JP2013540105A5 - - Google Patents
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- JP2013540105A5 JP2013540105A5 JP2013524254A JP2013524254A JP2013540105A5 JP 2013540105 A5 JP2013540105 A5 JP 2013540105A5 JP 2013524254 A JP2013524254 A JP 2013524254A JP 2013524254 A JP2013524254 A JP 2013524254A JP 2013540105 A5 JP2013540105 A5 JP 2013540105A5
- Authority
- JP
- Japan
- Prior art keywords
- hematopoietic stem
- cell population
- cells
- progenitor cells
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 205
- 210000004027 cell Anatomy 0.000 claims description 158
- 239000000203 mixture Substances 0.000 claims description 85
- 238000000034 method Methods 0.000 claims description 84
- 230000014509 gene expression Effects 0.000 claims description 79
- 230000001225 therapeutic effect Effects 0.000 claims description 74
- 108090000623 proteins and genes Proteins 0.000 claims description 54
- 239000003795 chemical substances by application Substances 0.000 claims description 53
- 210000000130 stem cell Anatomy 0.000 claims description 51
- 102000007299 Amphiregulin Human genes 0.000 claims description 28
- 108010033760 Amphiregulin Proteins 0.000 claims description 28
- 102000004134 Fos-related antigen 2 Human genes 0.000 claims description 28
- 108090000641 Fos-related antigen 2 Proteins 0.000 claims description 28
- 102100025626 GTP-binding protein GEM Human genes 0.000 claims description 28
- 102000003918 Hyaluronan Synthases Human genes 0.000 claims description 28
- 108090000320 Hyaluronan Synthases Proteins 0.000 claims description 28
- 102100028255 Renin Human genes 0.000 claims description 28
- 108090000783 Renin Proteins 0.000 claims description 28
- 102000005228 Cyclic AMP Response Element Modulator Human genes 0.000 claims description 27
- 108010056281 Cyclic AMP Response Element Modulator Proteins 0.000 claims description 27
- 210000004700 fetal blood Anatomy 0.000 claims description 26
- 210000001185 bone marrow Anatomy 0.000 claims description 24
- 230000001400 myeloablative effect Effects 0.000 claims description 24
- 108010061299 CXCR4 Receptors Proteins 0.000 claims description 21
- 102000012000 CXCR4 Receptors Human genes 0.000 claims description 21
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 18
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 18
- 210000005259 peripheral blood Anatomy 0.000 claims description 18
- 239000011886 peripheral blood Substances 0.000 claims description 18
- 239000003814 drug Substances 0.000 claims description 15
- 229940079593 drug Drugs 0.000 claims description 15
- 102100027085 Dual specificity protein phosphatase 4 Human genes 0.000 claims description 14
- 101710116158 GTP-binding protein GEM Proteins 0.000 claims description 14
- 101001057621 Homo sapiens Dual specificity protein phosphatase 4 Proteins 0.000 claims description 14
- 108010029483 alpha 1 Chain Collagen Type I Proteins 0.000 claims description 14
- 108010008370 protein phosphatase 4 Proteins 0.000 claims description 14
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 12
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims description 12
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims description 12
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 claims description 12
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 claims description 12
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- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 claims description 12
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- 108020005497 Nuclear hormone receptor Proteins 0.000 claims description 9
