JP2017523784A5 - - Google Patents
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- JP2017523784A5 JP2017523784A5 JP2017505792A JP2017505792A JP2017523784A5 JP 2017523784 A5 JP2017523784 A5 JP 2017523784A5 JP 2017505792 A JP2017505792 A JP 2017505792A JP 2017505792 A JP2017505792 A JP 2017505792A JP 2017523784 A5 JP2017523784 A5 JP 2017523784A5
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462033045P | 2014-08-04 | 2014-08-04 | |
| US62/033,045 | 2014-08-04 | ||
| US201562164783P | 2015-05-21 | 2015-05-21 | |
| US62/164,783 | 2015-05-21 | ||
| PCT/US2015/042986 WO2016022400A1 (en) | 2014-08-04 | 2015-07-30 | T cell immunotherapy specific for wt-1 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018142600A Division JP2018183175A (ja) | 2014-08-04 | 2018-07-30 | Wt−1に特異的なt細胞免疫治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017523784A JP2017523784A (ja) | 2017-08-24 |
| JP2017523784A5 true JP2017523784A5 (enExample) | 2018-09-06 |
| JP6712261B2 JP6712261B2 (ja) | 2020-06-24 |
Family
ID=53901124
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505792A Active JP6712261B2 (ja) | 2014-08-04 | 2015-07-30 | Wt−1に特異的なt細胞免疫治療 |
| JP2018142600A Pending JP2018183175A (ja) | 2014-08-04 | 2018-07-30 | Wt−1に特異的なt細胞免疫治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018142600A Pending JP2018183175A (ja) | 2014-08-04 | 2018-07-30 | Wt−1に特異的なt細胞免疫治療 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10538572B2 (enExample) |
| EP (1) | EP3177314B1 (enExample) |
| JP (2) | JP6712261B2 (enExample) |
| CN (1) | CN107074970B (enExample) |
| CA (1) | CA2956545A1 (enExample) |
| ES (1) | ES2841274T3 (enExample) |
| WO (1) | WO2016022400A1 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112016011567A2 (pt) * | 2013-11-22 | 2017-10-24 | Hutchinson Fred Cancer Res | receptores de célula t humana de alta afinidade geneticamente modificados. |
| HK1246317A1 (zh) | 2015-03-05 | 2018-09-07 | Fred Hutchinson Cancer Center | 免疫调节融合蛋白及其用途 |
| US10975436B2 (en) | 2016-01-05 | 2021-04-13 | Diamir, Llc | Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders |
| SG11201808797XA (en) | 2016-04-08 | 2018-11-29 | Immunocore Ltd | T cell receptors |
| US10188749B2 (en) | 2016-04-14 | 2019-01-29 | Fred Hutchinson Cancer Research Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
| US11332713B2 (en) | 2016-11-16 | 2022-05-17 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
| KR20250072712A (ko) * | 2016-12-02 | 2025-05-26 | 앤젤레스 테라퓨틱스, 인코포레이티드 | 합성 면역 수용체 및 이의 사용 방법 |
| US11566061B2 (en) | 2017-01-05 | 2023-01-31 | Fred Hutchinson Cancer Center | Systems and methods to improve vaccine efficacy |
| US11603519B2 (en) * | 2017-02-06 | 2023-03-14 | National Cancer Center Japan | T-cell receptor |
| CA3055983A1 (en) * | 2017-03-15 | 2018-09-20 | Fred Hutchinson Cancer Research Center | High affinity mage-a1-specific tcrs and uses thereof |
| JP2020511136A (ja) | 2017-03-17 | 2020-04-16 | フレッド ハッチンソン キャンサー リサーチ センター | 免疫調節性融合タンパク質およびその使用 |
| AU2018259029B2 (en) | 2017-04-24 | 2024-03-07 | Fondazione Centro San Raffaele | TCR and peptides |
| NL2019156B1 (en) * | 2017-06-30 | 2019-01-10 | Academisch Ziekenhuis Leiden H O D N Leids Univ Medisch Centrum | Treatment of haematological malignancies |
| EP4327819A3 (en) * | 2017-06-30 | 2024-05-29 | Academisch Ziekenhuis Leiden (H.O.D.N. Leids Universitair Medisch Centrum) | Treatment of haematological malignancies |
| CN107267463A (zh) * | 2017-08-23 | 2017-10-20 | 安徽惠恩生物科技股份有限公司 | 一种针对乳腺癌的Car‑NK细胞制备方法 |
