JP2018501211A5 - - Google Patents

Download PDF

Info

Publication number
JP2018501211A5
JP2018501211A5 JP2017528442A JP2017528442A JP2018501211A5 JP 2018501211 A5 JP2018501211 A5 JP 2018501211A5 JP 2017528442 A JP2017528442 A JP 2017528442A JP 2017528442 A JP2017528442 A JP 2017528442A JP 2018501211 A5 JP2018501211 A5 JP 2018501211A5
Authority
JP
Japan
Prior art keywords
seq
her2
tumor
pharmaceutical composition
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017528442A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018501211A (ja
JP6872482B2 (ja
Filing date
Publication date
Priority claimed from PCT/CA2014/051140 external-priority patent/WO2015077891A1/en
Application filed filed Critical
Priority claimed from PCT/CA2015/051238 external-priority patent/WO2016082044A1/en
Publication of JP2018501211A publication Critical patent/JP2018501211A/ja
Publication of JP2018501211A5 publication Critical patent/JP2018501211A5/ja
Application granted granted Critical
Publication of JP6872482B2 publication Critical patent/JP6872482B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017528442A 2014-11-27 2015-11-26 Her2を標的とする二重特異性抗原結合性構築物の使用方法 Active JP6872482B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/CA2014/051140 WO2015077891A1 (en) 2013-11-27 2014-11-27 Bispecific antigen-binding constructs targeting her2
CAPCT/CA2014/051140 2014-11-27
US201562166844P 2015-05-27 2015-05-27
US62/166,844 2015-05-27
PCT/CA2015/051238 WO2016082044A1 (en) 2014-11-27 2015-11-26 Methods of using bispecific antigen-binding constructs targeting her2

Publications (3)

Publication Number Publication Date
JP2018501211A JP2018501211A (ja) 2018-01-18
JP2018501211A5 true JP2018501211A5 (https=) 2019-01-17
JP6872482B2 JP6872482B2 (ja) 2021-05-19

Family

ID=56073259

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017528442A Active JP6872482B2 (ja) 2014-11-27 2015-11-26 Her2を標的とする二重特異性抗原結合性構築物の使用方法

Country Status (9)

Country Link
US (3) US20170355779A1 (https=)
EP (2) EP3223848B1 (https=)
JP (1) JP6872482B2 (https=)
AU (1) AU2015354360B2 (https=)
CA (1) CA2968258A1 (https=)
DK (1) DK3223848T3 (https=)
ES (1) ES3014819T3 (https=)
FI (1) FI3223848T3 (https=)
WO (1) WO2016082044A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20250551T1 (hr) 2013-11-27 2025-06-20 Zymeworks Bc Inc. Bispecifični antigen-vezujući konstrukti koji ciljaju her2
EP3223848B1 (en) 2014-11-27 2024-11-27 Zymeworks BC Inc. Methods of using bispecific antigen-binding constructs targeting her2
US11028182B2 (en) 2015-05-13 2021-06-08 Zymeworks Inc. Antigen-binding constructs targeting HER2
JP7556687B2 (ja) 2017-02-24 2024-09-26 中外製薬株式会社 薬学的組成物、抗原結合分子、治療方法、およびスクリーニング方法
JP6988158B2 (ja) * 2017-05-11 2022-01-05 株式会社島津製作所 液体クロマトグラフ質量分析方法及び液体クロマトグラフ質量分析装置
ES2958933T3 (es) 2018-03-13 2024-02-16 Zymeworks Bc Inc Conjugados de anticuerpo biparatópico anti-HER2-fármaco y métodos de uso
US20210188957A1 (en) * 2018-08-29 2021-06-24 Chugai Seiyaku Kabushiki Kaisha Antibody half-molecule, and method for inhibiting homodimer formation of antibody half-molecule
EP3988574A4 (en) * 2019-02-03 2022-10-12 Shanghai Bao Pharmaceuticals Co., Ltd. AGAINST HER2 BI-SPECIFIC ANTIBODIES AND THEIR USE
CN113646622B (zh) 2019-03-29 2024-11-12 豪夫迈·罗氏有限公司 用于多价分子的功能分析的基于spr的结合测定
BR112021023988A2 (pt) * 2019-05-31 2022-04-19 Zymeworks Inc Métodos de uso de um construto de ligação ao antígeno biespecífico que tem como alvo her2 para o tratamento de cânceres no trato biliar
US12535490B2 (en) 2019-07-22 2026-01-27 Regeneron Pharmaceuticals, Inc. Affinity chromatography-coupled native mass spectrometry for antibody analysis
EP4058150A2 (en) * 2019-11-15 2022-09-21 Genzyme Corporation Biparatopic cd73 antibodies
WO2023039672A1 (en) * 2021-09-15 2023-03-23 Zymeworks Bc Inc. Methods of treating cancer with anti-her2 biparatopic antibodies