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- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 6
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- 208000032467 Aplastic anaemia Diseases 0.000 claims description 6
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 6
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 6
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- 206010010356 Congenital anomaly Diseases 0.000 claims description 6
- 208000035366 Familial hemophagocytic lymphohistiocytosis Diseases 0.000 claims description 6
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- 208000036066 Hemophagocytic Lymphohistiocytosis Diseases 0.000 claims description 6
- 208000017604 Hodgkin disease Diseases 0.000 claims description 6
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims description 6
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims description 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 6
- 201000011442 Metachromatic leukodystrophy Diseases 0.000 claims description 6
- 208000034578 Multiple myelomas Diseases 0.000 claims description 6
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 6
- 206010028561 Myeloid metaplasia Diseases 0.000 claims description 6
- 208000037538 Myelomonocytic Juvenile Leukemia Diseases 0.000 claims description 6
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 6
- 206010033128 Ovarian cancer Diseases 0.000 claims description 6
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 6
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 6
- 206010055006 Pancreatic sarcoma Diseases 0.000 claims description 6
- 206010060862 Prostate cancer Diseases 0.000 claims description 6
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- 208000009527 Refractory anemia Diseases 0.000 claims description 6
- 206010072684 Refractory cytopenia with unilineage dysplasia Diseases 0.000 claims description 6
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 6
- 208000022806 beta-thalassemia major Diseases 0.000 claims description 6
- 208000029742 colonic neoplasm Diseases 0.000 claims description 6
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- 201000005992 juvenile myelomonocytic leukemia Diseases 0.000 claims description 6
- 201000007270 liver cancer Diseases 0.000 claims description 6
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- 201000005202 lung cancer Diseases 0.000 claims description 6
- 208000020816 lung neoplasm Diseases 0.000 claims description 6
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 6
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- 208000007056 sickle cell anemia Diseases 0.000 claims description 6
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- 206010043554 thrombocytopenia Diseases 0.000 claims description 6
- 206010006187 Breast cancer Diseases 0.000 claims description 5
- 208000026310 Breast neoplasm Diseases 0.000 claims description 5
- 101150066398 CXCR4 gene Proteins 0.000 claims description 5
- 108091006065 Gs proteins Proteins 0.000 claims description 5
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims description 5
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims description 5
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims description 5
- 102100040485 HLA class II histocompatibility antigen, DRB1 beta chain Human genes 0.000 claims description 5
- 108010075704 HLA-A Antigens Proteins 0.000 claims description 5
- 108010058607 HLA-B Antigens Proteins 0.000 claims description 5
- 108010052199 HLA-C Antigens Proteins 0.000 claims description 5
