HUE057272T2 - Vírusrészecskék fokozott bevitele a csíkolt testbe és az agykéregbe - Google Patents
Vírusrészecskék fokozott bevitele a csíkolt testbe és az agykéregbeInfo
- Publication number
- HUE057272T2 HUE057272T2 HUE16714066A HUE16714066A HUE057272T2 HU E057272 T2 HUE057272 T2 HU E057272T2 HU E16714066 A HUE16714066 A HU E16714066A HU E16714066 A HUE16714066 A HU E16714066A HU E057272 T2 HUE057272 T2 HU E057272T2
- Authority
- HU
- Hungary
- Prior art keywords
- striatum
- cortex
- viral particles
- enhanced delivery
- enhanced
- Prior art date
Links
- 210000001577 neostriatum Anatomy 0.000 title 1
- 239000002245 particle Substances 0.000 title 1
- 230000003612 virological effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
- C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Psychology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562114544P | 2015-02-10 | 2015-02-10 | |
US201562220997P | 2015-09-19 | 2015-09-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE057272T2 true HUE057272T2 (hu) | 2022-04-28 |
Family
ID=56614902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE16714066A HUE057272T2 (hu) | 2015-02-10 | 2016-02-09 | Vírusrészecskék fokozott bevitele a csíkolt testbe és az agykéregbe |
Country Status (27)
Country | Link |
---|---|
US (2) | US20190111157A1 (hu) |
EP (3) | EP4219728A3 (hu) |
JP (3) | JP6928558B2 (hu) |
KR (2) | KR20240010539A (hu) |
CN (2) | CN107530447A (hu) |
AU (2) | AU2016219398A1 (hu) |
BR (1) | BR112017017037A2 (hu) |
CA (1) | CA2976082A1 (hu) |
CL (1) | CL2017002028A1 (hu) |
CR (1) | CR20170407A (hu) |
DK (1) | DK3256594T3 (hu) |
EA (1) | EA201791803A1 (hu) |
ES (1) | ES2904504T3 (hu) |
HK (1) | HK1246340A1 (hu) |
HU (1) | HUE057272T2 (hu) |
IL (3) | IL296466A (hu) |
LT (1) | LT3256594T (hu) |
MX (2) | MX2017010370A (hu) |
PH (1) | PH12017501436A1 (hu) |
PL (1) | PL3256594T3 (hu) |
PT (1) | PT3256594T (hu) |
RS (1) | RS62811B1 (hu) |
SG (3) | SG10201907399RA (hu) |
SI (1) | SI3256594T1 (hu) |
TN (1) | TN2017000353A1 (hu) |
TW (1) | TWI730952B (hu) |
WO (1) | WO2016130591A2 (hu) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015191508A1 (en) | 2014-06-09 | 2015-12-17 | Voyager Therapeutics, Inc. | Chimeric capsids |
RU2020109343A (ru) | 2014-11-05 | 2020-03-17 | Вояджер Терапьютикс, Инк. | Полинуклеотиды aadc для лечения болезни паркинсона |
MX2017006216A (es) | 2014-11-14 | 2018-08-29 | Voyager Therapeutics Inc | Composiciones y métodos para tratar la esclerosis lateral amiotrófica (ela). |
DK3218386T3 (da) | 2014-11-14 | 2021-06-07 | Voyager Therapeutics Inc | Modulatorisk polynukleotid |
EP3230441A4 (en) | 2014-12-12 | 2018-10-03 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scaav |
SG10201907399RA (en) * | 2015-02-10 | 2019-09-27 | Genzyme Corp | Enhanced delivery of viral particles to the striatum and cortex |
TWI707951B (zh) | 2015-04-08 | 2020-10-21 | 美商健臻公司 | 過大腺相關載體之製造 |
CA3019315A1 (en) | 2015-04-23 | 2016-10-27 | University Of Massachusetts | Modulation of aav vector transgene expression |
GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
TWI756185B (zh) | 2015-09-24 | 2022-03-01 | 美商拜奧馬林製藥公司 | 腺相關病毒因子viii載體、相關病毒粒子及包含其之治療調配物 |
US11299751B2 (en) | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
WO2017189959A1 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
IL302748A (en) | 2016-05-18 | 2023-07-01 | Voyager Therapeutics Inc | modulatory polynucleotides |
CN109831916B (zh) | 2016-05-18 | 2023-07-21 | 沃雅戈治疗公司 | 治疗亨廷顿氏舞蹈病的组合物和方法 |
EP3831281A1 (en) | 2016-08-30 | 2021-06-09 | The Regents of The University of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
JP7059285B2 (ja) * | 2016-09-30 | 2022-04-25 | エステベ プアルマセウティカルス, エッセ.ア. | ムコ多糖症の治療のためのアデノ随伴ウイルスベクター |
