JP2018104457A5 - - Google Patents
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- JP2018104457A5 JP2018104457A5 JP2018031941A JP2018031941A JP2018104457A5 JP 2018104457 A5 JP2018104457 A5 JP 2018104457A5 JP 2018031941 A JP2018031941 A JP 2018031941A JP 2018031941 A JP2018031941 A JP 2018031941A JP 2018104457 A5 JP2018104457 A5 JP 2018104457A5
- Authority
- JP
- Japan
- Prior art keywords
- hematopoietic stem
- cell population
- cell
- cells
- pge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 41
- 210000004027 cell Anatomy 0.000 claims 34
- 230000014509 gene expression Effects 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 19
- 230000001225 therapeutic effect Effects 0.000 claims 19
- 108090000623 proteins and genes Proteins 0.000 claims 17
- 102000007299 Amphiregulin Human genes 0.000 claims 12
- 108010033760 Amphiregulin Proteins 0.000 claims 12
- 102000005228 Cyclic AMP Response Element Modulator Human genes 0.000 claims 12
- 108010056281 Cyclic AMP Response Element Modulator Proteins 0.000 claims 12
- 102100025626 GTP-binding protein GEM Human genes 0.000 claims 12
- 102000003918 Hyaluronan Synthases Human genes 0.000 claims 12
- 108090000320 Hyaluronan Synthases Proteins 0.000 claims 12
- 102100028255 Renin Human genes 0.000 claims 12
- 108090000783 Renin Proteins 0.000 claims 12
- 102000004134 Fos-related antigen 2 Human genes 0.000 claims 11
- 108090000641 Fos-related antigen 2 Proteins 0.000 claims 11
- 210000000130 stem cell Anatomy 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 7
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 7
- 102100027085 Dual specificity protein phosphatase 4 Human genes 0.000 claims 6
- 101710116158 GTP-binding protein GEM Proteins 0.000 claims 6
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 6
- 101001057621 Homo sapiens Dual specificity protein phosphatase 4 Proteins 0.000 claims 6
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 6
- 108010029483 alpha 1 Chain Collagen Type I Proteins 0.000 claims 6
- 108010008370 protein phosphatase 4 Proteins 0.000 claims 6
- 210000001185 bone marrow Anatomy 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 230000001400 myeloablative effect Effects 0.000 claims 4
- QAOBBBBDJSWHMU-WMBBNPMCSA-N 16,16-dimethylprostaglandin E2 Chemical compound CCCCC(C)(C)[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O QAOBBBBDJSWHMU-WMBBNPMCSA-N 0.000 claims 3
- 101150026563 NR4A2 gene Proteins 0.000 claims 3
- 108020005497 Nuclear hormone receptor Proteins 0.000 claims 3
- 210000004700 fetal blood Anatomy 0.000 claims 3
- 108020004017 nuclear receptors Proteins 0.000 claims 3
- 102000006255 nuclear receptors Human genes 0.000 claims 3
- 210000005259 peripheral blood Anatomy 0.000 claims 3
- 239000011886 peripheral blood Substances 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims 2
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims 2
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims 2
- 102100040485 HLA class II histocompatibility antigen, DRB1 beta chain Human genes 0.000 claims 2
- 108010075704 HLA-A Antigens Proteins 0.000 claims 2