- 108010039343 HLA-DRB1 Chains Proteins 0.000 claims description 5
- 208000033833 Myelomonocytic Chronic Leukemia Diseases 0.000 claims description 5
- 239000012190 activator Substances 0.000 claims description 5
- 230000001919 adrenal effect Effects 0.000 claims description 5
- 208000007502 anemia Diseases 0.000 claims description 5
- 201000010902 chronic myelomonocytic leukemia Diseases 0.000 claims description 5
- 230000003394 haemopoietic effect Effects 0.000 claims description 5
- 102000005962 receptors Human genes 0.000 claims description 5
- 108020003175 receptors Proteins 0.000 claims description 5
- 239000000725 suspension Substances 0.000 claims description 5
- 210000004885 white matter Anatomy 0.000 claims description 5
- 208000015178 Hurler syndrome Diseases 0.000 claims description 3
- 206010056886 Mucopolysaccharidosis I Diseases 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 102100036241 HLA class II histocompatibility antigen, DQ beta 1 chain Human genes 0.000 claims description 2
- 102100040482 HLA class II histocompatibility antigen, DR beta 3 chain Human genes 0.000 claims description 2
- 108010065026 HLA-DQB1 antigen Proteins 0.000 claims description 2
- 108010061311 HLA-DRB3 Chains Proteins 0.000 claims description 2
- 230000003511 endothelial effect Effects 0.000 claims description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 2
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 10
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 10
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 4
- 201000011452 Adrenoleukodystrophy Diseases 0.000 claims 1
- 206010053138 Congenital aplastic anaemia Diseases 0.000 claims 1
- 201000004939 Fanconi anemia Diseases 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 102000009030 Member 1 Subfamily D ATP Binding Cassette Transporter Human genes 0.000 claims 1
- 108010049137 Member 1 Subfamily D ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000007813 immunodeficiency Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 150000003166 prostaglandin E2 derivatives Chemical class 0.000 claims 1
- 238000005406 washing Methods 0.000 description 7
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- 239000002158 endotoxin Substances 0.000 description 5
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- 230000000735 allogeneic effect Effects 0.000 description 4
- 230000019491 signal transduction Effects 0.000 description 3
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- 102100025621 Cytochrome b-245 heavy chain Human genes 0.000 description 1
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- 206010028093 mucopolysaccharidosis Diseases 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37321210P | 2010-08-12 | 2010-08-12 | |
| US61/373,212 | 2010-08-12 | ||
| PCT/US2011/047657 WO2012021845A2 (en) | 2010-08-12 | 2011-08-12 | Improved hematopoietic stem and progenitor cell therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016124416A Division JP6346917B2 (ja) | 2010-08-12 | 2016-06-23 | 改善された造血幹細胞および前駆細胞療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013540105A JP2013540105A (ja) | 2013-10-31 |
| JP2013540105A5 true JP2013540105A5 (enExample) | 2014-08-21 |
| JP6047489B2 JP6047489B2 (ja) | 2016-12-21 |
Family
ID=45568224
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524254A Expired - Fee Related JP6047489B2 (ja) | 2010-08-12 | 2011-08-12 | 改善された造血幹細胞および前駆細胞療法 |
| JP2016124416A Expired - Fee Related JP6346917B2 (ja) | 2010-08-12 | 2016-06-23 | 改善された造血幹細胞および前駆細胞療法 |
