JP2018506585A5 - - Google Patents
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- JP2018506585A5 JP2018506585A5 JP2017560479A JP2017560479A JP2018506585A5 JP 2018506585 A5 JP2018506585 A5 JP 2018506585A5 JP 2017560479 A JP2017560479 A JP 2017560479A JP 2017560479 A JP2017560479 A JP 2017560479A JP 2018506585 A5 JP2018506585 A5 JP 2018506585A5
- Authority
- JP
- Japan
- Prior art keywords
- raav
- nucleic acid
- disease
- raav particle
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021129519A JP2021178861A (ja) | 2015-02-10 | 2021-08-06 | 線条体および皮質へのウイルス粒子の強化された送達 |
| JP2023018846A JP2023058630A (ja) | 2015-02-10 | 2023-02-10 | 線条体および皮質へのウイルス粒子の強化された送達 |
| JP2024228114A JP2025060823A (ja) | 2015-02-10 | 2024-12-25 | 線条体および皮質へのウイルス粒子の強化された送達 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562114544P | 2015-02-10 | 2015-02-10 | |
| US62/114,544 | 2015-02-10 | ||
| US201562220997P | 2015-09-19 | 2015-09-19 | |
| US62/220,997 | 2015-09-19 | ||
| PCT/US2016/017210 WO2016130591A2 (en) | 2015-02-10 | 2016-02-09 | Enhanced delivery of viral particles to the striatum and cortex |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021129519A Division JP2021178861A (ja) | 2015-02-10 | 2021-08-06 | 線条体および皮質へのウイルス粒子の強化された送達 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018506585A JP2018506585A (ja) | 2018-03-08 |
| JP2018506585A5 true JP2018506585A5 (https=) | 2019-03-22 |
| JP6928558B2 JP6928558B2 (ja) | 2021-09-01 |
Family
ID=56614902
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560479A Active JP6928558B2 (ja) | 2015-02-10 | 2016-02-09 | 線条体および皮質へのウイルス粒子の強化された送達 |
| JP2021129519A Pending JP2021178861A (ja) | 2015-02-10 | 2021-08-06 | 線条体および皮質へのウイルス粒子の強化された送達 |
| JP2023018846A Pending JP2023058630A (ja) | 2015-02-10 | 2023-02-10 | 線条体および皮質へのウイルス粒子の強化された送達 |
| JP2024228114A Pending JP2025060823A (ja) | 2015-02-10 | 2024-12-25 | 線条体および皮質へのウイルス粒子の強化された送達 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021129519A Pending JP2021178861A (ja) | 2015-02-10 | 2021-08-06 | 線条体および皮質へのウイルス粒子の強化された送達 |
| JP2023018846A Pending JP2023058630A (ja) | 2015-02-10 | 2023-02-10 | 線条体および皮質へのウイルス粒子の強化された送達 |
| JP2024228114A Pending JP2025060823A (ja) | 2015-02-10 | 2024-12-25 | 線条体および皮質へのウイルス粒子の強化された送達 |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US20190111157A1 (https=) |
| EP (3) | EP3256594B1 (https=) |
| JP (4) | JP6928558B2 (https=) |
| KR (2) | KR102625784B1 (https=) |
| CN (2) | CN107530447A (https=) |
| AU (3) | AU2016219398A1 (https=) |
| BR (1) | BR112017017037A2 (https=) |
| CA (1) | CA2976082A1 (https=) |
| CL (1) | CL2017002028A1 (https=) |
| CR (1) | CR20170407A (https=) |
| DK (1) | DK3256594T3 (https=) |
| EA (1) | EA201791803A1 (https=) |
| ES (1) | ES2904504T3 (https=) |
| HU (1) | HUE057272T2 (https=) |
| IL (4) | IL313840A (https=) |
| LT (1) | LT3256594T (https=) |
| MX (2) | MX388264B (https=) |
| NZ (1) | NZ772772A (https=) |
| PH (1) | PH12017501436A1 (https=) |
| PL (1) | PL3256594T3 (https=) |
| PT (1) | PT3256594T (https=) |
| RS (1) | RS62811B1 (https=) |
| SG (3) | SG10201907399RA (https=) |
| SI (1) | SI3256594T1 (https=) |
