|
EP2928474B1
(en)
|
2012-12-07 |
2018-11-14 |
ChemoCentryx, Inc. |
Diazole lactams
|
|
EA034496B1
(ru)
|
2014-09-11 |
2020-02-13 |
Бристол-Майерс Сквибб Компани |
Макроциклические ингибиторы белок/белковых взаимодействий pd-1/pd-l1 и cd80(b7-1)/pd-l1
|
|
US9732119B2
(en)
|
2014-10-10 |
2017-08-15 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US9856292B2
(en)
|
2014-11-14 |
2018-01-02 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
AU2015353573B2
(en)
|
2014-11-25 |
2020-09-03 |
Bristol-Myers Squibb Company |
Novel PD-L1 binding polypeptides for imaging
|
|
MX385081B
(es)
|
2014-11-25 |
2025-03-14 |
Bristol Myers Squibb Co |
Métodos y composiciones para radioetiquetado con 18f de productos biológicos.
|
|
US9861680B2
(en)
|
2014-12-18 |
2018-01-09 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US9944678B2
(en)
|
2014-12-19 |
2018-04-17 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US20160222060A1
(en)
|
2015-02-04 |
2016-08-04 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US9809625B2
(en)
|
2015-03-18 |
2017-11-07 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
PT3297438T
(pt)
|
2015-05-21 |
2022-01-25 |
Chemocentryx Inc |
Moduladores de ccr2
|
|
US10143746B2
(en)
|
2016-03-04 |
2018-12-04 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US10358463B2
(en)
|
2016-04-05 |
2019-07-23 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
CN109310677A
(zh)
|
2016-04-07 |
2019-02-05 |
凯莫森特里克斯股份有限公司 |
通过联合施用ccr1拮抗剂与pd-1抑制剂或pd-l1拮抗剂降低肿瘤负荷
|
|
TWI808055B
(zh)
|
2016-05-11 |
2023-07-11 |
美商滬亞生物國際有限公司 |
Hdac 抑制劑與 pd-1 抑制劑之組合治療
|
|
TWI794171B
(zh)
|
2016-05-11 |
2023-03-01 |
美商滬亞生物國際有限公司 |
Hdac抑制劑與pd-l1抑制劑之組合治療
|
|
MX2018014028A
(es)
|
2016-05-19 |
2019-04-04 |
Squibb Bristol Myers Co |
Inmunomoduladores de produccion de imagenes de tomografia por emision de positrones (pet).
|
|
EP3463486A1
(en)
*
|
2016-06-01 |
2019-04-10 |
Bristol-Myers Squibb Company |
Pet imaging with pd-l1 binding polypeptides
|
|
US10994033B2
(en)
|
2016-06-01 |
2021-05-04 |
Bristol-Myers Squibb Company |
Imaging methods using 18F-radiolabeled biologics
|
|
FI3526323T3
(fi)
|
2016-10-14 |
2023-06-06 |
Prec Biosciences Inc |
Hepatiitti B -viruksen genomissa oleville tunnistussekvensseille spesifisiä muokattuja meganukleaaseja
|
|
WO2018085750A2
(en)
*
|
2016-11-07 |
2018-05-11 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
JP7105235B2
(ja)
|
2016-12-01 |
2022-07-22 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
免疫petイメージングのための放射性標識された抗pd-l1抗体
|
|
US20190336533A1
(en)
|
2016-12-28 |
2019-11-07 |
Green Cross Lab Cell Corporation |
Chimeric antigen receptor and natural killer cells expressing same
|
|
CN110997698B
(zh)
*
|
2017-06-23 |
2023-12-26 |
百时美施贵宝公司 |
充当pd-1拮抗剂的免疫调节剂
|
|
CN111712242B
(zh)
|
2017-09-25 |
2023-11-24 |
凯莫森特里克斯股份有限公司 |
使用趋化因子受体2(ccr2)拮抗剂和pd-1/pd-l1抑制剂的联合治疗
|
|
EP3692053A1
(en)
|
2017-10-03 |
2020-08-12 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US11649294B2
(en)
|
2017-11-14 |
2023-05-16 |
GC Cell Corporation |
Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same
