JP2018503603A5 - - Google Patents
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- JP2018503603A5 JP2018503603A5 JP2017528894A JP2017528894A JP2018503603A5 JP 2018503603 A5 JP2018503603 A5 JP 2018503603A5 JP 2017528894 A JP2017528894 A JP 2017528894A JP 2017528894 A JP2017528894 A JP 2017528894A JP 2018503603 A5 JP2018503603 A5 JP 2018503603A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- cdr
- antibody
- complex compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 27
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 230000003115 biocidal effect Effects 0.000 claims 15
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000004452 carbocyclyl group Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 125000005647 linker group Chemical group 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 125000003003 spiro group Chemical group 0.000 claims 4
- 239000003242 anti bacterial agent Substances 0.000 claims 3
- 229940088710 antibiotic agent Drugs 0.000 claims 3
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 229930189077 Rifamycin Natural products 0.000 claims 2
- 241000191967 Staphylococcus aureus Species 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000000816 peptidomimetic Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229960003292 rifamycin Drugs 0.000 claims 2
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical compound OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- JUIKUQOUMZUFQT-UHFFFAOYSA-N 2-bromoacetamide Chemical compound NC(=O)CBr JUIKUQOUMZUFQT-UHFFFAOYSA-N 0.000 claims 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims 1
- HAXFWIACAGNFHA-UHFFFAOYSA-N aldrithiol Chemical compound C=1C=CC=NC=1SSC1=CC=CC=N1 HAXFWIACAGNFHA-UHFFFAOYSA-N 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 150000001412 amines Chemical group 0.000 claims 1
- FNXLCIKXHOPCKH-UHFFFAOYSA-N bromamine Chemical compound BrN FNXLCIKXHOPCKH-UHFFFAOYSA-N 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229960002626 clarithromycin Drugs 0.000 claims 1
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- -1 glidant Substances 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- SGHWBDUXKUSFOP-KYALZUAASA-N rifalazil Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)N=C2C(=O)C=3C(O)=C4C)C)OC)C4=C1C=3C(NC1=C(O)C=3)=C2OC1=CC=3N1CCN(CC(C)C)CC1 SGHWBDUXKUSFOP-KYALZUAASA-N 0.000 claims 1
- 229950005007 rifalazil Drugs 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462087184P | 2014-12-03 | 2014-12-03 | |
| US62/087,184 | 2014-12-03 | ||
| PCT/US2015/063510 WO2016090038A1 (en) | 2014-12-03 | 2015-12-02 | Anti-staphylococcus aureus antibody rifamycin conjugates and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018503603A JP2018503603A (ja) | 2018-02-08 |
| JP2018503603A5 true JP2018503603A5 (enExample) | 2019-01-17 |
| JP6742314B2 JP6742314B2 (ja) | 2020-08-19 |
Family
ID=55070136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528894A Expired - Fee Related JP6742314B2 (ja) | 2014-12-03 | 2015-12-02 | 抗黄色ブドウ球菌抗体リファマイシン複合体及びその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20180021450A1 (enExample) |
| EP (1) | EP3226911A1 (enExample) |
| JP (1) | JP6742314B2 (enExample) |
| KR (1) | KR20170086536A (enExample) |
| CN (1) | CN107206102A (enExample) |
| BR (1) | BR112017011325A2 (enExample) |
| CA (1) | CA2965540A1 (enExample) |
| HK (1) | HK1243931A1 (enExample) |
| MX (1) | MX2017007055A (enExample) |