| ES2915576T3 (es) | 2017-09-19 | 2022-06-23 | Tropic Biosciences Uk Ltd | Modificación de la especificidad de moléculas de ARN no codificantes de plantas para silenciar la expresión génica |
| AU2018345539A1 (en) | 2017-10-03 | 2020-04-16 | Editas Medicine, Inc. | HPV-specific binding molecules |
| CN109777778B (zh) * | 2017-11-14 | 2023-07-18 | 中国科学院广州生物医药与健康研究院 | 一种基因改造的γδT细胞 |
| BR112020011469A2 (pt) | 2017-12-21 | 2020-11-24 | F. Hoffmann-La Roche Ag | anticorpos, molécula de ligação ao antígeno biespecífica, um ou mais polinucleotídeos isolados, um ou mais vetores, célula hospedeira, método para produzir um anticorpo, composição farmacêutica, uso do anticorpo, método de tratamento de uma doença e invenção |
| US12280092B2 (en) | 2018-01-05 | 2025-04-22 | Nantbio, Inc. | Reprogrammed T cell-like NK cells |
| CA3093915A1 (en) | 2018-03-15 | 2019-09-19 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
| BR112020018658A2 (pt) | 2018-03-15 | 2020-12-29 | KSQ Therapeutics, Inc. | Composições de regulação gênica e métodos para imu-noterapia aprimorada |
| DE102018108612A1 (de) * | 2018-03-21 | 2019-09-26 | Immatics US, Inc. | Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen |
| CA3095027A1 (en) * | 2018-04-05 | 2019-10-10 | Juno Therapeutics, Inc. | T cell receptors and engineered cells expressing same |
| JP7630280B2 (ja) * | 2018-04-05 | 2025-02-17 | ジュノー セラピューティクス インコーポレイテッド | 組換え受容体を発現するt細胞、関連ポリヌクレオチド、および方法 |
| US20220403001A1 (en) | 2018-06-12 | 2022-12-22 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| CN112585162B (zh) * | 2018-08-06 | 2025-01-28 | 基因医疗免疫疗法有限责任公司 | Ha-1特异性t细胞受体及其用途 |
| US20210317184A1 (en) * | 2018-09-05 | 2021-10-14 | GlaxoSmithKline Intellectual Property Devolopment Limited | T cell modification |
| US12440546B2 (en) | 2018-10-05 | 2025-10-14 | International Institute Of Cancer Immunology, Inc. | Composition for preventing or treating benign tumor |
| SG11202103571XA (en) | 2018-10-16 | 2021-05-28 | Intellia Therapeutics Inc | Compositions and methods for immunotherapy |
| GB201817821D0 (en) * | 2018-10-31 | 2018-12-19 | Ospedale San Raffaele Srl | TCR and peptides |
| US12448430B2 (en) | 2019-03-11 | 2025-10-21 | Fred Hutchinson Cancer Center | High avidity WT1 T cell receptors and uses thereof |
| CN111714618B (zh) * | 2019-03-22 | 2024-07-12 | 香雪生命科学技术(广东)有限公司 | T细胞和高亲和力pd-1融合蛋白的组合 |
| EP3750547A1 (en) | 2019-06-13 | 2020-12-16 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Modified nk-92 cells, and therapeutic and diagnostic uses thereof |
| WO2021034976A1 (en) * | 2019-08-20 | 2021-02-25 | Fred Hutchinson Cancer Research Center | T-cell immunotherapy specific for wt-1 |
| EP4086281A4 (en) * | 2019-12-30 | 2024-02-14 | China Immunotech (Beijing) Biotechnology Co., Ltd | IMPROVED STAR T CELL RECEPTOR AND ITS APPLICATION |
| CN114106144B (zh) * | 2020-08-27 | 2024-01-26 | 溧阳瑅赛生物医药有限公司 | 识别hla-a*02/wt1靶点的tcr及其应用 |
| WO2022132836A2 (en) | 2020-12-14 | 2022-06-23 | Fred Hutchinson Cancer Research Center | Compositions and methods for cellular immunotherapy |
| JP2024514705A (ja) * | 2021-04-21 | 2024-04-02 | オックスフォード ユニヴァーシティ イノヴェーション リミテッド | 方法及び組成物 |
| EP4340853A4 (en) * | 2021-05-20 | 2025-05-07 | Washington University | Neuroprotective compositions and methods |
| CA3225252A1 (en) | 2021-07-14 | 2023-01-19 | Jordan JARJOUR | Engineered t cell receptors fused to binding domains from antibodies |
| CN113773378B (zh) * | 2021-10-14 | 2023-11-03 | 深圳大学总医院 | T细胞受体及其应用 |