|
|
JP7386796B2
(ja)
|
2017-11-14 |
2023-11-27 |
グリーン クロス ラボ セル コーポレーション |
抗-her2抗体又はその抗原結合フラグメント、及びこれを含むキメラ抗原受容体
|
|
AU2018392212B9
(en)
|
2017-12-20 |
2021-03-18 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein
|
|
WO2019123340A1
(en)
|
2017-12-20 |
2019-06-27 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
|
AU2019205784B2
(en)
|
2018-01-08 |
2024-07-25 |
Chemocentryx, Inc. |
Methods of treating solid tumors with CCR2 antagonists
|
|
US20190269664A1
(en)
|
2018-01-08 |
2019-09-05 |
Chemocentryx, Inc. |
Methods of treating solid tumors with ccr2 antagonists
|
|
KR20200116130A
(ko)
*
|
2018-02-01 |
2020-10-08 |
지앙수 헨그루이 메디슨 컴퍼니 리미티드 |
인간 인슐린 유사체의 아실화된 유도체를 포함하는 약학 조성물 및 이의 제조 방법
|
|
US20210048439A1
(en)
*
|
2018-02-02 |
2021-02-18 |
University Of Washington |
Caged amino acids for controlled metabolic incorporation and methods of use
|
|
CN108409830B
(zh)
*
|
2018-02-05 |
2021-04-23 |
郑州大学 |
一种人pd-1蛋白胞外段亲和环肽c8及其应用
|
|
KR102708681B1
(ko)
|
2018-02-13 |
2024-09-26 |
길리애드 사이언시즈, 인코포레이티드 |
Pd-1/pd-l1 억제제
|
|
CA3091142C
(en)
|
2018-02-26 |
2023-04-11 |
Gilead Sciences, Inc. |
Substituted pyrrolizine compounds and uses thereof
|
|
WO2019195181A1
(en)
|
2018-04-05 |
2019-10-10 |
Gilead Sciences, Inc. |
Antibodies and fragments thereof that bind hepatitis b virus protein x
|
|
TW202005654A
(zh)
|
2018-04-06 |
2020-02-01 |
捷克科學院有機化學與生物化學研究所 |
2,2,─環二核苷酸
|
|
TWI833744B
(zh)
|
2018-04-06 |
2024-03-01 |
捷克科學院有機化學與生物化學研究所 |
3'3'-環二核苷酸
|
|
TWI818007B
(zh)
|
2018-04-06 |
2023-10-11 |
捷克科學院有機化學與生物化學研究所 |
2'3'-環二核苷酸
|
|
US11142750B2
(en)
|
2018-04-12 |
2021-10-12 |
Precision Biosciences, Inc. |
Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome
|
|
EP3781556B1
(en)
|
2018-04-19 |
2025-06-18 |
Gilead Sciences, Inc. |
Pd-1/pd-l1 inhibitors
|
|
WO2019211799A1
(en)
|
2018-05-03 |
2019-11-07 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide
|
|
WO2019230919A1
(ja)
|
2018-05-31 |
2019-12-05 |
小野薬品工業株式会社 |
免疫チェックポイント阻害薬の有効性判定バイオマーカー
|
|
EP3810109B1
(en)
|
2018-05-31 |
2024-08-07 |
Peloton Therapeutics, Inc. |
Compounds and compositions for inhibiting cd73
|
|
PL3820572T3
(pl)
|
2018-07-13 |
2024-02-26 |
Gilead Sciences, Inc. |
Inhibitory pd-1/pd-l1
|
|
WO2020028097A1
(en)
|
2018-08-01 |
2020-02-06 |
Gilead Sciences, Inc. |
Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid
|
|
TWI855000B
(zh)
|
2018-10-11 |
2024-09-11 |
日商小野藥品工業股份有限公司 |
Sting促效化合物
|
|
CA3117199C
(en)
|
2018-10-24 |
2024-03-19 |
Gilead Sciences, Inc. |
Pd-1/pd-l1 inhibitors
|
|
CR20210215A
(es)
|
2018-10-31 |
2021-06-17 |
Gilead Sciences Inc |
Compuestos de 6-azabencimidazol sustituidos como inhibidores de hpk1
|
|
CN117105933A
(zh)
|
2018-10-31 |
2023-11-24 |
吉利德科学公司 |
具有hpk1抑制活性的取代的6-氮杂苯并咪唑化合物
|
|
WO2020178768A1
(en)
|
2019-03-07 |
2020-09-10 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
|
|
KR102808642B1
(ko)
|
2019-03-07 |
2025-05-14 |
인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. |
3'3'-사이클릭 다이뉴클레오티드 및 이의 프로드럭
|
|
CA3129022C
(en)
|
2019-03-07 |
2023-08-01 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2'3'-cyclic dinucleotides and prodrugs thereof
