JP2018082713A5 - - Google Patents
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- JP2018082713A5 JP2018082713A5 JP2017251778A JP2017251778A JP2018082713A5 JP 2018082713 A5 JP2018082713 A5 JP 2018082713A5 JP 2017251778 A JP2017251778 A JP 2017251778A JP 2017251778 A JP2017251778 A JP 2017251778A JP 2018082713 A5 JP2018082713 A5 JP 2018082713A5
- Authority
- JP
- Japan
- Prior art keywords
- notch1
- antibody
- nrr
- amino acid
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 13
- 102000001759 Notch1 Receptor Human genes 0.000 claims 12
- 108010029755 Notch1 Receptor Proteins 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 230000011664 signaling Effects 0.000 claims 4
- 239000013598 vector Substances 0.000 claims 4
- 101000978766 Homo sapiens Neurogenic locus notch homolog protein 1 Proteins 0.000 claims 3
- 101100294417 Mus musculus Notch1 gene Proteins 0.000 claims 3
- 102000045609 human NOTCH1 Human genes 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- -1 cetuximab Chemical compound 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 238000005734 heterodimerization reaction Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 239000013642 negative control Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- BFYIZQONLCFLEV-DAELLWKTSA-N Aromasine Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=C)C2=C1 BFYIZQONLCFLEV-DAELLWKTSA-N 0.000 claims 1
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010052360 Colorectal adenocarcinoma Diseases 0.000 claims 1
- VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 claims 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- 239000005517 L01XE01 - Imatinib Substances 0.000 claims 1
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 1
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims 1
- 239000002136 L01XE07 - Lapatinib Substances 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 230000036592 analgesia Effects 0.000 claims 1
- 229960002932 anastrozole Drugs 0.000 claims 1
- YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 230000003474 anti-emetic effect Effects 0.000 claims 1
- 229940125683 antiemetic agent Drugs 0.000 claims 1
- 239000002111 antiemetic agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 229940022399 cancer vaccine Drugs 0.000 claims 1
- 238000009566 cancer vaccine Methods 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 201000002758 colorectal adenoma Diseases 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 1
- 229960001433 erlotinib Drugs 0.000 claims 1
- 229960000255 exemestane Drugs 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 229960002258 fulvestrant Drugs 0.000 claims 1
- 229960002411 imatinib Drugs 0.000 claims 1
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 229960004768 irinotecan Drugs 0.000 claims 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
- 229960004891 lapatinib Drugs 0.000 claims 1
- BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 claims 1
- 229960003881 letrozole Drugs 0.000 claims 1
- HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 229960003787 sorafenib Drugs 0.000 claims 1
- 229960001603 tamoxifen Drugs 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 229960004528 vincristine Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 claims 1
- 229960002066 vinorelbine Drugs 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93307207P | 2007-06-04 | 2007-06-04 | |
| US60/933,072 | 2007-06-04 | ||
| US99464607P | 2007-09-20 | 2007-09-20 | |
