MX2017013376A - Metodo de monomerizacion de moleculas de anticuerpos recombinantes. - Google Patents

Metodo de monomerizacion de moleculas de anticuerpos recombinantes.

Info

Publication number
MX2017013376A
MX2017013376A MX2017013376A MX2017013376A MX2017013376A MX 2017013376 A MX2017013376 A MX 2017013376A MX 2017013376 A MX2017013376 A MX 2017013376A MX 2017013376 A MX2017013376 A MX 2017013376A MX 2017013376 A MX2017013376 A MX 2017013376A
Authority
MX
Mexico
Prior art keywords
antibody molecules
monomerisation
recombinant antibody
composition
reducing agent
Prior art date
Application number
MX2017013376A
Other languages
English (en)
Inventor
Philip Heywood Sam
Barry Wild Gavin
HANIF Razwan
John Le Page Christopher
Original Assignee
Ucb Biopharma Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
Publication of MX2017013376A publication Critical patent/MX2017013376A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/123—Tripeptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención proporciona un método para aumentar el porcentaje del monómero en una composición de moléculas del anticuerpo expresadas de manera recombinante, caracterizado porque la molécula del anticuerpo comprende al menos un Fv con especificidad hacia un antígeno de interés que comprende un VH y un VL, en donde el VH y el VL están conectados directa o indirectamente por medio de uno o más enlazadores y son estabilizados por medio de un enlace de disulfuro entre los mismos, el método comprende: a) una etapa de conversión de tratamiento de la composición con un desnaturalizante seleccionado de la urea y/o el clorhidrato de guanidina; b) en donde la etapa a) se lleva a cabo en la presencia de un agente reductor o después del tratamiento con un agente reductor.
MX2017013376A 2015-04-22 2016-04-22 Metodo de monomerizacion de moleculas de anticuerpos recombinantes. MX2017013376A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1506870.3A GB201506870D0 (en) 2015-04-22 2015-04-22 Method
PCT/EP2016/059051 WO2016170138A1 (en) 2015-04-22 2016-04-22 Method of monomerisation of recombinant antibody molecules

Publications (1)

Publication Number Publication Date
MX2017013376A true MX2017013376A (es) 2017-12-07

Family

ID=53299019

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017013376A MX2017013376A (es) 2015-04-22 2016-04-22 Metodo de monomerizacion de moleculas de anticuerpos recombinantes.

Country Status (17)

Country Link
US (2) US10828366B2 (es)
EP (1) EP3286204B1 (es)
JP (1) JP6898251B2 (es)
KR (1) KR20170138552A (es)
CN (1) CN108064230B (es)
AU (1) AU2016251620A1 (es)
BR (1) BR112017021812A2 (es)
CA (1) CA2981644C (es)
CL (1) CL2017002676A1 (es)
CO (1) CO2017010385A2 (es)
EA (1) EA201792329A1 (es)
ES (1) ES2846732T3 (es)
GB (1) GB201506870D0 (es)
IL (1) IL254765A0 (es)
MX (1) MX2017013376A (es)
SG (1) SG11201708151TA (es)
WO (1) WO2016170138A1 (es)

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GB201223276D0 (en) * 2012-12-21 2013-02-06 Ucb Pharma Sa Antibodies and methods of producing same
JP6807326B2 (ja) 2014-12-22 2021-01-06 ユーシービー バイオファルマ エスアールエル タンパク質製造方法
GB201506869D0 (en) 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method
GB201506870D0 (en) 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method
GB201506868D0 (en) 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method for protein purification
MX2021003976A (es) * 2018-10-11 2021-05-27 Amgen Inc Procesamiento posterior de constructos de anticuerpos biespecificos.
MX2023006650A (es) * 2020-12-07 2023-06-21 UCB Biopharma SRL Anticuerpos multiespecificos y combinaciones de anticuerpos.

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Also Published As

Publication number Publication date
KR20170138552A (ko) 2017-12-15
JP6898251B2 (ja) 2021-07-07
AU2016251620A1 (en) 2017-10-26
EP3286204B1 (en) 2020-11-18
CL2017002676A1 (es) 2018-03-23
US11786593B2 (en) 2023-10-17
SG11201708151TA (en) 2017-11-29
CA2981644A1 (en) 2016-10-27
US20180117153A1 (en) 2018-05-03
JP2018515449A (ja) 2018-06-14
EP3286204A1 (en) 2018-02-28
CN108064230B (zh) 2021-04-06
GB201506870D0 (en) 2015-06-03
WO2016170138A1 (en) 2016-10-27
CO2017010385A2 (es) 2018-03-20
US20210069328A1 (en) 2021-03-11
IL254765A0 (en) 2017-12-31
US10828366B2 (en) 2020-11-10
CN108064230A (zh) 2018-05-22
CA2981644C (en) 2023-07-04
BR112017021812A2 (pt) 2018-07-10
EA201792329A1 (ru) 2018-02-28
ES2846732T3 (es) 2021-07-29

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