|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4309989A
(en)
|
1976-02-09 |
1982-01-12 |
The Curators Of The University Of Missouri |
Topical application of medication by ultrasound with coupling agent
|
|
FR2374910A1
(fr)
|
1976-10-23 |
1978-07-21 |
Choay Sa |
Preparation a base d'heparine, comprenant des liposomes, procede pour l'obtenir et medicaments contenant de telles preparations
|
|
FR2413974A1
(fr)
|
1978-01-06 |
1979-08-03 |
David Bernard |
Sechoir pour feuilles imprimees par serigraphie
|
|
US4444887A
(en)
|
1979-12-10 |
1984-04-24 |
Sloan-Kettering Institute |
Process for making human antibody producing B-lymphocytes
|
|
US4716111A
(en)
|
1982-08-11 |
1987-12-29 |
Trustees Of Boston University |
Process for producing human antibodies
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
SE448277B
(sv)
|
1985-04-12 |
1987-02-09 |
Draco Ab |
Indikeringsanordning vid en doseringsanordning for lekemedel
|
|
US4824659A
(en)
|
1985-06-07 |
1989-04-25 |
Immunomedics, Inc. |
Antibody conjugates
|
|
US5776093A
(en)
|
1985-07-05 |
1998-07-07 |
Immunomedics, Inc. |
Method for imaging and treating organs and tissues
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
SE453566B
(sv)
|
1986-03-07 |
1988-02-15 |
Draco Ab |
Anordning vid pulverinhalatorer
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US4767402A
(en)
|
1986-07-08 |
1988-08-30 |
Massachusetts Institute Of Technology |
Ultrasound enhancement of transdermal drug delivery
|
|
EP0545913B1
(en)
|
1986-08-18 |
1999-02-24 |
Emisphere Technologies, Inc. |
Delivery systems for pharmacological agents
|
|
US5567610A
(en)
|
1986-09-04 |
1996-10-22 |
Bioinvent International Ab |
Method of producing human monoclonal antibodies and kit therefor
|
|
EP0279582A3
(en)
|
1987-02-17 |
1989-10-18 |
Pharming B.V. |
Dna sequences to target proteins to the mammary gland for efficient secretion
|
|
US4873316A
(en)
|
1987-06-23 |
1989-10-10 |
Biogen, Inc. |
Isolation of exogenous recombinant proteins from the milk of transgenic mammals
|
|
US6010902A
(en)
|
1988-04-04 |
2000-01-04 |
Bristol-Meyers Squibb Company |
Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity
|
|
US5601819A
(en)
|
1988-08-11 |
1997-02-11 |
The General Hospital Corporation |
Bispecific antibodies for selective immune regulation and for selective immune cell binding
|
|
EP0359096B1
(en)
|
1988-09-15 |
1997-11-05 |
The Trustees Of Columbia University In The City Of New York |
Antibodies having modified carbohydrate content and methods of preparation and use
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
DE3909708A1
(de)
|
1989-03-23 |
1990-09-27 |
Boehringer Mannheim Gmbh |
Verfahren zur herstellung bispezifischer antikoerper
|
|
ES2096590T3
(es)
|
1989-06-29 |
1997-03-16 |
Medarex Inc |
Reactivos biespecificos para la terapia del sida.
