JP2018188483A5 - - Google Patents
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- JP2018188483A5 JP2018188483A5 JP2018168811A JP2018168811A JP2018188483A5 JP 2018188483 A5 JP2018188483 A5 JP 2018188483A5 JP 2018168811 A JP2018168811 A JP 2018168811A JP 2018168811 A JP2018168811 A JP 2018168811A JP 2018188483 A5 JP2018188483 A5 JP 2018188483A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims 27
- 239000000203 mixture Substances 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 11
- 229940124597 therapeutic agent Drugs 0.000 claims 10
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000003386 piperidinyl group Chemical group 0.000 claims 6
- 229960004556 tenofovir Drugs 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 208000031886 HIV Infections Diseases 0.000 claims 4
- 208000037357 HIV infectious disease Diseases 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 4
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 239000002777 nucleoside Substances 0.000 claims 4
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 4
- 125000003003 spiro group Chemical group 0.000 claims 4
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 4
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000000160 oxazolidinyl group Chemical group 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
- -1 tetrahydro-1,3-oxazinyl Chemical group 0.000 claims 3
- 125000001984 thiazolidinyl group Chemical group 0.000 claims 3
- XQSPYNMVSIKCOC-NTSWFWBYSA-N Emtricitabine Chemical compound C1=C(F)C(N)=NC(=O)N1[C@H]1O[C@@H](CO)SC1 XQSPYNMVSIKCOC-NTSWFWBYSA-N 0.000 claims 2
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 claims 2
- 102100034343 Integrase Human genes 0.000 claims 2
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 2
- 229960000531 abacavir sulfate Drugs 0.000 claims 2
- WMHSRBZIJNQHKT-FFKFEZPRSA-N abacavir sulfate Chemical compound OS(O)(=O)=O.C=12N=CN([C@H]3C=C[C@@H](CO)C3)C2=NC(N)=NC=1NC1CC1.C=12N=CN([C@H]3C=C[C@@H](CO)C3)C2=NC(N)=NC=1NC1CC1 WMHSRBZIJNQHKT-FFKFEZPRSA-N 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 239000002259 anti human immunodeficiency virus agent Substances 0.000 claims 2
- 229940124411 anti-hiv antiviral agent Drugs 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 229960000366 emtricitabine Drugs 0.000 claims 2
- 239000004030 hiv protease inhibitor Substances 0.000 claims 2
- 229960001627 lamivudine Drugs 0.000 claims 2
- JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 229960004693 tenofovir disoproxil fumarate Drugs 0.000 claims 2
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000013160 medical therapy Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562142338P | 2015-04-02 | 2015-04-02 | |
| US62/142,338 | 2015-04-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017549768A Division JP6402259B2 (ja) | 2015-04-02 | 2016-04-01 | 多環式カルバモイルピリドン化合物およびそれらの薬学的使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018188483A JP2018188483A (ja) | 2018-11-29 |
| JP2018188483A5 true JP2018188483A5 (OSRAM) | 2019-01-17 |
| JP6745308B2 JP6745308B2 (ja) | 2020-08-26 |
Family
ID=55754453
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017549768A Active JP6402259B2 (ja) | 2015-04-02 | 2016-04-01 | 多環式カルバモイルピリドン化合物およびそれらの薬学的使用 |
| JP2018168811A Active JP6745308B2 (ja) | 2015-04-02 | 2018-09-10 | 多環式カルバモイルピリドン化合物およびそれらの薬学的使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017549768A Active JP6402259B2 (ja) | 2015-04-02 | 2016-04-01 | 多環式カルバモイルピリドン化合物およびそれらの薬学的使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9630978B2 (OSRAM) |
| EP (3) | EP3277691B1 (OSRAM) |
| JP (2) | JP6402259B2 (OSRAM) |
| KR (2) | KR20190057158A (OSRAM) |
| CN (2) | CN107531727B (OSRAM) |
| AU (3) | AU2016244035B2 (OSRAM) |
| BR (1) | BR112017020837A2 (OSRAM) |