|
|
KR20210146348A
(ko)
|
2019-03-28 |
2021-12-03 |
브리스톨-마이어스 스큅 컴퍼니 |
종양을 치료하는 방법
|
|
CN113891748A
(zh)
|
2019-03-28 |
2022-01-04 |
百时美施贵宝公司 |
治疗肿瘤的方法
|
|
TWI751517B
(zh)
|
2019-04-17 |
2022-01-01 |
美商基利科學股份有限公司 |
類鐸受體調節劑之固體形式
|
|
TWI751516B
(zh)
|
2019-04-17 |
2022-01-01 |
美商基利科學股份有限公司 |
類鐸受體調節劑之固體形式
|
|
US20220251141A1
(en)
*
|
2019-05-21 |
2022-08-11 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US11453681B2
(en)
|
2019-05-23 |
2022-09-27 |
Gilead Sciences, Inc. |
Substituted eneoxindoles and uses thereof
|
|
US20220233691A1
(en)
|
2019-05-30 |
2022-07-28 |
Bristol-Myers Squibb Company |
Cell localization signature and combination therapy
|
|
WO2020243563A1
(en)
|
2019-05-30 |
2020-12-03 |
Bristol-Myers Squibb Company |
Multi-tumor gene signatures for suitability to immuno-oncology therapy
|
|
KR20220016155A
(ko)
|
2019-05-30 |
2022-02-08 |
브리스톨-마이어스 스큅 컴퍼니 |
면역-종양학 (i-o) 요법에 적합한 대상체를 확인하는 방법
|
|
PH12022550244A1
(en)
|
2019-08-05 |
2022-12-12 |
Nat Cancer Ct |
Biomarkers for determining the efficacy of immune checkpoint inhibitors
|
|
EP4017476A1
(en)
|
2019-08-19 |
2022-06-29 |
Gilead Sciences, Inc. |
Pharmaceutical formulations of tenofovir alafenamide
|
|
CA3153777A1
(en)
|
2019-09-22 |
2021-03-25 |
Bristol-Myers Squibb Company |
Quantitative spatial profiling for lag-3 antagonist therapy
|
|
SI4037708T1
(sl)
|
2019-09-30 |
2025-01-31 |
Gilead Sciences, Inc. |
Cepiva proti hbv in postopki zdravljenja hbv
|
|
BR112022008191A2
(pt)
|
2019-11-08 |
2022-07-12 |
Bristol Myers Squibb Co |
Terapia com antagonista de lag-3 para melanoma
|
|
DK4069729T3
(da)
|
2019-12-06 |
2025-04-07 |
Prec Biosciences Inc |
Optimerede, modificerede meganukleaser med specificitet for en genkendelsessekvens i hepatitis b-virusgenomet
|
|
KR20220122752A
(ko)
|
2020-01-06 |
2022-09-02 |
브리스톨-마이어스 스큅 컴퍼니 |
면역조정제
|
|
CN115485288A
(zh)
*
|
2020-03-16 |
2022-12-16 |
百时美施贵宝公司 |
免疫调节剂
|
|
EP4121437A1
(en)
|
2020-03-20 |
2023-01-25 |
Gilead Sciences, Inc. |
Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same
|
|
KR20220161407A
(ko)
|
2020-03-30 |
2022-12-06 |
브리스톨-마이어스 스큅 컴퍼니 |
면역조정제
|
|
JPWO2021206158A1
(cg-RX-API-DMAC10.html)
|
2020-04-10 |
2021-10-14 |
|
|
|
EP4134134A4
(en)
|
2020-04-10 |
2023-12-27 |
ONO Pharmaceutical Co., Ltd. |
STING AGONISTIC COMPOUND
|
|
EP4146670A1
(en)
*
|
2020-05-08 |
2023-03-15 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
CN113754736A
(zh)
*
|
2020-06-02 |
2021-12-07 |
南京礼威生物医药有限公司 |
含酰肼结构的pd-l1环肽抑制剂
|
|
KR20230058442A
(ko)
|
2020-08-28 |
2023-05-03 |
브리스톨-마이어스 스큅 컴퍼니 |
간세포성 암종에 대한 lag-3 길항제 요법
|
|
EP4204453A1
(en)
|
2020-08-31 |
2023-07-05 |
Bristol-Myers Squibb Company |
Cell localization signature and immunotherapy
|
|
CA3193244A1
(en)
|
2020-09-22 |
2022-03-31 |
Geoffrey Martin Lynn |
Compositions and methods of manufacturing amphiphilic block copolymers that form nanoparticles in situ
|
|
IL301907A
(en)
|
2020-10-23 |
2023-06-01 |
Bristol Myers Squibb Co |
Lag-3 antagonist therapy for lung cancer
|
|
WO2022120179A1
(en)
|