| EP4423144A4 (en) * | 2021-10-29 | 2025-10-08 | Yafei Hou | T CELL RECEPTOR RECOGNIZING THE S37F MUTATION IN CTNNB1 AND ITS USE |
| JP2025513801A (ja) | 2022-04-08 | 2025-04-30 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 多部位受容体及びシグナル伝達複合体 |
| JP2025527575A (ja) | 2022-08-18 | 2025-08-22 | イミュノコア リミテッド | Mage a4に特異的なt細胞受容体融合タンパク質 |
| EP4609202A2 (en) * | 2022-10-28 | 2025-09-03 | Memorial Sloan-Kettering Cancer Center | T cell receptors targeting ewsr1-wt1 fusion protein and uses thereof |
| WO2024178397A2 (en) | 2023-02-24 | 2024-08-29 | Elevatebio Technologies, Inc. | Modified immune effector cells and methods of use |
| WO2025007073A2 (en) | 2023-06-29 | 2025-01-02 | Dispatch Biotherapeutics, Inc. | Synthetic cytokine receptors |
| WO2025240518A1 (en) | 2024-05-14 | 2025-11-20 | Dispatch Biotherapeutics, Inc. | Modified lentiviral transfer plasmids |
| GB202406990D0 (en) * | 2024-05-16 | 2024-07-03 | Univ Oxford Innovation Ltd | T cell receptors and uses thereof |
| WO2025245169A1 (en) | 2024-05-21 | 2025-11-27 | Fred Hutchinson Cancer Center | Immunotherapy cells equipped with a collagen-targeting payload |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| GB9518220D0 (en) | 1995-09-06 | 1995-11-08 | Medical Res Council | Checkpoint gene |
| CN1178956C (zh) | 1998-07-31 | 2004-12-08 | 杉山治夫 | 基于癌抑制基因wt1的产物的癌抗原 |
| GB9823897D0 (en) | 1998-11-02 | 1998-12-30 | Imp College Innovations Ltd | Immunotherapeutic methods and molecules |
| JP4611022B2 (ja) | 2002-09-12 | 2011-01-12 | 株式会社癌免疫研究所 | 癌抗原ペプチド製剤 |
| US7575925B2 (en) | 2002-12-10 | 2009-08-18 | Sunnybrook Health Sciences Centre | Cell preparations comprising cells of the T cell lineage and methods of making and using them |
| ES2556232T3 (es) | 2004-03-31 | 2016-01-14 | International Institute Of Cancer Immunology, Inc. | Péptidos antigénicos del cáncer derivados de WT1 |
| WO2006076678A2 (en) | 2005-01-13 | 2006-07-20 | The Johns Hopkins University | Prostate stem cell antigen vaccines and uses thereof |
| CN102272153B (zh) | 2008-11-24 | 2015-04-15 | 德国慕尼黑亥姆霍兹研究中心健康和环境有限公司 | 高亲和力t细胞受体及其应用 |
| EP2258719A1 (en) | 2009-05-19 | 2010-12-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Multiple target T cell receptor |
| GB0911566D0 (en) * | 2009-07-03 | 2009-08-12 | Immunocore Ltd | T cell receptors |
| US9586997B2 (en) * | 2010-09-20 | 2017-03-07 | Biontech Cell & Gene Therapies Gmbh | Antigen-specific T cell receptors and T cell epitopes |
| CN107557334B (zh) * | 2012-05-03 | 2021-06-25 | 弗雷德哈钦森癌症研究中心 | 增强亲和力的t细胞受体及其制备方法 |
| MX2015000979A (es) * | 2012-07-27 | 2015-11-23 | Univ Illinois | Ingenieria de receptores de celulas t. |
| DK2951202T3 (da) * | 2013-01-29 | 2020-07-13 | Max Delbrueck Centrum Fuer Molekulare Medizin Mdc Berlin Buch | Mage-a1-genkendende bindingsmolekyler med høj aviditet |
-
2015
- 2015-07-30 ES ES15753531T patent/ES2841274T3/es active Active
- 2015-07-30 US US14/813,782 patent/US10538572B2/en active Active
- 2015-07-30 EP EP15753531.1A patent/EP3177314B1/en active Active
- 2015-07-30 WO PCT/US2015/042986 patent/WO2016022400A1/en not_active Ceased
- 2015-07-30 CN CN201580049647.6A patent/CN107074970B/zh active Active
- 2015-07-30 JP JP2017505792A patent/JP6712261B2/ja active Active
- 2015-07-30 CA CA2956545A patent/CA2956545A1/en active Pending
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2018
- 2018-07-30 JP JP2018142600A patent/JP2018183175A/ja active Pending
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