|
|
US5413923A
(en)
|
1989-07-25 |
1995-05-09 |
Cell Genesys, Inc. |
Homologous recombination for universal donor cells and chimeric mammalian hosts
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
US5580575A
(en)
|
1989-12-22 |
1996-12-03 |
Imarx Pharmaceutical Corp. |
Therapeutic drug delivery systems
|
|
EP1690934A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US5314995A
(en)
|
1990-01-22 |
1994-05-24 |
Oncogen |
Therapeutic interleukin-2-antibody based fusion proteins
|
|
TW212184B
(https=)
|
1990-04-02 |
1993-09-01 |
Takeda Pharm Industry Co Ltd |
|
|
US5229275A
(en)
|
1990-04-26 |
1993-07-20 |
Akzo N.V. |
In-vitro method for producing antigen-specific human monoclonal antibodies
|
|
DE69132709T2
(de)
|
1990-06-29 |
2002-06-20 |
Large Scale Biology Corp., Vacaville |
Melaninproduktion durch transformierte mikroorganismen
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
ATE300615T1
(de)
|
1990-08-29 |
2005-08-15 |
Genpharm Int |
Transgene mäuse fähig zur produktion heterologer antikörper
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
EP0557300B1
(en)
|
1990-10-29 |
1997-11-19 |
Chiron Corporation |
Bispecific antibodies, method of production, and uses thereof
|
|
US5582996A
(en)
|
1990-12-04 |
1996-12-10 |
The Wistar Institute Of Anatomy & Biology |
Bifunctional antibodies and method of preparing same
|
|
US5404871A
(en)
|
1991-03-05 |
1995-04-11 |
Aradigm |
Delivery of aerosol medications for inspiration
|
|
DK0575545T3
(da)
|
1991-03-15 |
2003-09-15 |
Amgen Inc |
Pegylering af polypeptider
|
|
WO1992018629A1
(en)
*
|
1991-04-19 |
1992-10-29 |
Genetics Institute, Inc. |
Recombinant 3f8-type antibodies
|
|
DE4118120A1
(de)
|
1991-06-03 |
1992-12-10 |
Behringwerke Ag |
Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung
|
|
US5637481A
(en)
|
1993-02-01 |
1997-06-10 |
Bristol-Myers Squibb Company |
Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
|
|
WO1993000951A1
(en)
|
1991-07-02 |
1993-01-21 |
Inhale, Inc. |
Method and device for delivering aerosolized medicaments
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
US5932448A
(en)
|
1991-11-29 |
1999-08-03 |
Protein Design Labs., Inc. |
Bispecific antibody heterodimers
|
|
DE4207475A1
(de)
|
1992-03-10 |
1993-09-16 |
Goldwell Ag |
Mittel zum blondieren von menschlichen haaren und verfahren zu dessen herstellung
|
|
ZA932522B
(en)
|
1992-04-10 |
1993-12-20 |
Res Dev Foundation |
Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
|
|
ATE182651T1
(de)
|
1992-06-09 |
1999-08-15 |
Hoppe Ag |
Riegel und türschloss
|
|
AU4829593A
(en)
|
1992-09-23 |
1994-04-12 |
Fisons Plc |
Inhalation device
|
|
AU5322494A
(en)
|
1992-10-02 |
1994-04-26 |
Trustees Of Dartmouth College |
Bispecific reagents for redirected targeting of low density lipoprotein
|
|
CA2147260C
(en)
|
1992-10-19 |
1999-04-13 |
Mark Bernard Mecikalski |
Dry powder inhaler
|
|
US5643252A
(en)
|
1992-10-28 |
1997-07-01 |
Venisect, Inc. |
Laser perforator
|
|
MD1367C2
(ro)
|
1992-11-13 |
2000-11-30 |
Idec Pharmaceuticals Corporation |
Metode de tratament al limfomului celulelor B, anticorpi anti-CD20, hibridom.
