 2007-01-25 Trubion Pharmaceuticals, Inc. Compositions and methods for protein deaggregation
AU2006294644A1 (en) 2005-09-27 2007-04-05 Amunix, Inc. Proteinaceous pharmaceuticals and uses thereof
GB0619291D0 (en) 2006-09-29 2006-11-08 Ucb Sa Altered antibodies
EP2535350B1 (en) 2007-09-26 2018-01-24 UCB Biopharma SPRL Dual specificity antibody fusions
JP5529869B2 (ja) 2008-08-14 2014-06-25 メルク・シャープ・アンド・ドーム・コーポレーション プロテインaアフィニティークロマトグラフィーを用いる抗体の精製方法
RU2011116319A (ru) * 2008-09-26 2012-11-10 Шеринг Корпорейшн (US) Производство высокого титра антител
US10407513B2 (en) 2008-09-26 2019-09-10 Ucb Biopharma Sprl Biological products
LT3660032T (lt) 2009-06-25 2026-02-25 Amgen Inc. Ne žinduolių sistemoje ekspresuotų baltymų surišamojo gryninimo būdai
WO2011030107A1 (en) 2009-09-10 2011-03-17 Ucb Pharma S.A. Multivalent antibodies
GB201005063D0 (en) 2010-03-25 2010-05-12 Ucb Pharma Sa Biological products
GB0920127D0 (en) * 2009-11-17 2009-12-30 Ucb Pharma Sa Antibodies
GB201000467D0 (en) 2010-01-12 2010-02-24 Ucb Pharma Sa Antibodies
BR112012022518A2 (pt) * 2010-03-17 2020-10-13 Biogenerix Gmbh método para obtenção de g- csf recombinante humano biologicamente ativo
GB201005064D0 (en) 2010-03-25 2010-05-12 Ucb Pharma Sa Biological products
WO2011117653A1 (en) 2010-03-25 2011-09-29 Ucb Pharma S.A. Disulfide stabilized dvd-lg molecules
EP2619217B1 (en) * 2010-09-20 2016-11-09 Bio-Rad Laboratories, Inc. Dissociation of product-complexed contaminants in chromatography
US8759617B2 (en) * 2010-09-21 2014-06-24 National Institute Of Agrobiological Sciences Method for extraction and purification of recombinant proteins from transgenic plants
CA2847888A1 (en) * 2011-09-09 2013-03-14 Biomed Realty, L.P. Methods and compositions for controlling assembly of viral proteins
JP6411214B2 (ja) * 2011-11-11 2018-10-24 ユーシービー バイオファルマ エスピーアールエル アルブミン結合抗体及びその結合断片
UA112203C2 (uk) 2011-11-11 2016-08-10 Юсб Фарма С.А. Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини
US20160060291A1 (en) 2012-03-30 2016-03-03 Biogenomics Limited Process for renaturation of polypeptides
GB201208370D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Antibodies
KR102373193B1 (ko) 2012-11-21 2022-03-10 얀센 바이오테크 인코포레이티드 이중특이성 EGFR/c-Met 항체
US20170073666A1 (en) 2014-03-07 2017-03-16 Bionano Genomics, Inc. Processing of polynucleotides
GB201411320D0 (en) 2014-06-25 2014-08-06 Ucb Biopharma Sprl Antibody construct
GB201506868D0 (en) 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method for protein purification
GB201506869D0 (en) 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method
GB201506870D0 (en) * 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method
EP3485280A1 (en) 2016-08-12 2019-05-22 Lonza Ltd Proteomic analysis of host cell proteins

Similar Documents

Publication Publication Date Title
JP2025160458A5 (enExample)
JP2024167313A5 (enExample)
JP2017052784A5 (enExample)
JP2019515646A5 (enExample)
JP2020062036A5 (enExample)
JP2020524000A5 (enExample)
JP2020515518A5 (enExample)
EA202091590A1 (ru) Антитела против pd-l1 и варианты их применения
RU2014149553A (ru) Биспецифические анти-vegf/анти-ang-2 антитела
NZ602780A (en) Human antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof
RU2011116112A (ru) Биспецифические анти-egfr/анти-igf-1r антитела
JP2012525829A5 (enExample)
EA200970879A1 (ru) Связывающие белки, включающие антитела, производные антител и фрагменты антител, которые специфически связываются с cd154, и их применения
JP2009225799A5 (enExample)
JP2018505674A5 (enExample)
JP2017176174A5 (enExample)
JP2016512551A5 (enExample)
EA201190132A1 (ru) Гуманизированные антитела, связывающиеся с cd19, и их применение
PE20141564A1 (es) Moleculas de union para bcma y cd3
RU2018102606A (ru) Молекулы, связывающиеся с psl pseudomonas, и пути их применения
JP2009535021A5 (enExample)
JP2018510617A5 (enExample)
NZ602892A (en) Antibodies that bind human cd27 and uses thereof
RU2016100892A (ru) Антитела против tweakr и их применение
JP2016533763A5 (ja) ヒトpd−1に特異的に結合する抗体抗原結合ドメインおよびそれを含む医薬組成物