SG11201909136PA (en) * | 2017-03-31 | 2019-10-30 | Staidson Beijing Biopharmaceuticals Co Ltd | Shrna expression cassette, polynucleotide sequence carrying the same, and use thereof |
WO2018191450A2 (en) | 2017-04-14 | 2018-10-18 | National Taiwan University Hospital | Gene therapy for aadc deficiency |
US11752181B2 (en) | 2017-05-05 | 2023-09-12 | Voyager Therapeutics, Inc. | Compositions and methods of treating Huntington's disease |
CN110913866A (zh) | 2017-05-05 | 2020-03-24 | 沃雅戈治疗公司 | 治疗肌萎缩性侧索硬化(als)的组合物和方法 |
JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
WO2019018342A1 (en) | 2017-07-17 | 2019-01-24 | Voyager Therapeutics, Inc. | NETWORK EQUIPMENT TRACK GUIDE SYSTEM |
EP3662060A2 (en) | 2017-08-03 | 2020-06-10 | Voyager Therapeutics, Inc. | Compositions and methods for delivery of aav |
JP7502991B2 (ja) | 2017-10-16 | 2024-06-19 | ボイジャー セラピューティクス インコーポレイテッド | 筋萎縮性側索硬化症(als)の治療 |
US20200237799A1 (en) | 2017-10-16 | 2020-07-30 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
CN110876269B (zh) * | 2018-06-29 | 2021-07-30 | 武汉纽福斯生物科技有限公司 | 治疗遗传性视神经病变的组合物和方法 |
SG11202104295UA (en) * | 2018-11-14 | 2021-06-29 | Regenxbio Inc | Gene therapy for neuronal ceroid lipofuscinoses |
CN113710281A (zh) * | 2019-02-22 | 2021-11-26 | 宾夕法尼亚州大学信托人 | 用于治疗grn相关成人发作性神经退行性病变的重组腺相关病毒 |
EP3983077A4 (en) * | 2019-06-17 | 2023-12-20 | Alnylam Pharmaceuticals, Inc. | DELIVERY OF OLIGONUCLEOTIDES TO THE STRIATUM |
WO2021007382A1 (en) * | 2019-07-09 | 2021-01-14 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of parkinson's disease |
US20220275367A1 (en) * | 2019-07-24 | 2022-09-01 | Voyager Therapeutics, Inc. | Compositions and methods for treating huntington's disease |
US20230399655A1 (en) * | 2020-03-02 | 2023-12-14 | National University Corporation Gunma University | Microglial selective gene expression vector |
EP4093859A4 (en) * | 2020-03-11 | 2023-06-14 | Remotor Therapeutics, Inc. | METHODS AND MATERIALS FOR DISSEMINATING PROTEIN THROUGH THE CENTRAL NERVOUS SYSTEM |
CA3209471A1 (en) * | 2021-01-27 | 2022-08-04 | Research Institute At Nationwide Children's Hospital | Materials and methods for the treatment of lysosomal acid lipase deficiency (lal-d) |
WO2022221193A1 (en) | 2021-04-12 | 2022-10-20 | Affinia Therapeutics Inc. | Recombinant aav for treatment of neural disease |
WO2023113806A1 (en) | 2021-12-16 | 2023-06-22 | Affinia Therapeutics, Inc. | Recombinant aav for treatment of neural disease |
WO2023109911A1 (en) * | 2021-12-15 | 2023-06-22 | National Institute Of Biological Sciences, Beijing | Microglia having car and use thereof |
WO2023108507A1 (en) * | 2021-12-15 | 2023-06-22 | National Institute Of Biological Sciences, Beijing | Recombinant aav vectors and use thereof |
WO2024086747A1 (en) | 2022-10-19 | 2024-04-25 | Affinia Therapeutics Inc. | Recombinant aavs with improved tropism and specificity |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4692147A (en) | 1980-04-02 | 1987-09-08 | Medtronic, Inc. | Drug administration device |
US5735815A (en) | 1993-07-26 | 1998-04-07 | Sentinel Medical, Inc. | Method of using fluid jet surgical cutting tool |
JP2001500015A (ja) | 1996-09-06 | 2001-01-09 | トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | T7ポリメラーゼを利用する組換えアデノ随伴ウイルスの誘導可能な製造方法 |
US6042579A (en) | 1997-04-30 | 2000-03-28 | Medtronic, Inc. | Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain |
US6566118B1 (en) | 1997-09-05 | 2003-05-20 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
US6995006B2 (en) | 1997-09-05 | 2006-02-07 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
PT1080202E (pt) | 1998-05-27 | 2006-05-31 | Avigen Inc | Distribuicao de vectores aav codificando aadc intensificada por conveccao |