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
WO1993006217A1 (en) 1991-09-19 1993-04-01 Genentech, Inc. EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES
FI941572L (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
AU675929B2 (en) 1992-02-06 1997-02-27 Curis, Inc. Biosynthetic binding protein for cancer marker
WO1993021319A1 (en) 1992-04-08 1993-10-28 Cetus Oncology Corporation HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US7951917B1 (en) 1997-05-02 2011-05-31 Genentech, Inc. Method for making multispecific antibodies having heteromultimeric and common components
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
CA2376596C (en) 1999-06-25 2009-10-06 Genentech, Inc. Humanized anti-erbb2 antibodies and treatment with anti-erbb2 antibodies
US20030086924A1 (en) 1999-06-25 2003-05-08 Genentech, Inc. Treatment with anti-ErbB2 antibodies
TR200200472T2 (tr) 1999-08-27 2002-06-21 Genentech, Inc. Anti-Erb B2 antikorları ile tedavi için dozajlar
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
CN100427603C (zh) 1999-10-04 2008-10-22 麦迪卡格公司 调控外源基因转录的方法
FR2807767B1 (fr) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
AU2002241922B2 (en) 2001-01-17 2007-10-25 Aptevo Research And Development Llc Binding domain-immunoglobulin fusion proteins
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US7256257B2 (en) 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
ES2533963T3 (es) 2002-10-10 2015-04-16 Merck Patent Gmbh Composiciones farmacéuticas dirigidas a receptores Erb-B1
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
US8399618B2 (en) 2004-10-21 2013-03-19 Xencor, Inc. Immunoglobulin insertions, deletions, and substitutions
US7498298B2 (en) 2003-11-06 2009-03-03 Seattle Genetics, Inc. Monomethylvaline compounds capable of conjugation to ligands
KR20120064120A (ko) 2004-06-01 2012-06-18 제넨테크, 인크. 항체 약물 접합체 및 방법
KR20140032004A (ko) 2004-07-22 2014-03-13 제넨테크, 인크. Her2 항체 조성물
CA2592177A1 (en) * 2005-01-21 2006-07-27 Genentech, Inc. Fixed dosing of her antibodies
CA2602663A1 (en) 2005-03-31 2006-10-05 Xencor, Inc. Fc variants with optimized properties
US7498142B2 (en) 2006-01-31 2009-03-03 Yeda Research And Development Co., Ltd. Methods of identifying combinations of antibodies with an improved anti-tumor activity and compositions and methods using the antibodies
WO2008031531A1 (en) * 2006-09-15 2008-03-20 F. Hoffmann-La Roche Ag Tumor therapy with a combination of anti-her2 antibodies
EP2220120A2 (en) 2007-11-27 2010-08-25 Ablynx N.V. Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
CA2711256C (en) 2008-01-03 2019-01-15 The Scripps Research Institute Antibody targeting through a modular recognition domain
ES2563027T3 (es) 2008-01-07 2016-03-10 Amgen Inc. Método para fabricación de moléculas heterodímeras Fc de anticuerpos utilizando efectos de conducción electrostática
BRPI0910482A2 (pt) 2008-04-29 2019-09-24 Abbott Lab imunoglobinas de domínio variável duplo e usos das mesmas
BRPI0812682A2 (pt) 2008-06-16 2010-06-22 Genentech Inc tratamento de cáncer de mama metastático
BRPI1010620B8 (pt) 2009-06-03 2021-05-25 Immunogen Inc métodos de conjugação
ES2688978T3 (es) 2009-11-23 2018-11-07 Amgen Inc. Anticuerpo monomérico Fc
ES2751549T3 (es) 2009-11-30 2020-04-01 Janssen Biotech Inc Mutantes de anticuerpos Fc con funciones efectoras ablacionadas
US8609095B2 (en) 2010-03-04 2013-12-17 Symphogen A/S Anti-HER2 antibodies and compositions
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
BR112012024489A2 (pt) 2010-03-29 2016-05-31 Zymeworks Inc anticorpos com função efetora suprimida ou aumentada
WO2011135040A1 (en) 2010-04-30 2011-11-03 F. Hoffmann-La Roche Ag Fluorescent antibody fusion protein, its production and use
CN114805583A (zh) 2010-05-27 2022-07-29 根马布股份公司 针对her2的单克隆抗体
JP6082344B2 (ja) 2010-05-27 2017-02-15 ゲンマブ エー/エス Her2エピトープに対するモノクローナル抗体
PL2635607T3 (pl) 2010-11-05 2020-05-18 Zymeworks Inc. Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC
US20130245233A1 (en) 2010-11-24 2013-09-19 Ming Lei Multispecific Molecules
US9683052B2 (en) * 2011-03-25 2017-06-20 Glenmark Pharmaceuticals S.A. Hetero-dimeric immunoglobulins
SG10201602394QA (en) 2011-03-29 2016-05-30 Roche Glycart Ag Antibody FC Variants
US20130216523A1 (en) 2011-03-31 2013-08-22 Laboratory Corporation Of America Holdings Methods for Facilitating Diagnosis, Prognosis and Treatment of Cancer by Detecting HER1 Expression
JP6177231B2 (ja) * 2011-04-20 2017-08-09 ゲンマブ エー/エス Her2に対する二重特異性抗体
CN107266577B (zh) * 2011-10-11 2022-09-13 弗·哈夫曼-拉罗切有限公司 双特异性抗体的改进的组装
CA2854233C (en) * 2011-11-04 2020-05-12 Zymeworks Inc. Stable heterodimeric antibody design with mutations in the fc domain
NZ629283A (en) 2012-03-16 2016-04-29 Covagen Ag Novel binding molecules with antitumoral activity
US20150125449A1 (en) 2012-05-10 2015-05-07 Zymeworks Inc. Single-Arm Monovalent Antibody Constructs and Uses Thereof
WO2013166594A1 (en) 2012-05-10 2013-11-14 Zymeworks Inc. Heteromultimer constructs of immunoglobulin heavy chains with mutations in the fc domain
WO2014004586A1 (en) 2012-06-25 2014-01-03 Zymeworks Inc. Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
CA2883264A1 (en) 2012-10-15 2014-04-24 Universitat Zurich Prorektorat Mnw Bispecific her2 ligands for cancer therapy
EP2738180A1 (en) 2012-11-30 2014-06-04 Molecular Partners AG Binding proteins comprising at least two binding domains against HER2.
US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
WO2014182970A1 (en) 2013-05-08 2014-11-13 Zymeworks Inc. Bispecific her2 and her3 antigen binding constructs
WO2014190441A1 (en) 2013-05-31 2014-12-04 Zymeworks Inc. Heteromultimers with reduced or silenced effector function
HRP20250551T1 (hr) * 2013-11-27 2025-06-20 Zymeworks Bc Inc. Bispecifični antigen-vezujući konstrukti koji ciljaju her2
EP3327038B1 (en) 2013-12-20 2020-09-23 F. Hoffmann-La Roche AG Bispecific her2 antibodies and methods of use
EP3223848B1 (en) 2014-11-27 2024-11-27 Zymeworks BC Inc. Methods of using bispecific antigen-binding constructs targeting her2
US11028182B2 (en) 2015-05-13 2021-06-08 Zymeworks Inc. Antigen-binding constructs targeting HER2
ES2958933T3 (es) * 2018-03-13 2024-02-16 Zymeworks Bc Inc Conjugados de anticuerpo biparatópico anti-HER2-fármaco y métodos de uso