- 108010058607 HLA-B Antigens Proteins 0.000 claims 2
- 108010052199 HLA-C Antigens Proteins 0.000 claims 2
- 108010039343 HLA-DRB1 Chains Proteins 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 claims 2
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 2
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- WWMXHYUXIKWXSR-AAHOZRAYSA-N (z)-7-[(1r,2r,3r)-3-hydroxy-2-[(e,3r)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid Chemical compound C([C@H](O)\C=C\[C@@H]1[C@H](C(=O)C[C@H]1O)C\C=C/CCCC(O)=O)OC1=CC=CC(C(F)(F)F)=C1 WWMXHYUXIKWXSR-AAHOZRAYSA-N 0.000 claims 1
- AIOFTOLPMOTZKD-OPVFONCOSA-N (z)-7-[(1r,2r,3r,5r)-5-chloro-3-hydroxy-2-[(e,3r)-3-hydroxy-4,4-dimethyloct-1-enyl]cyclopentyl]hept-5-enoic acid Chemical compound CCCCC(C)(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1C\C=C/CCCC(O)=O AIOFTOLPMOTZKD-OPVFONCOSA-N 0.000 claims 1
- LLVVDFDWPQHXBA-QEJIITRLSA-N 11-Deoxy-16,16-dimethyl-PGE2 Chemical compound CCCCC(C)(C)[C@H](O)\C=C\[C@H]1CCC(=O)[C@@H]1C\C=C/CCCC(O)=O LLVVDFDWPQHXBA-QEJIITRLSA-N 0.000 claims 1
- DPNOTBLPQOITGU-LDDQNKHRSA-N 11-deoxyprostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1CCC(=O)[C@@H]1CCCCCCC(O)=O DPNOTBLPQOITGU-LDDQNKHRSA-N 0.000 claims 1
- XSGQFHNPNWBVPT-DSFPJDRCSA-N 15-Methyl-15S-PGE2 Chemical compound CCCCC[C@](C)(O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XSGQFHNPNWBVPT-DSFPJDRCSA-N 0.000 claims 1
- XSGQFHNPNWBVPT-VFXMVCAWSA-N 15-methyl-15R-PGE2 Chemical compound CCCCC[C@@](C)(O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XSGQFHNPNWBVPT-VFXMVCAWSA-N 0.000 claims 1
- DXWJXQSQVUJRNS-YYWARMNLSA-N 16-Phenyl-tetranor-PGE2 Chemical compound C([C@H](O)\C=C\[C@@H]1[C@H](C(=O)C[C@H]1O)C\C=C/CCCC(O)=O)C1=CC=CC=C1 DXWJXQSQVUJRNS-YYWARMNLSA-N 0.000 claims 1
- FOBVMYJQWZOGGJ-XYRJXBATSA-N 17-phenyl-18,19,20-trinor-prostaglandin E2 Chemical compound C([C@H](O)\C=C\[C@@H]1[C@H](C(=O)C[C@H]1O)C\C=C/CCCC(O)=O)CC1=CC=CC=C1 FOBVMYJQWZOGGJ-XYRJXBATSA-N 0.000 claims 1
- WTJYDBMHYPQFNJ-ZUVVJKHESA-N 19R-Hydroxy-PGE2 Chemical compound C[C@@H](O)CCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O WTJYDBMHYPQFNJ-ZUVVJKHESA-N 0.000 claims 1
- AZIGEYVZEVXWAD-NZGURKHLSA-N 20-hydroxyprostaglandin E2 Chemical compound OCCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O AZIGEYVZEVXWAD-NZGURKHLSA-N 0.000 claims 1
- YRTJDWROBKPZNV-RSNVZYGJSA-N 8-iso-15-keto-PGE2 Chemical compound CCCCCC(=O)\C=C\[C@H]1[C@H](O)CC(=O)[C@H]1C\C=C/CCCC(O)=O YRTJDWROBKPZNV-RSNVZYGJSA-N 0.000 claims 1
- WMLGLMGSFIXSGO-KTXJXPLISA-N 9-Deoxy-9-methylene-16,16-dimethyl -PGE2 Chemical compound CCCCC(C)(C)[C@H](O)\C=C\[C@H]1[C@H](O)CC(=C)[C@@H]1C\C=C/CCCC(O)=O WMLGLMGSFIXSGO-KTXJXPLISA-N 0.000 claims 1
- VKEJXDXJUFQESA-DLMPNJEASA-N 9-Deoxy-9-methylene-PGE2 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=C)[C@@H]1C\C=C/CCCC(O)=O VKEJXDXJUFQESA-DLMPNJEASA-N 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000032467 Aplastic anaemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000019838 Blood disease Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010010099 Combined immunodeficiency Diseases 0.000 claims 1
- 206010010356 Congenital anomaly Diseases 0.000 claims 1