|
|
US5849695A
(en)
|
1993-01-13 |
1998-12-15 |
The Regents Of The University Of California |
Parathyroid hormone analogues useful for treatment of osteoporosis and disorders of calcium meatabolism in mammals
|
|
ATE172933T1
(de)
|
1993-01-19 |
1998-11-15 |
Glaxo Group Ltd |
Aerosol-spender und verfahren zu seiner herstellung
|
|
CZ206195A3
(en)
|
1993-02-12 |
1996-04-17 |
Univ Leland Stanford Junior |
Controlled transcription of target genes and other biological materials
|
|
US5514670A
(en)
|
1993-08-13 |
1996-05-07 |
Pharmos Corporation |
Submicron emulsions for delivery of peptides
|
|
DE4337197C1
(de)
|
1993-10-30 |
1994-08-25 |
Biotest Pharma Gmbh |
Verfahren zur selektiven Herstellung von Hybridomazellinien, die monoklonale Antikörper mit hoher Zytotoxizität gegen humanes CD16-Antigen produzieren, sowie Herstellung bispezifischer monoklonaler Antikörper unter Verwendung derartiger monoklonaler Antikörper und des CD30-HRS-3-Antikörpers zur Therapie menschlicher Tumore
|
|
US5814599A
(en)
|
1995-08-04 |
1998-09-29 |
Massachusetts Insitiute Of Technology |
Transdermal delivery of encapsulated drugs
|
|
US5827690A
(en)
|
1993-12-20 |
1998-10-27 |
Genzyme Transgenics Corporatiion |
Transgenic production of antibodies in milk
|
|
JPH09510201A
(ja)
|
1994-03-07 |
1997-10-14 |
メダレツクス・インコーポレーテツド |
臨床的効用を有する二重特異性分子
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US6037453A
(en)
|
1995-03-15 |
2000-03-14 |
Genentech, Inc. |
Immunoglobulin variants
|
|
US5886793A
(en)
|
1995-04-04 |
1999-03-23 |
Oki Data Corporation |
Facsimile machine adapted to reduce risk of data loss
|
|
CA2219361C
(en)
|
1995-04-27 |
2012-02-28 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
EP0823941A4
(en)
|
1995-04-28 |
2001-09-19 |
Abgenix Inc |
HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
|
|
US5730723A
(en)
|
1995-10-10 |
1998-03-24 |
Visionary Medical Products Corporation, Inc. |
Gas pressured needle-less injection device and method
|
|
GB9526100D0
(en)
|
1995-12-20 |
1996-02-21 |
Intersurgical Ltd |
Nebulizer
|
|
JP2000503565A
(ja)
|
1996-01-03 |
2000-03-28 |
グラクソ、グループ、リミテッド |
吸入装置
|
|
WO1997034634A1
(en)
*
|
1996-03-20 |
1997-09-25 |
Sloan-Kettering Institute For Cancer Research |
Single chain fv constructs of anti-ganglioside gd2 antibodies
|
|
ES2169299T3
(es)
|
1996-09-03 |
2002-07-01 |
Gsf Forschungszentrum Umwelt |
Procedimiento para la destruccion de celulas tumorales contaminantes en transplantes de celulas madre utilizando anticuerpos especificos.
|
|
US5916771A
(en)
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
|
US5955186A
(en)
|
1996-10-15 |
1999-09-21 |
Kennametal Inc. |
Coated cutting insert with A C porosity substrate having non-stratified surface binder enrichment
|
|
EP1500329B1
(en)
|
1996-12-03 |
2012-03-21 |
Amgen Fremont Inc. |
Human antibodies that specifically bind human TNF alpha
|
|
US5879681A
(en)
|
1997-02-07 |
1999-03-09 |
Emisphere Technolgies Inc. |
Compounds and compositions for delivering active agents
|
|
US6090381A
(en)
|
1997-02-11 |
2000-07-18 |
Immunomedics, Inc. |
Stimulation of an immune response with antibodies labeled with the . .alpha-galactosyl epitope
|
|
US5921447A
(en)
|
1997-02-13 |
1999-07-13 |
Glaxo Wellcome Inc. |
Flow-through metered aerosol dispensing apparatus and method of use thereof
|
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
BRPI9809391B8
(pt)
|
1997-04-14 |
2021-05-25 |
Amgen Res Munich Gmbh |
processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