| JP2018031941A Expired - Fee Related JP6574279B2 (ja) | 2010-08-12 | 2018-02-26 | 改善された造血幹細胞および前駆細胞療法 |
| JP2018139536A Withdrawn JP2018184448A (ja) | 2010-08-12 | 2018-07-25 | 改善された造血幹細胞および前駆細胞療法 |
| JP2019197587A Withdrawn JP2020029458A (ja) | 2010-08-12 | 2019-10-30 | 改善された造血幹細胞および前駆細胞療法 |
| JP2021172986A Withdrawn JP2022009404A (ja) | 2010-08-12 | 2021-10-22 | 改善された造血幹細胞および前駆細胞療法 |
| JP2023071598A Pending JP2023109761A (ja) | 2010-08-12 | 2023-04-25 | 改善された造血幹細胞および前駆細胞療法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016124416A Expired - Fee Related JP6346917B2 (ja) | 2010-08-12 | 2016-06-23 | 改善された造血幹細胞および前駆細胞療法 |
| JP2018031941A Expired - Fee Related JP6574279B2 (ja) | 2010-08-12 | 2018-02-26 | 改善された造血幹細胞および前駆細胞療法 |
| JP2018139536A Withdrawn JP2018184448A (ja) | 2010-08-12 | 2018-07-25 | 改善された造血幹細胞および前駆細胞療法 |
| JP2019197587A Withdrawn JP2020029458A (ja) | 2010-08-12 | 2019-10-30 | 改善された造血幹細胞および前駆細胞療法 |
| JP2021172986A Withdrawn JP2022009404A (ja) | 2010-08-12 | 2021-10-22 | 改善された造血幹細胞および前駆細胞療法 |
| JP2023071598A Pending JP2023109761A (ja) | 2010-08-12 | 2023-04-25 | 改善された造血幹細胞および前駆細胞療法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20140030232A1 (enExample) |
| EP (2) | EP3278808A1 (enExample) |
| JP (7) | JP6047489B2 (enExample) |
| CN (5) | CN106214701B (enExample) |
| AU (1) | AU2011289245B2 (enExample) |
| BR (1) | BR112013003366A2 (enExample) |
| CA (1) | CA2807944C (enExample) |
| ES (1) | ES2654994T3 (enExample) |
| WO (1) | WO2012021845A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2807944C (en) * | 2010-08-12 | 2020-02-18 | Fate Therapeutics, Inc. | Improved hematopoietic stem and progenitor cell therapy |
| EP3785767A1 (en) | 2011-12-02 | 2021-03-03 | Fate Therapeutics, Inc. | Enhanced stem cell composition |
| US10111907B2 (en) | 2011-12-02 | 2018-10-30 | Fate Therapeutics, Inc. | Methods of treating ischemia |
| WO2014078617A1 (en) * | 2012-11-16 | 2014-05-22 | Albert Einstein College Of Medicine Of Yeshiva University | Identification and use of new tumor-promoting gene in hematological malignancies |
| SG11201506520TA (en) * | 2013-02-18 | 2015-09-29 | Univ Health Network | Methods for generating hepatocytes and cholangiocytes from pluripotent stem cells |
| WO2014153115A2 (en) * | 2013-03-14 | 2014-09-25 | Children's Medical Center Corporation | Compositions and methods for reprogramming hematopoietic stem cell lineages |
| US10851412B2 (en) | 2013-03-15 | 2020-12-01 | Fate Therapeutics, Inc. | Cell potency assay for therapeutic potential |
| US9943545B2 (en) | 2013-03-15 | 2018-04-17 | Fate Therapeutics, Inc. | Stem cell culture media and methods of enhancing cell survival |
| CN105408472A (zh) | 2013-03-15 | 2016-03-16 | 马卡斯凯尔·托莱夫·拉尔森 | 用于脐带血收集及细胞分离的细胞、方法和装置 |
| RU2525143C1 (ru) * | 2013-03-22 | 2014-08-10 | Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации-Институт медико-биологических проблем Российской академии наук | СПОСОБ ЭКСПАНСИИ МОНОНУКЛЕАРНЫХ КЛЕТОК ПУПОВИННОЙ КРОВИ (пкМНК) ex vivo В ПРИСУТСТВИИ МУЛЬТИПОТЕНТНЫХ СТРОМАЛЬНЫХ МЕЗЕНХИМАЛЬНЫХ КЛЕТОК (ММСК) |
| US20160299148A1 (en) * | 2013-11-22 | 2016-10-13 | Washington University | Biomarkers for multiple myeloma |
| US11278572B2 (en) | 2014-07-18 | 2022-03-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Reducing CXCR4 expression and/or function to enhance engraftment of hematopoietic stem cells |
| CN114058582A (zh) | 2015-01-26 | 2022-02-18 | 菲特治疗公司 | 用于诱导造血细胞分化的方法和组合物 |
| WO2016123117A1 (en) * | 2015-01-26 | 2016-08-04 | Fate Therapeutics, Inc. | Cells with increased immuno-regulatory properties and methods for their use and manufacture |