| CA (1) | CA2980362C (OSRAM) |
| EA (1) | EA201791872A1 (OSRAM) |
| ES (2) | ES2837383T3 (OSRAM) |
| HK (1) | HK1249103B (OSRAM) |
| IL (1) | IL254552A0 (OSRAM) |
| MX (1) | MX2017012393A (OSRAM) |
| NZ (1) | NZ735575A (OSRAM) |
| PL (1) | PL3277691T3 (OSRAM) |
| PT (2) | PT3466490T (OSRAM) |
| SG (1) | SG11201707905WA (OSRAM) |
| SI (2) | SI3466490T1 (OSRAM) |
| TR (1) | TR201905009T4 (OSRAM) |
| WO (1) | WO2016161382A1 (OSRAM) |
Families Citing this family (21)
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| DK3067358T3 (da) | 2012-12-21 | 2019-11-04 | Gilead Sciences Inc | Polycykliske carbamoylpyridon-forbindelser og deres farmaceutiske anvendelse |
| TWI695003B (zh) * | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| SG11201705069YA (en) | 2014-12-26 | 2017-07-28 | Univ Emory | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| EP3277691B1 (en) * | 2015-04-02 | 2019-01-30 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| PL3706762T3 (pl) | 2017-12-07 | 2025-02-10 | Emory University | N4-hydroksycytydyna i pochodne oraz związane z nimi zastosowania przeciwwirusowe |
| CN110526930B (zh) * | 2018-05-23 | 2022-06-03 | 莫云芬 | 抗hiv病毒的含硫多环-羟基吡啶酮甲酰胺类似物及其应用 |
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| EP4257137A3 (en) | 2018-05-31 | 2023-11-01 | Shionogi & Co., Ltd | Polycyclic carbamoylpyridone derivatives for the treatment of hiv |
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| RU2717101C1 (ru) * | 2019-06-03 | 2020-03-18 | Андрей Александрович Иващенко | Анелированные 9-гидрокси-1,8-диоксо-1,3,4,8-тетрагидро-2Н-пиридо[1,2-a]пиразин-7-карбоксамиды - ингибиторы интегразы ВИЧ, способы их получения и применения |
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| EP4066839A4 (en) | 2019-11-28 | 2023-12-27 | Shionogi & Co., Ltd | PROPHYLACTIC AND THERAPEUTIC MEDICINAL PRODUCT FOR HIV INFECTIOUS DISEASES, CHARACTERIZED BY CONTAINING THE COMBINATION OF INTEGRAS INHIBITORS AND ANTI-HIV AGENTS |
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| US12421235B2 (en) * | 2020-09-30 | 2025-09-23 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| CN114426540B (zh) * | 2020-10-29 | 2024-04-26 | 上海拓界生物医药科技有限公司 | 吡啶并[1,2-a]吡嗪-1,8-二酮类前药衍生物、其制备方法及其应用 |
| TW202227445A (zh) * | 2020-10-30 | 2022-07-16 | 大陸商上海拓界生物醫藥科技有限公司 | 抑制基因缺陷的ｈｉｖ病毒的用途 |
| PT4196479T (pt) | 2021-01-19 | 2024-01-03 | Gilead Sciences Inc | Compostos de piridotriazinas substituídos e suas utilizações |
| TWI856796B (zh) | 2022-04-06 | 2024-09-21 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| CN115015310B (zh) * | 2022-05-23 | 2024-12-10 | 宁波大学 | 一种巯基化合物的分析方法 |
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- 2016-04-01 EP EP16716776.6A patent/EP3277691B1/en active Active
- 2016-04-01 EA EA201791872A patent/EA201791872A1/ru unknown
- 2016-04-01 KR KR1020197014269A patent/KR20190057158A/ko not_active Withdrawn
- 2016-04-01 MX MX2017012393A patent/MX2017012393A/es unknown
- 2016-04-01 BR BR112017020837-7A patent/BR112017020837A2/pt not_active IP Right Cessation
- 2016-04-01 PT PT182078881T patent/PT3466490T/pt unknown
- 2016-04-01 CN CN201680025671.0A patent/CN107531727B/zh active Active
- 2016-04-01 ES ES18207888T patent/ES2837383T3/es active Active
- 2016-04-01 SI SI201630966T patent/SI3466490T1/sl unknown
- 2016-04-01 CN CN201911067354.7A patent/CN110790773A/zh active Pending
- 2016-04-01 EP EP18207888.1A patent/EP3466490B1/en active Active
- 2016-04-01 CA CA2980362A patent/CA2980362C/en active Active
- 2016-04-01 WO PCT/US2016/025740 patent/WO2016161382A1/en not_active Ceased
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- 2016-04-01 EP EP20167360.5A patent/EP3736274A1/en not_active Withdrawn
- 2016-04-01 PT PT16716776T patent/PT3277691T/pt unknown
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