| US60/994,646 | 2007-09-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013205246A Division JP2014033675A (ja) | 2007-06-04 | 2013-09-30 | 抗ｎｏｔｃｈ１ｎｒｒ抗体とその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018082713A JP2018082713A (ja) | 2018-05-31 |
| JP2018082713A5 true JP2018082713A5 (https=) | 2018-07-12 |
Family
ID=39735560
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010511175A Expired - Fee Related JP5623272B2 (ja) | 2007-06-04 | 2008-06-03 | 抗ｎｏｔｃｈ１ｎｒｒ抗体とその使用方法 |
| JP2013205246A Withdrawn JP2014033675A (ja) | 2007-06-04 | 2013-09-30 | 抗ｎｏｔｃｈ１ｎｒｒ抗体とその使用方法 |
| JP2016042395A Expired - Fee Related JP6426640B2 (ja) | 2007-06-04 | 2016-03-04 | 抗ｎｏｔｃｈ１ ｎｒｒ抗体とその使用方法 |
| JP2017251778A Pending JP2018082713A (ja) | 2007-06-04 | 2017-12-27 | 抗ｎｏｔｃｈ１ ｎｒｒ抗体とその使用方法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010511175A Expired - Fee Related JP5623272B2 (ja) | 2007-06-04 | 2008-06-03 | 抗ｎｏｔｃｈ１ｎｒｒ抗体とその使用方法 |
| JP2013205246A Withdrawn JP2014033675A (ja) | 2007-06-04 | 2013-09-30 | 抗ｎｏｔｃｈ１ｎｒｒ抗体とその使用方法 |
| JP2016042395A Expired - Fee Related JP6426640B2 (ja) | 2007-06-04 | 2016-03-04 | 抗ｎｏｔｃｈ１ ｎｒｒ抗体とその使用方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US8846871B2 (https=) |
| EP (1) | EP2152748B1 (https=) |
| JP (4) | JP5623272B2 (https=) |
| KR (2) | KR20100021581A (https=) |
| CN (1) | CN101796074B (https=) |
| AR (1) | AR066846A1 (https=) |
| BR (1) | BRPI0811382A2 (https=) |
| CA (1) | CA2687866C (https=) |
| CL (1) | CL2008001634A1 (https=) |
| CO (1) | CO6150200A2 (https=) |
| CR (2) | CR11139A (https=) |
| CY (1) | CY1114690T1 (https=) |
| DK (1) | DK2152748T3 (https=) |
| EC (1) | ECSP099785A (https=) |
| ES (1) | ES2432798T3 (https=) |
| HR (1) | HRP20131107T1 (https=) |
| IL (3) | IL202183A0 (https=) |
| MA (1) | MA31502B1 (https=) |
| MX (1) | MX2009013199A (https=) |
| NZ (1) | NZ581303A (https=) |
| PE (1) | PE20090321A1 (https=) |
| PH (1) | PH12015500550A1 (https=) |
| PL (1) | PL2152748T3 (https=) |
| PT (1) | PT2152748E (https=) |
| RU (1) | RU2476443C2 (https=) |
| SI (1) | SI2152748T1 (https=) |
| TW (1) | TWI458737B (https=) |
| WO (1) | WO2008150525A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| ES2413087T3 (es) | 2006-06-13 | 2013-07-15 | Oncomed Pharmaceuticals, Inc. | Composiciones y métodos para el diagnóstico y tratamiento del cáncer |
| PE20080891A1 (es) | 2006-10-19 | 2008-08-25 | Genentech Inc | Anticuerpos anti-notch3 y composiciones que los comprenden |
| RU2461569C2 (ru) | 2006-10-19 | 2012-09-20 | Дженентек, Инк. | Агонистические антитела против notch3 и их применение для лечения notch3-ассоциированных заболеваний |
| AU2007333805B2 (en) | 2006-12-18 | 2013-07-25 | Genentech, Inc. | Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases |
| WO2008091641A2 (en) | 2007-01-24 | 2008-07-31 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| PE20090321A1 (es) * | 2007-06-04 | 2009-04-20 | Genentech Inc | Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica |
| US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| CN102112490B (zh) | 2008-07-08 | 2014-10-22 | 昂考梅德药品有限公司 | Notch1受体结合剂和其使用方法 |
| AR073717A1 (es) | 2008-10-01 | 2010-11-24 | Genentech Inc | Anticuerpos anti-notch2 de murino y humano, y metodos de uso |
| EP3431501A1 (en) * | 2009-06-18 | 2019-01-23 | Pfizer Inc | Anti notch-1 antibodies |
| US20120129189A1 (en) * | 2009-07-17 | 2012-05-24 | Chulan Kwon | Methods of Controlling Cell Proliferation |
| MX342250B (es) * | 2009-09-30 | 2016-09-22 | Genentech Inc | Tratamiento de cánceres resistentes a antagonistas notch1, mediante el uso de antagonistas notch3. |