2020-12-03 |
2022-06-09 |
Bristol-Myers Squibb Company |
Multi-tumor gene signatures and uses thereof
|
|
KR20230160321A
(ko)
*
|
2021-03-24 |
2023-11-23 |
브리스톨-마이어스 스큅 컴퍼니 |
면역조정제
|
|
EP4313127A1
(en)
|
2021-03-29 |
2024-02-07 |
Juno Therapeutics, Inc. |
Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy
|
|
US20240269142A1
(en)
|
2021-05-13 |
2024-08-15 |
Gilead Sciences, Inc. |
COMBINATION OF A TLR8 MODULATING COMPOUND AND ANTI-HBV siRNA THERAPEUTICS
|
|
CA3222269A1
(en)
|
2021-06-11 |
2022-12-15 |
Gilead Sciences, Inc. |
Combination mcl-1 inhibitors with anti-cancer agents
|
|
KR20240019330A
(ko)
|
2021-06-11 |
2024-02-14 |
길리애드 사이언시즈, 인코포레이티드 |
Mcl-1 저해제와 항체 약물 접합체의 조합
|
|
JP7686086B2
(ja)
|
2021-06-23 |
2025-05-30 |
ギリアード サイエンシーズ, インコーポレイテッド |
ジアシルグリエルコール(diacylglyercol)キナーゼ調節化合物
|
|
WO2022271684A1
(en)
|
2021-06-23 |
2022-12-29 |
Gilead Sciences, Inc. |
Diacylglyercol kinase modulating compounds
|
|
CN117396478A
(zh)
|
2021-06-23 |
2024-01-12 |
吉利德科学公司 |
二酰基甘油激酶调节化合物
|
|
EP4359411A1
(en)
|
2021-06-23 |
2024-05-01 |
Gilead Sciences, Inc. |
Diacylglyercol kinase modulating compounds
|
|
CN113461519A
(zh)
*
|
2021-08-12 |
2021-10-01 |
浙江泽瑞生物医药有限公司 |
一种十八烷二酸单叔丁酯-pfp的制备方法
|
|
EP4419540A1
(en)
*
|
2021-10-20 |
2024-08-28 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
IL309227A
(en)
|
2021-10-29 |
2024-02-01 |
Bristol Myers Squibb Co |
LAG-3 antagonist therapy for hematological cancer
|
|
WO2023122945A1
(zh)
*
|
2021-12-28 |
2023-07-06 |
知和(山东)大药厂有限公司 |
环状多肽化合物及其用途
|
|
US20250215076A1
(en)
|
2022-01-26 |
2025-07-03 |
Bristol-Myers Squibb Company |
Combination therapy for hepatocellular carcinoma
|
|
US20250213548A1
(en)
|
2022-03-17 |
2025-07-03 |
Bristol-Myers Squibb Company |
Pharmaceutical compositions for improving oral bioavailability
|
|
CN119731651A
(zh)
|
2022-04-08 |
2025-03-28 |
百时美施贵宝公司 |
三级淋巴结构的机器学习标识、分类和量化
|
|
JP2025523048A
(ja)
*
|
2022-07-15 |
2025-07-17 |
ウニヴェルシテイト ユトレヒト ホールディング ベー.フェー. |
抗ウイルス環状化合物
|
|
EP4578876A1
(en)
|
2022-08-23 |
2025-07-02 |
ONO Pharmaceutical Co., Ltd. |
Bispecific antibody
|
|
WO2024059472A1
(en)
*
|
2022-09-12 |
2024-03-21 |
Bristol-Myers Squibb Company |
Macrocyclic immunomodulators
|
|
KR20250123912A
(ko)
|
2022-12-21 |
2025-08-18 |
브리스톨-마이어스 스큅 컴퍼니 |
폐암에 대한 병용 요법
|
|
WO2024196790A1
(en)
|
2023-03-17 |
2024-09-26 |
Bristol-Myers Squibb Company |
Pharmaceutical compositions for improving oral bioavailability
|
|
WO2024196952A1
(en)
|
2023-03-20 |
2024-09-26 |
Bristol-Myers Squibb Company |
Tumor subtype assessment for cancer therapy
|
|
WO2025240242A1
(en)
|
2024-05-13 |
2025-11-20 |
Gilead Sciences, Inc. |
Combination therapies with ribavirin
|
|
WO2025240243A1
(en)
|
2024-05-13 |
2025-11-20 |
Gilead Sciences, Inc. |
Combination therapies with bulevirtide and an inhibitory nucleic acid targeting hepatitis b virus
|
|
WO2025240244A1
(en)
|
2024-05-13 |
2025-11-20 |
Gilead Sciences, Inc. |
Combination therapies comprising bulevirtide and lonafarnib for use in the treatment of hepatitis d virus infection
|
|
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