| TN (1) | TN2017000353A1 (https=) |
| TW (1) | TWI730952B (https=) |
| WO (1) | WO2016130591A2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3151866B1 (en) | 2014-06-09 | 2023-03-08 | Voyager Therapeutics, Inc. | Chimeric capsids |
| RU2716991C2 (ru) | 2014-11-05 | 2020-03-17 | Вояджер Терапьютикс, Инк. | Полинуклеотиды aadc для лечения болезни паркинсона |
| WO2016077687A1 (en) | 2014-11-14 | 2016-05-19 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| KR20230145206A (ko) | 2014-11-14 | 2023-10-17 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| US11697825B2 (en) | 2014-12-12 | 2023-07-11 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scAAV |
| CN107530447A (zh) * | 2015-02-10 | 2018-01-02 | 建新公司 | 病毒颗粒至纹状体和皮质的增强递送 |
| TWI707951B (zh) | 2015-04-08 | 2020-10-21 | 美商健臻公司 | 過大腺相關載體之製造 |
| EP3285788B1 (en) | 2015-04-23 | 2024-12-18 | University of Massachusetts | Modulation of aav vector transgene expression |
| GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
| TW202446416A (zh) | 2015-09-24 | 2024-12-01 | 美商拜奧馬林製藥公司 | 腺相關病毒因子viii載體、相關病毒粒子及包含其之治療調配物 |
| US11299751B2 (en) | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| KR102427379B1 (ko) | 2016-05-18 | 2022-08-02 | 보이저 테라퓨틱스, 인크. | 헌팅톤 질환을 치료하기 위한 조성물 및 방법 |
| KR20240056729A (ko) | 2016-05-18 | 2024-04-30 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| WO2018044933A1 (en) | 2016-08-30 | 2018-03-08 | The Regents Of The University Of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
| US11338046B2 (en) | 2016-09-30 | 2022-05-24 | Esteve Pharmaceuticals, S.A. | Adenoassociated virus vectors for the treatment of mucopolysaccharidoses |
| CN118813559A (zh) * | 2017-03-31 | 2024-10-22 | 北京三诺佳邑生物技术有限责任公司 | shRNA表达框、携带其的多核苷酸序列及其应用 |
| US10898585B2 (en) | 2017-04-14 | 2021-01-26 | Ptc Therapeutics .Inc. | Gene therapy for AADC deficiency |
| JP2020518259A (ja) * | 2017-05-05 | 2020-06-25 | ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ハンチントン病治療組成物および方法 |
| JP2020518258A (ja) | 2017-05-05 | 2020-06-25 | ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 筋萎縮性側索硬化症（ａｌｓ）治療組成物および方法 |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| CA3070087A1 (en) | 2017-07-17 | 2019-01-24 | Voyager Therapeutics, Inc. | Trajectory array guide system |
| EP3808849A1 (en) | 2017-08-03 | 2021-04-21 | Voyager Therapeutics, Inc. | Compositions and methods for delivery of aav |
| AU2018338728B2 (en) | 2017-09-29 | 2025-01-02 | Centre National De La Recherche Scientifique (Cnrs) | Rescue of central and peripheral neurological phenotype of Friedreich's Ataxia by intravenous delivery |
| TW202413649A (zh) | 2017-10-16 | 2024-04-01 | 美商航海家醫療公司 | 肌萎縮性脊髓側索硬化症(als)之治療 |
| EP3697908A1 (en) | 2017-10-16 | 2020-08-26 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
| CN112203697A (zh) | 2018-04-13 | 2021-01-08 | 马萨诸塞大学 | 编码氨基己糖苷酶alpha和beta亚基的双顺反子AAV载体及其用途 |
| KR20210019996A (ko) | 2018-05-15 | 2021-02-23 | 보이저 테라퓨틱스, 인크. | 파킨슨병의 치료를 위한 조성물 및 방법 |
| CN113528510A (zh) * | 2018-06-29 | 2021-10-22 | 武汉纽福斯生物科技有限公司 | 治疗遗传性视神经病变的组合物和方法 |
| EP3856762A1 (en) | 2018-09-28 | 2021-08-04 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