| WO2011063237A2 (en) | 2009-11-19 | 2011-05-26 | Oncomed Pharmaceuticals, Inc. | Jagged-binding agents and uses thereof |
| MX2012008085A (es) * | 2010-01-13 | 2012-09-12 | Oncomed Pharm Inc | Agentes de union notch1 y metodos de uso de los mismos. |
| KR20130009760A (ko) | 2010-02-10 | 2013-01-23 | 이뮤노젠 아이엔씨 | Ｃｄ２０ 항체 및 이의 용도 |
| WO2012080891A1 (en) * | 2010-12-15 | 2012-06-21 | Rinat Neuroscience Corp. | Anti-notch-1 antibodies |
| AU2011342799B2 (en) * | 2010-12-15 | 2016-06-09 | Wyeth Llc | Anti-Notch1 antibodies |
| US9663573B2 (en) | 2011-10-05 | 2017-05-30 | Genentech, Inc. | Methods of treating liver conditions using Notch2 antagonists |
| EP2606884A1 (en) | 2011-12-21 | 2013-06-26 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Inhibitors of notch signaling pathway and use thereof in treatment of cancers |
| BR112015003032B1 (pt) | 2012-08-13 | 2023-03-28 | Genentech, Inc | Anticorpos isolados, imunoconjugado, formulação farmacêutica e uso do anticorpo |
| US20150209406A1 (en) | 2012-09-07 | 2015-07-30 | Massachusetts Eye And Ear Infirmary | Methods and compositions for regenerating hair cells and/or supporting cells |
| SG11201507427QA (en) | 2013-03-15 | 2015-10-29 | Genentech Inc | Compositions and methods for diagnosis and treatment of hepatic cancers |
| WO2014172653A2 (en) * | 2013-04-19 | 2014-10-23 | Aveo Pharmaceuticals, Inc. | Anti-notch1 antibodies |
| EA201691610A8 (ru) | 2014-02-12 | 2018-05-31 | Дженентек, Инк. | Анти-jagged1 антитела и способы применения |
| AU2015227247A1 (en) * | 2014-03-07 | 2016-09-15 | Oncomed Pharmaceuticals, Inc. | Methods for treating cancer with Notch 1 antibodies |
| CA2948871A1 (en) * | 2014-05-22 | 2015-11-26 | Fred Hutchinson Cancer Research Center | Lilrb2 and notch-mediated expansion of hematopoietic precursor cells |
| CN106488775A (zh) | 2014-07-11 | 2017-03-08 | 基因泰克公司 | Notch途径抑制 |
| US11370823B2 (en) | 2014-10-29 | 2022-06-28 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
| CA3035081A1 (en) | 2016-09-02 | 2018-03-08 | Dana-Farber Cancer Institute, Inc. | Composition and methods of treating b cell disorders |
| US20180230218A1 (en) | 2017-01-04 | 2018-08-16 | Immunogen, Inc. | Met antibodies and immunoconjugates and uses thereof |
| US10858443B2 (en) | 2017-05-31 | 2020-12-08 | Trustees Of Boston University | Synthetic notch protein for modulating gene expression |
| WO2019148067A1 (en) | 2018-01-26 | 2019-08-01 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss |
| WO2019243523A1 (en) | 2018-06-21 | 2019-12-26 | Cellestia Biotech Ag | Process for making amino diaryl ethers and amino diaryl ethers hydrochloride salts |
| WO2020014306A1 (en) | 2018-07-10 | 2020-01-16 | Immunogen, Inc. | Met antibodies and immunoconjugates and uses thereof |
| US20210253713A1 (en) * | 2018-07-23 | 2021-08-19 | Abexxa Biologics, Inc. | Antibodies targeting a complex comprising non-classical hla-i and neoantigen and their methods of use |
| WO2022046576A1 (en) * | 2020-08-22 | 2022-03-03 | The Broad Institute, Inc. | Pancreatic ductal adenocarcinoma signatures and uses thereof |
| WO2022232488A1 (en) | 2021-04-30 | 2022-11-03 | Celgene Corporation | Combination therapies using an anti-bcma antibody drug conjugate (adc) in combination with a gamma secretase inhibitor (gsi) |
| KR20240074772A (ko) * | 2021-10-10 | 2024-05-28 | 엘릭시론 이뮤노테라퓨틱스 (홍콩) 리미티드 | 항-pd-l1/il-10 융합 단백질을 이용한 질병 치료 방법 |
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