- 206010053138 Congenital aplastic anaemia Diseases 0.000 claims 1
- DPNOTBLPQOITGU-UHFFFAOYSA-N Doproston B Natural products CCCCCC(O)C=CC1CCC(=O)C1CCCCCCC(O)=O DPNOTBLPQOITGU-UHFFFAOYSA-N 0.000 claims 1
- 208000035366 Familial hemophagocytic lymphohistiocytosis Diseases 0.000 claims 1
- 201000004939 Fanconi anemia Diseases 0.000 claims 1
- 206010016717 Fistula Diseases 0.000 claims 1
- 102100036241 HLA class II histocompatibility antigen, DQ beta 1 chain Human genes 0.000 claims 1
- 102100040482 HLA class II histocompatibility antigen, DR beta 3 chain Human genes 0.000 claims 1
- 108010065026 HLA-DQB1 antigen Proteins 0.000 claims 1
- 108010061311 HLA-DRB3 Chains Proteins 0.000 claims 1
- 208000036066 Hemophagocytic Lymphohistiocytosis Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000015178 Hurler syndrome Diseases 0.000 claims 1
- -1 Isopropyl ester Chemical class 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 201000011442 Metachromatic leukodystrophy Diseases 0.000 claims 1
- 206010056886 Mucopolysaccharidosis I Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 206010028561 Myeloid metaplasia Diseases 0.000 claims 1
- 208000037538 Myelomonocytic Juvenile Leukemia Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010055006 Pancreatic sarcoma Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000009527 Refractory anemia Diseases 0.000 claims 1
- 206010072684 Refractory cytopenia with unilineage dysplasia Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 230000001919 adrenal effect Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 208000022806 beta-thalassemia major Diseases 0.000 claims 1
- 229950008654 butaprost Drugs 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000003511 endothelial effect Effects 0.000 claims 1
- 230000002449 erythroblastic effect Effects 0.000 claims 1
- 230000003890 fistula Effects 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000014951 hematologic disease Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 208000018706 hematopoietic system disease Diseases 0.000 claims 1
- 201000005992 juvenile myelomonocytic leukemia Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- XRISENIKJUKIHD-LHQZMKCDSA-N methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(e,4r)-4-hydroxy-4-(1-propylcyclobutyl)but-1-enyl]-5-oxocyclopentyl]heptanoate Chemical compound CCCC1([C@H](O)C\C=C\[C@@H]2[C@H](C(=O)C[C@H]2O)CCCCCCC(=O)OC)CCC1 XRISENIKJUKIHD-LHQZMKCDSA-N 0.000 claims 1
- 150000004702 methyl esters Chemical class 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 229950003144 nocloprost Drugs 0.000 claims 1
- 210000004967 non-hematopoietic stem cell Anatomy 0.000 claims 1
- 201000002526 pancreas sarcoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229930182884 serinolamide Natural products 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 208000007056 sickle cell anemia Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- UQZVCDCIMBLVNR-TWYODKAFSA-N sulprostone Chemical compound O[C@@H]1CC(=O)[C@H](C\C=C/CCCC(=O)NS(=O)(=O)C)[C@H]1\C=C\[C@@H](O)COC1=CC=CC=C1 UQZVCDCIMBLVNR-TWYODKAFSA-N 0.000 claims 1