ES2308989T3 (es) | 1999-08-09 | 2008-12-16 | Targeted Genetics Corporation | Aumento de la expresion de una secuencia nucleotidica heterologa a partir de vectores viricos recombinantes que contienen una secuencia que forman pares de bases intracatenarios. |
CA2410828C (en) | 2000-06-01 | 2012-01-24 | University Of North Carolina At Chapel Hill | Duplexed parvovirus vectors |
US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
ATE520707T1 (de) | 2001-11-13 | 2011-09-15 | Univ Pennsylvania | Verfahren für den nachweis und/oder die identifikation von sequenzen des adeno- assoziierten virus (aav) sowie isolation von dadurch identifizierten, neuen sequenzen |
GB2389791B (en) | 2002-04-30 | 2006-12-13 | Steven Gill | Implantable drug delivery pump |
SI2277996T1 (sl) | 2003-05-21 | 2014-12-31 | Genzyme Corporation | Postopki za izdelavo pripravkov rekombinantnih AAV virionov v bistvu brez praznih kapsid |
JP4838255B2 (ja) | 2004-10-05 | 2011-12-14 | ジェンザイム・コーポレーション | 階段状カニューレ |
WO2006119432A2 (en) | 2005-04-29 | 2006-11-09 | The Government Of The U.S.A., As Rep. By The Sec., Dept. Of Health & Human Services | Isolation, cloning and characterization of new adeno-associated virus (aav) serotypes |
CN104306986A (zh) * | 2005-05-02 | 2015-01-28 | 建新公司 | 神经代谢疾病的基因治疗 |
CA2619882C (en) | 2005-08-23 | 2015-05-26 | The Regents Of The University Of California | Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery |
WO2007120542A2 (en) | 2006-03-30 | 2007-10-25 | The Board Of Trustees Of The Leland Stanford Junior University | Aav capsid library and aav capsid proteins |
BRPI0710800A2 (pt) | 2006-04-25 | 2012-01-17 | Univ California | administração de fatores de crescimento para o tratamento de distúrbios de snc |
JP2009535360A (ja) | 2006-04-26 | 2009-10-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 高分子量神経治療薬の対流増加送達のための組成物および方法 |
US11305022B2 (en) | 2009-01-29 | 2022-04-19 | The Regents Of The University Of California | Methods for distributing high levels of therapeutic agent throughout the cortex to treat neurological disorders |
BRPI1015176B1 (pt) | 2009-06-16 | 2019-10-29 | Genzyme Corp | método para isolar uma população de partículas de vírus adenoassociado recombinante (raav) de impurezas de processo em uma corrente de alimentação |
US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
ES2739804T3 (es) * | 2011-02-12 | 2020-02-04 | Univ Iowa Res Found | Compuestos terapéuticos |
PL2675902T3 (pl) | 2011-02-17 | 2019-08-30 | The Trustees Of The University Of Pennsylvania | Kompozycje i sposoby do zmieniania specyficzności względem tkanki i poprawy transferu genu z udziałem aav9 |
MX2016014220A (es) * | 2014-05-02 | 2017-02-06 | Genzyme Corp | Vectores de aav para la terapia genica de la retina y el snc. |
SG10201907399RA (en) * | 2015-02-10 | 2019-09-27 | Genzyme Corp | Enhanced delivery of viral particles to the striatum and cortex |
-
2016
- 2016-02-09 SG SG10201907399RA patent/SG10201907399RA/en unknown
- 2016-02-09 SG SG11201706445SA patent/SG11201706445SA/en unknown
- 2016-02-09 LT LTEPPCT/US2016/017210T patent/LT3256594T/lt unknown
- 2016-02-09 HU HUE16714066A patent/HUE057272T2/hu unknown
- 2016-02-09 RS RS20220044A patent/RS62811B1/sr unknown
- 2016-02-09 PL PL16714066T patent/PL3256594T3/pl unknown
- 2016-02-09 ES ES16714066T patent/ES2904504T3/es active Active
- 2016-02-09 US US15/549,962 patent/US20190111157A1/en not_active Abandoned
- 2016-02-09 PT PT167140664T patent/PT3256594T/pt unknown
- 2016-02-09 CN CN201680020700.4A patent/CN107530447A/zh active Pending
- 2016-02-09 BR BR112017017037A patent/BR112017017037A2/pt active Search and Examination
- 2016-02-09 DK DK16714066.4T patent/DK3256594T3/da active
- 2016-02-09 MX MX2017010370A patent/MX2017010370A/es unknown