| US12448629B2 (en) | 2018-10-05 | 2025-10-21 | University Of Massachusetts | rAAV vectors for the treatment of GM1 and GM2 gangliosidosis |
| BR112021009370A2 (pt) * | 2018-11-14 | 2021-08-17 | Regenxbio Inc. | método de tratamento da doença de batten cln2, composição farmacêutica e kit |
| BR112021015817A2 (pt) * | 2019-02-22 | 2021-10-13 | The Trustees Of The University Of Pennsylvania | Vírus adeno-associado recombinante para tratamento de neurodegeneração com início na idade adulta associado a grn |
| EP3983077A4 (en) * | 2019-06-17 | 2023-12-20 | Alnylam Pharmaceuticals, Inc. | DELIVERY OF OLIGONUCLEOTIDES TO THE STRIATUM |
| WO2021007382A1 (en) * | 2019-07-09 | 2021-01-14 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of parkinson's disease |
| WO2021016505A1 (en) * | 2019-07-24 | 2021-01-28 | Voyager Therapeutics, Inc. | Compositions and methods for treating huntington's disease |
| US12442017B2 (en) | 2020-03-02 | 2025-10-14 | National University Corporation Gunma University | Microglial selective gene expression vector |
| CA3174928A1 (en) * | 2020-03-11 | 2021-09-16 | Remotor Therapeutics, Inc. | Methods and materials for disseminating a protein throughout the central nervous system |
| AU2021302954A1 (en) * | 2020-06-30 | 2023-02-16 | Seqirus UK Limited | Cold filtration of oil-in-water emulsion adjuvants |
| AU2022212922A1 (en) * | 2021-01-27 | 2023-08-17 | Research Institute At Nationwide Children's Hospital | Materials and methods for the treatment of lysosomal acid lipase deficiency (lal-d) |
| WO2023113806A1 (en) | 2021-12-16 | 2023-06-22 | Affinia Therapeutics, Inc. | Recombinant aav for treatment of neural disease |
| EP4323531A1 (en) | 2021-04-12 | 2024-02-21 | Affinia Therapeutics Inc. | Recombinant aav for treatment of neural disease |
| WO2023108507A1 (en) * | 2021-12-15 | 2023-06-22 | National Institute Of Biological Sciences, Beijing | Recombinant aav vectors and use thereof |
| WO2023109911A1 (en) * | 2021-12-15 | 2023-06-22 | National Institute Of Biological Sciences, Beijing | Microglia having car and use thereof |
| CN119256090A (zh) * | 2022-03-25 | 2025-01-03 | 阿斯克肋匹奥生物制药公司 | 用于治疗帕金森病的方法和组合物 |
| WO2024086747A1 (en) | 2022-10-19 | 2024-04-25 | Affinia Therapeutics Inc. | Recombinant aavs with improved tropism and specificity |
| WO2025151454A1 (en) * | 2024-01-08 | 2025-07-17 | AskBio Inc. | Method or system of infusing and/or predicting an infusate volume |
| WO2025227063A1 (en) | 2024-04-26 | 2025-10-30 | Affinia Therapeutics Inc. | Recombinant aavs with improved tropism and specificity |
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| US4692147A (en) | 1980-04-02 | 1987-09-08 | Medtronic, Inc. | Drug administration device |
| US5735815A (en) | 1993-07-26 | 1998-04-07 | Sentinel Medical, Inc. | Method of using fluid jet surgical cutting tool |
| EP0931158A1 (en) | 1996-09-06 | 1999-07-28 | The Trustees Of The University Of Pennsylvania | An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase |
| US6042579A (en) | 1997-04-30 | 2000-03-28 | Medtronic, Inc. | Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain |
| US6989264B2 (en) | 1997-09-05 | 2006-01-24 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| US6566118B1 (en) | 1997-09-05 | 2003-05-20 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| WO1999061066A2 (en) * | 1998-05-27 | 1999-12-02 | Avigen, Inc. | Convection-enhanced delivery of aav vectors |
| CA2379166C (en) | 1999-08-09 | 2013-03-26 | Targeted Genetics Corporation | Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms instrastrand base pairs |
| ATE318923T1 (de) | 2000-06-01 | 2006-03-15 | Univ North Carolina | Doppelsträngige parvovirus-vektoren |
| EP1402043A1 (en) | 2001-07-03 | 2004-03-31 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods of administering vectors to synaptically connected neurons |
| US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| MX359371B (es) | 2001-11-13 | 2018-09-25 | Univ Pennsylvania | Un metodo para detectar y/o identificar secuencias del virus adeno-asociado y aislamiento de secuencias novedosas identificadas de ese modo. |
| GB2389791B (en) | 2002-04-30 | 2006-12-13 | Steven Gill | Implantable drug delivery pump |
| US7261544B2 (en) | 2003-05-21 | 2007-08-28 | Genzyme Corporation | Methods for producing preparations of recombinant AAV virions substantially free of empty capsids |
| MX2007003850A (es) * | 2004-10-05 | 2007-11-21 | Genzyme Corp | Canula escalonada. |
| WO2006119432A2 (en) | 2005-04-29 | 2006-11-09 | The Government Of The U.S.A., As Rep. By The Sec., Dept. Of Health & Human Services | Isolation, cloning and characterization of new adeno-associated virus (aav) serotypes |
| JP5829372B2 (ja) | 2005-05-02 | 2015-12-09 | ジェンザイム・コーポレーション | 神経代謝性疾患のための遺伝子治療 |
| EP1928557B1 (en) * | 2005-08-23 | 2018-06-06 | The Regents of The University of California | Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery |
| US7588772B2 (en) | 2006-03-30 | 2009-09-15 | Board Of Trustees Of The Leland Stamford Junior University | AAV capsid library and AAV capsid proteins |
| DK2019683T4 (da) | 2006-04-25 | 2022-08-29 | Univ California | Indgivelse af vækstfaktorer til behandling af CNS-lidelser |
| US20070259031A1 (en) | 2006-04-26 | 2007-11-08 | The Regents Of The University Of California | Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics |
| WO2008144585A1 (en) | 2007-05-17 | 2008-11-27 | Medgenesis Therapeutix Inc. | Convection-enhanced delivery catheter with removable stiffening member and method for using same |
| JP2012516357A (ja) | 2009-01-29 | 2012-07-19 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 神経学的障害を治療するための皮質全体に亘る高レベルの治療薬の分布方法 |
| KR20180000341A (ko) | 2009-06-16 | 2018-01-02 | 젠자임 코포레이션 | 재조합 ａａｖ 벡터에 대한 개선된 정제 방법 |
| US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| WO2012109667A1 (en) * | 2011-02-12 | 2012-08-16 | University Of Iowa Research Foundation | Therapeutic compounds |
| TR201908020T4 (tr) | 2011-02-17 | 2019-06-21 | Univ Pennsylvania | Doku özgüllüğünü değiştirmek ve aav9-aracılı gen transferini geliştirmek için bileşimler ve yöntemler. |
| LT3137497T (lt) * | 2014-05-02 | 2021-07-26 | Genzyme Corporation | Aav vektoriai, skirti tinklainės ir cns genų terapijai |