Similar Documents

Publication Publication Date Title
JP2018501211A5 (https=)
JP7118117B2 (ja) 抗体-薬物コンジュゲートの選択的製造方法
JP2017503480A5 (https=)
RU2016125551A (ru) Биспецифические антигенсвязывающие конструкции против her2
JP2021531764A5 (https=)
JP2016520586A5 (https=)
TWI417106B (zh) 巨噬細胞-刺激蛋白質受體(ron)之抑制及其治療方法
JP2020501531A5 (https=)
JP2019523630A5 (https=)
JP2019524693A5 (https=)
RU2018139339A (ru) Новые биспецифические полипептиды против cd137
WO2006020258A2 (en) Novel tetravalent bispecific antibody
JP2017506067A5 (https=)
JPWO2020135201A5 (https=)
JP2012501626A5 (https=)
JP2018531994A5 (https=)
CN110997000A (zh) 用于治疗ErbB-2/ErbB-3阳性肿瘤的抗体
JP2023531042A (ja) 4-1bb結合タンパク質及びその用途
CA3202374A1 (en) Combination therapy for the treatment of cancer
JP2025172885A (ja) 腫瘍治療のための二重特異性融合タンパク質
JP2021500320A (ja) 癌の治療のための配合剤
TW202207993A (zh) 位點特異性her2抗體-藥物共軛物之治療
CN103417965B (zh) 一种含有抗vegf抗体的药物组合物
KR20250167678A (ko) 이중특이적 항체 및 이의 응용
JP6887944B2 (ja) 抗fgfr2抗体と他剤を含む組成物