IL120943A
(en)
|
1997-05-29 |
2004-03-28 |
Univ Ben Gurion |
A system for administering drugs through the skin
|
|
AU750767B2
(en)
|
1998-01-23 |
2002-07-25 |
Immunex Corporation |
ACPL DNA and polypeptides
|
|
ES2434961T5
(es)
|
1998-04-20 |
2018-01-18 |
Roche Glycart Ag |
Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo
|
|
JP2002532079A
(ja)
|
1998-12-15 |
2002-10-02 |
ザ ブライハム アンド ウイミンズ ホスピタル， インコーポレイテッド |
補体活性化に関連するレクチン補体経路を調節するための方法および産物
|
|
US7273925B1
(en)
|
1998-12-15 |
2007-09-25 |
Brigham And Women's Hospital, Inc. |
Methods and products for regulating lectin complement pathway associated complement activation
|
|
EP1176195B1
(en)
|
1999-04-09 |
2013-05-22 |
Kyowa Hakko Kirin Co., Ltd. |
Method for controlling the activity of immunologically functional molecule
|
|
CA2388245C
(en)
|
1999-10-19 |
2012-01-10 |
Kyowa Kirin Co., Ltd. |
The use of serum-free adapted rat cells for producing heterologous polypeptides
|
|
CA2424977C
(en)
|
2000-10-06 |
2008-03-18 |
Kyowa Hakko Kogyo Co., Ltd. |
Process for purifying antibody
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
ES2639222T5
(es)
|
2000-10-06 |
2023-11-24 |
Kyowa Kirin Co Ltd |
Células que producen unas composiciones de anticuerpo
|
|
US7666424B2
(en)
|
2001-10-17 |
2010-02-23 |
Sloan-Kettering Institute For Cancer Research |
Methods of preparing and using single chain anti-tumor antibodies
|
|
US20030003097A1
(en)
|
2001-04-02 |
2003-01-02 |
Idec Pharmaceutical Corporation |
Recombinant antibodies coexpressed with GnTIII
|
|
HUP0600342A3
(en)
|
2001-10-25 |
2011-03-28 |
Genentech Inc |
Glycoprotein compositions
|
|
AU2002359568B2
(en)
|
2001-12-03 |
2008-02-21 |
Alexion Pharmaceuticals, Inc. |
Hybrid antibodies
|
|
JP2006516241A
(ja)
|
2002-09-20 |
2006-06-29 |
マクギル ユニヴァーシティー |
Ｇｄ２リガンド
|
|
CN100432105C
(zh)
*
|
2002-12-17 |
2008-11-12 |
默克专利有限公司 |
与gd2结合的小鼠14.18抗体的人源化抗体(h14.18)以及其与il-2的融合
|
|
EP1625165A2
(en)
|
2003-04-03 |
2006-02-15 |
Protein Design Labs, Inc. |
Inhibitors of integrin alpha5beta1 and their use for the control of tissue granulation
|
|
US20040220084A1
(en)
|
2003-05-02 |
2004-11-04 |
Jasbir Sandhu |
Methods for nucleic acid delivery
|
|
PE20050925A1
(es)
|
2003-11-10 |
2005-11-29 |
Schering Corp |
Anticuerpo recombinante humanizado anti-interleuquina 10
|
|
PL1706428T3
(pl)
*
|
2004-01-22 |
2010-02-26 |
Merck Patent Gmbh |
Przeciwciała przeciwnowotworowe o zredukowanym wiązaniu dopełniacza
|
|
CN103172731A
(zh)
|
2004-07-15 |
2013-06-26 |
赞科股份有限公司 |
优化的Fc变体
|
|
US20090304721A1
(en)
|
2005-09-07 |
2009-12-10 |
Medlmmune, Inc |
Toxin conjugated eph receptor antibodies
|
|
FR2906808B1
(fr)
*
|
2006-10-10 |
2012-10-05 |
Univ Nantes |
Utilisation d'anticorps monoclonaux specifiques de la forme o-acetylee du ganglioside gd2 dans le traitement de certains cancers
|
|
MY153074A
(en)
|
2008-08-14 |
2014-12-31 |
Teva Pharmaceuticals Australia Pty Ltd |
Anti-il-12/11-23 antibodies
|
|
DK3323830T3
(da)
|
2010-06-19 |
2023-09-25 |
Memorial Sloan Kettering Cancer Center |
Anti-gd2 antibodies
|
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
|
RU2714733C2
(ru)
*
|
2013-03-15 |
2020-02-19 |
Мемориал Слоан-Кеттеринг Кэнсер Сентер |
Технологии мультимеризации
|
|
CN105705165B
(zh)
|
2013-03-15 |
2020-04-24 |
纪念斯隆-凯特琳癌症中心 |
高亲和力抗gd2抗体
|
|
US11392902B2
(en)
|
2017-06-06 |
2022-07-19 |
United Parcel Service Of America, Inc. |
Systems, methods, apparatuses and computer program products for providing notification of items for pickup and delivery
|