| WO2016164502A1 (en) * | 2015-04-06 | 2016-10-13 | President And Fellows Of Harvard College | Compositions and methods for non-myeloablative conditioning |
| KR20180048617A (ko) * | 2015-07-20 | 2018-05-10 | 앤지오크린 바이오사이언스 인코포레이티드 | 줄기 세포 이식 방법 및 조성물 |
| CA2993201A1 (en) | 2015-07-21 | 2017-01-26 | The Children's Medical Center Corporation | Pd-l1 expressing hematopoietic stem cells and uses |
| EP3371301A4 (en) | 2015-11-04 | 2019-06-26 | Fate Therapeutics, Inc. | METHOD AND COMPOSITIONS FOR INDUCING THE DIFFERENTIATION OF HEMATOPOIETIC CELLS |
| CN115806940A (zh) | 2015-11-04 | 2023-03-17 | 菲特治疗公司 | 多能细胞的基因组工程改造 |
| RU2628092C1 (ru) * | 2016-02-10 | 2017-08-14 | Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации - Институт медико-биологических проблем Российской академии наук (ГНЦ РФ - ИМБП РАН) | Способ получения МСК-ассоциированных недифференцированных гемопоэтических клеток-предшественников с фенотипов CD34+/CD133+ |
| CN105779386B (zh) * | 2016-04-06 | 2019-09-20 | 南京大学 | 一种间充质干细胞在制备治疗m5型白血病药物中的应用 |
| CN105886457A (zh) * | 2016-05-16 | 2016-08-24 | 中国人民解放军军事医学科学院野战输血研究所 | 诱导干细胞分化成外胚层祖细胞的方法 |
| WO2018073615A1 (en) * | 2016-10-21 | 2018-04-26 | Longboat Explorers Ab | Methods and compositions for generating hematopoietic cells |
| CN106754726A (zh) * | 2016-12-28 | 2017-05-31 | 溯源生命科技股份有限公司 | 一种提高人间充质干细胞移植和归巢效率的基因治疗方法 |
| WO2018170046A1 (en) * | 2017-03-14 | 2018-09-20 | Orig3N, Inc. | Hla-indexed repository of ipscs and ipsc-derived stem cells, and related systems and methods |
| WO2019060708A1 (en) | 2017-09-22 | 2019-03-28 | The Children's Medical Center Corporation | TREATMENT OF TYPE 1 DIABETES AND AUTOIMMUNE DISEASES OR DISORDERS |
| EP3647413A1 (en) * | 2018-10-31 | 2020-05-06 | Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas O.A., M.P. (CIEMAT) | Improvements for performing and facilitating the recovery after hematopoietic stem cell transplantation |
| CA3138292A1 (en) * | 2019-05-17 | 2020-11-26 | Deverra Therapeutics Inc. | Compositions and methods for improving treatment outcomes for patients having hematological malignancies using an expanded stem cell product |
| EP3980036A4 (en) * | 2019-06-06 | 2023-01-25 | Medeor Therapeutics, Inc. | Methods of making cellular products by post-mortem mobilization and harvesting of hematopoietic cells |
| EP3986358A4 (en) | 2019-06-20 | 2023-06-21 | Amniotics AB | DEVICE FOR FILTERING FRUIT WATER |
| CN110585432B (zh) * | 2019-08-27 | 2021-10-15 | 中国人民解放军第二军医大学 | 成纤维细胞生长因子受体1在制备防治肠道病毒71型感染药物中的应用 |
| CN114765957B (zh) | 2019-10-18 | 2025-09-12 | Amniotics公司 | 从羊水中获得羊膜间充质干细胞的方法和设备及其来源的细胞 |
| US20220411755A1 (en) * | 2019-11-14 | 2022-12-29 | Amgen Inc. | Hematopoietic precursor cell production |
| JP2023543248A (ja) * | 2020-09-24 | 2023-10-13 | ▲広▼州▲輯▼因医▲療▼科技有限公司 | ヒト造血幹細胞移植効率を向上させるための化合物の使用 |
| WO2022089606A1 (en) * | 2020-10-30 | 2022-05-05 | Westlake Therapeutics (Hangzhou) Co. Limited | Methods for preparing mature red blood cells in vitro |
| US12435308B2 (en) | 2020-11-06 | 2025-10-07 | Amniotics Ab | Immunomodulation by amniotic fluid mesenchymal stem cells |
| WO2024040061A2 (en) * | 2022-08-16 | 2024-02-22 | The Regents Of The University Of California | Alleviating graft versus host disease using engineered inkt cells |
| WO2024186146A1 (ko) * | 2023-03-07 | 2024-09-12 | 인제대학교 산학협력단 | 조혈 줄기세포 증식 또는 가동화 촉진용 조성물 및 가동화 조혈 줄기세포 수집방법 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4843155A (en) | 1987-11-19 | 1989-06-27 | Piotr Chomczynski | Product and process for isolating RNA |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5635387A (en) | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| US5460964A (en) | 1992-04-03 | 1995-10-24 | Regents Of The University Of Minnesota | Method for culturing hematopoietic cells |