| RU (1) | RU2731055C2 (enExample) |
| WO (1) | WO2016090038A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014364927A1 (en) | 2013-12-16 | 2016-07-07 | Genentech, Inc. | Peptidomimetic compounds and antibody-drug conjugates thereof |
| US10533058B2 (en) | 2013-12-16 | 2020-01-14 | Genentech Inc. | Peptidomimetic compounds and antibody-drug conjugates thereof |
| CN108064246A (zh) | 2015-06-15 | 2018-05-22 | 基因泰克公司 | 抗体和免疫结合物 |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| SG11201804268RA (en) | 2015-12-04 | 2018-06-28 | Seattle Genetics Inc | Conjugates of quaternized tubulysin compounds |
| WO2017152083A1 (en) * | 2016-03-04 | 2017-09-08 | Genentech, Inc. | Process for the preparation of an antibody-rifamycin conjugate |
| AU2017359043B2 (en) | 2016-11-08 | 2022-06-16 | Regeneron Pharmaceuticals, Inc. | Steroids and protein-conjugates thereof |
| KR20200007905A (ko) | 2017-05-18 | 2020-01-22 | 리제너론 파마슈티칼스 인코포레이티드 | 사이클로덱스트린 단백질 약물 접합체 |
| CA3080857A1 (en) | 2017-11-07 | 2019-05-16 | Regeneron Pharmaceuticals, Inc. | Hydrophilic linkers for antibody drug conjugates |
| EA202091672A1 (ru) | 2018-01-08 | 2021-02-01 | Регенерон Фармасьютикалз, Инк. | Стероиды и их антитело-конъюгаты |
| US11325920B2 (en) | 2018-01-24 | 2022-05-10 | The Rockefeller University | Antibacterial compounds, compositions thereof, and methods using same |
| WO2019217591A1 (en) | 2018-05-09 | 2019-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-msr1 antibodies and methods of use thereof |
| CN113226470B (zh) | 2018-12-21 | 2025-05-06 | 瑞泽恩制药公司 | 利福霉素类似物及其抗体-药物缀合物 |
| CN110174363A (zh) * | 2019-01-09 | 2019-08-27 | 北京九强生物技术股份有限公司 | 6-磷酸葡萄糖脱氢酶突变体及其在制备检测试剂中的用途 |
| EP4003200A4 (en) | 2019-07-23 | 2023-08-02 | The Rockefeller University | ANTIBACTERIAL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF USE THEREOF |
| WO2021242849A1 (en) * | 2020-05-28 | 2021-12-02 | The Rockefeller University | Antibacterial compounds, compositions thereof, and methods using same |
| EP4349373A1 (en) | 2021-06-01 | 2024-04-10 | Ajinomoto Co., Inc. | Conjugate of antibody and functional substance or salt of said conjugate, and compound for use in production of said conjugate or salt of said compound |
| CN117659042B (zh) * | 2023-12-05 | 2024-12-27 | 北京大学第三医院（北京大学第三临床医学院） | 利福霉素衍生物及其制备方法和用途 |
| CN118598380B (zh) * | 2024-08-08 | 2024-10-22 | 生态环境部南京环境科学研究所 | 一种长效修复石油化工企业地下水石油烃污染的方法 |
| CN119701000A (zh) * | 2024-12-25 | 2025-03-28 | 中国人民解放军空军军医大学 | 一类多肽偶联药物及其制备方法和应用 |
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-
2015
- 2015-12-02 WO PCT/US2015/063510 patent/WO2016090038A1/en not_active Ceased
- 2015-12-02 EP EP15820347.1A patent/EP3226911A1/en not_active Withdrawn
- 2015-12-02 JP JP2017528894A patent/JP6742314B2/ja not_active Expired - Fee Related
- 2015-12-02 CA CA2965540A patent/CA2965540A1/en not_active Abandoned
- 2015-12-02 MX MX2017007055A patent/MX2017007055A/es unknown
- 2015-12-02 RU RU2017118793A patent/RU2731055C2/ru active
- 2015-12-02 HK HK18103430.2A patent/HK1243931A1/zh unknown
- 2015-12-02 KR KR1020177014576A patent/KR20170086536A/ko not_active Withdrawn
- 2015-12-02 BR BR112017011325-2A patent/BR112017011325A2/pt not_active Application Discontinuation
- 2015-12-02 CN CN201580075298.5A patent/CN107206102A/zh active Pending
-
2017
- 2017-06-02 US US15/611,985 patent/US20180021450A1/en not_active Abandoned
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