| CN107530447A (zh) * | 2015-02-10 | 2018-01-02 | 建新公司 | 病毒颗粒至纹状体和皮质的增强递送 |
| CN111417231A (zh) | 2019-01-04 | 2020-07-14 | 青岛海尔股份有限公司 | 电磁波发生系统及具有该电磁波发生系统的加热装置 |
-
2016
- 2016-02-09 CN CN201680020700.4A patent/CN107530447A/zh active Pending
- 2016-02-09 AU AU2016219398A patent/AU2016219398A1/en not_active Abandoned
- 2016-02-09 EP EP16714066.4A patent/EP3256594B1/en active Active
- 2016-02-09 IL IL313840A patent/IL313840A/en unknown
- 2016-02-09 SG SG10201907399RA patent/SG10201907399RA/en unknown
- 2016-02-09 CR CR20170407A patent/CR20170407A/es unknown
- 2016-02-09 CN CN202210805297.3A patent/CN116019934A/zh active Pending
- 2016-02-09 ES ES16714066T patent/ES2904504T3/es active Active
- 2016-02-09 MX MX2017010370A patent/MX388264B/es unknown
- 2016-02-09 EP EP23150591.8A patent/EP4219728A3/en active Pending
- 2016-02-09 EA EA201791803A patent/EA201791803A1/ru unknown
- 2016-02-09 IL IL296466A patent/IL296466B2/en unknown
- 2016-02-09 KR KR1020177025285A patent/KR102625784B1/ko active Active
- 2016-02-09 CA CA2976082A patent/CA2976082A1/en active Pending
- 2016-02-09 WO PCT/US2016/017210 patent/WO2016130591A2/en not_active Ceased
- 2016-02-09 LT LTEPPCT/US2016/017210T patent/LT3256594T/lt unknown
- 2016-02-09 JP JP2017560479A patent/JP6928558B2/ja active Active
- 2016-02-09 HU HUE16714066A patent/HUE057272T2/hu unknown
- 2016-02-09 KR KR1020247000976A patent/KR102863734B1/ko active Active
- 2016-02-09 RS RS20220044A patent/RS62811B1/sr unknown
- 2016-02-09 BR BR112017017037A patent/BR112017017037A2/pt not_active Application Discontinuation
- 2016-02-09 DK DK16714066.4T patent/DK3256594T3/da active
- 2016-02-09 SG SG11201706445SA patent/SG11201706445SA/en unknown
- 2016-02-09 PT PT167140664T patent/PT3256594T/pt unknown
- 2016-02-09 SI SI201631446T patent/SI3256594T1/sl unknown
- 2016-02-09 TN TNP/2017/000353A patent/TN2017000353A1/en unknown
- 2016-02-09 NZ NZ772772A patent/NZ772772A/en unknown
- 2016-02-09 EP EP21198081.8A patent/EP4023758A1/en not_active Withdrawn
- 2016-02-09 US US15/549,962 patent/US20190111157A1/en not_active Abandoned
- 2016-02-09 PL PL16714066T patent/PL3256594T3/pl unknown
- 2016-02-10 SG SG10201912926VA patent/SG10201912926VA/en unknown
- 2016-02-15 TW TW105104342A patent/TWI730952B/zh active
-
2017
- 2017-08-08 IL IL253894A patent/IL253894B/en unknown
- 2017-08-08 CL CL2017002028A patent/CL2017002028A1/es unknown
- 2017-08-10 MX MX2021004294A patent/MX2021004294A/es unknown
- 2017-08-10 PH PH12017501436A patent/PH12017501436A1/en unknown
-
2021
- 2021-07-22 IL IL285060A patent/IL285060B2/en unknown
- 2021-08-06 JP JP2021129519A patent/JP2021178861A/ja active Pending
-
2022
- 2022-06-28 AU AU2022204583A patent/AU2022204583A1/en not_active Abandoned
- 2022-07-29 US US17/816,139 patent/US12465657B2/en active Active
-
2023
- 2023-02-10 JP JP2023018846A patent/JP2023058630A/ja active Pending
-
2024
- 2024-12-25 JP JP2024228114A patent/JP2025060823A/ja active Pending
-
2025
- 2025-02-26 AU AU2025201381A patent/AU2025201381A1/en active Pending
- 2025-08-01 US US19/288,561 patent/US20260048149A1/en active Pending
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