| US5409813A (en) | 1993-09-30 | 1995-04-25 | Systemix, Inc. | Method for mammalian cell separation from a mixture of cell populations |
| US5677136A (en) | 1994-11-14 | 1997-10-14 | Systemix, Inc. | Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof |
| US5709472A (en) * | 1995-10-23 | 1998-01-20 | Lifelines Technology, Inc. | Time-temperature indicator device and method of manufacture |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
| US5945337A (en) | 1996-10-18 | 1999-08-31 | Quality Biological, Inc. | Method for culturing CD34+ cells in a serum-free medium |
| JP2001521753A (ja) | 1997-10-31 | 2001-11-13 | アフィメトリックス インコーポレイテッド | 成人臓器及び胎児臓器中の発現プロフィール |
| US6020135A (en) | 1998-03-27 | 2000-02-01 | Affymetrix, Inc. | P53-regulated genes |
| WO2000038663A2 (en) | 1998-12-24 | 2000-07-06 | Alcon Laboratories, Inc. | Ep4 receptor agonists for treatment of dry eye |
| KR20020022798A (ko) | 1999-08-13 | 2002-03-27 | 후미에 사토 | 프로스타글란딘 유도체 |
| ATE327751T1 (de) | 2000-01-31 | 2006-06-15 | Pfizer Prod Inc | Verwendung von aktivatoren des prostaglandinrezeptores 4 zur behandlung von akuter oder chronischer niereninsuffizienz |
| US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| FR2825261B1 (fr) | 2001-06-01 | 2003-09-12 | Maco Pharma Sa | Ligne de prelevement du sang placentaire comprenant une poche de rincage |
| WO2003091280A1 (en) * | 2002-04-26 | 2003-11-06 | Kirin Beer Kabushiki Kaisha | Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell or hematopoietic progenitor cell, and dna coding for the same |
| US6747037B1 (en) | 2003-06-06 | 2004-06-08 | Allergan, Inc. | Piperidinyl prostaglandin E analogs |
| US20050176140A1 (en) * | 2004-02-10 | 2005-08-11 | Benedict Daniel J. | Method and apparatus for cell culture using a two liquid phase bioreactor |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| WO2006047476A2 (en) | 2004-10-26 | 2006-05-04 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin ep4 agonists |
| DE102005062741A1 (de) | 2005-12-22 | 2007-06-28 | Bayer Schering Pharma Ag | Fluorene und Carbazole als Liganden des EP2 Rezeptors |
| EP1999255A2 (en) * | 2006-03-24 | 2008-12-10 | The Children's Medical Center Corporation | Method to modulate hematopoietic stem cell growth |
| CN101517070A (zh) * | 2006-05-31 | 2009-08-26 | Styx有限责任公司 | 选择干细胞的方法及其用途 |
| CN101506353A (zh) * | 2006-06-15 | 2009-08-12 | 尼奥斯泰姆公司 | 外周造血干细胞的处理方法 |
| US20110165128A1 (en) * | 2008-03-07 | 2011-07-07 | Columbia University In The City Of New York | Homing in mesenchymal stem cells |
| EP3031907B1 (en) * | 2008-11-06 | 2021-01-06 | Indiana University Research and Technology Corporation | Materials and methods to enhance hematopoietic stem cells engraftment procedures |
| WO2010065601A1 (en) * | 2008-12-03 | 2010-06-10 | Amorcyte, Inc. | Infarct area perfusion-improving compositions and methods of vascular injury repair |
| JP2010193879A (ja) * | 2009-01-27 | 2010-09-09 | Jms Co Ltd | 臍帯血造血幹細胞の増殖制御方法およびその用途 |
| CA2807944C (en) * | 2010-08-12 | 2020-02-18 | Fate Therapeutics, Inc. | Improved hematopoietic stem and progenitor cell therapy |
-
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- 2011-08-12 EP EP17188681.5A patent/EP3278808A1/en not_active Withdrawn
- 2011-08-12 US US13/816,723 patent/US20140030232A1/en not_active Abandoned
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