JP2018510135A - ＲＯＲγＴ阻害剤としての置換ピラゾール化合物及びその使用 - Google Patents

ＲＯＲγＴ阻害剤としての置換ピラゾール化合物及びその使用 Download PDF

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JP2018510135A
JP2018510135A JP2017541959A JP2017541959A JP2018510135A JP 2018510135 A JP2018510135 A JP 2018510135A JP 2017541959 A JP2017541959 A JP 2017541959A JP 2017541959 A JP2017541959 A JP 2017541959A JP 2018510135 A JP2018510135 A JP 2018510135A
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chloro
alkyl
tetrahydro
mmol
cyclopropylbenzoyl
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JP2018510135A5 (https=
Inventor
ラポイント，ブレア・ティー
フラー，ピーター・エイチ
ギュナイドゥン，ハカン
リュー，クン
スキアメッタ，ヌンチオ
トロッター，ベンジャミン・ウェルズリー
ジャーン，ホンジュン
バー，ケネス・ジェイ
マクリーン，ジョン・ケイ・エフ
モリナーリ，ダニエル・エフ
シモフ，ウラディミール
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Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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Publication of JP2018510135A publication Critical patent/JP2018510135A/ja
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    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2017541959A 2015-02-11 2016-02-11 ＲＯＲγＴ阻害剤としての置換ピラゾール化合物及びその使用 Pending JP2018510135A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562114854P 2015-02-11 2015-02-11
US62/114,854 2015-02-11
PCT/US2016/017566 WO2016130818A1 (en) 2015-02-11 2016-02-11 SUBSTITUTED PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF

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JP2018510135A true JP2018510135A (ja) 2018-04-12
JP2018510135A5 JP2018510135A5 (https=) 2019-03-07

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US (1) US10221142B2 (https=)
EP (1) EP3256450B1 (https=)
JP (1) JP2018510135A (https=)
AU (1) AU2016219183B2 (https=)
CA (1) CA2975997A1 (https=)
WO (1) WO2016130818A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021527650A (ja) * 2018-06-15 2021-10-14 リアタ ファーマシューティカルズ インコーポレイテッド ＩＬ−１７およびＲＯＲγの阻害用のピラゾール化合物およびイミダゾール化合物
JP2024501520A (ja) * 2020-12-22 2024-01-12 メルク・シャープ・アンド・ドーム・エルエルシー 新規ジアシルグリセリドｏ－アシルトランスフェラーゼ２阻害薬としてのテトラヒドロインダゾール誘導体の調製

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Publication number Priority date Publication date Assignee Title
WO2015095795A1 (en) 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE, AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE
EP3256450B1 (en) 2015-02-11 2020-12-02 Merck Sharp & Dohme Corp. Substituted pyrazole compounds as ror-gamma-t inhibitors and uses thereof
WO2017075178A1 (en) * 2015-10-27 2017-05-04 Merck Sharp & Dohme Corp. SUBSTITUTED BICYCLIC PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
AU2016344118A1 (en) 2015-10-27 2018-05-10 Merck Sharp & Dohme Corp. Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof
RU2018117503A (ru) * 2015-10-27 2019-11-28 Мерк Шарп И Доум Корп. ЗАМЕЩЕННЫЕ ИНДАЗОЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ RORγТ И ИХ ПРИМЕНЕНИЕ
EP3806958B1 (en) * 2018-06-18 2022-09-07 Janssen Pharmaceutica NV 6-aminopyridin-3-yl pyrazoles as modulators of roryt
WO2020117715A1 (en) 2018-12-03 2020-06-11 Board Of Regents, The University Of Texas System Oligo-benzamide analogs and their use in cancer treatment
US12398097B2 (en) 2019-07-29 2025-08-26 Vanderbilt University WDR5-MYC inhibitors

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JP2007505908A (ja) * 2003-09-17 2007-03-15 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 縮合複素環式化合物
WO2014028591A2 (en) * 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. N-ALKYLATED INDOLE AND INDAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
WO2014028589A2 (en) * 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. 4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
JP2014509316A (ja) * 2011-02-11 2014-04-17 メルク・シャープ・アンド・ドーム・コーポレーション ＲＯＲγＴ阻害薬
WO2015139621A1 (zh) * 2014-03-18 2015-09-24 北京韩美药品有限公司 4-杂芳基取代的苯甲酸或苯甲酰胺类化合物
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