- 229960003400 sulprostone Drugs 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 206010043554 thrombocytopenia Diseases 0.000 claims 1
- 210000004885 white matter Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37321210P | 2010-08-12 | 2010-08-12 | |
| US61/373,212 | 2010-08-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016124416A Division JP6346917B2 (ja) | 2010-08-12 | 2016-06-23 | 改善された造血幹細胞および前駆細胞療法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018139536A Division JP2018184448A (ja) | 2010-08-12 | 2018-07-25 | 改善された造血幹細胞および前駆細胞療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018104457A JP2018104457A (ja) | 2018-07-05 |
| JP2018104457A5 true JP2018104457A5 (enExample) | 2018-09-06 |
| JP6574279B2 JP6574279B2 (ja) | 2019-09-11 |
Family
ID=45568224
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524254A Expired - Fee Related JP6047489B2 (ja) | 2010-08-12 | 2011-08-12 | 改善された造血幹細胞および前駆細胞療法 |
| JP2016124416A Expired - Fee Related JP6346917B2 (ja) | 2010-08-12 | 2016-06-23 | 改善された造血幹細胞および前駆細胞療法 |
| JP2018031941A Expired - Fee Related JP6574279B2 (ja) | 2010-08-12 | 2018-02-26 | 改善された造血幹細胞および前駆細胞療法 |
| JP2018139536A Withdrawn JP2018184448A (ja) | 2010-08-12 | 2018-07-25 | 改善された造血幹細胞および前駆細胞療法 |
| JP2019197587A Withdrawn JP2020029458A (ja) | 2010-08-12 | 2019-10-30 | 改善された造血幹細胞および前駆細胞療法 |
| JP2021172986A Withdrawn JP2022009404A (ja) | 2010-08-12 | 2021-10-22 | 改善された造血幹細胞および前駆細胞療法 |
| JP2023071598A Pending JP2023109761A (ja) | 2010-08-12 | 2023-04-25 | 改善された造血幹細胞および前駆細胞療法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524254A Expired - Fee Related JP6047489B2 (ja) | 2010-08-12 | 2011-08-12 | 改善された造血幹細胞および前駆細胞療法 |
| JP2016124416A Expired - Fee Related JP6346917B2 (ja) | 2010-08-12 | 2016-06-23 | 改善された造血幹細胞および前駆細胞療法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018139536A Withdrawn JP2018184448A (ja) | 2010-08-12 | 2018-07-25 | 改善された造血幹細胞および前駆細胞療法 |
| JP2019197587A Withdrawn JP2020029458A (ja) | 2010-08-12 | 2019-10-30 | 改善された造血幹細胞および前駆細胞療法 |
| JP2021172986A Withdrawn JP2022009404A (ja) | 2010-08-12 | 2021-10-22 | 改善された造血幹細胞および前駆細胞療法 |
| JP2023071598A Pending JP2023109761A (ja) | 2010-08-12 | 2023-04-25 | 改善された造血幹細胞および前駆細胞療法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20140030232A1 (enExample) |
| EP (2) | EP3278808A1 (enExample) |
| JP (7) | JP6047489B2 (enExample) |
| CN (5) | CN106214701B (enExample) |
| AU (1) | AU2011289245B2 (enExample) |
| BR (1) | BR112013003366A2 (enExample) |
| CA (1) | CA2807944C (enExample) |
| ES (1) | ES2654994T3 (enExample) |
| WO (1) | WO2012021845A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2807944C (en) * | 2010-08-12 | 2020-02-18 | Fate Therapeutics, Inc. | Improved hematopoietic stem and progenitor cell therapy |
| EP3785767A1 (en) | 2011-12-02 | 2021-03-03 | Fate Therapeutics, Inc. | Enhanced stem cell composition |
| US10111907B2 (en) | 2011-12-02 | 2018-10-30 | Fate Therapeutics, Inc. | Methods of treating ischemia |
| WO2014078617A1 (en) * | 2012-11-16 | 2014-05-22 | Albert Einstein College Of Medicine Of Yeshiva University | Identification and use of new tumor-promoting gene in hematological malignancies |