- 2016-02-09 CR CR20170407A patent/CR20170407A/es unknown
- 2016-02-09 KR KR1020247000976A patent/KR20240010539A/ko active Application Filing
- 2016-02-09 CN CN202210805297.3A patent/CN116019934A/zh active Pending
- 2016-02-09 SI SI201631446T patent/SI3256594T1/sl unknown
- 2016-02-09 EP EP23150591.8A patent/EP4219728A3/en active Pending
- 2016-02-09 EP EP21198081.8A patent/EP4023758A1/en not_active Withdrawn
- 2016-02-09 AU AU2016219398A patent/AU2016219398A1/en not_active Abandoned
- 2016-02-09 IL IL296466A patent/IL296466A/en unknown
- 2016-02-09 EP EP16714066.4A patent/EP3256594B1/en active Active
- 2016-02-09 EA EA201791803A patent/EA201791803A1/ru unknown
- 2016-02-09 WO PCT/US2016/017210 patent/WO2016130591A2/en active Application Filing
- 2016-02-09 JP JP2017560479A patent/JP6928558B2/ja active Active
- 2016-02-09 CA CA2976082A patent/CA2976082A1/en active Pending
- 2016-02-09 KR KR1020177025285A patent/KR102625784B1/ko active IP Right Grant
- 2016-02-09 TN TNP/2017/000353A patent/TN2017000353A1/en unknown
- 2016-02-10 SG SG10201912926VA patent/SG10201912926VA/en unknown
- 2016-02-15 TW TW105104342A patent/TWI730952B/zh active
-
2017
- 2017-08-08 IL IL253894A patent/IL253894B/en unknown
- 2017-08-08 CL CL2017002028A patent/CL2017002028A1/es unknown
- 2017-08-10 PH PH12017501436A patent/PH12017501436A1/en unknown
- 2017-08-10 MX MX2021004294A patent/MX2021004294A/es unknown
-
2018
- 2018-04-25 HK HK18105355.8A patent/HK1246340A1/zh unknown
-
2021
- 2021-07-22 IL IL285060A patent/IL285060B2/en unknown
- 2021-08-06 JP JP2021129519A patent/JP2021178861A/ja active Pending
-
2022
- 2022-06-28 AU AU2022204583A patent/AU2022204583A1/en active Pending
- 2022-07-29 US US17/816,139 patent/US20220395586A1/en active Pending
-
2023
- 2023-02-10 JP JP2023018846A patent/JP2023058630A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL285060A (en) | Increased transmission of viral particles to the striatum and cortex | |
IL258723A (en) | A particle and a system for creating a spray containing such particles | |
HK1253018A1 (zh) | 紫杉烷顆粒及其用途 | |
IL266679A (en) | administration of neoantigens in the virus | |
SG11201703083QA (en) | Modified virus-like particles of cmv | |
IL259894A (en) | Improved compositions and improved methods for viral delivery of neoepitopes and their use | |
ZA201704662B (en) | Friable ceramic-bonded diamond composite particles and methods to produce same | |
IL260022A (en) | Preparation of respirable zafirlukast particles | |
ZA201605492B (en) | Pharmaceutical compositions comprising 15-hepe and methods of treating asthma and lung disorders using same | |
HK1256875A1 (zh) | 加强對大腦的藥物輸送 | |
GB201517478D0 (en) | Particle surface treatment | |
GB201522512D0 (en) | Flourescent diamond particles and methods of fabricating the same | |
PL3233233T3 (pl) | Kompozycje odpieniające zawierające cząstki amfifilowe i sposoby ich stosowania | |
SG11201704486TA (en) | Improvements in and relating to the treatment of matrices and/or the contents of matrices | |
HK1248652A1 (zh) | 由漿滴製造支撐劑顆粒的方法及支撐劑顆粒的使用方法 | |
ZA201801211B (en) | Cleaning particles and their use | |
HK1254366A1 (zh) | 由漿滴形成的支撐劑顆粒及其使用方法 | |
GB201421261D0 (en) | Improvements in and relating to the processing of matrices and/or the contents of matrices | |
HUE061732T2 (hu) | Eljárás részecskék elõállítására | |
GB201402556D0 (en) | Improvements relating to inhalable particles | |
GB2545716B (en) | Improvements in or relating to the separation of radon | |
GB201517790D0 (en) | Preparation of inhalable particles | |
EP3359618A4 (en) | SANDING COMPOSITIONS AND METHOD FOR USE THEREOF FOR DUST CONTROL | |
GB201517030D0 (en) | Preparation of articles comprising graphitic particles | |
GB201520019D0 (en) | The genome and self-evolution of AI |