| SG11201506520TA (en) * | 2013-02-18 | 2015-09-29 | Univ Health Network | Methods for generating hepatocytes and cholangiocytes from pluripotent stem cells |
| WO2014153115A2 (en) * | 2013-03-14 | 2014-09-25 | Children's Medical Center Corporation | Compositions and methods for reprogramming hematopoietic stem cell lineages |
| US10851412B2 (en) | 2013-03-15 | 2020-12-01 | Fate Therapeutics, Inc. | Cell potency assay for therapeutic potential |
| US9943545B2 (en) | 2013-03-15 | 2018-04-17 | Fate Therapeutics, Inc. | Stem cell culture media and methods of enhancing cell survival |
| CN105408472A (zh) | 2013-03-15 | 2016-03-16 | 马卡斯凯尔·托莱夫·拉尔森 | 用于脐带血收集及细胞分离的细胞、方法和装置 |
| RU2525143C1 (ru) * | 2013-03-22 | 2014-08-10 | Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации-Институт медико-биологических проблем Российской академии наук | СПОСОБ ЭКСПАНСИИ МОНОНУКЛЕАРНЫХ КЛЕТОК ПУПОВИННОЙ КРОВИ (пкМНК) ex vivo В ПРИСУТСТВИИ МУЛЬТИПОТЕНТНЫХ СТРОМАЛЬНЫХ МЕЗЕНХИМАЛЬНЫХ КЛЕТОК (ММСК) |
| US20160299148A1 (en) * | 2013-11-22 | 2016-10-13 | Washington University | Biomarkers for multiple myeloma |
| US11278572B2 (en) | 2014-07-18 | 2022-03-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Reducing CXCR4 expression and/or function to enhance engraftment of hematopoietic stem cells |
| CN114058582A (zh) | 2015-01-26 | 2022-02-18 | 菲特治疗公司 | 用于诱导造血细胞分化的方法和组合物 |
| WO2016123117A1 (en) * | 2015-01-26 | 2016-08-04 | Fate Therapeutics, Inc. | Cells with increased immuno-regulatory properties and methods for their use and manufacture |
| WO2016164502A1 (en) * | 2015-04-06 | 2016-10-13 | President And Fellows Of Harvard College | Compositions and methods for non-myeloablative conditioning |
| KR20180048617A (ko) * | 2015-07-20 | 2018-05-10 | 앤지오크린 바이오사이언스 인코포레이티드 | 줄기 세포 이식 방법 및 조성물 |
| CA2993201A1 (en) | 2015-07-21 | 2017-01-26 | The Children's Medical Center Corporation | Pd-l1 expressing hematopoietic stem cells and uses |
| EP3371301A4 (en) | 2015-11-04 | 2019-06-26 | Fate Therapeutics, Inc. | METHOD AND COMPOSITIONS FOR INDUCING THE DIFFERENTIATION OF HEMATOPOIETIC CELLS |
| CN115806940A (zh) | 2015-11-04 | 2023-03-17 | 菲特治疗公司 | 多能细胞的基因组工程改造 |
| RU2628092C1 (ru) * | 2016-02-10 | 2017-08-14 | Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации - Институт медико-биологических проблем Российской академии наук (ГНЦ РФ - ИМБП РАН) | Способ получения МСК-ассоциированных недифференцированных гемопоэтических клеток-предшественников с фенотипов CD34+/CD133+ |
| CN105779386B (zh) * | 2016-04-06 | 2019-09-20 | 南京大学 | 一种间充质干细胞在制备治疗m5型白血病药物中的应用 |
| CN105886457A (zh) * | 2016-05-16 | 2016-08-24 | 中国人民解放军军事医学科学院野战输血研究所 | 诱导干细胞分化成外胚层祖细胞的方法 |
| WO2018073615A1 (en) * | 2016-10-21 | 2018-04-26 | Longboat Explorers Ab | Methods and compositions for generating hematopoietic cells |
| CN106754726A (zh) * | 2016-12-28 | 2017-05-31 | 溯源生命科技股份有限公司 | 一种提高人间充质干细胞移植和归巢效率的基因治疗方法 |
| WO2018170046A1 (en) * | 2017-03-14 | 2018-09-20 | Orig3N, Inc. | Hla-indexed repository of ipscs and ipsc-derived stem cells, and related systems and methods |
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